Determinants of childhood obesity in representative sample of children in north east of iran

Childhood obesity has become, a global public health problem, and epidemiological studies are important to identify its determinants in different populations. This study aimed to investigate factors associated with obesity in a representative sample of children in Neishabour, Iran. This study was conducted among 1500 randomly selected 6-12-year-old students from urban areas of Neishabour, northeast of Iran. Then, through a case-control study, 114 obese (BMI � 95 th percentile of Iranian reference) children were selected as the case group and were compared with 102 controls (15 th � BMI 85 th percentile). Factors suggested to be associated with weight status were investigated, for example, parental obesity, child physical activity levels, socio-economic status (SES), and so forth. The analysis was conducted using univariate and multivariate logistic regression (MLR) in SPSS version 16. In univariate logistic regression model, birth weight, birth order, family extension, TV watching, sleep duration, physical activity, parents job, parents education, parental obesity history, and SES were significantly associated with childrens obesity. After MLR analysis, physical activity and parental obesity history remained statistically significant in the model. Our findings showed that physical activity and parental obesity history are the most important determinants for childhood obesity in our population. This finding should be considered in implementation of preventive interventions. Copyright © 2012 Fereshteh Baygi et al

Prevalence and associated factors of cardio-metabolic risk factors in Iranian seafarers

BACKGROUND: Since Iran's economy is based on the sale of petroleum products, seafaring is considered a crucial job. Little research has been done on issues related to seafarers' health in Iranian maritime industry. The present study investigated the prevalence and associated factors of cardio-metabolic risk factors in seafarers of National Iranian Tanker Company (NITC). MATERIALS AND METHODS: A cross-sectional study was performed on 234 Iranian male seafarers of NITC in 2015. Metabolic syndrome (MetS) was diagnosed according to the reports of National Committee of Obesity. Three main blood parameters (of elevated total cholesterol, elevated low-density lipoprotein cholesterol, and elevated very low-density lipoprotein cholesterol) and general obesity were included as additional cardio-metabolic risk factors. RESULTS: The mean age of the participants was 36.0 ± 10.3 years. The prevalence of MetS was 14.9. The common cardio-metabolic risk factors were excess weight (51.1), abdominal obesity (38.5), and smoking (27.8) among Iranian seafarers. In multivariate analysis, age (OR: 1.05, 95 CI: 1.01-1.09) and body mass index (OR: 1.14, 95 CI: 1.01-1.27) were associated with the increase in hypertension risk. CONCLUSIONS: Our finding showed that the current prevalence of MetS among Iranian male seafarers working on tankers can affect negatively their health and career at sea

Prevalence and associated factors of cardio-metabolic risk factors in Iranian seafarers

BACKGROUND: Since Iran's economy is based on the sale of petroleum products, seafaring is considered a crucial job. Little research has been done on issues related to seafarers' health in Iranian maritime industry. The present study investigated the prevalence and associated factors of cardio-metabolic risk factors in seafarers of National Iranian Tanker Company (NITC). MATERIALS AND METHODS: A cross-sectional study was performed on 234 Iranian male seafarers of NITC in 2015. Metabolic syndrome (MetS) was diagnosed according to the reports of National Committee of Obesity. Three main blood parameters (of elevated total cholesterol, elevated low-density lipoprotein cholesterol, and elevated very low-density lipoprotein cholesterol) and general obesity were included as additional cardio-metabolic risk factors. RESULTS: The mean age of the participants was 36.0 ± 10.3 years. The prevalence of MetS was 14.9. The common cardio-metabolic risk factors were excess weight (51.1), abdominal obesity (38.5), and smoking (27.8) among Iranian seafarers. In multivariate analysis, age (OR: 1.05, 95 CI: 1.01-1.09) and body mass index (OR: 1.14, 95 CI: 1.01-1.27) were associated with the increase in hypertension risk. CONCLUSIONS: Our finding showed that the current prevalence of MetS among Iranian male seafarers working on tankers can affect negatively their health and career at sea

Dormancy removal in pistachio nut: Influences of Hydrogen Cyanamid (Dormex®) as compared to ordinary seed chemical pre-treatments

