Forma que se ha de guardar en armar cavalleros, y dar los abitos profesiones, y colaziones de las Enmiendas a los Cavalleros de la Orden de Santiago

Copia digital. Valladolid : Junta de Castilla y León. Consejería de Cultura y Turismo, 2009-2010Esc. xil. en port.Sign.: []4, B-F

Cation exchange testsof natural zeoliteswith rare earth elements

he present work aims to analyze the effectiveness of natural zeolites for the concentration of certain elements in the rare earth group, as well as some associated cations. The work has been centered on four samples of natural zeolites from Cuba that are characterized by physical, chemical and mineralogical methods, which confirm their membership to the mordenite zeolite family, except one that was discarded in the exchange tests because it belonged to the heulandite family. The elements exchange tests were carried out over a period of 168 hours with the cations: Y3+, Eu3+, Yb3+, Ba2+, Pb2+, Cu2+ y Ni2+. Initial concentrations were set based on the average cation exchange capacity of the zeolite samples. It was concluded that this family of zeolites did not have the utility sought, because its composition contained some of the selected elements, resulting in a leaching of these cations

Large area arrays of discrete single-molecule junctions derived from host-guest complexes.

The desire to continually reduce the lower limits of semiconductor integrated circuit (IC) fabrication methods continues to inspire interest in unimolecular electronics as a platform technology for the realization of future (opto)electronic devices. However, despite successes in developing methods for the construction and measurement of single-molecule and large-area molecular junctions, exercising control over the precise junction geometry remains a significant challenge. Here, host-guest complexes of the wire-like viologen derivative 1,1'-bis(4-(methylthio)-phenyl)-[4,4'-bipyridine]-1,1'-diium chloride ([1][Cl] ) and cucurbit[7]uril (CB[7]) have been self-assembled in a regular pattern over a gold substrate. Subsequently, ligandless gold nanoparticles (AuNPs) synthesized are deposited over the host-guest array. The agreement between the conductance of individual mono-molecular junctions, appropriately chosen as a function of the AuNP diameter, within this array determined by conductive probe atomic force microscope (c-AFM) and true single-molecule measurements for a closely similar host-guest complex within a scanning tunneling microscope break-junction (STM-BJ) indicates the formation of molecular junctions derived from these host-guest complexes without deleterious intermolecular coupling effects

Índice de provisión de hábitat potencial para la biodiversidad de controladores biológicos en un paisaje de interfase urbano rural en Mendoza, Argentina

