New approaches to the management of adult acute lymphoblastic leukemia

Traditional treatment regimens for adult acute lymphoblastic leukemia, including allogeneic hematopoietic cell transplantation, result in an overall survival of about 40%, a figure hardly comparable with the extraordinary 80-90% cure rate currently reported in children. When translated to the adult setting, modern pediatric-type regimens improve the survival to about 60% in young adults. The addition of tyrosine kinase inhibitors for patients with Philadelphia chromosome positive disease and the measurement of minimal residual disease to guide risk stratification and post-remission approaches has led to further improvements in outcomes. Relapsed disease and treatment toxicity - sparing no patient but representing a major concern especially in the elderly - are the most critical current issues awaiting further therapeutic advancement. Recently, there has been considerable progress in understanding the disease biology, specifically the Philadelphia-like signature as well as other high-risk subgroups. In addition, there are several new agents that will undoubtedly contribute to further improvement in the current outcomes. The most promising agents are new the monoclonal antibodies, immunomodulators, and chimeric antigen receptor T cells and, to a lesser extent, several new drugs targeting key molecular pathways involved in leukemic cell growth and proliferation. This review examines the evidence supporting the increasing role of the new therapeutic tools and treatment options in different disease subgroups, including frontline and relapsed/refractory disease. It is now possible to define the best individual approach based on to the emerging concepts of precision medicine

Distributed Temperature Sensing System Using A Commercial Otdr And A Standard Edfa With Controlled Gain

The distributed temperature sensor system based in the spontaneous Raman backscattering is demonstrated for the first time to our knowledge, using a commercial OTDR (Optical Time Domain Reflectometer) and a standard erbium doped fiber amplifier (EDFA) with controlled gain. We evaluated this approach in a 30 km of single mode fiber using an OTDR pulse width of 100 ns and an EDFA with 17 dBm of output power.9852Conference on Fiber Optic Sensors and Applications XIIIAPR 18-21, 2016Baltimore, M

Increasing the bandwidth of resonant gravitational antennas: The case of Explorer

Resonant gravitational wave detectors with an observation bandwidth of tens of hertz are a reality: the antenna Explorer, operated at CERN by the ROG collaboration, has been upgraded with a new read-out. In this new configuration, it exhibits an unprecedented useful bandwidth: in over 55 Hz about its frequency of operation of 919 Hz the spectral sensitivity is better than 10^{-20} /sqrt(Hz) . We describe the detector and its sensitivity and discuss the foreseable upgrades to even larger bandwidths.Comment: 4 pages- 4 figures Acceted for publication on Physical Review Letter

Superconducting cavity transducer for resonant gravitational radiation antennas

Parametric transducers, such as superconducting rf cavities, can boost the bandwidth and sensitivity of the next generation resonant antennas, thanks to a readily available technology. We have developed a fully coupled dynamic model of the system "antenna--transducer" and worked out some estimates of signal--to--noise ratio and the stability conditions in various experimental configurations. We also show the design and the prototype of a rf cavity which, together with a suitable read--out electronic, will be used as a test bench for the parametric transducer.Comment: 7 pages, 3 eps figures. Presented at the 6th Amaldi Conference on Gravitational Waves (2005). Accepted for publication in Journal of Physics: Conference Serie

Raman-based Distributed Temperature Sensor Using Simplex Code And Gain Controlled Edfa

In this work we present a comparison between simplex coded and optical amplified simplex coded Raman based Distributed Temperature Sensing (DTS). An increase in performance is demonstrated using erbium doped fiber amplifier (EDFA) with proper gain control scheme that allows a DTS operates with simplex code. Using 63-bit simplex code and gain controlled EDFA we demonstrated the temperature resolution and dynamic range improvement in 16 degrees C @ 10 km and 4 dB, respectively.963

Axion-like particle effects on the polarization of cosmic high-energy gamma sources

Various satellite-borne missions are being planned whose goal is to measure the polarization of a large number of gamma-ray bursts (GRBs). We show that the polarization pattern predicted by current models of GRB emission can be drastically modified by the existence of very light axion-like particles (ALPs), which are present in many extensions of the Standard Model of particle physics. Basically, the propagation of photons emitted by a GRB through cosmic magnetic fields with a domain-like structure induces photon-ALP mixing, which is expected to produce a strong modification of the original photon polarization. Because of the random orientation of the magnetic field in each domain, this effect strongly depends on the orientation of the photon line of sight. As a consequence, photon-ALP conversion considerably broadens the original polarization distribution. Searching for such a peculiar feature through future high-statistics polarimetric measurements is therefore a new opportunity to discover very light ALPs.Comment: Final version (21 pages, 8 eps figures). Matches the version published on JCAP. Added a Section on the effects of cosmic expansion on photon-ALP conversions. Figures modified to take into account this effect. References updated. Conclusions unchanged

Optimizing the Earth-LISA "rendez-vous"

We present a general survey of heliocentric LISA orbits, hoping it might help in the exercise of rescoping the mission. We try to semi-analytically optimize the orbital parameters in order to minimize the disturbances coming from the Earth-LISA interaction. In a set of numerical simulations we include nonautonomous perturbations and provide an estimate of Doppler shift and breathing as a function of the trailing angle.Comment: 18 pages, 16 figures. Submitted on CQ

On the Sensitivity of a Hollow Sphere as a Multi-modal Resonant Gravitational Wave Detector

We present a numerical analysis to simulate the response of a spherical resonant gravitational wave detector and to compute its sensitivity. Under the assump- tion of optimal filtering, we work out the sensitivity curve for a sphere first taking into account only a single transducer, and then using a coherent analysis of the whole set of transducers.Comment: 24 pages, 11 figures, published versio

Reversing conditional orderings

We analyze some specific aspects concerning conditional orderings and relations among them. To this purpose we define a suitable concept of reversed conditional ordering and prove some related results. In particular we aim to compare the univariate stochastic orderings ≤ st, ≤ hr, and ≤ lr in terms of differences among different notions of conditional orderings. Some applications of our result to the analysis of positive dependence will be detailed. We concentrate attention to the case of a pair of scalar random variables X, Y ​. Suitable extensions to multivariate cases are possible