Seed germination is considered an important phenological stage of plant growth during which the viable, nondormant embryos develop into seedlings under favorable conditions. Currently, various seed priming treatments may be used to enhance germination values (germination percentage, Lag phase, time to reach 50% germination) and breaking dormancy; gibberellins and KNO3 are applied as common treatments in this regard. In the present study, efficacy of Hydrogen Cyanamid (HCN, Dormex®) on seed germination of two cultivated pistachio varieties (Abasali, Shahpasand) were studied and the results were compared to ordinary ingredients, namely gibberellic acid (GA3) and KNO3. The extraction of parameters was carried out using four-parameter Hill function. The results reveal that HCN may significantly improve critical parameters involved in pistachio seed germination. In Shahpasand variety, seeds treated with HCN germinated prior to other treatments (150.53 hours after treatment) and achieved 50% germination earlier than other treatments (199.00 hours only). According to the results, utilization of HCN in seed testing experiments may be encouraged

Dormancy removal in pistachio nut: Influences of Hydrogen Cyanamid (Dormex®) as compared to ordinary seed chemical pre-treatments

Seed germination is considered an important phenological stage of plant growth during which the viable, nondormant embryos develop into seedlings under favorable conditions. Currently, various seed priming treatments may be used to enhance germination values (germination percentage, Lag phase, time to reach 50% germination) and breaking dormancy; gibberellins and KNO3 are applied as common treatments in this regard. In the present study, efficacy of Hydrogen Cyanamid (HCN, Dormex®) on seed germination of two cultivated pistachio varieties (Abasali, Shahpasand) were studied and the results were compared to ordinary ingredients, namely gibberellic acid (GA3) and KNO3. The extraction of parameters was carried out using four-parameter Hill function. The results reveal that HCN may significantly improve critical parameters involved in pistachio seed germination. In Shahpasand variety, seeds treated with HCN germinated prior to other treatments (150.53 hours after treatment) and achieved 50% germination earlier than other treatments (199.00 hours only). According to the results, utilization of HCN in seed testing experiments may be encouraged

Hypothesis: A challenge of overexpression Zfp521 in neural tendency of derived dental pulp stem cells

Neurodegenerative diseases have now become a major challenge, especially in aged societies. Most of the traditional strategies used for treatment of these diseases are untargeted and have little efficiency. Developments in stem cell investigations have given much attention to cell therapy as an alternative concept in the regeneration of neural tissues. Dental pulp stem cells (DPSCs) can be readily obtained by noninvasive procedures and have been shown to possess properties similar to well-known mesenchymal stem cells. Furthermore, based on their neural crest origin, DPSCs are considered to have a good potential to differentiate into neural cells. Zfp521 is a transcription factor that regulates expression of many genes, including ones involved in the neural differentiation process. There for based on neural crest origin of the cell and high expression of neural progenitor markers, we speculate that sole overexpression of Zfp521 protein can facilitate differentiation of dental stem cells to neural cells and researchers may find these cells suitable for therapeutic treatment of neurodegenerative disease

Dietary predictors of childhood obesity in a representative sample of children in North East of Iran

Objective: The prevalence of obesity is increasing in Iranian youngsters. This study aimed to assess some dietary determinants of obesity in a representative sample of children in Neishabour, a city in northeastern, Iran. Methods: This case-control study was conducted among 114 school students, aged 6-12 years, with a body mass index (BMI) �95th (based on percentile of Iranian children) as the case group and 102 age- and gender-matched controls, who were selected from their non-obese classmates. Nutrient intake data were collected by trained nutritionists by using two 24-hour-dietary recalls through maternal interviews in the presence of their child. A food frequency questionnaire was used for detecting the snack consumption patterns. Statistical analysis was done using univariate and multivariate logistic regression (MLR) by SPSS version 16. Results: In univariate logistic regression, total energy, protein, carbohydrate, fat (including saturated, mono- and poly-unsaturated fat), and dietary fiber were the positive predictors of obesity in studied children. The estimated crude ORs for frequency of corn-based extruded snacks, carbonated beverages, potato chips, fast foods, and chocolate consumption were statistically significant. After MLR analysis, the association of obesity remained significant with energy intake (OR = 2.489, 95 CI: 1.667-3.716), frequency of corn-based extruded snacks (OR = 1.122, 95 CI; 1.007-1.250), and potato chips (OR = 1.143, 95 CI: 1.024-1.276). The MLR analysis showed that dietary fiber (OR = 0. 01, 95 CI; 0.368-0.983) and natural fruit juice intake (OR = 0.909, 95 CI; 0.835-0.988) were protective factors against obesity. Conclusions: The findings serve to confirm the role of an unhealthy diet, notably caloriedense snacks, in childhood obesity. Healthy dietary habits, such as the consumption of high-fiber foods, should be encouraged among children

