Stellar explosion in the weak field approximation of the Brans-Dicke theory

We treat a very crude model of an exploding star, in the weak field approximation of the Brans-Dicke theory, in a scenario that resembles some characteristics data of a Type Ia Supernova. The most noticeable feature, in the electromagnetic component, is the relationship between the absolute magnitude at maximum brightness of the star and the decline rate in one magnitude from that maximum. This characteristic has become one of the most accurate method to measure luminosity distances to objects at cosmological distances. An interesting result is that the active mass associated with the scalar field is totally radiated to infinity, representing a mass loss in the ratio of the "tensor" component to the scalar component of 1 to $(2 \omega + 3)$ ($\omega$ is the Brans-Dicke parameter), in agreement with a general result of Hawking. Then, this model shows explicitly, in a dynamical case, the mechanism of radiation of scalar field, which is necessary to understand the Hawking result.Comment: 11 pages, no figures. Published in Class. Quantum Gravity V22 (2005

Equilibrium hydrostatic equation and Newtonian limit of the singular f(R) gravity

We derive the equilibrium hydrostatic equation of a spherical star for any gravitational Lagrangian density of the form $L=\sqrt{-g}f(R)$. The Palatini variational principle for the Helmholtz Lagrangian in the Einstein gauge is used to obtain the field equations in this gauge. The equilibrium hydrostatic equation is obtained and is used to study the Newtonian limit for $f(R)=R-\frac{a^{2}}{3R}$. The same procedure is carried out for the more generally case $f(R)=R-\frac{1}{n+2}\frac{a^{n+1}}{R^{n}}$ giving a good Newtonian limit.Comment: Revised version, to appear in Classical and Quantum Gravity

An Examination of the Most Recent Episode of Molly Use Among College Students

OBJECTIVE--The current study examined event-level characteristics (e.g., contextual factors, risk behaviors) during the most recent episode of Molly use among a sample of college students who reported previously using Molly. PARTICIPANTS--Participants (N = 151; 66.7% female) were drinkers aged 18 to 25. Data were collected from October to November 2014, February to April 2015, and September to November 2015. METHOD--Participants completed measures regarding typical Molly use and items related to context and behaviors during their most recent episode of Molly use. RESULTS--Findings revealed that our sample most commonly reported using Molly earlier in the evening while hanging out with friends or at a party. Additionally, sexual and other drug use behaviors commonly occurred when using Molly. CONCLUSIONS--Findings provide preliminary information in guiding future work exploring Molly use and potential substance-related issues associated with the context of when and how Molly is consumed

Relativistic dynamics of cylindrical shells of counter-rotating particles

Although infinite cylinders are not astrophysical entities, it is possible to learn a great deal about the basic qualitative features of generation of gravitational waves and the behavior of the matter conforming such shells in the limits of very small radius. We describe the analytical model using kinetic theory for the matter and the junction conditions through the shell to obtain its equation of motion. The nature of the static solutions are analyzed, both for a single shell as well as for two concentric shells. In this second case, for a time dependent external shell, we integrate numerically the equation of motion for several values of the constants of the system. Also, a brief description in terms of the Komar mass is given to account for the gravitational wave energy emitted by the system.Comment: 19 pages, 8 figure

Biobased supramolecular ionic networks with optimized crystallinity and mechanical properties as promising dynamic materials for eutectogels design

Ionic supramolecular networks are attractive materials for technological applications with unique properties such as ionic conductivity, stimuli-responsiveness, recyclability, and self-healing. Herein, new semicrystalline supramolecular ionic networks are designed from fully biobased building blocks such as tartaric acid, phytic acid, sebacic acid, and a fatty dimer diamine (Priamine™ 1071). The combination of tartaric acid with Priamine™ 1071 results in a crystalline and brittle polymer, but its molecular regularity can be controlled by incorporating sebacic acid or phytic acid, affording tough materials with appropriate mechanical properties (elastic moduli ranging 19–42 MPa). Furthermore, the ionic polymers show network-to-liquid phase transitions between 75 and 127 °C, and in the liquid state, they were found to be miscible with a lithium-based deep eutectic solvent, yielding flexible and conductive eutectogels. Altogether, these dynamic networks could open new prospects for developing fully green soft ionic materials from their combination with other innovative and low-cost eutectic mixtures.Open Access funding provided by the University of Basque Country. The financial support received from CONICET and ANPCyT (PICT 2018-01032) (Argentina) is gratefully acknowledged

Accelerated Cosmological Models in Ricci squared Gravity

Alternative gravitational theories described by Lagrangians depending on general functions of the Ricci scalar have been proven to give coherent theoretical models to describe the experimental evidence of the acceleration of universe at present time. In this paper we proceed further in this analysis of cosmological applications of alternative gravitational theories depending on (other) curvature invariants. We introduce Ricci squared Lagrangians in minimal interaction with matter (perfect fluid); we find modified Einstein equations and consequently modified Friedmann equations in the Palatini formalism. It is striking that both Ricci scalar and Ricci squared theories are described in the same mathematical framework and both the generalized Einstein equations and generalized Friedmann equations have the same structure. In the framework of the cosmological principle, without the introduction of exotic forms of dark energy, we thus obtain modified equations providing values of w_{eff}<-1 in accordance with the experimental data. The spacetime bi-metric structure plays a fundamental role in the physical interpretation of results and gives them a clear and very rich geometrical interpretation.Comment: New version: 26 pages, 1 figure (now included), Revtex

Inflation and Transition to a Slowly Accelerating Phase from S.S.B. of Scale Invariance

