The consequence of the servant's suffering for the relationship between God and the others in Isaiah 53

This thesis studies the relation between the servant's suffering and the others' reconciliation with God as it is presented in Isaiah 53. Commonly, reconciliation in Isaiah 53 is suggested to be by the servant's message causing contrition or faith, or by his suffering being atoning. Reconciliation by message is commonly based on interpreting the servant as a prophet. Reconciliation by atonement is commonly based on expressions in Isaiah 53 which can be related to cultic expiation of sin. The thesis is based on a thorough study of the text of Isaiah 53. This study suggests uncommon answers to textcritical questions. It also suggests uncommon translations of some verses of Isaiah 53. Further, it suggests that Isaiah 53 is intentionally ambiguous, both concerning the identity of the servant, and concerning reconciliation. Isaiah 53 depicts the servant both as in need of reconciliation and as righteous, and thus not in need of reconciliation. This contradiction can be resolved by an ambiguous identity of the servant. Isaiah 53 depicts the servant ambiguously both as the servant Israel, in need of reconciliation, and as a righteous servant, who reconciles Israel. Isaiah 53 states reconciliation by chastisement and insight, and by transfer of the burden of sin. Isaiah 53 also alludes to cultic expiation of sin. Concerning chastisement, the servant Israel is chastised by being sent into exile. This chastisement fosters the servant's insight and resulting righteous conduct, and thereby, the servant's peace with God. Concerning transfer of the burden of sin, Isaiah 53 states that the we-group's and the many's burden of sin, that is, the guilt incurred by sin and the punishment for this guilt, is transferred to the righteous servant. By this transfer, the others are freed from their guilt and thus reconciled. Concerning cultic expiation of sin, Isaiah 53 clearly alludes to both the Day of Atonement and the liability offering, but does not decisively depict the servant as scapegoat or liability offering. Reconciliation by transfer of the burden of sin amounts to vicarious suffering. The concept of vicarious suffering has been criticized for being unique to the Old Testament. However, vicarious substitution is a concept commonly found in the Old Testament. Vicarious substitution may have inspired the concept of vicarious suffering as a specific application

Developing winter forages for the far north Queensland dairy industry

The far north Queensland (FNQ) dairy industry has historically relied on the use of maize silage in dairy diets either year-round in partial mixed ration systems, or as a supplement in pasture-based systems during dry times. Maize grows very well during summer in the north Queensland environment and has therefore been readily available to farmers at reasonable cost. However, there are several challenges which can significantly impact the quality of the end product. Harvesting the crop at the correct dry matter percentage, lack of contractors and machinery to harvest large areas that mature at the same time, and more recently the impact that fall army worm has had on yields and cost of production. Inclusion of protein in adequate amounts in FNQ dairy diets is also a challenge due to the cost of freight required to transport typically used protein meals such as canola and soybean. Is there an opportunity to grow winter forages in far north Queensland which are higher in protein than maize silage which can offset the high cost of protein meals in cow diets? These crops can be harvested at a time of year when competition for silage contractors and machinery does not exist therefore increasing the likelihood of harvest occurring at optimum crop dry matter

E-Health for Individualized Prevention of Eating Disorders

In the field of illness prevention, it is becoming increasingly important that effective treatments be broadly disseminated and easily accessible to large populations located over wide geographical areas. The internet offers many opportunities to improve illness prevention and has become an important tool for both providers and users. An increasing number of users are looking for help on web-pages, in forums and chat rooms, to access information and exchange experiences with other users or counselors. Appetite for Life is an Internet-based program for the prevention of eating disorders (ED) in college students. It provides individualized support to students at-risk of developing an ED. Depending on initial screening results, specific program modules are recommended to the user, matching their individual needs. The program contains a web-page with psychoeducational information on ED, an anonymous forum to receive and provide peer support, a supportive monitoring and feedback program and a chat platform, which can be used to communicate with professional counselors and other users. If needed, users can be referred to face-to-face counseling

