Supporting Parent Engagement in Linguistically Diverse Families to Promote Young Children’s Life Success

This paper examines research that can inform policies aimed at building the capacity of early care and education programs to promote parent engagement in linguistically diverse families. The key questions addressed include:1 )What factors affect linguistically diverse families’ access to early care and education programs?; 2)What do we know about linguistically diverse families and how parents in these families support their young children’s learning and development?; 3) What features of early care and education programs appear to contribute to high levels of parent engagement in linguistically diverse families?; and 4) What policies can help increase the capacity of early care and education programs to support parent engagement in linguistically diverse families

Supporting parent engagement in linguistically diverse families to promote young children's learning: Implications for early care and education policy

There is wide agreement that early care and education programs should support parent engagement linked to early learning for all families, including families from diverse language and cultural backgrounds. This brief highlights research that can inform policies to expand the capacity of early care and education programs to promote parent engagement in linguistically diverse families with young children. Policy initiatives that could strengthen the capacity of early care and education programs to support parent engagement in these families include: establishing program requirements and quality standards that specifically address the needs and interests of families whose home language is not English; providing educational opportunities to individuals who can increase the linguistic diversity and cultural competency of the early care and education workforce; providing resources to support programs' use of parent engagement practices and activities that are most promising for linguistically diverse families; and using data to understand the participation of linguistically diverse families in parent engagement activities and inform efforts to strengthen programs' capacity to engage diverse families

Addressing the Needs of Young Children and Families:Early Childhood Education and Services in Catholic Schools and Catholic Charities

Nationally, focus is increasing on the developmental experiences of young children (birth to age 8). Twenty four (arch)dioceses in large metropolitan areas participated in a survey identifying the extent and nature of services provided by Catholic schools and Catholic Charities programs to young children and their families. Six hundred and seventy Catholic schools and 100 Catholic Charities programs completed surveys. Key findings suggest that Catholic schools and Catholic Charities programs are engaged in a plethora of early childhood services and educational activities with young children and families. Both entities provide direct education and services to young children, are engaged in supporting families through a variety of initiatives, and have complementary as well as distinctive approaches. Opportunities were identified within Catholic Schools and within Catholic Charities programs. The potential benefits of increasing collaborations between Catholic schools and Catholic Charities programs, and with others, were highlighted to comprehensively meet the varied (and, at times, extensive) needs of young children and families. Abordando las necesidades de los niños y sus familias: educación en la primera infancia y servicios en las escuelas católicas y los centros católicos de beneficencia A nivel nacional, el foco se incrementa en las experiencias de desarrollo de niños pequeños (desde el nacimiento hasta los ocho años). Veinticuatro diócesis y archidiócesis en grandes zonas metropolitanas participaron en una encuesta con el objetivo de identificar el alcance y la índole de los servicios ofrecidos por las Escuelas católicas y los programas católicos de beneficencia a los niños pequeños y sus familias. Completaron la encuesta seiscientas setenta escuelas católicas y cien programas católicos de beneficencia. Los resultados clave sugieren que las escuelas católicas y los programas católicos de beneficencia están comprometidos en un sinfín de servicios para la primera infancia y actividades educativas para niños y familias. Ambas entidades proveen educación y servicios directos a niños y están comprometidas en el apoyo a las familias mediante una variedad de iniciativas, y disponen de planteamientos complementarios así como distintivos. Se identificaron oportunidades en las escuelas católicas y en los programas católicos de beneficencia. Se resaltaron las ventajas potenciales del aumento de colaboración entre las escuelas católicas y los programas católicos de beneficencia con otros para cumplir de manera comprensiva con las necesidades variadas (y a veces extensas) de los niños pequeños y las familias. Palabras clave: escuelas católicas, centros católicos de beneficencia, primera infancia, servicios a la familia, colaboración Répondre aux besoins des jeunes enfants et des familles : éducation et services à la petite enfance dans les écoles et organisations caritatives catholiques Au plan national, l’attention est de plus en plus axée sur le développement et les expériences vécues par les jeunes enfants (de la naissance à huit ans. Dans les grandes zones métropolitaines, 24 diocèses et archidiocèses ont participé à des enquêtes pour établir l\u27étendue et la nature des services rendus aux jeunes enfants et à leurs familles par les écoles et programmes caritatifs catholiques. 670 écoles catholiques et 100 programmes caritatifs ont répondu aux enquêtes. Les principales constatations montrent que les écoles et organisations caritatives catholiques sont impliquées dans une pléthore de services et activités éducatives pour la petite enfance, destinés aux jeunes enfants et aux familles. Les deux entités fournissent directement un enseignement et des services aux jeunes enfants, agissent pour aider les familles par le biais d\u27initiatives diverses et adoptent des approches complémentaires bien que distinctes. Des possibilités d’action ont été établies au sein des écoles catholiques et des programmes caritatifs. L\u27accent a été mis sur les avantages potentiels qu\u27apporterait une collaboration accrue entre les écoles et organisations caritatives catholiques, et autres, en vue de satisfaire totalement les besoins variés (parfois substantiels) des jeunes enfants et des familles. Mots-clés : Écoles catholiques, organisations caritatives, petite enfance, services familiaux, collaboratio

