Production of the neutral toppion at the e gamma colliders

In the framework of topcolor-assisted technicolor(TC2) model, we study a neutral toppion production process $e^{-}\gamma\to e^{-}\Pi^{0}_{t}$ in this paper. Our results show that the production cross section of $e^{-}\gamma\to e^{-}\Pi^{0}_{t}$ can reach the level of several tens fb, and over $10^{3}$ neutral toppion events can be produced in the planned $e^+e^-$ linear colliders each year. Therefore, such a toppion production process provides us a unique chance to detect toppion events and test the TC2 model. On the other hand, the cross section of $e^{-}\gamma\to e^{-}\Pi^{0}_{t}$ is about one order of magnitude larger than those of some similar processes in SM and MSSM(i.e., $e^{-}\gamma\to e^{-}H$ in SM and $e^{-}\gamma\to e^{-}H^{0}(A^0,h^0)$ in MSSM). So, we can easily distinguish the neutral toppion from other neutral Higgs bosons in SM and MSSM.Comment: 12 pages, 4 figures, The paper has been accepted by Phys.Rev.

Adiponectin receptor genes: mutation screening in syndromes of insulin resistance and association studies for type 2 diabetes and metabolic traits in UK populations

AIMS/HYPOTHESIS: Adiponectin is an adipokine with insulin-sensitising and anti-atherogenic properties. Several reports suggest that genetic variants in the adiponectin gene are associated with circulating levels of adiponectin, insulin sensitivity and type 2 diabetes risk. Recently two receptors for adiponectin have been cloned. Genetic studies have yielded conflicting results on the role of these genes and type 2 diabetes predisposition. In this study we aimed to evaluate the potential role of genetic variation in these genes in syndromes of severe insulin resistance, type 2 diabetes and in related metabolic traits in UK Europid populations. MATERIALS AND METHODS: Exons and splice junctions of the adiponectin receptor 1 and 2 genes (ADIPOR1; ADIPOR2) were sequenced in patients from our severe insulin resistance cohort (n=129). Subsequently, 24 polymorphisms were tested for association with type 2 diabetes in population-based type 2 diabetes case–control studies (n=2,127) and with quantitative traits in a population-based longitudinal study (n=1,721). RESULTS: No missense or nonsense mutations in ADIPOR1 and ADIPOR2 were detected in the cohort of patients with severe insulin resistance. None of the 24 polymorphisms (allele frequency 2.3–48.3%) tested was associated with type 2 diabetes in the case–control study. Similarly, none of the polymorphisms was associated with fasting plasma insulin, fasting and 2-h post-load plasma glucose, 30-min insulin increment or BMI. CONCLUSIONS/INTERPRETATION: Genetic variation in ADIPOR1 and ADIPOR2 is not a major cause of extreme insulin resistance in humans, nor does it contribute in a significant manner to type 2 diabetes risk and related traits in UK Europid populations. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00125-006-0534-7) contains supplementary material, which is accessible to authorised users

Increased Adiposity, Dysregulated Glucose Metabolism and Systemic Inflammation in Galectin-3 KO Mice

PMCID: PMC3579848This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

Qualidade das silagens de maniçoba "Manihot pseudoglaziovii" e pornunça "Manihot spp" sob diferentes épocas de abertura dos silos.

Avaliou-se silagens de maniçoba "Manihot pseudoglaziovii" e pornunça "Manihot spp", produzidas em tubos de PVC com 7, 14, 28 e 56 dias de fermenta~ção, determinando-se os valores de matéria seca (MS), proteína bruta (PB), fibra em detergente neutro (FDN), fibra em detergente ácido (FDA), extrato etéreo (EE), carboidratos não estruturais (CNE), o pH e digestibilidade "in vitro" da matéria seca (DIVMS). Houve diferenças significativas (P<0,05) entre os parâmetros avaliados para as espécies forrageiras utilizadas, exceto para MS e EE. A silagem de pornunça apresentou maiores valores de PB, FDN, FDA e pH em relação a maniçoba, entretanto, a DIVMS e o teor de CNE foram maiores para a silagem de maniçoba. Os valores de pH encontrados demonstraram a qualidade das silagens estudadas. Apesar dos baixos teores de DIVMS e de MS baixos, ambas podem ser utilizadas na alimentação animal

A western route of prehistoric human migration from Africa into the Iberian Peninsula

Being at the western fringe of Europe, Iberia had a peculiar prehistory and a complex pattern of Neolithization. A few studies, all based on modern populations, reported the presence of DNA of likely African origin in this region, generally concluding it was the result of recent gene flow, probably during the Islamic period. Here, we provide evidence of much older gene flow from Africa to Iberia by sequencing whole genomes from four human remains from northern Portugal and southern Spain dated around 4000 years BP (from the Middle Neolithic to the Bronze Age). We found one of them to carry an unequivocal sub-Saharan mitogenome of most probably West or West-Central African origin, to our knowledge never reported before in prehistoric remains outside Africa. Our analyses of ancient nuclear genomes show small but significant levels of sub-Saharan African affinity in several ancient Iberian samples, which indicates that what we detected was not an occasional individual phenomenon, but an admixture event recognizable at the population level. We interpret this result as evidence of an early migration process from Africa into the Iberian Peninsula through a western route, possibly across the Strait of Gibraltar

Metaloproteinases (MMPS) no plasma seminal de caprinos infectados experimentalmente pelo Vírus da Artrite Encefalite Caprina (CAE).

Resumo: As Metaloproteinases de Matriz (MMPs) estão presentes nos fluidos do epidídimo de carneiros, suínos e equinos. Elas estão envolvidas no processo de fertilização durante a penetração do espermatozoide através da membrana plasmática do óvulo. Recentemente as MMPs estão sendo foco de estudo na medicina humana, pois, estão envolvidas em tumores, metástases, doenças periodontais, pneumonia, entre outras. Nesse contexto, as mesmas estão sendo investigadas como possíveis biomarcadores. Na espécie caprina os estudos são incipientes, especialmente com relação à Artrite Encefalite Caprina (CAE). Objetiva-se nesse trabalho determinar a presença das gelatinases MMP-2 e MMP-9 e sua atividade no plasma seminal de caprinos experimentalmente infectados pelo vírus da CAE.Edición de las Memorias de la 25a. Reunión de la Asociación Latinoamericana de Producción Animal (ALPA), 2016, Recife, Brasil

Efeito do tipo de manejo sobre a orientação sexual de caprinos.

O objetivo deste trabalho foi observar o comportamento sexual de caprinos jovens da raça Anglo-Nubiano após o desaleitamento.Edición de las Memorias de la 25a. Reunión de la Asociación Latinoamericana de Producción Animal (ALPA), 2016, Recife, Brasil