Spill-Overs from Good Jobs

Does attracting or losing jobs in high paying sectors have important spill-over effects on wages in other sectors? The answer to this question is central to a proper assessment of many trade and industrial policies. In this paper, we explore this question by examining how predictable changes in industrial composition in favor of high paying sectors affect wage determination at the industry-city level. In particular, we use US Census data over the years 1970 to 2000 to quantify the relationship between changes in industry-specific city-level wages and changes in industrial composition. Our finding is that the spill-over (i.e., general equilibrium) effects associated with changes in the fraction of jobs in high paying sectors are very substantial and persistent. Our point estimates indicate that the total effect on average wages of a change in industrial composition that favors high paying sectors is about 3.5 times greater than that obtained from a commonly used composition-adjustment approach which neglects general equilibrium effects. We interpret our results as being most likely driven by a variant of the mechanism recently emphasized in the heterogenous firm literature whereby changes in competitive pressure cause a reallocation of employment toward the most efficient firms.

The origin of the E+ transition in GaAsN alloys

Optical properties of GaAsN system with nitrogen concentrations in the range of 0.9-3.7% are studied by full-potential LAPW method in a supercell approach. The E+ transition is identified by calculating the imaginary part of the dielectric function. The evolution of the energy of this transition with nitrogen concentration is studied and the origin of this transition is identified by analyzing the contributions to the dielectric function from different band combinations. The L_1c-derived states are shown to play an important role in the formation of the E+ transition, which was also suggested by recent experiments. At the same time the nitrogen-induced modification of the first conduction band of the host compound are also found to contribute significantly to the E+ transition. Further, the study of several model supercells demonstrated the significant influence of the nitrogen potential on the optical properties of the GaAsN system.Comment: 5 pages, 3 figure

Crew Motion and the Dynamic Environment of Spaceborne Experiments

Analytical study of crew motion on dynamic environment of orbiting laboratorie

Constructing the determinant sphere using a Tate twist

Following an idea of Hopkins, we construct a model of the determinant sphere $S\langle det \rangle$ in the category of $K(n)$-local spectra. To do this, we build a spectrum which we call the Tate sphere $S(1)$. This is a $p$-complete sphere with a natural continuous action of $\mathbb{Z}_p^\times$. The Tate sphere inherits an action of $\mathbb{G}_n$ via the determinant and smashing Morava $E$-theory with $S(1)$ has the effect of twisting the action of $\mathbb{G}_n$. A large part of this paper consists of analyzing continuous $\mathbb{G}_n$-actions and their homotopy fixed points in the setup of Devinatz and Hopkins

The topological modular forms of RP2\mathbb{R}P^2 and RP2∧CP2\mathbb{R}P^2 \wedge \mathbb{C}P^2

In this paper, we study the elliptic spectral sequence computing $tmf_*(\mathbb{R} P^2)$ and $tmf_* (\mathbb{R} P^2 \wedge \mathbb{C} P^2)$. Specifically, we compute all differentials and resolve exotic extensions by 2, $\eta$, and $\nu$. For $tmf_* (\mathbb{R} P^2 \wedge \mathbb{C} P^2)$, we also compute the effect of the $v_1$-self maps of $\mathbb{R} P^2 \wedge \mathbb{C} P^2$ on $tmf$-homology

Actinobacillus pleuropneumoniae induces SJPL cell cycle arrest in G2/M-phase and inhibits porcine reproductive and respiratory syndrome virus replication

Background: Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most important pathogens in the swine industry and causes important economic losses. No effective antiviral drugs against it are commercially available. We recently reported that the culture supernatant of Actinobacillus pleuropneumoniae, the porcine pleuropneumonia causative agent, has an antiviral activity in vitro against PRRSV in SJPL cells. Objectives of this study were (i) to identify the mechanism behind the antiviral activity displayed by A. pleuropneumoniae and (ii) to characterize the active molecules present in the bacterial culture supernatant. Methods: Antibody microarray analysis was used in order to point out cellular pathways modulated by the A. pleuropneumoniae supernatant. Subsequent, flow cytometry analysis and cell cycle inhibitors were used to confirm antibody microarray data and to link them to the antiviral activity of the A. pleuropneumoniae supernatant. Finally, A. pleuropneumoniae supernatant characterization was partially achieved using mass spectrometry. Results: Using antibody microarray, we observed modulations in G2/M-phase cell cycle regulation pathway when SJPL cells were treated with A. pleuropneumoniae culture supernatant. These modulations were confirmed by a cell cycle arrest at the G2/M-phase when cells were treated with the A. pleuropneumoniae culture supernatant. Furthermore, two G2/M-phase cell cycle inhibitors demonstrated the ability to inhibit PRRSV infection, indicating a potential key role for PRRSV infection. Finally, mass spectrometry lead to identify two molecules (m/z 515.2 and m/z 663.6) present only in the culture supernatant. Conclusions: We demonstrated for the first time that A. pleuropneumoniae is able to disrupt SJPL cell cycle resulting in inhibitory activity against PRRSV. Furthermore, two putative molecules were identified from the culture supernatant. This study highlighted the cell cycle importance for PRRSV and will allow the development of new prophylactic or therapeutic approaches against PRRSV