Clinical evaluation of antiseptic mouth rinses to reduce salivary load of SARS-CoV-2

Most public health measures to contain the COVID-19 pandemic are based on preventing the pathogen spread, and the use of oral antiseptics has been proposed as a strategy to reduce transmission risk. The aim of this manuscript is to test the efficacy of mouthwashes to reduce salivary viral load in vivo. This is a multi-centre, blinded, parallel-group, placebo-controlled randomised clinical trial that tests the effect of four mouthwashes (cetylpyridinium chloride, chlorhexidine, povidone-iodine and hydrogen peroxide) in SARS-CoV-2 salivary load measured by qPCR at baseline and 30, 60 and 120 min after the mouthrinse. A fifth group of patients used distilled water mouthrinse as a control. Eighty-four participants were recruited and divided into 12-15 per group. There were no statistically significant changes in salivary viral load after the use of the different mouthwashes. Although oral antiseptics have shown virucidal effects in vitro, our data show that salivary viral load in COVID-19 patients was not affected by the tested treatments. This could reflect that those mouthwashes are not effective in vivo, or that viral particles are not infective but viral RNA is still detected by PCR. Viral infectivity studies after the use of mouthwashes are therefore required

Generation and integrated analysis of advanced patient-derived orthoxenograft models (PDOX) for the rational assessment of targeted therapies in endometrial cancer

Clinical management of endometrial cancer (EC) is handicapped by the limited availability of second line treatments and bona fide molecular biomarkers to predict recurrence. These limitations have hampered the treatment of these patients, whose survival rates have not improved over the last four decades. The advent of coordinated studies such as The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma (TCGA_UCEC) has partially solved this issue, but the lack of proper experimental systems still represents a bottleneck that precludes translational studies from successful clinical testing in EC patients. Within this context, the first study reporting the generation of a collection of endometrioid-EC-patient-derived orthoxenograft (PDOX) mouse models is presented that is believed to overcome these experimental constraints and pave the way toward state-of-the-art precision medicine in EC. The collection of primary tumors and derived PDOXs is characterized through an integrative approach based on transcriptomics, mutational profiles, and morphological analysis; and it is demonstrated that EC tumors engrafted in the mouse uterus retain the main molecular and morphological features from analogous tumor donors. Finally, the molecular properties of these tumors are harnessed to assess the therapeutic potential of trastuzumab, a human epidermal growth factor receptor 2 (HER2) inhibitor with growing interest in EC, using patient-derived organotypic multicellular tumor spheroids and in vivo experiments

Lugar(es)

Catálogo de la exposición colectiva celebrada en la sala de exposiciones de la Facultad de Bellas Artes de la Universidad Complutense de Madrid entre el 14 y el 30 de enero de 201

Early mobilisation in critically ill COVID-19 patients: a subanalysis of the ESICM-initiated UNITE-COVID observational study

Background Early mobilisation (EM) is an intervention that may improve the outcome of critically ill patients. There is limited data on EM in COVID-19 patients and its use during the first pandemic wave. Methods This is a pre-planned subanalysis of the ESICM UNITE-COVID, an international multicenter observational study involving critically ill COVID-19 patients in the ICU between February 15th and May 15th, 2020. We analysed variables associated with the initiation of EM (within 72 h of ICU admission) and explored the impact of EM on mortality, ICU and hospital length of stay, as well as discharge location. Statistical analyses were done using (generalised) linear mixed-effect models and ANOVAs. Results Mobilisation data from 4190 patients from 280 ICUs in 45 countries were analysed. 1114 (26.6%) of these patients received mobilisation within 72 h after ICU admission; 3076 (73.4%) did not. In our analysis of factors associated with EM, mechanical ventilation at admission (OR 0.29; 95% CI 0.25, 0.35; p = 0.001), higher age (OR 0.99; 95% CI 0.98, 1.00; p ≤ 0.001), pre-existing asthma (OR 0.84; 95% CI 0.73, 0.98; p = 0.028), and pre-existing kidney disease (OR 0.84; 95% CI 0.71, 0.99; p = 0.036) were negatively associated with the initiation of EM. EM was associated with a higher chance of being discharged home (OR 1.31; 95% CI 1.08, 1.58; p = 0.007) but was not associated with length of stay in ICU (adj. difference 0.91 days; 95% CI − 0.47, 1.37, p = 0.34) and hospital (adj. difference 1.4 days; 95% CI − 0.62, 2.35, p = 0.24) or mortality (OR 0.88; 95% CI 0.7, 1.09, p = 0.24) when adjusted for covariates. Conclusions Our findings demonstrate that a quarter of COVID-19 patients received EM. There was no association found between EM in COVID-19 patients' ICU and hospital length of stay or mortality. However, EM in COVID-19 patients was associated with increased odds of being discharged home rather than to a care facility. Trial registration ClinicalTrials.gov: NCT04836065 (retrospectively registered April 8th 2021)

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

The original version of this article unfortunately contained a mistake

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat