Holter STAT-ON™ against other tools for detecting MF in advanced Parkinson’s disease: an observational study

BackgroundDifferent screening tools to identify advanced Parkinson’s disease (APD) have emerged in recent years. Among them, wearable medical devices, such as STAT-ON™, have been proposed to help to objectively detect APD.ObjectivesTo analyze the correlation between STAT-ON™ reports and other assessment tools to identify APD and to assess the accuracy of screening tools in APD patients, using the STAT-ON™ as the gold standard.MethodsIn this retrospective, observational study, data from the University Hospital Complex of Pontevedra database on 44 patients with potential APD who wore STAT-ON™ were extracted. Data were collected according to different sources of tools for identifying APD: (1) STAT-ON™, (2) information provided by the patient, (3) questionnaire for advanced Parkinson’s disease (CDEPA), (4) 5-2-1 Criteria, and (5) Making Informed Decisions to Aid Timely Management of Parkinson’s Disease (MANAGE-PD). Considering STAT-ON™ recordings as a reference, the sensitivity, specificity, and positive and negative predictive values for each tool were calculated. The kappa index assessed the degree of agreement between the gold standard and the other instruments.ResultsAlthough no statistically significant association was found between STAT-ON™ recordings and any screening methods evaluated, the CDEPA questionnaire demonstrated the highest sensitivity and VPN values to detect patients with APD candidates for second-line therapy (SLT). According to the correlation analyses, MANAGE-PD demonstrated the highest degree of concordance with STAT-ON™ recordings to identify the SLT indication and to predict the SLT decision.ConclusionSTAT-ON™ device may be a helpful tool to detect APD and to guide treatment decisions

Sequential oral antibiotic in uncomplicated Staphylococcus aureus bacteraemia: a propensity-matched cohort analysis

Objectives: We aimed to analyse the efficacy and safety of oral sequential therapy (OST) in uncomplicated Staphylococcus aureus bacteraemia (SAB). Methods: Single-centre observational cohort at a tertiary hospital in Spain, including all patients with the first SAB episode from January 2015 to December 2020. We excluded patients with complicated SAB and those who died during the first week. Patients were classified into the OST group (patients who received oral therapy after initial intravenous antibiotic therapy [IVT]), and IVT group (patients who received exclusively IVT). We performed a propensity-score matching to balance baseline differences. The primary composite endpoint was 90-day mortality or microbiological failure. Secondary endpoints included 90-day SAB relapse. Results: Out of 407 SAB first episodes, 230 (56.5%) were included. Of these, 112 (n = 48.7%) received OST and 118 (51.3%) IVT exclusively. Transition to oral therapy was performed after 7 days (interquartile range, 4–11). The primary endpoint occurred in 10.7% (11/112) in OST vs. 30.5% (36/118) in IVT (p < 0.001). SAB relapses occurred in 3.6% (4/112) vs. 1.7% (2/118) (p 0.436). None of the deaths in OST were related to SAB or its complications. After propensity-score matching, the primary endpoint was not more frequent in the OST group (relative risk, 0.42; 95% CI, 0.22–0.79). Ninety-day relapses occurred similarly in both groups (relative risk, 1.35; 95% CI, 0.75–2.39). Discussion: After an initial intravenous antibiotic, patients with uncomplicated SAB can safely be switched to oral antibiotics without apparent adverse outcomes. This strategy could save costs and complications of prolonged hospital stays. Prospective randomized studies are needed

DataSheet_2_IP-10 and MIG are sensitive markers of early virological response to HIV-1 integrase inhibitors.docx

