Rejection of mismatched disturbances for systems with input delay via a predictive extended state observer

[EN] The problem of output stabilization and disturbance rejection for input-delayed systems is tackled in this work. First, a suitable transformation is introduced to translate mismatched disturbances into an equivalent input disturbance. Then, an extended state observer is combined with a predictive observer structure to obtain a future estimation of both the state and the disturbance. A disturbance model is assumed to be known but attenuation of unmodeled components is also considered. The stabilization is proved via Lyapunov-Krasovskii functionals, leading to sufficient conditions in terms of linear matrix inequalities for the closed-loop analysis and parameter tuning. The proposed strategy is illustrated through a numerical example.PROMETEOII/2013/004; Conselleria d'Educacio; Generalitat Valenciana, Grant/Award Number: TIN2014-56158-C4-4-P-AR; Ministerio de Economia y Competitividad, Grant/Award Number: FPI-UPV 2014; Universitat Politecnica de ValenciaSanz Diaz, R.; García Gil, PJ.; Fridman, E.; Albertos Pérez, P. (2018). Rejection of mismatched disturbances for systems with input delay via a predictive extended state observer. International Journal of Robust and Nonlinear Control. 28(6):2457-2467. https://doi.org/10.1002/rnc.4027S24572467286Stability and Stabilization of Systems with Time Delay. (2011). IEEE Control Systems, 31(1), 38-65. doi:10.1109/mcs.2010.939135Fridman, E. (2014). Introduction to Time-Delay Systems. Systems & Control: Foundations & Applications. doi:10.1007/978-3-319-09393-2Watanabe, K., & Ito, M. (1981). A process-model control for linear systems with delay. IEEE Transactions on Automatic Control, 26(6), 1261-1269. doi:10.1109/tac.1981.1102802Astrom, K. J., Hang, C. C., & Lim, B. C. (1994). A new Smith predictor for controlling a process with an integrator and long dead-time. IEEE Transactions on Automatic Control, 39(2), 343-345. doi:10.1109/9.272329Matausek, M. R., & Micic, A. D. (1996). A modified Smith predictor for controlling a process with an integrator and long dead-time. IEEE Transactions on Automatic Control, 41(8), 1199-1203. doi:10.1109/9.533684García, P., & Albertos, P. (2008). A new dead-time compensator to control stable and integrating processes with long dead-time. Automatica, 44(4), 1062-1071. doi:10.1016/j.automatica.2007.08.022Normey-Rico, J. E., & Camacho, E. F. (2009). Unified approach for robust dead-time compensator design. Journal of Process Control, 19(1), 38-47. doi:10.1016/j.jprocont.2008.02.003Manitius, A., & Olbrot, A. (1979). Finite spectrum assignment problem for systems with delays. IEEE Transactions on Automatic Control, 24(4), 541-552. doi:10.1109/tac.1979.1102124Artstein, Z. (1982). Linear systems with delayed controls: A reduction. IEEE Transactions on Automatic Control, 27(4), 869-879. doi:10.1109/tac.1982.1103023Krstic, M. (2008). Lyapunov tools for predictor feedbacks for delay systems: Inverse optimality and robustness to delay mismatch. Automatica, 44(11), 2930-2935. doi:10.1016/j.automatica.2008.04.010Léchappé, V., Moulay, E., Plestan, F., Glumineau, A., & Chriette, A. (2015). New predictive scheme for the control of LTI systems with input delay and unknown disturbances. Automatica, 52, 179-184. doi:10.1016/j.automatica.2014.11.003Sanz, R., Garcia, P., & Albertos, P. (2016). Enhanced disturbance rejection for a predictor-based control of LTI systems with input delay. Automatica, 72, 205-208. doi:10.1016/j.automatica.2016.05.019Basturk, H. I., & Krstic, M. (2015). Adaptive sinusoidal disturbance cancellation for unknown LTI systems despite input delay. Automatica, 58, 131-138. doi:10.1016/j.automatica.2015.05.013Basturk, H. I. (2017). Cancellation of unmatched biased sinusoidal disturbances for unknown LTI systems in the presence of state delay. Automatica, 76, 169-176. doi:10.1016/j.automatica.2016.10.006Sanz, R., Garcia, P., Albertos, P., & Zhong, Q.