Multitrophic diversity effects depend on consumer specialization and species-specific growth and grazing rates

Ecosystem functioning is affected by horizontal (within trophic groups) and vertical (across trophic levels) biodiversity. Theory predicts that the effects of vertical biodiversity depend on consumer specialization. In a microcosm experiment, we investigated ciliate consumer diversity and specialization effects on algal prey biovolume, evenness and composition, and on ciliate biovolume production. The experimental data was complemented by a process-based model further analyzing the ecological mechanisms behind the observed diversity effects. Overall, increasing consumer diversity had no significant effect on prey biovolume or evenness. However, consumer specialization affected the prey community. Specialist consumers showed a stronger negative impact on prey biovolume and evenness than generalists. The model confirmed that this pattern was mainly driven by a single specialist with a high per capita grazing rate, consuming the two most productive prey species. When these were suppressed, the prey assemblage became dominated by a less productive species, consequently decreasing prey biovolume and evenness. Consumer diversity increased consumer biovolume, which was stronger for generalists than for specialists and highest in mixed combinations, indicating that consumer functional diversity, i.e. more diverse feeding strategies, increased resource use efficiency. Overall, our results indicate that consumer diversity effects on prey and consumers strongly depend on species-specific growth and grazing rates, which may be at least equally important as consumer specialization in driving consumer diversity effects across trophic levels

Nanomedicine-driven molecular targeting, drug delivery, and therapeutic approaches to cancer chemoresistance

Cancer cell resistance to chemotherapeutics (chemoresistance) poses a significant clinical challenge that oncology research seeks to understand and overcome. Multiple anticancer drugs and targeting agents can be incorporated in nanomedicines, in addition to different treatment modalities, forming a single nanoplatform that can be used to address tumor chemoresistance. Nanomedicine-driven molecular assemblies using nucleic acids, small interfering (si)RNAs, miRNAs, and aptamers in combination with stimuli-responsive therapy improve the pharmacokinetic (PK) profile of the drugs and enhance their accumulation in tumors and, thus, therapeutic outcomes. In this review, we highlight nanomedicine-driven molecular targeting and therapy combination used to improve the 3Rs (right place, right time, and right dose) for chemoresistant tumor therapies

Transcriptome analysis of Aspergillus niger xlnR and xkiA mutants grown on corn Stover and soybean hulls reveals a highly complex regulatory network.

BACKGROUND:Enzymatic plant biomass degradation by fungi is a highly complex process and one of the leading challenges in developing a biobased economy. Some industrial fungi (e.g. Aspergillus niger) have a long history of use with respect to plant biomass degradation and for that reason have become 'model' species for this topic. A. niger is a major industrial enzyme producer that has a broad ability to degrade plant based polysaccharides. A. niger wild-type, the (hemi-)cellulolytic regulator (xlnR) and xylulokinase (xkiA1) mutant strains were grown on a monocot (corn stover, CS) and dicot (soybean hulls, SBH) substrate. The xkiA1 mutant is unable to utilize the pentoses D-xylose and L-arabinose and the polysaccharide xylan, and was previously shown to accumulate inducers for the (hemi-)cellulolytic transcriptional activator XlnR and the arabinanolytic transcriptional activator AraR in the presence of pentoses, resulting in overexpression of their target genes. The xlnR mutant has reduced growth on xylan and down-regulation of its target genes. The mutants therefore have a similar phenotype on xylan, but an opposite transcriptional effect. D-xylose and L-arabinose are the most abundant monosaccharides after D-glucose in nearly all plant-derived biomass materials. In this study we evaluated the effect of the xlnR and xkiA1 mutation during growth on two pentose-rich substrates by transcriptome analysis. RESULTS:Particular attention was given to CAZymes, metabolic pathways and transcription factors related to the plant biomass degradation. Genes coding for the main enzymes involved in plant biomass degradation were down-regulated at the beginning of the growth on CS and SBH. However, at a later time point, significant differences were found in the expression profiles of both mutants on CS compared to SBH. CONCLUSION:This study demonstrates the high complexity of the plant biomass degradation process by fungi, by showing that mutant strains with fairly straightforward phenotypes on pure mono- and polysaccharides, have much less clear-cut phenotypes and transcriptomes on crude plant biomass