La expansión urbana sobre paisajes agrícolas genera interfases urbano-rurales. La coexistencia de usos del suelo agrícolas y residenciales puede promover conflictos en torno al uso de plaguicidas. En Mendoza, Argentina, la escasez del recurso hídrico limita el traslado de la agricultura más allá de las áreas irrigadas, por lo que es importante mejorar esta convivencia. Para disminuir el uso de plaguicidas se necesitan estrategias asentadas en funciones ecosistémicas como el control biológico de plagas por conservación. Esta estrategia depende de la biodiversidad funcional presente en el paisaje; en especial, de las comunidades vegetales con capacidad de brindar hábitat a especies de artrópodos, parasitoides y depredadores generalistas. El objetivo de este trabajo fue construir un índice para evaluar la capacidad de proveer hábitat potencial para los controladores biológicos (IHPB) en diferentes ambientes de un paisaje, con el fin de aportar conocimientos para el ordenamiento ambiental territorial de áreas de interfase. El IHPB se construyó a partir de 5 indicadores y se puso a prueba en el distrito de Lunlunta (Maipú, Mendoza). Se clasificó el área de estudio en 6 unidades de paisaje (UP): Natural de secano, Natural de ribera, Seminatural, Agrícola convencional, Agrícola biodiverso y Urbana. En ellas se realizaron censos de vegetación para calcular los indicadores. El valor más alto de IHPB ocurrió en la UP Natural de secano por la alta diversidad y la cobertura total y de especies arbóreas y arbustivas nativas presentes en su comunidad vegetal; el IHPB más bajo ocurrió en la UP Agrícola convencional. Su aplicación confirmó la importancia de las áreas naturales en cuanto a su potencialidad para sostener a la entomofauna benéfica base para el control biológico de plagas, y la necesidad de mejorar las condiciones de hábitat en los ambientes agrícolas.Urban sprawl over agricultural landscapes generates urban-rural interfaces. The coexistence of agricultural and residential land uses can promote conflicts over the use of pesticides. In Mendoza (Argentina), the scarcity of water resources is a constraint for moving agriculture beyond irrigated areas, so it is important to improve this coexistence. In order to reduce the use of pesticides, strategies based on ecosystem functions such as biological pest control through conservation are necessary. This strategy depends on the functional biodiversity present in the landscape, especially on plant communities with the capacity to provide habitat for arthropod species, parasitoids and generalist predators. The objective of this work was to construct an index to evaluate the capacity to provide potential habitat for biological controllers (IHPB) in different areas of a landscape, in order to provide knowledge for the territorial environmental management of interface areas. The IHPB was constructed from five indicators and evaluated in the Lunlunta district (Maipú, Mendoza). The study area was classified into six landscape units (UP): Dryland natural, Riverside natural, Semi-natural, Conventional agricultural, Biodiverse agricultural and Urban, in which vegetation censuses were conducted for the calculation of the indicators. The IHPB showed the highest value in the Dryland natural UP due to the high diversity, total cover and native tree and shrub species present in its plant community; the lowest was registered in Conventional agriculture. Its application confirmed the importance of natural areas in terms of their potential to sustain the beneficial entomofauna base for the biological control of pests, and the need to improve habitat conditions in agricultural environments.Fil: del Barrio, Lucia. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Mendoza-San Juan; ArgentinaFil: Fruitos, Andrea Beatríz. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Mendoza-san Juan. Estación Experimental Agropecuaria Junin; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza; ArgentinaFil: Sarandon, Santiago Javier. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Agrarias y Forestales; Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Agrarias y Forestales. Laboratorio de Investigación y Reflexión en Agroecología; ArgentinaFil: Portela, José Antonio. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Mendoza-San Juan. Estación Experimental Agropecuaria La Consulta; ArgentinaFil: D'Amario, Julieta. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias; ArgentinaFil: Martín Velasco, María José. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Geología de Costas y del Cuaternario. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto de Geología de Costas y del Cuaternario; ArgentinaFil: Perez, Martín. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Mendoza-San Juan. Estación Experimental Agropecuaria Mendoza; Argentin

Índice de provisión de hábitat potencial para la biodiversidad de controladores biológicos en un paisaje de interfase urbano rural en Mendoza, Argentina

La expansión urbana sobre paisajes agrícolas genera interfases urbano-rurales. La coexistencia de usos del suelo agrícolas y residenciales puede promover conflictos en torno al uso de plaguicidas. En Mendoza, Argentina, la escasez del recurso hídrico limita el traslado de la agricultura más allá de las áreas irrigadas, por lo que es importante mejorar esta convivencia. Para disminuir el uso de plaguicidas se necesitan estrategias asentadas en funciones ecosistémicas como el control biológico de plagas por conservación. Esta estrategia depende de la biodiversidad funcional presente en el paisaje; en especial, de las comunidades vegetales con capacidad de brindar hábitat a especies de artrópodos, parasitoides y depredadores generalistas. El objetivo de este trabajo fue construir un índice para evaluar la capacidad de proveer hábitat potencial para los controladores biológicos (IHPB) en diferentes ambientes de un paisaje, con el fin de aportar conocimientos para el ordenamiento ambiental territorial de áreas de interfase. El IHPB se construyó a partir de 5 indicadores y se puso a prueba en el distrito de Lunlunta (Maipú, Mendoza). Se clasificó el área de estudio en 6 unidades de paisaje (UP): Natural de secano, Natural de ribera, Seminatural, Agrícola convencional, Agrícola biodiverso y Urbana. En ellas se realizaron censos de vegetación para calcular los indicadores. El valor más alto de IHPB ocurrió en la UP Natural de secano por la alta diversidad y la cobertura total y de especies arbóreas y arbustivas nativas presentes en su comunidad vegetal; el IHPB más bajo ocurrió en la UP Agrícola convencional. Su aplicación confirmó la importancia de las áreas naturales en cuanto a su potencialidad para sostener a la entomofauna benéfica base para el control biológico de plagas, y la necesidad de mejorar las condiciones de hábitat en los ambientes agrícolas.Urban sprawl over agricultural landscapes generates urban-rural interfaces. The coexistence of agricultural and residential land uses can promote conflicts over the use of pesticides. In Mendoza (Argentina), the scarcity of water resources is a constraint for moving agriculture beyond irrigated areas, so it is important to improve this coexistence. In order to reduce the use of pesticides, strategies based on ecosystem functions such as biological pest control through conservation are necessary. This strategy depends on the functional biodiversity present in the landscape, especially on plant communities with the capacity to provide habitat for arthropod species, parasitoids and generalist predators. The objective of this work was to construct an index to evaluate the capacity to provide potential habitat for biological controllers (IHPB) in different areas of a landscape, in order to provide knowledge for the territorial environmental management of interface areas. The IHPB was constructed from five indicators and evaluated in the Lunlunta district (Maipú, Mendoza). The study area was classified into six landscape units (UP): Dryland natural, Riverside natural, Semi-natural, Conventional agricultural, Biodiverse agricultural and Urban, in which vegetation censuses were conducted for the calculation of the indicators. The IHPB showed the highest value in the Dryland natural UP due to the high diversity, total cover and native tree and shrub species present in its plant community; the lowest was registered in Conventional agriculture. Its application confirmed the importance of natural areas in terms of their potential to sustain the beneficial entomofauna base for the biological control of pests, and the need to improve habitat conditions in agricultural environments.EEA MendozaFil: Del Barrio, Lucia. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Mendoza; ArgentinaFil: Fruitos, Andrea. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Junin; ArgentinaFil: Fruitos, Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Sarandon, Santiago. Universidad Nacional de La Plata. Facultad de Ciencias Agrarias y Forestales. CIC-LIRA; ArgentinaFil: Portela, Jose Antonio. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria La Consulta; ArgentinaFil: D'Amario, Julieta. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias; ArgentinaFil: Martin Velasco, Maria J. Universidad Nacional de Mar del Plata. Instituto de Geología de Costas y del Cuaternario; ArgentinaFil: Perez, Martin Alberto. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Mendoza; Argentin

