Propuesta de diseño del sistema de agua potable del asentamiento humano Los Libertadores distrito de Castilla, departamento de Piura

El presente trabajo de investigación se enmarca en el tipo no experimental, descriptiva y de corte transversal (periodo diciembre 2021). Tiene como finalidad proponer una solución al problema del abastecimiento del agua en el asentamiento humano Los Libertadores, realizando una propuesta de diseño para el sistema de agua potable. Se determinó un periodo de diseño de 20 años, una población actual de 3408 habitantes (año 2022) y una población de diseño de 5389 habitantes (año 2042). En el caso del asentamiento humano Los Libertadores, se aprovechó al máximo los recursos existentes dentro del área de intervención, siendo la fuente de agua un pozo profundo existente, perforado en el año 2020, encontrándose actualmente en funcionamiento, que cuenta con la capacidad necesaria para poder satisfacer la demanda de la población durante la vida útil del sistema. El agua es dirigida a un reservorio elevado a través de una tubería de PVC clase C-10 de 6” de diámetro e impulsado mediante una bomba sumergible con impulsores de tazones (23.09 hp – 34.80 hp). El reservorio elevado cuenta con un volumen de 400 m3 que se distribuye a la población con un sistema de tuberías PVC clase C-7.5 que consta de una línea de aducción de 8” de diámetro con una longitud de 35.00 m y 6” de diámetro con una longitud de 432.23 m, una red primaria de 4” de diámetro con una longitud de 2777.03 m, una red secundaria de 3” de diámetro con una longitud 4697.69 m, cumpliendo con los parámetros de presión y velocidad establecidos en el Reglamento Nacional de Edificaciones, obteniendo como resultado presiones mínimas de 12.52 m H2O y máximas de 23.84 m H2O, así como, velocidades mínimas de 0.01 m/s y máximas de 1.61 m/s

Instalación de la cátedra de la Constitución política de la monarquía española en la ciudad de Valencia

Fecha del doc. tomada del títSign.: [1]-4(4), 5(3

Modelo prolab: Sanabien Vr una solución de realidad virtual para combatir la depresión, ansiedad, y estrés

Según el Plan de Salud Mental del Perú 2020-2021, el 20% de la población padece algún trastorno mental, siendo la depresión, ansiedad y estrés las dolencias más comunes; sin embargo, el Ministerio de Salud no consigue tratar a toda la población quedando alrededor de 5 millones de peruanos sin atención, de este segmento algunos optan por algún tratamiento, pero otros no lo continúan por motivos de costo, por otro lado, existen quienes no se atienden debido al estigma social de visitar un psicólogo o porque no reconocen tener una dolencia. El proyecto SANABIEN VR busca contribuir en la atención de esta población y a su vez diferenciarse de otros tratamientos, para ello utilizará la terapia de exposición con el apoyo de tecnología mediante la aplicación de realidad virtual junto a consultorios móviles. El usuario experimentará escenarios virtuales, los cuales le permitirán abrir emociones las que posteriormente serán tratadas y gestionadas por un equipo de profesionales, siendo la realidad virtual una herramienta altamente innovadora y potente, apuntando a que la población se interese en el cuidado de la salud mental y haya menos deserción en sus terapias. Este proyecto tiene el potencial de ser escalable a otras regiones, además de tener un impacto social alineado con el ODS 3. El impacto económico se estima en S/2,365,312 de VAN y un impacto social de S/3,026,178 de VANS, por lo cual la solución es rentable y socialmente sostenible.According to the Mental Health Plan of Peru 2020-2021, 20% of the population suffers from some mental disorder, with depression, anxiety, and stress being the most common ailments; however, the Ministry of Health is unable to treat the entire population, leaving around 5 million Peruvians without care. From this segment some people opt for some kind of treatment, but others do not continue it due to cost reasons. On the other hand, there are those who do not seek help due to the social stigma of visiting a psychologist or because they do not recognize having an ailment. The SANABIEN VR project seeks to contribute to the care of this population, also, to differentiate itself from other treatments, to do this it will use exposure therapy with the support of technology through the application of virtual reality together with mobile clinics. The user will experience virtual scenarios, which will allow them to open emotions that will later be treated and managed by a team of professionals, virtual reality being a highly innovative and powerful tool, aiming to get the population interested in caring for mental health and there is less desertion in their therapies. This project has the potential to be scalable to other regions, in addition to having a social impact aligned with SDG 3. The economic impact is estimated at S/2,365,312 of NPV and a social impact of S/3,026,178 of VANS, for which the solution is profitable and socially sustainable