Supplementary Data Sheet 2 | Centres and investigators involved in CoRIS.[Background] Interferon-inducible protein-10 (IP-10) and monokine induced by interferon-gamma (MIG) are chemokines recognized as inflammatory biomarkers during HIV-1 infection. We assessed their early and long-term dynamics after initiation of antiretroviral treatment (ART).[Methods] Persons with HIV-1 (PWH) aged>18 years starting their first ART in 2015-2021 in a prospective cohort (n=73) were included. IP-10 and MIG plasma levels were quantified using a multiplexed bead-based assay.[Results] IP-10 and MIG plasma levels showed a significant and consistent reduction following ART (80% integrase inhibitor [INSTI]-based) initiation, starting at day 20 and maintained throughout the study period (48 months), paralleling the HIV-1 RNA decay and CD4+ count recovery (p<0·001). At baseline, PWH≥ 50 years, CDC stage C and CD4+ count<350cells/mm3 had higher levels of IP-10 (p=0·022, p=0·001 and p=0·002, respectively) and MIG (p<0·001, p=0·024 and p=0·069, respectively). All of them matched their counterparts several months following ART initiation. MIG levels showed a greater decrease at day 10 in those treated with INSTI (p=0·038). Low-level HIV-1 viremia did not impact MIG or IP-10 levels.[Conclusion] Plasma IP-10 and MIG showed an early significant decline following ART initiation, with greater early declines in MIG levels in INSTI-based regimens. These findings suggest a strong impact of HIV-1 viremia on IP-10 and MIG levels.Peer reviewe

IP-10 and MIG are sensitive markers of early virological response to HIV-1 integrase inhibitors

© 2023 Álvarez, Gutiérrez-Valencia, Mariño, Saborido-Alconchel, Calderón-Cruz, Pérez-González, Alonso-Domínguez, Martínez-Barros, Gallego-Rodríguez, Moreno, Aldamiz, Montero-Alonso, Bernal, Galera, Llibre and Poveda. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Background: Interferon-inducible protein-10 (IP-10) and monokine induced by interferon-gamma (MIG) are chemokines recognized as inflammatory biomarkers during HIV-1 infection. We assessed their early and long-term dynamics after initiation of antiretroviral treatment (ART).Methods: Persons with HIV-1 (PWH) aged>18 years starting their first ART in 2015-2021 in a prospective cohort (n=73) were included. IP-10 and MIG plasma levels were quantified using a multiplexed bead-based assay.Results: IP-10 and MIG plasma levels showed a significant and consistent reduction following ART (80% integrase inhibitor [INSTI]-based) initiation, starting at day 20 and maintained throughout the study period (48 months), paralleling the HIV-1 RNA decay and CD4+ count recovery (p<0·001). At baseline, PWH≥ 50 years, CDC stage C and CD4+ count<350cells/mm3 had higher levels of IP-10 (p=0·022, p=0·001 and p=0·002, respectively) and MIG (p<0·001, p=0·024 and p=0·069, respectively). All of them matched their counterparts several months following ART initiation. MIG levels showed a greater decrease at day 10 in those treated with INSTI (p=0·038). Low-level HIV-1 viremia did not impact MIG or IP-10 levels.Conclusion: Plasma IP-10 and MIG showed an early significant decline following ART initiation, with greater early declines in MIG levels in INSTI-based regimens. These findings suggest a strong impact of HIV-1 viremia on IP-10 and MIG levels.The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study has been funded by Instituto de Salud Carlos III [PI16/02159, BA18/00034, PI19/00747, PI22/01341, CM20/00243] and cofunded by the European Regional Development Fund, “A way to make Europe”; Red Española de Investigación en SIDA; Xunta de Galicia-Axencia Galega de Innovación (IN606A-2022/019); INVESTIGO Next GenerationEU Program TR349V-2022-10000052-00; Intramural Grant Program Galicia Sur Health Research Institute (CI22-A-2).Peer reviewe

School coexistence through values training supported by information and communication technologies

En Colombia existe una preocupación en las instituciones educativas por los altos índices de violencia escolar, por lo cual se hace necesario impartir una formación en valores que permitan al estudiante tomar decisiones asertivas al enfrentarse a una situación conflictiva, fortaleciendo así la convivencia escolar. El estudio busco promover la convivencia escolar mediante la formación en valores apoyada en las tecnologías de la información y comunicación. Está guiado bajo los lineamientos metodológicos de la IEP con un diseño basado en las trayectorias de indagación, la unidad de análisis se conformó por sesenta (60) estudiantes de la institución educativa Thelma Rosa de Arévalo ubicada en el municipio de Zona bananera Magdalena. Los resultados dejaron en evidencia la importancia de implementar nuevas estrategias pedagógicas al aula de clase, observando un impacto positivo en la convivencia escolar de los estudiantes mediante la formación en valores apoyada en el uso de las TIC.In Colombia there is a concern in educational institutions for the high rates of school violence, which is why it is necessary to provide training in values that allow the student to make assertive decisions when facing a conflictive situation, thus strengthening school coexistence. The study sought to promote school coexistence through training in values supported by information and communication technologies. It is guided under the methodological guidelines of the IEP with a design based on the trajectories of inquiry, the analysis unit was formed by sixty (60) students from the educational institution Thelma Rosa de Arévalo located in the municipality of Magdalena banana zone. The results showed the importance of implementing new pedagogical strategies to the classroom, observing a positive impact on students’ school coexistence through the formation of values supported by the use of TIC