El tratamiento integral de los sulfuros masivos: un reto para la mineralogía y para la geometalurgia, analizado a partir de la Faja Pirítica Ibérica (FPI).

La Faja Pirítica Ibérica se ha mencionado muchas veces como la provincia metalogenética que contiene la mayor concentración conocida hasta la fecha de yacimientos VMS del mundo. Esta región que se extiende por el sur de la Península Ibérica entre dos países, Portugal y España, posee una significación histórica muy notable, está considerada entre los lugares con una actividad minera más antigua (incluso se menciona en la Biblia) y ha influenciado el desarrollo histórico de varias culturas en su aspecto económico y tecnológico

Prediction of peripheral neuropathy in multiple myeloma patients receiving bortezomib and thalidomide: a genetic study based on a single nucleotide polymorphism array

GEM (Grupo Español de MM)/PETHEMA (Programa para el Estudio de la Terapéutica en Hemopatías Malignas) cooperative study group.Bortezomib- and thalidomide-based therapies have significantly contributed to improved survival of multiple myeloma (MM) patients. However, treatment-induced peripheral neuropathy (TiPN) is a common adverse event associated with them. Risk factors for TiPN in MM patients include advanced age, prior neuropathy, and other drugs, but there are conflicting results about the role of genetics in predicting the risk of TiPN. Thus, we carried out a genome-wide association study based on more than 300 000 exome single nucleotide polymorphisms in 172 MM patients receiving therapy involving bortezomib and thalidomide. We compared patients developing and not developing TiPN under similar treatment conditions (GEM05MAS65, NCT00443235). The highest-ranking single nucleotide polymorphism was rs45443101, located in the PLCG2 gene, but no significant differences were found after multiple comparison correction (adjusted P =.1708). Prediction analyses, cytoband enrichment, and pathway analyses were also performed, but none yielded any significant findings. A copy number approach was also explored, but this gave no significant results either. In summary, our study did not find a consistent genetic component associated with TiPN under bortezomib and thalidomide therapies that could be used for prediction, which makes clinical judgment essential in the practical management of MM treatment.This work has been partially supported by grants of the Instituto de Salud Carlos III (ISCIII) (CP13/00080), ISCIII (PI12/02311), Red Temática de Investigación Cooperativa en Cáncer (RD12/0036/0069) (RD12/0036/0061), Ministerio de Economía y Competitividad/ Fondo Europeo de Desarrollo Regional (FEDER) “Una manera de hacer Europa” (Innocampus; CEI‐2010‐1‐0010), Asociación Española Contra el Cancer (GCB120981SAN), and Joan Rodes (JR 14/00016). M.E.S. is supported by the Miguel Servet program (CP13/00080) of the ISCIII (Ministerio de Economía y Competitividad).Peer Reviewe

Discovery and validation of an NMR-based metabolomic profile in urine as TB biomarker