Physically stimulated nanotheranostics for next generation cancer therapy: Focus on magnetic and light stimulations

Physically or externally stimulated nanostructures often employ multimodality and show encouraging results at preclinical stage in cancer therapy. Specially designed smart nanostructures such as hybrid nanostructures are responsive to external physical stimuli such as light, magnetic field, electric, ultrasound, radio frequency, X-ray, etc. These physically responsive nanostructures have been widely explored as nonconventional innovative “nanotheranostics” in cancer therapies. Physically stimulated (particularly magnetic and light) nanotheranostics provide a unique combination of important properties to address key challenges in modern cancer therapy: (i) an active tumor targeting mechanism of therapeutic drugs driven by a physical force rather than passive antibody matching, (ii) an externally/remotely controlled drugs on-demand release mechanism, and (iii) a capability for advanced image guided tumor therapy and therapy monitoring. Although primarily addressed to the scientific community, this review offers valuable and accessible information for a wide range of readers interested in the current technological progress with direct relevance to the physics, chemistry, biomedical field, and theranostics. We herein cover magnetic and light-triggered modalities currently being developed for nonconventional cancer treatments. The physical basis of each modality is explained; so readers with a physics or, materials science background can easily grasp new developments in this field

Clinical efficacy of omalizumab in chronic spontaneous urticaria is associated with a reduction of FcεRI-positive cells in the skin

Background. Treatment with omalizumab, a humanized recombinant monoclonal anti-IgE antibody, results in clinical efficacy in patients with Chronic Spontaneous Urticaria (CSU). The mechanism of action of omalizumab in CSU has not been elucidated in detail. Objectives. To determine the effects of omalizumab on levels of high affinity IgE receptor-positive (FcεRI+) and IgE- positive (IgE+) dermal cells and blood basophils. Treatment efficacy and safety were also assessed. Study design. In a double-blind study, CSU patients aged 18‑75 years were randomized to receive 300 mg omalizumab (n=20) or placebo (n=10) subcutaneously every 4 weeks for 12 weeks. Changes in disease activity were assessed by use of the weekly Urticaria Activity Score (UAS7). Circulating IgE levels, basophil numbers and levels of expression of FcεRI+ and IgE+ cells in the skin and in blood basophils were determined. Results. Patients receiving omalizumab showed a significantly greater decrease in UAS7 compared with patients receiving placebo. At Week 12 the mean difference in UAS7 between treatment groups was -14.82 (p=0.0027), consistent with previous studies. Total IgE levels in serum were increased after omalizumab treatment and remained elevated up to Week 12. Free IgE levels decreased after omalizumab treatment. Mean levels of FcεRI+ skin cells in patients treated with omalizumab 300 mg were decreased at Week 12 compared with baseline in the dermis of both non-lesional and lesional skin, reaching levels comparable with those seen in healthy volunteers (HVs). There were no statistically significant changes in mean FcɛRI+ cell levels in the placebo group. Similar results were seen for changes in IgE+ cells, although the changes were not statistically significant. The level of peripheral blood basophils increased immediately after treatment start and returned to Baseline values after the follow-up period. The levels of FcεRI and IgE expression on peripheral blood basophils were rapidly reduced by omalizumab treatment up to Week 12. Conclusions. Treatment with omalizumab resulted in rapid clinical benefits in patients with CSU. Treatment with omalizumab was associated with reduction in FcɛRI+ and IgE+ basophils and intradermal cells