Visiones transversales de Puerto Rico y el Caribe

Con autorización de la editorial para este libro. La edición del libro estuvo a cargo de Beatriz Cruz Sotomayor y Félix R. Huertas González.Visiones transversales de Puerto Rico y el Caribe es producto de un proyecto internacional de investigación en el que han venido participando, por los pasados años, un grupo de historiadores y especialistas de diversas disciplinas en el área de los estudios caribeños. Como lo sugiere su título, el libro apuesta a la transversalidad como enfoque que permite explorar, desde múltiples perspectivas, la diversidad que ya de por sí implica la región caribeña y, en particular, la isla de Puerto Rico. Este persigue innovar en su metodología, marcos teóricos, perspectivas críticas y en una rica variedad de campos de estudio sobre Puerto Rico en el contexto del Caribe. Desde una diversidad de análisis, los ensayos transitan también un amplio espectro temático: esclavitud, urbanismo, ambiente, identidad, cultura, diáspora, economía, arte, literatura y política, entre otros.Connected Worlds: The Caribbean, Origin of the Modern World. Este proyecto ha recibido fondos del programa de investigación e innovación Horizon 2020 de la Unión Europea en virtud del acuerdo de subvención Marie Sklodowska-Curie Nº 823846. El proyecto está dirigido por la profesora Consuelo Naranjo Orovio del Instituto de Historia-CSIC.Peer reviewe

Améliorer l'auto-efficacité et l'activation des patients chez les survivants du cancer grâce à des interventions de santé numérique: résultats du projet PERSIST (préimpression)

Cancer survivors face various challenges but also demonstrate resilience and find ways to adapt and cope with life after cancer. Self-efficacy and patient activation are two crucial factors that significantly impact the well-being of cancer survivors. These concepts play a vital role in enabling cancer survivors to take control of their health, manage their treatment effectively, and achieve positive long-term outcomes. The aim of this study is to assess the impact of a mobile health system (mHealthApp) to improve the self-efficacy and patient activation of breast cancer and colorectal cancer survivors. This study presents the findings from clinical trials conducted according to the published study protocol of the PERSIST project that was funded by European Commision to support cancer survivors using digital health technologies. The acceptability and usability of the mHealthApp, as well as the perceived self-efficacy and satisfaction with care, were assessed using validated tools such as CASE-cancer, PAM, and SUS. The results indicate that the PERSIST project partially achieved its predefined objectives and hypotheses by enhancing the self-confidence and satisfaction of cancer survivors with healthcare and improving the effectiveness of cancer treatment and follow-up procedures to some extent. The PERSIST project demonstrates the potential to improve clinical outcomes, empower patients, and contribute to broader social goals in cancer survivorship. However, larger studies involving a more diverse patient population and a greater number of clinicians are necessary to establish the effectiveness of digital therapies in cancer survivorship care and to provide additional data and evidence.Patients-centered SurvivorShIp care plan after Cancer treatments based on Big Data and Artificial Intelligence technologie

POR UNA CULTURA DE PAZ: UNA MIRADA DESDE LAS CIENCIAS DE LA CONDUCTA

En
 virtud
 de
 lo
 anterior,
 los
 estudiosos
 de
 las
 ciencias
 de
 la
 conducta
 
de
 la
 Universidad
Autónoma 
del
 Estado 
de 
México,

ante 
la
persistencia
 y 
proliferación
 de
 estos 
hechos
 en
 diversas
 partes
 del
Mundo
 y
 de
 nuestro 
país 
en 
particular, se
 convocó
 a
 los
 estudiosos
 interesados
 y
 a
 la
 sociedad
 en
 general
 a
 presentar
 trabajos
 para
 analizar,
 debatir
 y
 proponer
 estrategias
 de
 acción
 y
 dirección,
 que
 fortalezcan
 una
 convivencia y bienestar con sentido humanista para una cultura de paz. El
 presente
 texto
 es
 producto
 de 
esta convocatoria 
que
 recoge 
los
trabajos 
de 