Evaluation of TGFβ, XPO4, elF5A2 and ANGPTL4 as biomarkers in HCC

Hepatocellular carcinoma (HCC) is the most common type of liver cancer, and the fourth leading cause of cancer mortality worldwide. It is often diagnosed at an advanced stage, and hence typically has a poor prognosis. A number of distinct molecules have been recently identified as playing a role in the control of cancer progression. However, patients with HCC have a highly variable clinical course, indicating that HCC comprises several biologically distinctive subgroups reflecting a molecular heterogeneity of the tumors. To evaluate potential biomarkers in HCC, we employed multiple methods in this study, including qPCR, immunostaining methods and tissue microarrays (TMAs), as well as histological and pathological analysis, to assess TGF beta, XPO4, elF5A2 and ANGPTL4 in cancerous and paracancerous liver tissues from 280 patients suffering from liver cancer. Our results found that all four indicators were located in the cytoplasm and distributed in cancerous and paracancerous liver tissues. Generally, there were higher levels of these indicators in paracancerous, compared with cancerous, liver tissues. These four indicators were correlated and modulated among each other. In connection with patient clinical and revisit information, statistical analysis determined that TGF beta 1 in paracancerous liver tissue was positively correlated with tumor size. Higher production of TGF beta 1 in paracancerous liver tissue was always associated with bigger liver tumors. XPO4 in cancerous liver tissue and TGF beta 1 in paracancerous liver tissue were positively correlated with tumor differentiation. TGF beta 1, ANGPTL4 and elF5A2 were also positively correlated with the T classification of tumors. Additionally, higher levels of XPO4 in cancerous liver tissue suggested that the patient would have a better prognosis and survival rate. However, higher production of XPO4 in paracancerous liver tissue suggested a worse prognosis. All the results above provide new insights into better understanding biological indicators, such as XPO4, TGF beta 1, ANGPTL4 and elF5A2, in the prediction and evaluation of liver cancer, as well as signaling pathways in the control of liver cancer. XPO4 and TGF beta 1 may serve as useful markers to evaluate the size and prognosis of liver cancer.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000312236400020&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Medicine, Research & ExperimentalSCI(E)6ARTICLE1119-127

Expression of CD99 in Pleomorphic Carcinomas of the Lung

Pleomorphic carcinoma of the lung (PCL) is characterized by a mixture of sarcomatoid and carcinoma components, and a poor prognosis. However, no immunophenotype of tumor markers has been characterized in PCL. To charaterize the immunophenotype for CD99 in PCL, we performed an immunohistochemical evaluation of PCLs for thyroid transcription factor-1 (TTF-1), cytokeratin (CK) 7 and 20, and for CD99. CD99 was found to be expressed in both carcinomatous (47%) and sarcomatous components such as spindle cells (92%) and giant cells (57%). In the case of spindle cells, CK7 was expressed in 6 cases (46%) and TTF-1 in 2 cases (15%), whereas for giant cells CK7 was expressed in 8 cases (57%) and TTF-1 in one case (7%). However, CK20 was not expressed in either the carcinomatous or sarcomatous components in any case. Thus, CD99 was found to be widely expressed in both sarcomatous and carcinoma component in PCL. A clinicopathological analysis showed no direct correlation between the expression of CD99 and the clinical indices (stage, survival rate, invasion) of PCL

E-cadherin and Cytokeratin Subtype Profiling in Effusion Cytology

Diagnostic utility of E-cadherin (E-CD) and cytokeratin (CK) subtype profiling in effusion cytology was investigated, employing immunocytochemistry on cellblock sections available from 211 metastatic carcinomas (MC), 6 mesotheliomas and 73 reactive mesothelial hyperplasias (MH). E-CD and monoclonal carcinoembryonic anti-gen (mCEA) stained 85% (120/141) and 65% (138/211) of MC, respectively. E-CD staining of MC was frequently heterogeneous (76/120) and absent in all anaplastic carcinomas (0/2). E-CD stained none (0/57) of MH while mCEA and epithelial membrane antigen (EMA) stained 12% (9/73) and 32% (16/32) of MH, respectively. Of 6 mesotheliomas, E-CD focally stained in 2 while mCEA stained none and EMA stained all. CK20 and CK17 stained none of MH or mesotheliomas. CK20 stained 15% of MC and CK 17 stained 22% of MC. CK5/6 and high molecular weight CK stained all mesotheliomas, 56% and 88% of MH, 26% and 39% of MC, respectively. MC showed predominant CK7+/20- expression, with the exceptions of MC from mucinous type of colon/rectum and ovary showing predominant CK20 positive. E-CD may be a useful positive marker for MC in effusion cytology, although it may focally stain in some mesotheliomas. Any positive staining for CK20 of MC suggests MC from the gastrointestinal tract or ovary among others

Pleural mesothelioma in a nine-month-old dog

This paper reports on an unusual case of pleural epitheloid mesothelioma in a nine-month-old male, mixed breed dog. The dog was presented in-extremis and, on post mortem examination, multiple, exophytic, frequently pedunculated, yellowish-red, soft to firm masses ranging from 3 mm to 6 cm in diameter were diffusely distributed over, and attached to, the pericardial and parietal pleural surfaces. Microscopically, these masses consisted of round to partially polygonalshaped, anaplastic cells with minimal cytoplasm and hyperchromatic nuclei covering papillomatous projections or as part of more densely cellular masses. A supporting fibrovascular stroma and mitotic figures were also evident. Constituent tumour cells were labeled positively with antibodies against both vimentin and cytokeratin. In contrast, the same cells exhibited equivocal labeling with an antibody directed against calretinin antigen and did not label with antibodies against carcinoembryonic antigen (CEA) and milk fat globule-related antigen (MFGRA). Such tumours are rare in dogs, particularly in such a young animal