3,982 research outputs found
Spin orbit alignment for KELT-7b and HAT-P-56b via Doppler tomography with TRES
We present Doppler tomographic analyses for the spectroscopic transits of
KELT-7b and HAT-P-56b, two hot-Jupiters orbiting rapidly rotating F-dwarf host
stars. These include analyses of archival TRES observations for KELT-7b, and a
new TRES transit observation of HAT-P-56b. We report spin-orbit aligned
geometries for KELT-7b (2.7 +/- 0.6 deg) and HAT-P-56b (8 +/- 2 deg). The host
stars KELT-7 and HAT-P-56 are among some of the most rapidly rotating
planet-hosting stars known. We examine the tidal re-alignment model for the
evolution of the spin-orbit angle in the context of the spin rates of these
stars. We find no evidence that the rotation rates of KELT-7 and HAT-P-56 have
been modified by star-planet tidal interactions, suggesting that the spin-orbit
angle of systems around these hot stars may represent their primordial
configuration. In fact, KELT-7 and HAT-P-56 are two of three systems in
super-synchronous, spin-orbit aligned states, where the rotation periods of the
host stars are faster than the orbital periods of the planets.Comment: 9 pages, accepted for publication in MNRA
Nuclear reactor power as applied to a space-based radar mission
The SP-100 Project was established to develop and demonstrate feasibility of a space reactor power system (SRPS) at power levels of 10's of kilowatts to a megawatt. To help determine systems requirements for the SRPS, a mission and spacecraft were examined which utilize this power system for a space-based radar to observe moving objects. Aspects of the mission and spacecraft bearing on the power system were the primary objectives of this study; performance of the radar itself was not within the scope. The study was carried out by the Systems Design Audit Team of the SP-100 Project
Nurses\u27 Alumnae Association Bulletin - Volume 6 Number 10
Financial Report
Calendar of Events
Attention, Class of 1945!
Miss Shafer Retires
Review of the Alumnae Association Meetings
Institutional Staff Nurses\u27 Section
Report of Staff Activites - 1948-1949
The Staff
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Pop-Up Toaster
It\u27s Not Too Soon
Any White Elephants?
Private Duty Section
The Jefferson Hospital Private Duty Nurses\u27 Register
Report for Barton Memorial Hospital
Progress of the Orthopedic Department
Just Under the Date Line
Pediatrics at Jefferson
Controlled Respiration in Anesthesia
Anesthesia Progress
Physical Advances at Jefferson During the Past Year
The White Haven Division
The Clara Melville Scholarship Fund
The Relief Fund
The Busy Year for the Nurses\u27 Home Committee of the Women\u27s Board
The Gray Ladies
Memories
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Medical College News
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District No. 1 Dues
Help! Help! Help!
Jap Prison School Spurs Nurse to Win University Degree
Twenty Ways to Kill an Organization
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New Addresse
High-resolution infrared spectroscopy as a tool to detect false positives of transit search programs
Transit search programs such as CoRoT and Kepler now have the capability of
detecting planets as small as the Earth. The detection of these planets however
requires the removal of all false positives. Although many false positives can
be identified by a detailed analysis of the LCs, the detections of others
require additional observations. An important source of false positives are
faint eclipsing binaries within the PSF of the target stars. We develop a new
method that allows us to detect faint eclipsing binaries with a separation
smaller than one arcsec from target stars. We thereby focus on binaries that
mimic the transits of terrestrial planets. These binaries can be either at the
same distance as the target star (triple stars), or at either larger, or
smaller distances. A close inspection of the problem indicates that in all
relevant cases the binaries are brighter in the infrared than in the optical
regime. We show how high resolution IR spectroscopy can be used to remove these
false positives. For the triple star case, we find that the brightness
difference between a primary and an eclipsing secondary is about 9-10 mag in
the visual but only about 4.5-5.9 magnitudes in the K-band. We demonstrate how
the triple star hypothesis can be excluded by taking a high-resolution IR