Despite efforts to improve tuberculosis (TB) detection, limitations in access, quality and timeliness of diagnostic services in low- and middle-income countries are challenging for current TB diagnostics. This study aimed to identify and characterise a metabolic profile of TB in urine by high-field nuclear magnetic resonance (NMR) spectrometry and assess whether the TB metabolic profile is also detected by a low-field benchtop NMR spectrometer. We included 189 patients with tuberculosis, 42 patients with pneumococcal pneumonia, 61 individuals infected with latent tuberculosis and 40 uninfected individuals. We acquired the urine spectra from high and low-field NMR. We characterised a TB metabolic fingerprint from the Principal Component Analysis. We developed a classification model from the Partial Least Squares-Discriminant Analysis and evaluated its performance. We identified a metabolic fingerprint of 31 chemical shift regions assigned to eight metabolites (aminoadipic acid, citrate, creatine, creatinine, glucose, mannitol, phenylalanine, and hippurate). The model developed using low-field NMR urine spectra correctly classified 87.32%, 85.21% and 100% of the TB patients compared to pneumococcal pneumonia patients, LTBI and uninfected individuals, respectively. The model validation correctly classified 84.10% of the TB patients. We have identified and characterised a metabolic profile of TB in urine from a high-field NMR spectrometer and have also detected it using a low-field benchtop NMR spectrometer. The models developed from the metabolic profile of TB identified by both NMR technologies were able to discriminate TB patients from the rest of the study groups and the results were not influenced by anti-TB treatment or TB location. This provides a new approach in the search for possible biomarkers for the diagnosis of TB

Modelos de crecimiento y producción en España: historia, ejemplos contemporáneos y perspectivas

[EN] In this paper we present a review of forest models developed in Spain in recent years for both timber and non timber production and forest dynamics (regeneration, mortality). Models developed are whole stand, size (diameter) class and individual-tree. The models developed to date have been developed using data from permanent plots, experimental sites and the National Forest Inventory. In this paper we show the different sub-models developed so far and the friendly use software. Main perspectives of forest modeling in Spain are presented[ES] En el presente trabajo se presenta una revisión sobre los modelos forestales desarrollados en España durante los últimos años, tanto para la producción maderable como no maderable y, para la dinámica de los bosques (regeneración, mortalidad). Se presentan modelos tanto de rodal completo como de clases diamétricas y de árbol individual. Los modelos desarrollados hasta la fecha se han desarrollado a partir de datos procedentes de parcelas permanentes, ensayos y el Inventario Forestal Nacional. En el trabajo se muestran los diferentes submodelos desarrollados hasta la fecha, así como las plataformas informáticas que permiten utilizar dichos modelos. Se incluyen las principales perspectivas de desarrollo de la modelización forestal en EspañaSIThe models described in this paper were funded by different regional, national and European projects, and some of them were elaborated by the authors. This work was funded by the Spanish Government by the SELVIRED network (code AGL2008-03740) and the strategic project «Restauración y Gestión Forestal» (code PSE-310000-2009-4

Detection of kinase domain mutations in BCR::ABL1 leukemia by ultra-deep sequencing of genomic DNA

The screening of the BCR::ABL1 kinase domain (KD) mutation has become a routine analysis in case of warning/failure for chronic myeloid leukemia (CML) and B-cell precursor acute lymphoblastic leukemia (ALL) Philadelphia (Ph)-positive patients. In this study, we present a novel DNA-based next-generation sequencing (NGS) methodology for KD ABL1 mutation detection and monitoring with a 1.0E−4 sensitivity. This approach was validated with a well-stablished RNA-based nested NGS method. The correlation of both techniques for the quantification of ABL1 mutations was high (Pearson r = 0.858, p < 0.001), offering DNA-DeepNGS a sensitivity of 92% and specificity of 82%. The clinical impact was studied in a cohort of 129 patients (n = 67 for CML and n = 62 for B-ALL patients). A total of 162 samples (n = 86 CML and n = 76 B-ALL) were studied. Of them, 27 out of 86 harbored mutations (6 in warning and 21 in failure) for CML, and 13 out of 76 (2 diagnostic and 11 relapse samples) did in B-ALL patients. In addition, in four cases were detected mutation despite BCR::ABL1 < 1%. In conclusion, we were able to detect KD ABL1 mutations with a 1.0E−4 sensitivity by NGS using DNA as starting material even in patients with low levels of disease.Tis project was funded in part by CRIS CANCER FOUNDATION