A Tale of Resistance and Love

The nature of this piece asks us to open ourselves up to operating at a different level of awareness, calling on a more creative, intuitive, and more abstract/poetic epistemological frame. This piece is a short fable-like story exploring the ethics of the human within moments of immense struggle. For those of us who grapple with living within dynamics of various forms of oppression, this is essential reading for deeper discovery into ways of maintaining a sense of freedom

A Tale of Resistance and Love

The nature of this piece asks us to open ourselves up to operating at a different level of awareness, calling on a more creative, intuitive, and more abstract/poetic epistemological frame. This piece is a short fable-like story exploring the ethics of the human within moments of immense struggle. For those of us who grapple with living within dynamics of various forms of oppression, this is essential reading for deeper discovery into ways of maintaining a sense of freedom

Development and Validation of a Stability-Indicating HPLC Method for the Simultaneous Determination of Florfenicol and Flunixin Meglumine Combination in an Injectable Solution

Thecombination of the powerful antimicrobial agent florfenicol and the nonsteroidal anti-inflammatory flunixin meglumine is used for the treatment of bovine respiratory disease (BRD) and control of BRD-associated pyrexia, in beef and nonlactating dairy cattle. This study describes the development and validation of an HPLC-UVmethod for the simultaneous determination of florfenicol and flunixin, in an injectable preparation with a mixture of excipients.The proposed RP-HPLC method was developed by a reversed phase- (RP-) C18e (250mm× 4.6 mm, 5 m) column at roomtemperature, with an isocraticmobile phase of acetonitrile and water mixture, and pH was adjusted to 2.8 using diluted phosphoric acid, a flow rate of 1.0 mL/min, and ultraviolet detection at 268 nm. The stability-indicating method was developed by exposing the drugs to stress conditions of acid and base hydrolysis, oxidation, photodegradation, and thermal degradation; the obtained degraded products were successfully separated from the APIs. This method was validated in accordance with FDA and ICH guidelines and showed excellent linearity, accuracy, precision, specificity, robustness, LOD, LOQ, and system suitability results within the acceptance criteria.This research was supported by the Advanced Veterinary Manufacturing Company (Palestine)

A Validated Stability-Indicating HPLC Method for Simultaneous Determination of Amoxicillin and Enrofloxacin Combination in an Injectable Suspension

The combination of amoxicillin and enrofloxacin is a well-known mixture of veterinary drugs; it is used for the treatment of Gram-positive and Gram-negative bacteria. In the scientific literature, there is no high-performance liquid chromatography (HPLC)-UV method for the simultaneous determination of this combination. The objective of this work is to develop and validate an HPLC method for the determination of this combination. In this regard, a new, simple and efficient reversed-phase HPLC method for simultaneous qualitative and quantitative determination of amoxicillin and enrofloxacin, in an injectable preparation with a mixture of inactive excipients, has been developed and validated. The HPLC separation method was performed using a reversed-phase (RP)-C18e (250 mm 4.0 mm, 5 m) column at room temperature, with a gradient mobile phase of acetonitrile and phosphate buffer containing methanol at pH 5.0, a flow rate of 0.8 mL/min and ultraviolet detection at 267 nm. This method was validated in accordance with the Food and Drug Administration (FDA) and the International Conference on Harmonisation (ICH) guidelines and showed excellent linearity, accuracy, precision, specificity, robustness, ruggedness, and system suitability results within the acceptance criteria. A stability-indicating study was also carried out and indicated that this method can also be used for purity and degradation evaluation of these formulations.The authors are thankful to The Advanced Veterinary Manufacturing Company (Palestine) for supporting this research

Global Journalist: Unrest in Israel

In this October 28, 2004 program, host Stuart Loory discusses the implications of the Israeli Knesset's approval of a plan to withdraw from the Gaza Strip, and the reportedly serious illness of Palestinian leader Yasser Arafat on peace talks in the region

Development and Evaluation of Parenteral Solution containing Florfenicol and Flunixin Meglumine for Veterinary Use