spectrum. Simulations of these systems show that the companions can be detected
with a false-alarm probability of 2%, if the spectrum has a S/N-ratio > 100. We
show that high-resolution IR spectra also allows to detect most of the false
positives caused by foreground or background binaries. If high resolution IR
spectroscopy is combined with photometric methods, virtually all false
positives can be detected without RV measurements. It is thus possible to
confirm transiting terrestrial planets with a modest investment of observing
time.Comment: 6 pages, 7 figure
The ROTSE-III Robotic Telescope System
The observation of a prompt optical flash from GRB990123 convincingly
demonstrated the value of autonomous robotic telescope systems. Pursuing a
program of rapid follow-up observations of gamma-ray bursts, the Robotic
Optical Transient Search Experiment (ROTSE) has developed a next-generation
instrument, ROTSE-III, that will continue the search for fast optical
transients. The entire system was designed as an economical robotic facility to
be installed at remote sites throughout the world. There are seven major system
components: optics, optical tube assembly, CCD camera, telescope mount,
enclosure, environmental sensing & protection and data acquisition. Each is
described in turn in the hope that the techniques developed here will be useful
in similar contexts elsewhere.Comment: 19 pages, including 4 figures. To be published in PASP in January,
2003. PASP Number IP02-11
A noncanonical autophagy pathway restricts Toxoplasma gondii growth in a strain-specific manner in IFN-γ-activated human cells
ABSTRACT A core set of autophagy proteins is required for gamma interferon (IFN-γ)-mediated clearance of Toxoplasma gondii in the mouse because of their control of several downstream effectors, including immunity-related GTPases (IRGs) and guanylate-binding proteins (GBPs). However, these effectors are absent (i.e., IRGs) from or nonessential (i.e., GBPs) in IFN-γ-activated human cells, raising the question of how these cells control parasite replication. Here, we define a novel role for ubiquitination and recruitment of autophagy adaptors in the strain-specific control of T. gondii replication in IFN-γ-activated human cells. Vacuoles containing susceptible strains of T. gondii became ubiquitinated, recruited the adaptors p62 and NDP52, and were decorated with LC3. Parasites within LC3-positive vacuoles became enclosed in multiple layers of host membranes, resulting in stunting of parasite replication. However, LC3-positive T. gondii-containing vacuoles did not fuse with endosomes and lysosomes, indicating that this process is fundamentally different from xenophagy, a form of autophagy involved in the control of intracellular bacterial pathogens. Genetic knockout of ATG16L or ATG7 reverted the membrane encapsulation and restored parasite replication, indicating that core autophagy proteins involved in LC3 conjugation are important in the control of parasite growth. Despite a role for the core autophagy machinery in this process, upstream activation through Beclin 1 was not sufficient to enhance the ubiquitination of T. gondii-containing vacuoles, suggesting a lack of reliance on canonical autophagy. These findings demonstrate a new mechanism for IFN-γ-dependent control of T. gondii in human cells that depends on ubiquitination and core autophagy proteins that mediate membrane engulfment and restricted growth
Observations of Microwave Continuum Emission from Air Shower Plasmas
We investigate a possible new technique for microwave measurements of
ultra-high energy cosmic ray (UHECR) extensive air showers which relies on
detection of expected continuum radiation in the microwave range, caused by
free-electron collisions with neutrals in the tenuous plasma left after the
passage of the shower. We performed an initial experiment at the AWA (Argonne
Wakefield Accelerator) laboratory in 2003 and measured broadband microwave
emission from air ionized via high energy electrons and photons. A follow-up
experiment at SLAC (Stanford Linear Accelerator Center) in summer of 2004
confirmed the major features of the previous AWA observations with better
precision and made additional measurements relevant to the calorimetric
capabilities of the method. Prompted by these results we built a prototype
detector using satellite television technology, and have made measurements
indicating possible detection of cosmic ray extensive air showers. The method,
