50 research outputs found
Enhanced binding and cold compression of nuclei due to admixture of antibaryons
We discuss the possibility of producing a new kind of nuclear system by
putting a few antibaryons inside ordinary nuclei. The structure of such systems
is calculated within the relativistic mean--field model assuming that the
nucleon and antinucleon potentials are related by the G-parity transformation.
The presence of antinucleons leads to decreasing vector potential and
increasing scalar potential for the nucleons. As a result, a strongly bound
system of high density is formed. Due to the significant reduction of the
available phase space the annihilation probability might be strongly suppressed
in such systems.Comment: 10 pages, 3 figures, to be submitted to Phys. Lett.
-Nucleus Scattering at Low and Intermediate Energies
We calculate -nucleus elastic differential, reaction and total cross
sections for different nuclei (C,Ca and Pb) at several
laboratory antikaon momenta, ranging from 127 MeV to 800 MeV. We use different
antikaon-nucleus optical potentials, some of them fitted to kaonic atom data,
and study the sensitivity of the cross sections to the considered
antikaon-nucleus dynamics.Comment: Only 4 pages, Latex, 3 Figures. This version is much shorter than the
previous one. Some details and references have been omitte
Recent progress on the chiral unitary approach to meson meson and meson baryon interactions
We report on recent progress on the chiral unitary approach, analogous to the
effective range expansion in Quantum Mechanics, which is shown to have a much
larger convergence radius than ordinary chiral perturbation theory, allowing
one to reproduce data for meson meson interaction up to 1.2 GeV. Applications
to physical processes so far unsuited for a standard chiral perturbative
approach are presented. Results for the extension of these ideas to the meson
baryon sector are discussed, together with applications to kaons in a nuclear
medium and atoms.Comment: Contribution to the KEK Tanashi Symposium on Physics of Hadrons and
Nuclei, Tokyo, December 1998, 10 pages, 3 postscript figures. To be published
as a special issue of Nuclear Physics
Health outcomes after myocardial infarction: A population study of 56 million people in England
Background
The occurrence of a range of health outcomes following myocardial infarction (MI) is unknown. Therefore, this study aimed to determine the long-term risk of major health outcomes following MI and generate sociodemographic stratified risk charts in order to inform care recommendations in the post-MI period and underpin shared decision making.
Methods and findings
This nationwide cohort study includes all individuals aged â„18 years admitted to one of 229 National Health Service (NHS) Trusts in England between 1 January 2008 and 31 January 2017 (final follow-up 27 March 2017). We analysed 11 non-fatal health outcomes (subsequent MI and first hospitalisation for heart failure, atrial fibrillation, cerebrovascular disease, peripheral arterial disease, severe bleeding, renal failure, diabetes mellitus, dementia, depression, and cancer) and all-cause mortality. Of the 55,619,430 population of England, 34,116,257 individuals contributing to 145,912,852 hospitalisations were included (mean age 41.7 years (standard deviation [SD 26.1]); n = 14,747,198 (44.2%) male). There were 433,361 individuals with MI (mean age 67.4 years [SD 14.4)]; n = 283,742 (65.5%) male). Following MI, all-cause mortality was the most frequent event (adjusted cumulative incidence at 9 years 37.8% (95% confidence interval [CI] [37.6,37.9]), followed by heart failure (29.6%; 95% CI [29.4,29.7]), renal failure (27.2%; 95% CI [27.0,27.4]), atrial fibrillation (22.3%; 95% CI [22.2,22.5]), severe bleeding (19.0%; 95% CI [18.8,19.1]), diabetes (17.0%; 95% CI [16.9,17.1]), cancer (13.5%; 95% CI [13.3,13.6]), cerebrovascular disease (12.5%; 95% CI [12.4,12.7]), depression (8.9%; 95% CI [8.7,9.0]), dementia (7.8%; 95% CI [7.7,7.9]), subsequent MI (7.1%; 95% CI [7.0,7.2]), and peripheral arterial disease (6.5%; 95% CI [6.4,6.6]). Compared with a risk-set matched population of 2,001,310 individuals, first hospitalisation of all non-fatal health outcomes were increased after MI, except for dementia (adjusted hazard ratio [aHR] 1.01; 95% CI [0.99,1.02];p = 0.468) and cancer (aHR 0.56; 95% CI [0.56,0.57];p < 0.001).
The study includes data from secondary care onlyâas such diagnoses made outside of secondary care may have been missed leading to the potential underestimation of the total burden of disease following MI.
