Sanjad-Sakati Syndrome Dental Management: A Case Report

Sanjad-Sakati syndrome (SSS) is a rare genetic disorder with autosomal recessive pattern of inheritance characterized by hypoparathyroidism, sever growth failure, mental retardation, susceptibility to chest infection, and dentofacial anomalies. A child with SSS was referred to the dental departmentseeking dental help for sever dental caries which was attributed to his dietary habits and quality of dental tissues. Full restorative rehabilitation was done under general anesthesia. Two years later, the child presented with recurrent caries affecting uncrowned teeth. High carries recurrence rate was blamed for the nutritional habits endorsed by the parents. Only steel crowned teeth survived such hostile oral environment which suggested shifting of treatment strategy towards full coverage restorations instead of classical cavity preparations and fillings during a second attempt for dental treatment under general anesthesia and for the dental treatment of two cousins of the same child. The author recommends effective health education for parents including the nature of their child’s genetic disorder, nutritional needs, and dental health education to improve the life style of such children

CYTOTOXICITY OF FIVE PLANT EXTRACTS AGAINST DIFFERENT HUMAN CANCER CELL LINES AND THEIR MOLECULAR MECHANISM

Objective: Five methanol plant extracts namely, Euphorbia hierosolymitana, Dracaena marginata, Cordyline terminalis, and Sapium sebifera were screened in vitro for their cytotoxic effect on human tumor cell lines; namely, PC-3, HepG-2, HCT-116, and MCF-7 (prostate, liver, colon, and breast cancer) and human normal cell lines, namely, BJ-1. Methods: E. hierosolymitana (extract A) selectively inhibited HCT-116 cell proliferation with IC50 of 4.22 μg/ml, both Dracaena marginata (extract B) (bark, leaves, and branches) showed moderate cytotoxicity on MCF-7 with IC50 of 22.4 and 48.2 μg/ml, respectively. The remaining two extracts showed minimal to insignificant percentage inhibition on all cell lines. Results: E. hierosolymitana extract was selected for further studying, where the effect of the extract on the HCT116 cells showed a downregulation of her2 and Bcl-2 gene and overexpression of the Bax gene. Flow cytometry analysis was also performed to understand the effect of E. hierosolymitana on the apoptosis induction and the cell cycle. The results showed the induction of early and late apoptosis by 5.81 and 10.01%, respectively. Conclusion: Our results infer that E. hierosolymitana has a promising chance in fighting colorectal cancer due to its high cytotoxic effects on HCT116 cancer cells while having minimal effects on the BJ-1 normal cell lines

Analysis of Mercury (Hg) Distribution In The Waeapo River Irrigation Area, Buru Regency, Maluku Province, Gold Mining Without Permission Result In Botak Mountain Area

The Waeapo River has 13 watersheds, which are irrigated area for thousand hectare of rice field in the District of Buru. Buru District is one of the area that can supply thousands of tons of rice. But, yields to be reduced by the presence of gold mining activities in the Botak Mountain. Gold mining activities not only impact for the decline in yields, but also impact on the quality of rice by mercury pollution generated by mining waste. This research aims to determine the accumulation of mercury in sediment of Waeapo river. The research method is used survey and analysis method. In this research, observations were done and field sampling with the laboratory analyze. The result showed that concentration of analyzed mercury at four point, one point has exceeded standard of mercury limits in the sediment, i.e 0.1 pp

Producing Foils From Direct Cast Titanium Alloy Strip

This research was undertaken to demonstrate the feasibility of producing high-quality, thin-gage, titanium foil from direct cast titanium strip. Melt Overflow Rapid Solidification Technology (MORST) was used to cast several different titanium alloys into 500 microns thick strip, 10 cm wide and up to 3 m long. The strip was then either ground, hot pack rolled or cold rolled, as appropriate, into foil. Gamma titanium aluminide (TiAl) was cast and ground to approximately 100 microns thick foil and alpha-2 titanium aluminide (Ti3AI) was cast and hot pack rolled to approximately 70 microns thick foil. CP Ti, Ti6Al2Sn4Zr2Mo, and Ti22AI23Nb (Orthorhombic), were successfully cast and cold-rolled into good quality foil (less than 125 microns thick). The foils were generally fully dense with smooth surfaces, had fine, uniform microstructures, and demonstrated mechanical properties equivalent to conventionally produced titanium. By eliminating many manufacturing steps, this technology has the potential to produce thin gage, titanium foil with good engineering properties at significantly reduced cost relative to conventional ingot metallurgy processing

Analysis of Mercury (Hg) Distribution In The Waeapo River Irrigation Area, Buru Regency, Maluku Province, Gold Mining Without Permission Result In Botak Mountain Area

The Waeapo River has 13 watersheds, which are irrigated area for thousand hectare of rice field in the District of Buru. Buru District is one of the area that can supply thousands of tons of rice. But, yields to be reduced by the presence of gold mining activities in the Botak Mountain. Gold mining activities not only impact for the decline in yields, but also impact on the quality of rice by mercury pollution generated by mining waste. This research aims to determine the accumulation of mercury in sediment of Waeapo river. The research method is used survey and analysis method. In this research, observations were done and field sampling with the laboratory analyze. The result showed that concentration of analyzed mercury at four point, one point has exceeded standard of mercury limits in the sediment, i.e 0.1 pp

Change in children's oral health-related quality of life following dental treatment under general anaesthesia for the management of dental caries: a systematic review.

BACKGROUND: Dental caries has significant impact on children and their families and may necessitate treatment under general anaesthesia (GA). The use of oral health-related quality-of-life (OHRQoL) measures enables evaluation of dental treatment from a patient's perspective. OBJECTIVE: This systematic review aimed to assess change in OHRQoL in children following treatment under GA for the management of dental caries. METHODS: A comprehensive search was conducted to identify articles which were assessed against inclusion criteria before data extraction. Studies involving children under 16 years, having treatment for dental caries under GA, were considered eligible. Included studies were quality assessed. RESULTS: Twenty studies were included, which demonstrated significant heterogeneity. Most studies employed a pre-test-post-test design. All but one study relied on proxy reports of OHRQoL. Only half the studies used instruments validated in the study population. Whereas all studies reported improved OHRQoL overall, some subscales showed changes which were not significant or worsened OHRQoL. The scientific quality of the studies varied considerably. CONCLUSION: Heterogeneity of included papers limited the conclusions which could be drawn. Treatment under GA appears to result in overall improvements in proxy-reported OHRQoL; however, there is a need for further high-quality studies employing validated, child-reported measures of OHRQoL

Production of virgin coconut oil via centrifugation and oven methods

The conventional ways of breaking emulsions using heat is disadvantageous from the both economic and environmental perspectives. In this study, the production of virgin coconut oil from coconut oil milk was investigated. Centrifugation and hot method were used for separation of oil. Analysis was carried out by gas chromatography. Results show that, production of virgin coconut oil increases with increasing centrifugal speed. The optimum temperature required to maintain the nutrition oil oil was found to be 60oC. Experimental data also presented to show the influence of Triton –X-100, Tween 20 and SDDS on stability of virgin coconut oil emulsion