1,490 research outputs found
The Probability Density of the Higgs Boson Mass
The LEP Collaborations have reported a small excess of events in their
combined Higgs boson analysis at center of mass energies up to about 208 GeV.
In this communication, I present the result of a calculation of the probability
distribution function of the Higgs boson mass which can be rigorously obtained
if the validity of the Standard Model is assumed. It arises from the
combination of the most recent set of precision electroweak data and the
current results of the Higgs searches at LEP 2.Comment: 3 pages, 2 figure
Detectors for leptonic CP violation at the neutrino factory
Studies carried out in the framework of the International Design Study for the Neutrino Factory (the IDS-NF) show that the sensitivity to the CP violating phase and the last unknown mixing angle θ13 is maximised when two far detectors optimized to detect the sub-leading νe to νμ oscillation are combined. Several technologies are being discussed for these detectors: magnetised iron calorimeters; giant liquid argon TPCs; and totally active scintillating detectors. The IDS-NF baseline option, a compromise between feasibility, cost, and performance, is documented in the Interim Design Report (IDR) that has recently been completed. It consists of two magnetised iron sampling calorimeters, similar to the existing MINOS detector, but with 10-20 times more mass and improved performance. A detector of mass 100 kton is assumed at the intermediate baseline (between 2500 km and 5000 km) and a 50 kton detector at the long baseline (between 7000 km and 8000 km). The other far-detector options, which have better granularity, may be able to detect additional oscillation channels, thus improving the overall performance of the facility. However, these options are likely to be more expensive and require significant R&D
A simple formula for pooling knowledge about a quantum system
When various observers obtain information in an independent fashion about a
classical system, there is a simple rule which allows them to pool their
knowledge, and this requires only the states-of-knowledge of the respective
observers. Here we derive an equivalent quantum formula. While its realm of
applicability is necessarily more limited, it does apply to a large class of
measurements, and we show explicitly for a single qubit that it satisfies the
intuitive notions of what it means to pool knowledge about a quantum system.
This analysis also provides a physical interpretation for the trace of the
product of two density matrices.Comment: 5 pages, Revtex
Overlapping Effects of miR-21 Inhibition and Drugs for Idiopathic Pulmonary Fibrosis: Rationale for Repurposing Nintedanib as a Novel Treatment for Ischemia/Reperfusion Injury
ABSTRACT: A specific anti-miR-21 has emerged as an effective treatment for ischemia/reperfusion injury in a pig model of myocardial infarction (MI), but the perspectives for clinical translation are limited. Anti-miR-21 blunts profibrotic pathways, whose excessive activation is detrimental in the post-MI setting. Repurposing antifibrotic drugs approved for other indications is a possible strategy. We compared the molecular effects of anti-miR-21 and the 2 drugs approved for idiopathic pulmonary fibrosis (nintedanib and pirfenidone) through a bioinformatic approach. We report that nintedanib and anti-miR-21 share many targets, including the proto-oncogene Rous sarcoma oncogene cellular homolog. Conversely, pirfenidone and anti-miR-21 do not have common mechanisms of action. In summary, the molecular mechanisms activated by nintedanib are partially overlapping with those elicited by anti-miR-21. Nintedanib could be evaluated in animal studies or clinical trials on MI
The Golden Channel at a Neutrino Factory revisited: improved sensitivities from a Magnetised Iron Neutrino Detector
This paper describes the performance and sensitivity to neutrino mixing
parameters of a Magnetised Iron Neutrino Detector (MIND) at a Neutrino Factory
with a neutrino beam created from the decay of 10 GeV muons. Specifically, it
is concerned with the ability of such a detector to detect muons of the
opposite sign to those stored (wrong-sign muons) while suppressing
contamination of the signal from the interactions of other neutrino species in
the beam. A new more realistic simulation and analysis, which improves the
efficiency of this detector at low energies, has been developed using the GENIE
neutrino event generator and the GEANT4 simulation toolkit. Low energy neutrino
events down to 1 GeV were selected, while reducing backgrounds to the
level. Signal efficiency plateaus of ~60% for and ~70% for
events were achieved starting at ~5 GeV. Contamination from the
oscillation channel was studied for the first
time and was found to be at the level between 1% and 4%. Full response matrices
are supplied for all the signal and background channels from 1 GeV to 10 GeV.
