15,505 research outputs found
Variability Of Water Mass Interleaving Off N.W. Africa
Water mass interleaving observed over the N.W. African continental slope during Upwelling 75 has been investigated. A water mass census demonstrated that the most common temperature-salinity characteristics over the slope at 23N lay between those of the North and South Atlantic Central Water masses...
Sensitivity of Ru(bpy)_2dppz^(2+) Luminescence to DNA Defects
The luminescent characteristics of Ru(bpy)_2dppz^(2+) (dppz = dipyrido[3,2-a:2′,3′-c]phenazine), a DNA light switch, were investigated in the presence of oligonucleotides containing single base mismatches or an abasic site. In water, the ruthenium luminescence is quenched, but, bound to well matched duplex DNA, the Ru complex luminesces. Here we show that with DNAs containing a defect, rac-, Δ-, and Λ-Ru(bpy)_2dppz^(2+) exhibit significant luminescent enhancements above that with well matched DNA. In the presence of a single base mismatch, large luminescent enhancements are evident for the Δ-Ru isomer; the Λ-isomer shows particularly high luminescence bound to an oligonucleotide containing an abasic site. Similar increases are not evident with two common DNA-binding organic fluorophores, ethidium bromide and TO-PRO-3. Titrations with hairpin oligonucleotides containing a variable mismatch site show correlation between the level of luminescent enhancement and the thermodynamic destabilization associated with the mismatch. This correlation is reminiscent of that found earlier for a bulky rhodium complex that binds mismatched DNA sites through metalloinsertion, where the complex binds the DNA from the minor groove side, ejecting the mismatched bases into the major groove. Differential quenching studies with minor and major groove quenchers and time-resolved emission studies support this metalloinsertion mode for the dppz complex at the defect site. Certainly these data underscore the utility of Ru(bpy)_2dppz^(2+) as a sensitive luminescent reporter of DNA and its defects
Continental-scale patterns of pathogen prevalence: a case study on the corncrake
Pathogen infections can represent a substantial threat to wild populations, especially those already limited in size. To determine how much variation in the pathogens observed among fragmented populations is caused by ecological factors, one needs to examine systems where host genetic diversity is consistent among the populations, thus controlling for any potentially confounding genetic effects. Here, we report geographic variation in haemosporidian infection among European populations of corncrake. This species now occurs in fragmented populations, but there is little genetic structure and equally high levels of genetic diversity among these populations. We observed a longitudinal gradient of prevalence from western to Eastern Europe negatively correlated with national agricultural yield, but positively correlated with corncrake census population sizes when only the most widespread lineage is considered. This likely reveals a possible impact of local agriculture intensity, which reduced host population densities in Western Europe and, potentially, insect vector abundance, thus reducing the transmission of pathogens. We conclude that in the corncrake system, where metapopulation dynamics resulted in variations in local census population sizes, but not in the genetic impoverishment of these populations, anthropogenic activity has led to a reduction in host populations and pathogen prevalence
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Public Performance Metrics: Driving Physician Motivation and Performance
Introduction: As providers transition from “fee-for-service” to “pay-for-performance” models, focus has shifted to improving performance. This trend extends to the emergency department (ED) where visits continue to increase across the United States. Our objective was to determine whether displaying public performance metrics of physician triage data could drive intangible motivators and improve triage performance in the ED.Methods: This is a single institution, time-series performance study on a physician-in-triage system. Individual physician baseline metrics—number of patients triaged and dispositioned per shift—were obtained and prominently displayed with identifiable labels during each quarterly physician group meeting. Physicians were informed that metrics would be collected and displayed quarterly and that there would be no bonuses, punishments, or required training; physicians were essentially free to do as they wished. It was made explicit that the goal was to increase the number triaged, and while the number dispositioned would also be displayed, it would not be a focus, thereby acting as this study’s control. At the end of one year, we analyzed metrics.Results: The group’s average number of patients triaged per shift were as follows: Q1-29.2; Q2-31.9; Q3-34.4; Q4-36.5 (Q1 vs Q4, p < 0.00001). The average numbers of patients dispositioned per shift were Q1-16.4; Q2-17.8; Q3-16.9; Q4-15.3 (Q1 vs Q4, p = 0.14). The top 25% of Q1 performers increased their average numbers triaged from Q1-36.5 to Q4-40.3 (ie, a statistically insignificant increase of 3.8 patients per shift [p = 0.07]). The bottom 25% of Q1 performers, on the other hand, increased their averages from Q1-22.4 to Q4-34.5 (ie, a statistically significant increase of 12.2 patients per shift [p = 0.0013]).Conclusion: Public performance metrics can drive intangible motivators (eg, purpose, mastery, and peer pressure), which can be an effective, low-cost strategy to improve individual performance, achieve institutional goals, and thrive in the pay-for-performance era
