1,215 research outputs found
A Meta-Analysis of Genome-Wide Association Scans Identifies IL18RAP, PTPN2, TAGAP, and PUS10 As Shared Risk Loci for Crohn's Disease and Celiac Disease
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Treating patients as persons : a capabilities approach to support delivery of person-centered care
Peer reviewedPublisher PD
Spatio-temporal dynamics and plastic flow of vortices in superconductors with periodic arrays of pinning sites
We present simulations of flux-gradient-driven superconducting rigid vortices
interacting with square and triangular arrays of columnar pinning sites in an
increasing external magnetic field. These simulations allow us to
quantitatively relate spatio-temporal microscopic information of the vortex
lattice with typically measured macroscopic quantities, such as the
magnetization . The flux lattice does not become completely commensurate
with the pinning sites throughout the sample at the magnetization matching
peaks, but forms a commensurate lattice in a region close to the edge of the
sample. Matching fields related to unstable vortex configurations do not
produce peaks in . We observe a variety of evolving complex flux
profiles, including flat terraces or plateaus separated by winding
current-carrying strings and, near the peaks in , plateaus only in
certain regions, which move through the sample as the field increases
Magnetic properties of submicron Co islands and their use as artificial pinning centers
We report on the magnetic properties of elongated submicron magnetic islands
and their influence on a superconducting film. The magnetic properties were
studied by magnetization hysteresis loop measurements and scanning-force
microscopy. In the as-grown state, the islands have a magnetic structure
consisting of two antiparallel domains. This stable domain configuration has
been directly visualized as a 2x2-checkerboard pattern by magnetic-force
microscopy. In the remanent state, after magnetic saturation along the easy
axis, all islands have a single-domain structure with the magnetic moment
oriented along the magnetizing field direction. Periodic lattices of these Co
islands act as efficient artificial pinning arrays for the flux lines in a
superconducting Pb film deposited on top of the Co islands. The influence of
the magnetic state of the dots on their pinning efficiency is investigated in
these films, before and after the Co dots are magnetized.Comment: 6 pages including figure
Investigating human audio-visual object perception with a combination of hypothesis-generating and hypothesis-testing fMRI analysis tools
Primate multisensory object perception involves distributed brain regions. To investigate the network character of these regions of the human brain, we applied data-driven group spatial independent component analysis (ICA) to a functional magnetic resonance imaging (fMRI) data set acquired during a passive audio-visual (AV) experiment with common object stimuli. We labeled three group-level independent component (IC) maps as auditory (A), visual (V), and AV, based on their spatial layouts and activation time courses. The overlap between these IC maps served as definition of a distributed network of multisensory candidate regions including superior temporal, ventral occipito-temporal, posterior parietal and prefrontal regions. During an independent second fMRI experiment, we explicitly tested their involvement in AV integration. Activations in nine out of these twelve regions met the max-criterion (A < AV > V) for multisensory integration. Comparison of this approach with a general linear model-based region-of-interest definition revealed its complementary value for multisensory neuroimaging. In conclusion, we estimated functional networks of uni- and multisensory functional connectivity from one dataset and validated their functional roles in an independent dataset. These findings demonstrate the particular value of ICA for multisensory neuroimaging research and using independent datasets to test hypotheses generated from a data-driven analysis
Social Interactions vs Revisions, What is important for Promotion in Wikipedia?
In epistemic community, people are said to be selected on their knowledge
contribution to the project (articles, codes, etc.) However, the socialization
process is an important factor for inclusion, sustainability as a contributor,
and promotion. Finally, what does matter to be promoted? being a good
contributor? being a good animator? knowing the boss? We explore this question
looking at the process of election for administrator in the English Wikipedia
community. We modeled the candidates according to their revisions and/or social
attributes. These attributes are used to construct a predictive model of
promotion success, based on the candidates's past behavior, computed thanks to
a random forest algorithm.
Our model combining knowledge contribution variables and social networking
variables successfully explain 78% of the results which is better than the
former models. It also helps to refine the criterion for election. If the
number of knowledge contributions is the most important element, social
interactions come close second to explain the election. But being connected
with the future peers (the admins) can make the difference between success and
failure, making this epistemic community a very social community too
Continental weathering and recovery from ocean nutrient stress during the Early Triassic Biotic Crisis
Following the latest Permian extinction âŒ252 million years ago, normal marine and terrestrial
ecosystems did not recover for another 5-9 million years. The driver(s) for the Early Triassic
biotic crisis, marked by high atmospheric CO2 concentration, extreme ocean warming, and
marine anoxia, remains unclear. Here we constrain the timing of authigenic K-bearing mineral
formation extracted from supergene weathering profiles of NW-Pangea by Argon geochronology,
to demonstrate that an accelerated hydrological cycle causing intense chemical
alteration of the continents occurred between âŒ254 and 248 Ma, and continued throughout
the Triassic period. We show that enhanced ocean nutrient supply from this intense continental
weathering did not trigger increased ocean productivity during the Early Triassic
biotic crisis, due to strong thermal ocean stratification off NW Pangea. Nitrogen isotope
constraints suggest, instead, that full recovery from ocean nutrient stress, despite some brief
amelioration âŒ1.5 million years after the latest Permian extinction, did not commence until
climate cooling revitalized the global upwelling systems and ocean mixing âŒ10 million years
after the mass extinction
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