-C. (2016). Robust controller design for input-delayed systems using predictive feedback and an uncertainty estimator. International Journal of Robust and Nonlinear Control, 27(10), 1826-1840. doi:10.1002/rnc.3639Mondie, S., & Michiels, W. (2003). Finite spectrum assignment of unstable time-delay systems with a safe implementation. IEEE Transactions on Automatic Control, 48(12), 2207-2212. doi:10.1109/tac.2003.820147Zhong, Q.-C. (2004). On Distributed Delay in Linear Control Laws—Part I: Discrete-Delay Implementations. IEEE Transactions on Automatic Control, 49(11), 2074-2080. doi:10.1109/tac.2004.837531Zhou, B., Lin, Z., & Duan, G.-R. (2012). Truncated predictor feedback for linear systems with long time-varying input delays. Automatica, 48(10), 2387-2399. doi:10.1016/j.automatica.2012.06.032Zhou, B., Li, Z.-Y., & Lin, Z. (2013). On higher-order truncated predictor feedback for linear systems with input delay. International Journal of Robust and Nonlinear Control, 24(17), 2609-2627. doi:10.1002/rnc.3012Besançon G Georges D Benayache Z Asymptotic state prediction for continuous-time systems with delayed input and application to control IEEE 2007 Kos, GreeceNajafi, M., Hosseinnia, S., Sheikholeslam, F., & Karimadini, M. (2013). Closed-loop control of dead time systems via sequential sub-predictors. International Journal of Control, 86(4), 599-609. doi:10.1080/00207179.2012.751627Léchappé V Moulay E Plestan F Dynamic observation-prediction for LTI systems with a time-varying delay in the input IEEE 2016 Las Vegas, NVCacace, F., Conte, F., Germani, A., & Pepe, P. (2016). Stabilization of strict-feedback nonlinear systems with input delay using closed-loop predictors. International Journal of Robust and Nonlinear Control, 26(16), 3524-3540. doi:10.1002/rnc.3517Mazenc, F., & Malisoff, M. (2017). Stabilization of Nonlinear Time-Varying Systems Through a New Prediction Based Approach. IEEE Transactions on Automatic Control, 62(6), 2908-2915. doi:10.1109/tac.2016.2600500Guo, L., & Chen, W.-H. (2005). Disturbance attenuation and rejection for systems with nonlinearity via DOBC approach. International Journal of Robust and Nonlinear Control, 15(3), 109-125. doi:10.1002/rnc.978Fridman, E. (2003). Output regulation of nonlinear systems with delay. Systems & Control Letters, 50(2), 81-93. doi:10.1016/s0167-6911(03)00131-2Isidori, A., & Byrnes, C. I. (1990). Output regulation of nonlinear systems. IEEE Transactions on Automatic Control, 35(2), 131-140. doi:10.1109/9.45168Ding, Z. (2003). Global stabilization and disturbance suppression of a class of nonlinear systems with uncertain internal model. Automatica, 39(3), 471-479. doi:10.1016/s0005-1098(02)00251-0Chen, W.-H., Yang, J., Guo, L., & Li, S. (2016). Disturbance-Observer-Based Control and Related Methods—An Overview. IEEE Transactions on Industrial Electronics, 63(2), 1083-1095. doi:10.1109/tie.2015.2478397Fridman, E., & Shaked, U. (2002). An improved stabilization method for linear time-delay systems. IEEE Transactions on Automatic Control, 47(11), 1931-1937. doi:10.1109/tac.2002.804462Fridman, E., & Orlov, Y. (2009). Exponential stability of linear distributed parameter systems with time-varying delays. Automatica, 45(1), 194-201. doi:10.1016/j.automatica.2008.06.00