Conclusions
In this study, up to a third of patients with MI developed heart failure or renal failure, 7% had another MI, and 38% died within 9 years (compared with 35% deaths among matched individuals). The incidence of all health outcomes, except dementia and cancer, was higher than expected during the normal life course without MI following adjustment for age, sex, year, and socioeconomic deprivation. Efforts targeted to prevent or limit the accrual of chronic, multisystem disease states following MI are needed and should be guided by the demographic-specific risk charts derived in this study
Negative Kaons in Dense Baryonic Matter
Kaon polarization operator in dense baryonic matter of arbitrary isotopic
composition is calculated including s- and p-wave kaon-baryon interactions. The
regular part of the polarization operator is extracted from the realistic
kaon-nucleon interaction based on the chiral and 1/N_c expansion. Contributions
of the Lambda(1116), Sigma(1195), Sigma*(1385) resonances are taken explicitly
into account in the pole and regular terms with inclusion of mean-field
potentials. The baryon-baryon correlations are incorporated and fluctuation
contributions are estimated. Results are applied for K- in neutron star matter.
Within our model a second-order phase transition to the s-wave K- condensate
state occurs at rho_c \gsim 4 \rho_0 once the baryon-baryon correlations are
included. We show that the second-order phase transition to the p-wave
condensate state may occur at densities in
dependence on the parameter choice. We demonstrate that a first-order phase
transition to a proton-enriched (approximately isospin-symmetric) nucleon
matter with a p-wave K- condensate can occur at smaller densities, \rho\lsim 2
\rho_0. The transition is accompanied by the suppression of hyperon
concentrations.Comment: 41 pages, 24 figures, revtex4 styl
Determinants of multimorbidity in older adults in Iran: a cross-sectional study using latent class analysis on the Bushehr Elderly Health (BEH) program
Background and objectives
Multimorbidity, defined as the presence of two or more long-term health conditions in an individual, is one of the most significant challenges facing health systems worldwide. This study aimed to identify determinants of classes of multimorbidity among older adults in Iran.
Research Design and methods
In a cross-sectional sample of older adults (agedââ„â60 years) from the second stage of the Bushehr Elderly Health (BEH) program in southern Iran, latent class analysis (LCA) was used to identify patterns of multimorbidity. Multinomial logistic regression was conducted to investigate factors associated with each multimorbidity class, including age, gender, education, household income, physical activity, smoking status, and polypharmacy.
Results
In 2,426 study participants (mean age 69 years, 52% female), the overall prevalence of multimorbidity was 80.2%. Among those with multimorbidity, 3 latent classes were identified. These comprised: class 1, individuals with a low burden of multisystem disease (56.9%); class 2, individuals with predominantly cardiovascular-metabolic disorders (25.8%) and class 3, individuals with predominantly cognitive and metabolic disorders (17.1%). Compared with men, women were more likely to belong to class 2 (odds ratio [OR] 1.96, 95% confidence interval [CI] 1.52â2.54) and class 3 (OR 4.52, 95% CI 3.22â6.35). Polypharmacy was associated with membership class 2 (OR 3.52, 95% CI: 2.65â4.68) and class 3 (OR 1.84, 95% CI 1.28â2.63). Smoking was associated with membership in class 3 (OR 1.44, 95% CI 1.01â2.08). Individuals with higher education levels (59%) and higher levels of physical activity (39%) were less likely to belong to class 3 (OR 0.41; 95% CI: 0.28â0.62) and to class 2 (OR 0.61; 95% CI: 0.38â0.97), respectively. Those at older age were less likely to belong to class 2 (OR 0.95).
Discussion and implications
A large proportion of older adults in Iran have multimorbidity. Female sex, polypharmacy, sedentary lifestyle, and poor education levels were associated with cardiovascular-metabolic multimorbidity and cognitive and metabolic multimorbidity. A greater understanding of the determinants of multimorbidity may lead to strategies to prevent its development
SL(2,Z) symmetries, Supermembranes and Symplectic Torus Bundles
We give the explicit formulation of the 11D supermembrane as a symplectic
torus bundle with non trivial monodromy and non vanishing Euler class. This
construction allows a classification of all supermembranes showing explicitly
the discrete SL(2,Z) symmetries associated to dualities. It hints as the origin
in M-theory of the gauging of the effective theories associated to string
theories.Comment: 13 pages, Late
Nucleon charge exchange on the deuteron: A critical review
The existing experimental data on the d(n,p)nn and d(p,n)pp cross sections in
the forward direction are reviewed in terms of the Dean sum rule. It is shown
that the measurement of the ratio of the charge exchange on the deuteron to
that on the proton might, if taken together with other experimental data, allow
a direct construction of the np -> np scattering amplitude in the backward
direction with few ambiguities.Comment: 7 pages with 3 figure
Antikaon condensation and the metastability of protoneutron stars
We investigate the condensation of meson along with
condensation in the neutrino trapped matter with and without hyperons.
