VSX J003909.7+611233: a new slowly pulsating B (SPB) star in Cassiopeia?

We report the discovery of a new 13th magnitude variable star in Cassiopeia close to the variable KP Cas.Analysis of six days of intensive photometry shows a regular, near sinusoidal modulation with an amplitude of 0.024 mag and a period of 0.43815(31)d.Although its colour indicates a spectral type around F0 the star probably suffers up to 2−2.5 magnitudes of extinction, so could be an Aor B-type star. Given the period, the low amplitude, the shape of the lightcurve and the probable spectral type we consider it most likely to be a slowly pulsating B-type (SPB) star.The variable has been registered in the International Variable Star Index with the identifier VSX J003909.7+611233

Emerging small molecule drugs

Dyslipidaemia is a major risk factor for cardiovascular diseases. Pharmacological lowering of LDL-C levels using statins reduces cardiovascular risk. However, a substantial residual risk persists especially in patients with type 2 diabetes mellitus. Because of the inverse association observed in epidemiological studies of HDL-C with the risk for cardiovascular diseases, novel therapeutic strategies to raise HDL-C levels or improve HDL functionality are developed as complementary therapy for cardiovascular diseases. However, until now most therapies targeting HDL-C levels failed in clinical trials because of side effects or absence of clinical benefits. This chapter will highlight the emerging small molecules currently developed and tested in clinical trials to pharmacologically modulate HDL-C and functionality including new CETP inhibitors (anacetrapib, evacetrapib), novel PPAR agonists (K-877, CER-002, DSP-8658, INT131 and GFT505), LXR agonists (ATI-111, LXR-623, XL-652) and RVX-208

SMEs entry mode decision making process: Rational or cybernetic?

Entry mode choice is a critical decision when a firm expends its business to foreign markets. By applying rational and cybernetic strategies to international strategic decision-making process, this paper investigates how small and medium sized firms (SMEs) decision makers decide their entry mode choices. By focusing on the entry decision making process, this research distinguishes the prior entry mode studies that emphasize the relationship between influencing factors and their impacts on entry mode choices. The results of this study show that SME managers normally adapt a combination of rational and cybernetic strategies in their international entry decision making process. This highlights that SMEs’ international entry decision making process is dynamic and complex