Pancreatoblastoma: Cytologic and histologic analysis of 12 adult cases reveals helpful criteria in their diagnosis and distinction from common mimics

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/152894/1/cncy22187_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/152894/2/cncy22187.pd

Cytologic features and clinical implications of undifferentiated carcinoma with osteoclastic giant cells of the pancreas: An analysis of 15 cases

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/137765/1/cncy21859.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/137765/2/cncy21859_am.pd

Genome-wide analysis of macrosatellite repeat copy number variation in worldwide populations: Evidence for differences and commonalities in size distributions and size restrictions

Background: Macrosatellite repeats (MSRs), usually spanning hundreds of kilobases of genomic DNA, comprise a significant proportion of the human genome. Because of their highly polymorphic nature, MSRs represent an extreme example of copy number variation, but their structure and function is largely understudied. Here, we describe a detailed study of six autosomal and two X chromosomal MSRs among 270 HapMap individuals from Central Europe, Asia and Africa. Copy number variation, stability and genetic heterogeneity of the autosomal macrosatellite repeats RS447 (chromosome 4p), MSR5p (5p), FLJ40296 (13q), RNU2 (17q) and D4Z4 (4q and 10q) and X chromosomal DXZ4 and CT47 were investigated. Results: Repeat array size distribution analysis shows that all of these MSRs are highly polymorphic with the most genetic variation among Africans and the least among Asians. A mitotic mutation rate of 0.4-2.2% was observed, exceeding meiotic mutation rates and possibly explaining the large size variability found for these MSRs. By means of a novel Bayesian approach, statistical support for a distinct multimodal rather than a uniform allele size distribution was detected in seven out of eight MSRs, with evidence for equidistant intervals between the modes. Conclusions: The multimodal distributions with evidence for equidistant intervals, in combination with the observation of MSR-specific constraints on minimum array size, suggest that MSRs are limited in their configurations and that deviations thereof may cause disease, as is the case for facioscapulohumeral muscular dystrophy. However, at present we cannot exclude that there are mechanistic constraints for MSRs that are not directly disease-related. This study represents the first comprehensive study of MSRs in different human populations by applying novel statistical methods and identifies commonalities and differences in their organization and function in the human genome

The genetic architecture of membranous nephropathy and its potential to improve non-invasive diagnosis

Membranous Nephropathy (MN) is a rare autoimmune cause of kidney failure. Here we report a genome-wide association study (GWAS) for primary MN in 3,782 cases and 9,038 controls of East Asian and European ancestries. We discover two previously unreported loci, NFKB1 (rs230540, OR = 1.25, P = 3.4 × 10-12) and IRF4 (rs9405192, OR = 1.29, P = 1.4 × 10-14), fine-map the PLA2R1 locus (rs17831251, OR = 2.25, P = 4.7 × 10-103) and report ancestry-specific effects of three classical HLA alleles: DRB1*1501 in East Asians (OR = 3.81, P = 2.0 × 10-49), DQA1*0501 in Europeans (OR = 2.88, P = 5.7 × 10-93), and DRB1*0301 in both ethnicities (OR = 3.50, P = 9.2 × 10-23 and OR = 3.39, P = 5.2 × 10-82, respectively). GWAS loci explain 32% of disease risk in East Asians and 25% in Europeans, and correctly re-classify 20-37% of the cases in validation cohorts that are antibody-negative by the serum anti-PLA2R ELISA diagnostic test. Our findings highlight an unusual genetic architecture of MN, with four loci and their interactions accounting for nearly one-third of the disease risk

Proteostasis Dysregulation in Pancreatic Cancer

The most common form of pancreatic cancer, pancreatic ductal adenocarcinoma (PDAC), has a dismal 5-year survival rate of less than 5%. Radical surgical resection, in combination with adjuvant chemotherapy, provides the best option for long-term patient survival. However, only approximately 20% of patients are resectable at the time of diagnosis, due to locally advanced or metastatic disease. There is an urgent need for the identification of new, specific, and more sensitive biomarkers for diagnosis, prognosis, and prediction to improve the treatment options for pancreatic cancer patients. Dysregulation of proteostasis is linked to many pathophysiological conditions, including various types of cancer. In this review, we report on findings relating to the main cellular protein degradation systems, the ubiquitin-proteasome system (UPS) and autophagy, in pancreatic cancer. The expression of several components of the proteolytic network, including E3 ubiquitinligases and deubiquitinating enzymes, are dysregulated in PDAC, which accounts for approximately 90% of all pancreatic malignancies. In the future, a deeper understanding of the emerging role of proteostasis in pancreatic cancer has the potential to provide clinically relevant biomarkers and new strategies for combinatorial therapeutic options to better help treat the patients.Peer reviewe

Implications of the polymorphism of HLA-G on its function, regulation, evolution and disease association

The HLA-G gene displays several peculiarities that are distinct from those of classical HLA class I genes. The unique structure of the HLA-G molecule permits a restricted peptide presentation and allows the modulation of the cells of the immune system. Although polymorphic sites may potentially influence all biological functions of HLA-G, those present at the promoter and 3′ untranslated regions have been particularly studied in experimental and pathological conditions. The relatively low polymorphism observed in the MHC-G coding region both in humans and apes may represent a strong selective pressure for invariance, whereas, in regulatory regions several lines of evidence support the role of balancing selection. Since HLA-G has immunomodulatory properties, the understanding of gene regulation and the role of polymorphic sites on gene function may permit an individualized approach for the future use of HLA-G for therapeutic purposes