336 research outputs found
The Case for Quantum Key Distribution
Quantum key distribution (QKD) promises secure key agreement by using quantum
mechanical systems. We argue that QKD will be an important part of future
cryptographic infrastructures. It can provide long-term confidentiality for
encrypted information without reliance on computational assumptions. Although
QKD still requires authentication to prevent man-in-the-middle attacks, it can
make use of either information-theoretically secure symmetric key
authentication or computationally secure public key authentication: even when
using public key authentication, we argue that QKD still offers stronger
security than classical key agreement.Comment: 12 pages, 1 figure; to appear in proceedings of QuantumComm 2009
Workshop on Quantum and Classical Information Security; version 2 minor
content revision
Observables in 3d spinfoam quantum gravity with fermions
We study expectation values of observables in three-dimensional spinfoam
quantum gravity coupled to Dirac fermions. We revisit the model introduced by
one of the authors and extend it to the case of massless fermionic fields. We
introduce observables, analyse their symmetries and the corresponding proper
gauge fixing. The Berezin integral over the fermionic fields is performed and
the fermionic observables are expanded in open paths and closed loops
associated to pure quantum gravity observables. We obtain the vertex amplitudes
for gauge-invariant observables, while the expectation values of gauge-variant
observables, such as the fermion propagator, are given by the evaluation of
particular spin networks.Comment: 32 pages, many diagrams, uses psfrag
Some investigations into non passive listening
Our knowledge of the function of the auditory nervous system is based upon a wealth of data obtained, for the most part, in anaesthetised animals. More recently, it has been generally acknowledged that factors such as attention profoundly modulate the activity of sensory systems and this can take place at many levels of processing. Imaging studies, in particular, have revealed the greater activation of auditory areas and areas outside of sensory processing areas when attending to a stimulus. We present here a brief review of the consequences of such non-passive listening and go on to describe some of the experiments we are conducting to investigate them. In imaging studies, using fMRI, we can demonstrate the activation of attention networks that are non-specific to the sensory modality as well as greater and different activation of the areas of the supra-temporal plane that includes primary and secondary auditory areas. The profuse descending connections of the auditory system seem likely to be part of the mechanisms subserving attention to sound. These are generally thought to be largely inactivated by anaesthesia. However, we have been able to demonstrate that even in an anaesthetised preparation, removing the descending control from the cortex leads to quite profound changes in the temporal patterns of activation by sounds in thalamus and inferior colliculus. Some of these effects seem to be specific to the ear of stimulation and affect interaural processing. To bridge these observations we are developing an awake behaving preparation involving freely moving animals in which it will be possible to investigate the effects of consciousness (by contrasting awake and anaesthetized), passive and active listening
Diagnostic and prognostic significance of systemic alkyl quinolones for P. aeruginosa in cystic fibrosis: a longitudinal study
Background
Pulmonary P. aeruginosa infection is associated with poor outcomes in cystic fibrosis (CF) and early diagnosis is challenging, particularly in those who are unable to expectorate sputum. Specific P. aeruginosa 2-alkyl-4-quinolones are detectable in the sputum, plasma and urine of adults with CF, suggesting that they have potential as biomarkers for P. aeruginosa infection.
Aim
To investigate systemic 2-alkyl-4-quinolones as potential biomarkers for pulmonary P. aeruginosa infection.
Methods
A multicentre observational study of 176 adults and 68 children with CF. Cross-sectionally, comparisons were made between current P. aeruginosa infection using six 2-alkyl-4-quinolones detected in sputum, plasma and urine against hospital microbiological culture results. All participants without P. aeruginosa infection at baseline were followed up for one year to determine if 2-alkyl-4-quinolones were early biomarkers of pulmonary P. aeruginosa infection.
