Crédito público e potência da política monetária: uma análise do caso brasileiro

Este trabalho tem o objetivo de analisar o comportamento do crédito público e o debate acerca da hipótese de redução da potência da política monetária no Brasil. As taxas ofertadas pelos bancos públicos tendem a apresentar historicamente níveis inferiores às taxas de mercado, resultando em uma menor correlação com a taxa de juros básica da economia. O nível de resposta da inflação e do produto diante de um choque monetário, por sua vez, dependerá dos canais de transmissão envolvidos e da sensibilidade da taxa de juros. Assim, serão abordados os canais de transmissão convencionais do Novo Consenso, incluindo os canais de custos e a possibilidade de ocorrência de enigma dos preços, defendidos pelos heterodoxos. Da mesma forma, será apresentado o debate das escolas macroeconômicas acerca da atuação dos bancos públicos. Por fim, serão analisados os estudos microeconômicos e macroeconômicos relativos ao efeito da presença do crédito público sobre a política monetária, demonstrando o importante papel dos bancos públicos na manutenção dos níveis de investimento e produto

“SUPORTE NA ATENÇÃO BÁSICA E OS DESAFIOS NA SUA INTEGRALIDADE COM ÊNFASE NA MATRICIAL

to investigate the development of matrix support activities between the Expanded Family Health Center, Psychosocial Care Center and Family Health Strategy Teams. Method: This is a qualitative research developed from the perspective of institutional analysis in the municipality of Currais Novos, in the interior of Rio Grande do Norte, between June and September 2020. Semi-structured interviews were carried out with 22 professionals from the aforementioned health services. Results: Three categories were identified as a result of content analysis from the stories obtained in the interviews: weaknesses and challenges in mental health intake practices. Matrix support and paths forward. Fragmented attention and lack of responsibility for care. Conclusion: It was possible to verify that matrix support still has a long way to go so that the way in which requirements and equipment are guided and articulated is truly recommended. investigar o desenvolvimento das atividades do matriciamento entre Núcleo Ampliado de Saúde da Família, Centro de Atenção Psicossocial e Equipes da Estratégia de Saúde da Família. Método: Trata-se de uma pesquisa qualitativa desenvolvida na perspectiva da análise institucional no município de Currais Novos, interior do Rio Grande do Norte, entre junho e setembro de 2020. Foram realizadas entrevistas semiestruturadas com 22 profissionais dos referidos serviços de saúde. Resultados: Três categorias foram identificadas como resultado da análise de conteúdo a partir das estórias obtidas nas entrevistas: fraquezas e desafios nas práticas de ingestão de saúde mental. Apoio matricial e caminhos a seguir. Atenção fragmentada e falta de responsabilidade pelo cuidado. Conclusão: Foi possível constatar que o apoio matricial ainda tem um longo caminho a percorrer para que a forma como são guiados e articulados requisitos e equipamentos seja realmente o recomendado

Síndrome de Hutchinson: Hutchinson syndrome

Introdução: A doença de Huntington (DH) é uma doença neurodegenerativa autossômica dominante que ocorre devido a mutação no gene da huntingtina, em seu terminal 5 ́, levando a uma expansão instável do tripleto de bases nitrogenadas CAG (citosina-adenina-guanina). Sua transmissão é autossômica dominante. Apresentação do caso Paciente do sexo feminino, com idade de 1 ano 5 meses, deu entrada no serviço ambulatorial de pediatria para acompanhamento devido atraso do crescimento e baixo peso corporal para faixa etária. Nascida com 37 semanas, de parto normal, a termo, com peso 3000 gramas, estatura de 51 cm, perímetro cefálico 34cm, APGAR 7. Discussão: a doença de huntington (DH) foi descrita no século 19 por George Huntington, o qual identificou características clínicas da doença e sua natureza hereditária. No entanto, foi apenas em 1993 que conseguiu isolar o gene e descobrir que a mutação responsável pela doença é a expansão da repetição dos trinucleotídeos CAG(citosina- adenina- guanina) localizada na região 5 do gene IT15 no braço curto do cromossomo 4.  O gene IT15 é responsável pela codificação da proteína Huntingtina, que está presente em vários tecidos do corpo, principalmente no cérebro. Quando no tecido cerebral, ela é quase exclusiva do citoplasma neural, sendo vista nos axônios, dendritos e corpo celular. Conclusão: é possível compreender a importância do manejo da Síndrome de Hutchinson desde sua apresentação até o tratamento de complicações visto que sua cura ainda está em investigação científica

