1,010 research outputs found
Critical holes in undercooled wetting layers
The profile of a critical hole in an undercooled wetting layer is determined
by the saddle-point equation of a standard interface Hamiltonian supported by
convenient boundary conditions. It is shown that this saddle-point equation can
be mapped onto an autonomous dynamical system in a three-dimensional phase
space. The corresponding flux has a polynomial form and in general displays
four fixed points, each with different stability properties. On the basis of
this picture we derive the thermodynamic behaviour of critical holes in three
different nucleation regimes of the phase diagram.Comment: 18 pages, LaTeX, 6 figures Postscript, submitted to J. Phys.
Consolidating and Dispatching Truck Shipments of Mobil Heavy Petroleum Products
Interfaces, 25, pp. 1-17.Mobil Oil Coporation consolidates and dispatches truck shipments of heavy petroleum products-lubricants in packages and in bulk from 10 lubricant plants nationwide. It dispatches hundreds of orders daily either individually or as consolidated truckloads, using a very nonhomogeneous fleet of Mobil controlled and contract vehicles and common carriers..
Gravity of Monopole and String and Gravitational Constant in 3He-A
We discuss the effective metric produced in superfluid 3He-A by such
topological objects as radial disgyration and monopole. In relativistic
theories these metrics are similar to that of the local string and global
monopole correspondingly. But in 3He-A they have the negative angle deficit,
which corresponds to the negative mass of the topological objects. The
effective gravitational constant G in superfluid 3He-A, derived from the
comparison with relativistic theories, is inversely proportional to the square
of the gap amplitude Delta, which plays the part of the Planck energy cut-off.
G depends on temperature and increases with T, which corresponds to the vacuum
screening of the Newton's constant.Comment: Latex file, 10 pages, no figure
Identifizierung VHL-assoziierter Veränderungen im klarzelligen Nierenzellkarzinom: Anwendung von kombinierten Genom- und Expressionsanalysen
Zusammenfassung: Das sporadische Nierenzellkarzinom (NZK) ist ein heterogener solider Tumor, der traditionell basierend auf morphologischen Kriterien in weitere Subtypen unterteilt wird. In den letzten Jahren konnten unter Anwendung molekularer Hochdurchsatzanalysen genetische, transkriptionelle und translationale Alterationen identifiziert werden. Diese Marker eignen sich zum einen für die molekulare Klassifizierung des NZK und haben zum anderen prognostische Wertigkeit. Die isolierte Betrachtung genetischer, transkriptioneller und translationaler Veränderungen verhindert jedoch ein tieferes Verständnis für die komplexen Vorgänge der Karzinogenese. Wir fassen hier aktuelle Forschungsergebnisse zur molekularen Charakterisierung des NZK zusammen und stellen ein systembiologisches Konzept zur Identifizierung neuer Tumormarker vor. Diese könnten zukünftig Einsatz in der Diagnostik und Therapie des sporadischen NZK finde
Treatment of Marburg and Ebola hemorrhagic fevers: A strategy for testing new drugs and vaccines under outbreak conditions.
The filoviruses, Marburg and Ebola, have the dubious distinction of being associated with some of the highest case-fatality rates of any known infectious disease-approaching 90% in many outbreaks. In recent years, laboratory research on the filoviruses has produced treatments and vaccines that are effective in laboratory animals and that could potentially drastically reduce case-fatality rates and curtail outbreaks in humans. However, there are significant challenges in clinical testing of these products and eventual delivery to populations in need. Most cases of filovirus infection are recognized only in the setting of large outbreaks, often in the most remote and resource-poor areas of sub-Saharan Africa, with little infrastructure and few personnel experienced in clinical research. Significant political, legal, and socio-cultural barriers also exist. Here, we review the present research priorities and environment for field study of the filovirus hemorrhagic fevers and outline a strategy for future prospective clinical research on treatment and vaccine prevention
- …