los
 interesados 
en 
la
 temática,

 de
 diferentes 
países
(España,
Argentina,
Cuba,
Brasil,
Costa
 Rica
 y
 México)
 retomando
 con
 ello
 sus
 experiencias
 relativas
 al
 estudio,
 análisis,
 comprensión
 e
 instrumentación
 de
 la
 cultura
 de
 paz
 en
 los
 distintos
 ámbitos
 institucionales
 en
 los
 que
 participan:
 educativo,
 salud,
 penitenciario,
 social,
laboral,
familia,
alimentario,
psicológico,
por 
mencionar 
algunos.
 El
 presente
 libro,
 propicia
 un
 espacio
 de
 reflexión,
 diálogo
 y
 posicionamiento
 de
 las 
ciencias 
de 
la 
conducta
 para 
la 
apropiación,
análisis,
debate
 y 
propuestas 
que
 fortalezcan 
una
 cultura
 de 
paz
 a
través
 de 
la
 convivencia 
y
 el 
bienestar
 social 
con
 sentido 
humanista.
El
 sistema 
económico
 neoliberal
 y 
el 
proceso
 de 
globalización 
han
 contribuido
al
 logro
 de
 avances
 significativos
 en
 la
 ciencia
 y
 la
 tecnología,
 pero
 también
 han
 propiciado
 la
 polarización
 de
 las
 sociedades
 lo
 que
 ha
 impactado
 de
 manera
 negativa
 a
 la
 sociedad
 en
 su
 conjunto,
 pero
 en
 mayor
 medida
 a
 los grupos
 vulnerables. Dicha
 polarización
 ha
 traído
 consigo
 un
 desarrollo
 desigual
 del
 mundo
 que
 se
 expresa
 de
 diferentes
 maneras
 tanto
 en
 países
 desarrollados
 como
 en
 los
 llamados
 del
 tercer
 mundo,
 en
 donde
 no
 están
 satisfechas
 las
 necesidades
 humanas 
elementales
 de
 todos 
los
sectores 
de 
la 
población,
siempre 
falta 
algo. 
Si 
a
 esto 
le
 sumamos 
los
conflictos
 internacionales por
 diferentes
 motivos
 que
 enfrentan
 algunas
 naciones,
 una
 insuficiente
 cobertura
 educativa
 y
 de
 salud,

 desempleo
 y
 pobreza 
extrema,
 entre 
otras
 cosas; 
estamos
 frente
 a
retos 
de
 gran
 envergadura
 para
 los
 gobiernos,
 para
 los
 estudiosos
 y
 para
 la
 sociedad
 civil
 en
 general. Uno 
de 
los
 intentos
 para
 frenar 
y prevenir 
la
 agudización
 de 
estas 
problemáticas
 es
 la
 cultura 
de 
paz,
cuyo
 estudio
y propuestas 
han 
ido 
avanzando 
en 
diferentes
 sentidos 
y 
de 
manera 
favorable,
el 
tema 
está 
presente 
en 
diferentes 
Organismos
 Internacionales
 como
 la
 ONU,
 la
 UNESCO,
 la
 OCDE,
 El
 Banco
 Mundial,
 entre
 otros.
 Pero
 falta 
mucho 
por 
hacer.Universidad Autónoma del Estado de Méxic

una mirada desde las Ciencias de la Conducta

Este libro es el resultado de los trabajos presentados en el 1er Congreso Internacional "Convivencia y bienestar con sentido humanista para una cultura de paz"

Formando educadores en el sur de Colombia : Investigación educativa en licenciatura en educación infantil.

Este libro ofrece al lector reflexión continua de los retos de la universidad en la formación de licenciados para la transformación y emancipación de Colombia hacia la construcción de paz, revela las realidades socio críticas del XXI en los programas académicos de licenciados y visualiza las niñeces como sujetos políticos y sociales, logrando un despliegue significativo de metodologías pertinentes para la formación de maestros en Colombia y Latinoamérica