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear un derstanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5–7 vast areas of the tropics remain understudied.8–11 In the American tropics, Amazonia stands out as the world’s most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepre sented in biodiversity databases.13–15 To worsen this situation, human-induced modifications16,17 may elim inate pieces of the Amazon’s biodiversity puzzle before we can use them to understand how ecological com munities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple or ganism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region’s vulnerability to environmental change. 15%–18% of the most ne glected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lostinfo:eu-repo/semantics/publishedVersio

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear understanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5,6,7 vast areas of the tropics remain understudied.8,9,10,11 In the American tropics, Amazonia stands out as the world's most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepresented in biodiversity databases.13,14,15 To worsen this situation, human-induced modifications16,17 may eliminate pieces of the Amazon's biodiversity puzzle before we can use them to understand how ecological communities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple organism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region's vulnerability to environmental change. 15%–18% of the most neglected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lost

Ionic and biochemical characterization of bovine intervertebral disk

Introduction: Intervertebral disks have been associated with low back pain, and many therapies have been proposed for its treatment. The cellular and molecular knowledge of intervertebral disks composition and precise methods to quantify disk components are important for any type of proposed therapy. Thus, the aim of this study was to correlate glycosaminoglycans presence with the quantitation of cells, ions and collagen fiber distributions in different intervertebral disk sections. Methods: In total, 14 intervertebral disks were used from cattle. All of the disks were dehydrated, separated in seven sections and digested in sodium-free papain buffer. Glycosaminoglycan measurements were performed in the samples according to agarose electrophoresis methodtotal cells were measured using the PicoGreen (R) technique, ions were quantified, and collagen fiber birefringence was analyzed with polarized light. Results: Cations Na+ and K+ are more concentrate in the nucleus (Na+ = 1688.50 +/- 110 mmol/LK+ = 111.9 +/- 28 mmol/L) of intervertebral disks than the annulus (Na+ = 652.80 +/- 75 mmol/LK+ = 55.6 +/- 8 mmol/L). A negative correlation between cells number and sodium/potassium was observed (p < 0.001) Additionally, thin collagen fibers were largest in the nucleus, similar to hyaluronate distribution. Conclusions: The results suggest that annulus fibrosus cells are also sensitive to changes in ionic concentrations such as nucleus pulposus cells. Additionally, hyaluronate is related to thin collagen fibers type II.Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2009/54793-6]CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior)Department of Orthopaedics and Traumatology, Escola Paulista de Medicina , Universidade Federal de São Paulo , São Paulo , BrazilDepartment of Biochemistry , Universidade Federal de Juiz de Fora , Minas Gerais , BrazilDepartment of Biochemistry, Escola Paulista de Medicina , Universidade Federal de São Paulo , São Paulo , BrazilCentro Interdisciplinar de Investigacao Bioquimica , Universidade de Mogi das Cruzes , Mogi das Cruzes , BrazilDepartment of Morphology and Genetics, Escola Paulista de Medicina , Universidade Federal de São Paulo , São Paulo , BrazilDepartment of Orthopaedics and Traumatology, Escola Paulista de Medicina , Universidade Federal de São Paulo , São Paulo , BrazilDepartment of Biochemistry, Escola Paulista de Medicina , Universidade Federal de São Paulo , São Paulo , BrazilDepartment of Morphology and Genetics, Escola Paulista de Medicina , Universidade Federal de São Paulo , São Paulo , BrazilFAPESP: 2009/54793-6Web of Scienc

Effects of Copaiba oil in the healing process of urinary bladder in rats

ABSTRACT Introduction The appropriate closure of the urinary bladder is important to many urologic procedures to avoid the formation of fistulas and strictures by excessive fibrosis. This paper presents the alterations in the bladder healing process of rats after the topical use of Copaiba oil (Copaifera reticulata). Material and Methods Ten male Wistar rats were used and randomly divided into two groups: Control group (CG): injected 1ml/kg of saline solution on the suture line; and Copaiba group (CpG): 0.63ml/kg of copaiba oil applied to the suture line. Euthanasia was performed on the seventh day after surgery. The criteria observed were adherences formation, histopathological modifications and stereology for collagen. Results Both groups showed adhesions to the bladder, with no statistically significant difference (p=0.1481). The microscopic evaluation revealed a trend to more severe acute inflammation process on the CpG, but there was statistical difference only in the giant cells reaction (p=0.0472) and vascular proliferation (p=0.0472). The stereology showed no difference. Conclusion The copaiba oil modified the healing process, improving the quantity of giant cells and vascular proliferation, but not interfered in the collagen physiology