if confirmed by experiments now in progress, could provide a high-duty cycle
complement to current nitrogen fluorescence observations of UHECR, which are
limited to dark, clear nights. By contrast, decimeter microwave observations
can be made both night and day, in clear or cloudy weather, or even in the
presence of moderate precipitation.Comment: 15 pages, 13 figure
KELT-3b: A Hot Jupiter Transiting a V=9.8 Late-F Star
We report the discovery of KELT-3b, a moderately inflated transiting hot
Jupiter with a mass of 1.477 (-0.067, +0.066) M_J, and radius of 1.345 +/-
0.072 R_J, with an orbital period of 2.7033904 +/- 0.000010 days. The host
star, KELT-3, is a V=9.8 late F star with M_* = 1.278 (-0.061, +0.063) M_sun,
R_* = 1.472 (-0.067, +0.065) R_sun, T_eff = 6306 (-49, +50) K, log(g) = 4.209
(-0.031, +0.033), and [Fe/H] = 0.044 (-0.082, +0.080), and has a likely proper
motion companion. KELT-3b is the third transiting exoplanet discovered by the
KELT survey, and is orbiting one of the 20 brightest known transiting planet
host stars, making it a promising candidate for detailed characterization
studies. Although we infer that KELT-3 is significantly evolved, a preliminary
analysis of the stellar and orbital evolution of the system suggests that the
planet has likely always received a level of incident flux above the
empirically-identified threshold for radius inflation suggested by Demory &
Seager (2011).Comment: 12 pages, 12 figures, accepted to Ap
SLC2A8 (GLUT8) is a mammalian trehalose transporter required for trehalose-induced autophagy
Trehalose is a disaccharide demonstrated to mitigate disease burden in multiple murine neurodegenerative models. We recently revealed that trehalose rapidly induces hepatic autophagy and abrogates hepatic steatosis by inhibiting hexose transport via the SLC2A family of facilitative transporters. Prior studies, however, postulate that intracellular trehalose is sufficient to induce cellular autophagy. The objective of the current study was to identify the means by which trehalose accesses the hepatocyte cytoplasm, and define the distal signaling mechanisms by which trehalose induces autophagy. We provide gas chromatographic/mass spectrometric, fluorescence microscopic and radiolabeled uptake evidence that trehalose traverses the plasma membrane via SLC2A8 (GLUT8), a homolog of the trehalose transporter-1 (Tret1). Moreover, GLUT8-deficient hepatocytes and GLUT8-deficient mice exposed to trehalose resisted trehalose-induced AMP-activated protein kinase (AMPK) phosphorylation and autophagic induction in vitro and in vivo. Although trehalose profoundly attenuated mTORC1 signaling, trehalose-induced mTORC1 suppression was insufficient to activate autophagy in the absence of AMPK or GLUT8. Strikingly, transient, heterologous Tret1 overexpression reconstituted autophagic flux and AMPK signaling defects in GLUT8-deficient hepatocyte cultures. Together, these data suggest that cytoplasmic trehalose access is carrier-mediated, and that GLUT8 is a mammalian trehalose transporter required for hepatocyte trehalose-induced autophagy and signal transduction
Sporadic paediatric diarrhoeal illness in urban and rural sites in Nyanza province, Kenya
Objective: Investigate differences in the infectious aetiology, health seeking behaviour, and provider practices with regard to diarrhoeal illness among children presenting to urban versus rural clinics in Western Kenya.Design: Laboratory-based, passive surveillance.Setting: The urban portion of the study was conducted at the paediatric outpatient clinic of Nyanza Provincial Hospital in Kisumu. The rural portion of the study was conducted at four outpatient clinics in the Asembo Bay community approximately 20 kilometers west of Kisumu.Subjects: Children aged less than five years presenting to medical facilities for the treatment of diarrhoea from October 2001-October 2003 at the urban site and May 1997-April 2003 for the rural sites.Results: Among the 1303 urban and 1247 rural specimens collected, 24% of specimens yielded a bacterial pathogen (24% urban, 25% rural). Campylobacter was the predominant bacterial pathogen (17% urban, 15% rural), followed by Shigella and nontyphoidal Salmonella (both 4% urban and 5% rural). In both communities, susceptibilities of these pathogens to the most commonly prescribed antibiotics was low
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