We consider the effects of adding a scale invariant $R^{2}$ term to the action of the scale invariant model (SIM) studied previously by one of us (E.I.G., Mod. Phys. Lett. A14, 1043 (1999)). The SIM belongs to the general class of theories, where an integration measure independent of the metric is introduced. To implement scale invariance (S.I.), a dilaton field is introduced. The integration of the equations of motion associated with the new measure gives rise to the spontaneous symmetry breaking (S.S.B) of S.I.. After S.S.B. of S.I. in the model with the $R^{2}$ term, it is found that a non trivial potential for the dilaton is generated. This potential contains two flat regions: one associated with the Planck scale and with an inflationary phase, while the other flat region is associated to a very small vacuum energy (V.E.) and is associated to the present slowly accelerated phase of the universe (S.A.PH). The smallness of the V.E. in the S.A.PH. is understood through the see saw mechanism introduced in S.I.M.Comment: 22 pages, latex, three figures now in separate file

Impact of deleterious variants in other genes beyond BRCA1/2 detected in breast/ovarian and pancreatic cancer patients by NGS-based multi-gene panel testing: looking over the hedge

Background: Hereditary breast cancer (BC), ovarian cancer (OC), and pancreatic cancer (PC) are the major BRCA-associated tumours. However, some BRCA1/2-wild-type (wt) patients with a strong personal and/or family history of cancer need a further genetic testing through a multi-gene panel containing other high- and moderate-risk susceptibility genes. Patients and methods: Our study was aimed to assess if some BC, OC, or PC patients should be offered multi-gene panel testing, based on well-defined criteria concerning their personal and/or family history of cancer, such as earliness of cancer onset, occurrence of multiple tumours, or presence of at least two or more affected first-degree relatives. For this purpose, 205 out of 915 BC, OC, or PC patients, resulted negative for BRCA1/2 and with significant personal and/or family history of cancer, were genetically tested for germline pathogenic or likely pathogenic variants (PVs/LPVs) in genes different from BRCA1/2. Results: Our investigation revealed that 31 (15.1%) out of 205 patients harboured germline PVs/LPVs in no-BRCA genes, including PALB2, CHEK2, ATM, MUTYH, MSH2, and RAD51C. Interestingly, in the absence of an analysis conducted through multi-gene panel, a considerable percentage (15.1%) of PVs/LPVs would have been lost. Conclusions: Providing a multi-gene panel testing to BRCA1/2-wt BC/OC/PC patients with a strong personal and/or family history of cancer could significantly increase the detection rates of germline PVs/LPVs in other cancer predisposition genes beyond BRCA1/2. The use of a multi-gene panel testing could improve the inherited cancer risk estimation and clinical management of patients and unaffected family members

Injury Due to Mechanical Falls: Future Directions in Gender-specific Surveillance, Screening, and Interventions in Emergency Department Patients.

The Centers for Disease Control and Prevention report that among older adults (≥65 years), falls are the leading cause of injury-related death. Fall-related fractures among older women are more than twice as frequent as those for men. Gender-specific evidence-based fall prevention strategy and intervention studies show that improved patient-centered outcomes are elusive. There is a paucity of emergency medicine literature on the topic. As part of the 2014 Academic Emergency Medicine (AEM) consensus conference on Gender-Specific Research in Emergency Care: Investigate, Understand, and Translate How Gender Affects Patient Outcomes, a breakout group convened to generate a research agenda on priority questions to be answered on this topic. The consensus-based priority research agenda is presented in this article

Not all KIT 557/558 codons mutations have the same prognostic influence on recurrence-free survival: breaking the exon 11 mutations in gastrointestinal stromal tumors (GISTs)

Background: Although the gastrointestinal stromal tumor (GIST) genotype is not currently included in risk-stratification systems, a growing body of evidence shows that the pathogenic variant (PV) type and codon location hold a strong prognostic influence on recurrence-free survival (RFS). This information has particular relevance in the adjuvant setting, where an accurate prognostication could help to better identify high-risk tumors and guide clinical decision-making. Materials and Methods: Between January 2005 and December 2020, 96 patients with completely resected GISTs harboring a KIT proto-oncogene receptor tyrosine kinase (KIT) exon 11 PV were included in the study. We analyzed the type and codon location of the PV according to clinicopathological characteristics and clinical outcome; the metastatic sites in relapsed patients were also investigated. Results: Tumors harboring a KIT exon 11 deletion or deletion/insertion involving the 557 and/or 558 codons, showed a more aggressive clinical behavior compared with tumors carrying deletion/deletion/insertion in other codons, or tumors with duplication/insertion/single-nucleotide variant (SNV) (7-year RFS: 50% versus 73.1% versus 88.2%, respectively; p &lt; 0.001). Notably, among 18 relapsed patients with 557 and/or 558 deletion or deletion/insertion, 14 patients (77.8%) harbored deletions simultaneously involving 557 and 558 codons, while only 4 patients (22.2%) harbored deletions involving only 1 of the 557/558 codons. Thus, when 557 or 558 deletions occurred separately, the tumor showed a prognostic behavior similar to the GIST carrying deletions outside the 557/558 position. Remarkably, patients with GISTs stratified as intermediate risk, but carrying the 557/558 deletion, showed a similar outcome to the high-risk patients with tumors harboring deletions in codons other than 557/558, or duplication/insertion/SNV. Conclusion: Our data support the inclusion of the PV type and codon location in routine risk prediction models, and suggest that intermediate-risk patients whose GISTs harbor 557/558 deletions may also need to be treated with adjuvant imatinib like the high-risk patients