Unitarity and the color confinement
We discuss how confinement property of QCD results in the rational
unitarization scheme and how unitarity saturation leads to appearance of a
hadron liquid phase at very high temperatures.Comment: 10 pages, no figire
The dehydration, rehydration and tectonic setting of greenstone belts in a portion of the northern Kaapvaal Craton, South Africa
High-grade gneiss terranes and low-grade granite-greenstone terranes are well known in several Archaean domains. The geological relationship between these different crustal regions, however, is still controversial. One school of thought favors fundamental genetic differences between high-grade and low-grade terranes while others argue for a depth-controlled crustal evolution. The detailed examination of well-exposed Archaean terranes at different metamorphic grades, therefore, is not only an important source of information about the crustal levels exposed, but also is critical to the understanding of the possible tectonic and metamorphic evolution of greenstone belts with time. Three South African greenstone belts are compared
`Operational' Energy Conditions
I show that a quantized Klein-Gordon field in Minkowski space obeys an
`operational' weak energy condition: the energy of an isolated device
constructed to measure or trap the energy in a region, plus the energy it
measures or traps, cannot be negative. There are good reasons for thinking that
similar results hold locally for linear quantum fields in curved space-times. A
thought experiment to measure energy density is analyzed in some detail, and
the operational positivity is clearly manifested.
If operational energy conditions do hold for quantum fields, then the
negative energy densities predicted by theory have a will-o'-the-wisp
character: any local attempt to verify a total negative energy density will be
self-defeating on account of quantum measurement difficulties. Similarly,
attempts to drive exotic effects (wormholes, violations of the second law,
etc.) by such densities may be defeated by quantum measurement problems. As an
example, I show that certain attempts to violate the Cosmic Censorship
principle by negative energy densities are defeated.
These quantum measurement limitations are investigated in some detail, and
are shown to indicate that space-time cannot be adequately modeled classically
in negative energy density regimes.Comment: 18 pages, plain Tex, IOP macros. Expanded treatment of measurement
problems for space-time, with implications for Cosmic Censorship as an
example. Accepted by Classical and Quantum Gravit
Structural disorder, magnetism, and electrical and thermoelectric properties of pyrochlore Nd2Ru2O7
Polycrystalline Nd2Ru2O7 samples have been prepared and examined using a
combination of structural, magnetic, and electrical and thermal transport
studies. Analysis of synchrotron X-ray and neutron diffraction patterns
suggests some site disorder on the A-site in the pyrochlore sublattice: Ru
substitutes on the Nd-site up to 7.0(3)%, regardless of the different
preparative conditions explored. Intrinsic magnetic and electrical transport
properties have been measured. Ru 4d spins order antiferromagnetically at 143 K
as seen both in susceptibility and specific heat, and there is a corresponding
change in the electrical resistivity behaviour. A second antiferromagnetic
ordering transition seen below 10 K is attributed to ordering of Nd 4f spins.
Nd2Ru2O7 is an electrical insulator, and this behaviour is believed to be
independent of the Ru-antisite disorder on the Nd site. The electrical
properties of Nd2Ru2O7 are presented in the light of data published on all
A2Ru2O7 pyrochlores, and we emphasize the special structural role that Bi3+
ions on the A-site play in driving metallic behaviour. High-temperature
thermoelectric properties have also been measured. When considered in the
context of known thermoelectric materials with useful figures-of-merit, it is
clear that Nd2Ru2O7 has excessively high electrical resistivity which prevents
it from being an effective thermoelectric. A method for screening candidate
thermoelectrics is suggested.Comment: 19 pages, 10 figure
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