Parenteral dosage forms are one of the most commonly used pharmaceutical dosage forms in veterinary medicine, at the same time the combination therapy of multiple drug products is a common practice in this field. The aim of this research was to develop a high quality, stable solution that combines Florfenicol and Flunixin meglumine in a multidose injectable dosage form. Different organic solvents were tested to determine the optimal solvent for the active substances in the formulation. Citric acid was used in the formulation to overcome the problem of Flunixin instability and ethyl alcohol was incorporated in the formula in order to enhance syringeability and injectability of the solution. All prepared formulations were evaluated for their chemical and physical stabilities. The candidate formula showed good physical and chemical stability after two weeks of storage at both room temperature and accelerated conditions. Samples from three pilot scale batches were stored at accelerated stability conditions for 6 months and didn’t show any significant physical or chemical instability. A generic parenteral solution drug product containing Florfenicol and Flunixin meglumine for veterinary use was successfully developed using mixture of organic solvents and excipients.This research was supported by The Advanced Veterinary Manufacturing Company (Palestine)

A Validated Stability-Indicating HPLC Method for Simultaneous Determination of Amoxicillin and Enrofloxacin Combination in an Injectable Suspension

The combination of amoxicillin and enrofloxacin is a well-known mixture of veterinary drugs; it is used for the treatment of Gram-positive and Gram-negative bacteria. In the scientific literature, there is no high-performance liquid chromatography (HPLC)-UV method for the simultaneous determination of this combination. The objective of this work is to develop and validate an HPLC method for the determination of this combination. In this regard, a new, simple and efficient reversed-phase HPLC method for simultaneous qualitative and quantitative determination of amoxicillin and enrofloxacin, in an injectable preparation with a mixture of inactive excipients, has been developed and validated. The HPLC separation method was performed using a reversed-phase (RP)-C18e (250 mm × 4.0 mm, 5 μm) column at room temperature, with a gradient mobile phase of acetonitrile and phosphate buffer containing methanol at pH 5.0, a flow rate of 0.8 mL/min and ultraviolet detection at 267 nm. This method was validated in accordance with the Food and Drug Administration (FDA) and the International Conference on Harmonisation (ICH) guidelines and showed excellent linearity, accuracy, precision, specificity, robustness, ruggedness, and system suitability results within the acceptance criteria. A stability-indicating study was also carried out and indicated that this method can also be used for purity and degradation evaluation of these formulations

The Impact of Internet of Things unification with Project Management Disciplines in project-based organizations

The greatest advantage of Information Technology (IT) is its ability in entitling personnel to achieve their goals. Allowing personnel to grasp knowledge and skills they weren’t aware of previously, rendering to a sense that it’s all about potential; as expressed by former CEO of Microsoft Steve Ballmer. Internet of Things (IoT) data, according to ORACLE (2017), provides insight from new data collected and provides solutions. Thus, allowing businesses to achieve new innovative services at a more efficient and productive manner while reducing the risk factors. Proving that the connections between the organisation and devices are securely connected, analysed, and integrated simultaneously with IoT data. Project Management (PM) the leading discipline in management that benefits enterprises through actual and operative management of change through its systematic approach of initiating, planning, executing, monitoring & controlling, Testing & Commissioning and finally Handing Over to the client the project; managing various types of projects with various drivers of change and uncertainty. (Sawyer, L. 2016). As significant as technology has become in our lives, this study aims in highlighting the importance of Internet of Things and the synergic implementation of Project Management disciplines in project-oriented organisations. It also explores the challenges, barriers, and benefits of IoT in synergy with PM disciplines. The paper also considered one of the most crucial elements of any organization or business, people, fixating on project managers and how the role of a project manager is affected in the innovative project oriented organizations

The Impact of Internet of Things unification with Project Management Disciplines in project-based organizations

The greatest advantage of Information Technology (IT) is its ability in entitling personnel to achieve their goals. Allowing personnel to grasp knowledge and skills they weren’t aware of previously, rendering to a sense that it’s all about potential; as expressed by former CEO of Microsoft Steve Ballmer. Internet of Things (IoT) data, according to ORACLE (2017), provides insight from new data collected and provides solutions. Thus, allowing businesses to achieve new innovative services at a more efficient and productive manner while reducing the risk factors. Proving that the connections between the organisation and devices are securely connected, analysed, and integrated simultaneously with IoT data. Project Management (PM) the leading discipline in management that benefits enterprises through actual and operative management of change through its systematic approach of initiating, planning, executing, monitoring & controlling, Testing & Commissioning and finally Handing Over to the client the project; managing various types of projects with various drivers of change and uncertainty. (Sawyer, L. 2016). As significant as technology has become in our lives, this study aims in highlighting the importance of Internet of Things and the synergic implementation of Project Management disciplines in project-oriented organisations. It also explores the challenges, barriers, and benefits of IoT in synergy with PM disciplines. The paper also considered one of the most crucial elements of any organization or business, people, fixating on project managers and how the role of a project manager is affected in the innovative project oriented organizations