Results
Cross-sectional analysis: the most promising biomarker with the greatest diagnostic accuracy was 2-heptyl-4-hydroxyquinoline (HHQ). In adults, areas under the ROC curves (95% confidence intervals) for HHQ analyses were 0.82 (0.75–0.89) in sputum, 0.76 (0.69–0.82) in plasma and 0.82 (0.77–0.88) in urine. In children, the corresponding values for HHQ analyses were 0.88 (0.77–0.99) in plasma and 0.83 (0.68–0.97) in urine.
Longitudinal analysis: Ten adults and six children had a new positive respiratory culture for P. aeruginosa in follow-up. A positive plasma HHQ test at baseline was significantly associated with a new positive culture for P. aeruginosa in both adults and children in follow-up (odds ratio (OR) = 6.67;-95% CI:-1.48–30.1;-p = 0.01 and OR = 70; 95% CI: 5–956;-p < 0.001 respectively).
Conclusions
AQs measured in sputum, plasma and urine may be used to diagnose current infection with P. aeruginosa in adults and children with CF. These preliminary data show that plasma HHQ may have potential as an early biomarker of pulmonary P. aeruginosa. Further studies are necessary to evaluate if HHQ could be used in clinical practice to aid early diagnosis of P. aeruginosa infection in the future
The effect of two-temperature post-shock accretion flow on the linear polarization pulse in magnetic cataclysmic variables
The temperatures of electrons and ions in the post-shock accretion region of
a magnetic cataclysmic variable (mCV) will be equal at sufficiently high mass
flow rates or for sufficiently weak magnetic fields. At lower mass flow rates
or in stronger magnetic fields, efficient cyclotron cooling will cool the
electrons faster than the electrons can cool the ions and a two-temperature
flow will result. Here we investigate the differences in polarized radiation
expected from mCV post-shock accretion columns modeled with one- and
two-temperature hydrodynamics. In an mCV model with one accretion region, a
magnetic field >~30 MG and a specific mass flow rate of ~0.5 g/cm/cm/s, along
with a relatively generic geometric orientation of the system, we find that in
the ultraviolet either a single linear polarization pulse per binary orbit or
two pulses per binary orbit can be expected, depending on the accretion column
hydrodynamic structure (one- or two-temperature) modeled. Under conditions
where the physical flow is two-temperature, one pulse per orbit is predicted
from a single accretion region where a one-temperature model predicts two
pulses. The intensity light curves show similar pulse behavior but there is
very little difference between the circular polarization predictions of one-
and two-temperature models. Such discrepancies indicate that it is important to
model some aspect of two-temperature flow in indirect imaging procedures, like
Stokes imaging, especially at the edges of extended accretion regions, were the
specific mass flow is low, and especially for ultraviolet data.Comment: Accepted for publication in Astrophysics & Space Scienc
Benchmark Test Calculation of a Four-Nucleon Bound State
In the past, several efficient methods have been developed to solve the
Schroedinger equation for four-nucleon bound states accurately. These are the
Faddeev-Yakubovsky, the coupled-rearrangement-channel Gaussian-basis
variational, the stochastic variational, the hyperspherical variational, the
Green's function Monte Carlo, the no-core shell model and the effective
interaction hyperspherical harmonic methods. In this article we compare the
energy eigenvalue results and some wave function properties using the realistic
AV8' NN interaction. The results of all schemes agree very well showing the
high accuracy of our present ability to calculate the four-nucleon bound state.Comment: 17 pages, 1 figure
Quantitative Treatment of Decoherence
We outline different approaches to define and quantify decoherence. We argue
that a measure based on a properly defined norm of deviation of the density
matrix is appropriate for quantifying decoherence in quantum registers. For a
semiconductor double quantum dot qubit, evaluation of this measure is reviewed.
For a general class of decoherence processes, including those occurring in
semiconductor qubits, we argue that this measure is additive: It scales
linearly with the number of qubits.Comment: Revised version, 26 pages, in LaTeX, 3 EPS figure
An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics
For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types
Moral courage in the workplace: moving to and from the desire and decision to act
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72135/1/j.1467-8608.2007.00484.x.pd
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