Calculations are performed in the relativistic mean field models in which both
the baryon-baryon and (anti)kaon-baryon interactions are mediated by meson
exchange. In the neutrino trapped matter relevant to protoneutron stars, the
critical density of condensation is shifted considerably to higher
density whereas that of condensation is shifted slightly to higher
density with respect to that of the neutrino free case. The onset of
condensation always occurs earlier than that of condensation. A
significant region of maximum mass protoneutron stars is found to contain condensate for larger values of the antikaon potential. With the
appearance of condensation, there is a region of symmetric nuclear
matter in the inner core of a protoneutron star. It is found that the maximum
mass of a protoneutron star containing and condensate is
greater than that of the corresponding neutron star. We revisit the implication
of this scenario in the context of the metastability of protoneutron stars and
their evolution to low mass black holes.Comment: 26 pages; Revtex; 8 figures include
A de novo paradigm for male infertility
Genetics of Male Infertility Initiative (GEMINI) consortium: Donald F. Conrad, Liina Nagirnaja, Kenneth I. Aston, Douglas T. Carrell, James M. Hotaling, Timothy G. Jenkins, Rob McLachlan, Moira K. OâBryan, Peter N. Schlegel, Michael L. Eisenberg, Jay I. Sandlow, Emily S. Jungheim, Kenan R. Omurtag, Alexandra M. Lopes, Susana Seixas, Filipa Carvalho, Susana Fernandes, Alberto Barros, JoĂŁo Gonçalves, Iris Caetano, Graça Pinto, SĂłnia Correia, Maris Laan, Margus Punab, Ewa Rajpert-De Meyts, Niels JĂžrgensen, Kristian Almstrup, Csilla G. Krausz & Keith A. Jarvi.De novo mutations are known to play a prominent role in sporadic disorders with reduced fitness.
We hypothesize that de novo mutations play an important role in severe male infertility and
explain a portion of the genetic causes of this understudied disorder. To test this hypothesis, we
utilize trio-based exome sequencing in a cohort of 185 infertile males and their unaffected parents.
Following a systematic analysis, 29 of 145 rare (MAF < 0.1%) protein-altering de novo mutations
are classified as possibly causative of the male infertility phenotype. We observed a significant
enrichment of loss-of-function de novo mutations in loss-of-function-intolerant genes (p-value =
1.00 Ă 10â5) in infertile men compared to controls. Additionally, we detected a significant
increase in predicted pathogenic de novo missense mutations affecting missense-intolerant genes
(p-value = 5.01 Ă 10â4) in contrast to predicted benign de novo mutations. One gene we identify,
RBM5, is an essential regulator of male germ cell pre-mRNA splicing and has been previously
implicated in male infertility in mice. In a follow-up study, 6 rare pathogenic missense mutations
affecting this gene are observed in a cohort of 2,506 infertile patients, whilst we find no such
mutations in a cohort of 5,784 fertile men (p-value = 0.03). Our results provide evidence for the
role of de novo mutations in severe male infertility and point to new candidate genes affecting
fertility.This project was funded by The Netherlands Organization for Scientific Research (918-15-667) to J.A.V. as well as an Investigator Award in Science from the Wellcome Trust (209451) to J.A.V. a grant from the Catherine van Tussenbroek Foundation to M.S.O. a grant from MERCK to R.S. a UUKi Rutherford Fund Fellowship awarded to B.J.H. and the German Research Foundation Clinical Research Unit âMale Germ Cellsâ (DFG, CRU326) to C.F. and F.T. This project was also supported in part by funding from the Australian National Health and Medical Research Council (APP1120356) to M.K.O.B., by grants from the National Institutes of Health of the United States of America (R01HD078641 to D.F.C. and K.I.A., P50HD096723 to D.F.C.) and from the Biotechnology and Biological Sciences Research Council (BB/S008039/1) to D.J.E.info:eu-repo/semantics/publishedVersio