The sensitivity of an experiment involving a MIND detector of 100 ktonnes at
2000 km from the Neutrino Factory is calculated for the case of . For this value of , the accuracy in the
measurement of the CP violating phase is estimated to be , depending on the value of ,
the CP coverage at is 85% and the mass hierarchy would be determined
with better than level for all values of
A difference boosting neural network for automated star-galaxy classification
In this paper we describe the use of a new artificial neural network, called
the difference boosting neural network (DBNN), for automated classification
problems in astronomical data analysis. We illustrate the capabilities of the
network by applying it to star galaxy classification using recently released,
deep imaging data. We have compared our results with classification made by the
widely used Source Extractor (SExtractor) package. We show that while the
performance of the DBNN in star-galaxy classification is comparable to that of
SExtractor, it has the advantage of significantly higher speed and flexibility
during training as well as classification.Comment: 9 pages, 1figure, 7 tables, accepted for publication in Astronomy and
Astrophysic
Toroidal magnetized iron neutrino detector for a neutrino factory
A neutrino factory has unparalleled physics reach for the discovery and measurement of CP violation in the neutrino sector. A far detector for a neutrino factory must have good charge identification with excellent background rejection and a large mass. An elegant solution is to construct a magnetized iron neutrino detector (MIND) along the lines of MINOS, where iron plates provide a toroidal magnetic field and scintillator planes provide 3D space points. In this paper, the current status of a simulation of a toroidal MIND for a neutrino factory is discussed in light of the recent measurements of large θ13. The response and performance using the 10 GeV neutrino factory configuration are presented. It is shown that this setup has equivalent δCP reach to a MIND with a dipole field and is sensitive to the discovery of CP violation over 85% of the values of δCP
Potential role for clinical calibration to increase engagement with and application of home telemonitoring: a report from the HeartCycle programme
Aims: There is a need for alternative strategies that might avoid recurrent admissions in patients with heart failure. Home Telemonitoring (HTM) to monitor patient’s symptoms from a distance may be useful. This study attempts to assess changes in HTM vital signs in response to daily life activities (variations in medication, salt intake, exercise and stress) and to stablish which variations affect weight, blood pressure (BP) and heart rate (HR). Methods and results: We assessed 76 patients with heart failure (mean age 76 ± 10.8 years, 75% male, mainly in NYHA class II/III and from ischaemic etiology cause). Patients were given a calendar of interventions scheduling activities approximately twice-a-week before measuring their vital signs. Eating salty food or a large meal were the activities that had a significant impact on weight gain (+0.3 kg; p<0.001 and p=0.006, respectively). Exercise and skipping a dose of medication other than diuretics increased heart rate (+3 bpm, p=0.001 and almost +2 bpm, p=0.016, respectively). Conclusions: Our HTM system was able to detect small changes in vital signs related to these activities. Further studies should assess if providing such a schedule of activities might be useful for patient education and could improve long-term adherence to recommended lifestyle changes
Forward Flux Sampling-type schemes for simulating rare events: Efficiency analysis
We analyse the efficiency of several simulation methods which we have
recently proposed for calculating rate constants for rare events in stochastic
dynamical systems, in or out of equilibrium. We derive analytical expressions
for the computational cost of using these methods, and for the statistical
error in the final estimate of the rate constant, for a given computational
cost. These expressions can be used to determine which method to use for a
given problem, to optimize the choice of parameters, and to evaluate the
significance of the results obtained. We apply the expressions to the
two-dimensional non-equilibrium rare event problem proposed by Maier and Stein.
For this problem, our analysis gives accurate quantitative predictions for the
computational efficiency of the three methods.Comment: 19 pages, 13 figure
Fitting in a complex chi^2 landscape using an optimized hypersurface sampling
Fitting a data set with a parametrized model can be seen geometrically as
finding the global minimum of the chi^2 hypersurface, depending on a set of
parameters {P_i}. This is usually done using the Levenberg-Marquardt algorithm.
The main drawback of this algorithm is that despite of its fast convergence, it
can get stuck if the parameters are not initialized close to the final
solution. We propose a modification of the Metropolis algorithm introducing a
parameter step tuning that optimizes the sampling of parameter space. The
ability of the parameter tuning algorithm together with simulated annealing to
find the global chi^2 hypersurface minimum, jumping across chi^2{P_i} barriers
when necessary, is demonstrated with synthetic functions and with real data
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