Association of some psychosocial factors with anthropometric measures in nationally representative sample of Iranian adolescents: The CASPIAN-III study

Background: During the last two decades, adolescent obesity has increased in western countries. In Iran-as a developing country- the prevalence of obesity is raised among youngsters as well. This study conducted to identify an association of adolescents' loneliness, self-confidence and relationship with others in home and school environment with their weight status. Methods: In this cross-sectional national survey, 5682 students aged 10-18 years from urban and rural districts of 27 provinces of Iran were selected via stratified multi-stage sampling method. Data on psychological problems of students was gathered through a questionnaire. Height, weight, and waist circumferences were measured according to standard protocols. Body mass index (BMI) and waist- to-height ratio was calculated. Results: Boys which did not have best friends, spend time with their friends after school or get acceptance from them, had higher BMI than others. Only girls who did not spend time with their friends had higher BMI (19.48 ± 4.28) vs. (19.09 ± 3.92) and WC (71.04 ± 21.29) vs. (69.15 ± 17.43) than others, P < 0.05. In both sexes, adolescents who had sense of pressure about doing homework or had difficulties in relationship with their parents had higher BMI and WC values. Girls who reported being victim of violent behaviors (being bullied), had lower BMI compared to others. Risk of being overweight and obese, but not abdominal obese was statistically higher in adolescents not having close friends (OR = 1.81, CI: 1.11-2.95). Lack of self-confidence increased only the risk of obesity in teens (OR = 1033, CI: 1.09-1.64). Conclusions: Our findings suggest that strategies for prevention of overweight and obesity in adolescent should be taking into account a deeper knowledge of psychosocial issues due to be able to design more effective programs for treating overweight teens. © 2016 Baygi et al

The consequences of regular methamphetamine use in Tehran: Qualitative content analysis

Background: In recent years, methamphetamine use has increased noticeably in Iran, and this can make harmful consequences for the health of individuals and society. Therefore, the study aimed to investigate the consequences of regular methamphetamine use in Tehran. Methods: This study was conducted based on a conventional content analysis approach. Data were collected through observation and in-depth interviews with 20 regular adult users of methamphetamine in Tehran (including 15 males and 5 females). Participants were selected using snowball sampling and purposeful sampling, which continued until data saturation. Guba and Lincoln's criteria were used to assess the strength of the study. Results: The extraction of the codes resulted in three main categories: (1)the short-term consequences, consisting of the sub-categories of individual and social consequences, (2) the long-term consequences, consisting of the sub-categories of psychological and physical consequences, high-risk behaviors, severely decayed memory and changes in the eating pattern, and (3) hallucinations and delusions including the sub-categories of visual and auditory hallucinations, persecutory delusions and delusion of having supernatural power. Conclusion: Regular methamphetamine use may have serious adverse effects on the overall health of individuals. It is therefore highly recommended that educational programs must implement with the use of methamphetamine in the high-risk groups in order to raise awareness and change attitudes about the short and long term consequences. is highly recommended. © 2020 The Author(s)

SLUG transcription factor : a pro-survival and prognostic factor in gastrointestinal stromal tumour

Background: The SLUG transcription factor has been linked with the KIT signalling pathway that is important for gastrointestinal stromal tumour (GIST) tumourigenesis. Its clinical significance in GIST is unknown. Methods: Influence of SLUG expression on cell proliferation and viability were investigated in GIST48 and GIST882 cell lines. The association between tumour SLUG expression in immunohistochemistry and recurrence-free survival (RFS) was studied in two clinical GIST series, one with 187 patients treated with surgery alone, and another one with 313 patients treated with surgery and adjuvant imatinib. Results: SLUG downregulation inhibited cell proliferation, induced cell death in both cell lines, and sensitised GIST882 cells to lower imatinib concentrations. SLUG was expressed in 125 (25.0%) of the 500 clinical GISTs evaluated, and expression was associated with several factors linked with unfavourable prognosis. SLUG expression was associated with unfavourable RFS both when patients were treated with surgery alone (HR = 3.40, 95% CI = 1.67-6.89, P = 0.001) and when treated with surgery plus adjuvant imatinib (HR = 1.83, 95% CI = 1.29-2.60, P = 0.001). Conclusions: GIST patients with high tumour SLUG expression have unfavourable RFS. SLUG may mediate pro-survival signalling in GISTs.Peer reviewe