Production of sheep milk cheese with high γ-aminobutyric acid and ornithine concentration and with reduced biogenic amines level using autochthonous lactic acid bacteria strains

[EN] Consumer demand for health-promoting foods is generating the need to develop biofunctional dairy products. Lactic acid bacteria are employed in cheese-making and some of them are able to produce beneficial compounds on human health such as γ-aminobutyric acid (GABA) and ornithine but also to synthetize biogenic amines. The aim was to investigate the effect of four selected autochthonous co-cultures on the free amino acid profile, with special emphasis on GABA and ornithine, and on the biogenic amine content of pasteurized sheep milk cheese during ripening. High average concentrations of GABA (1296.75 mg/kg cheese) and ornithine (2355.76 mg/kg cheese) were found in all the cheese batches at 240 days of ripening. Batch 2, manufactured with the co-culture containing autochthonous Lactococcus lactis strains as starter and Lactobacillus plantarum TAUL1588 as adjunct, showed 2.37 fold reduced biogenic amines concentration with respect to the batch 1 made with the starter during the ripening time. The microstructure and microbiological counts of cheeses were affected (P≤0.001) by the ripening time, without appreciating differences (P≥0.05) in the physico-chemical composition between batches. This study could be a good approach to the development of functional sheep milk cheeseSIThe authors are grateful to the University of León (León, Spain) for granting a PhD fellowship to Erica Renes Bañuelo

Evolving weighting schemes for the Bag of Visual Words

The Bag of Visual Words (BoVW) is an established representation in computer vision. Taking inspiration from text mining, this representation has proved to be very effective in many domains. However, in most cases, standard term-weighting schemes are adopted (e.g., term-frequency or TF-IDF). It remains open the question of whether alternative weighting schemes could boost the performance of methods based on BoVW. More importantly, it is unknown whether it is possible to automatically learn and determine effective weighting schemes from scratch. This paper brings some light into both of these unknowns. On the one hand, we report an evaluation of the most common weighting schemes used in text mining, but rarely used in computer vision tasks. Besides, we propose an evolutionary algorithm capable of automatically learning weighting schemes for computer vision problems. We report empirical results of an extensive study in several computer vision problems. Results show the usefulness of the proposed method

Impact of Using Unedited CT-Based DIR-Propagated Autocontours on Online ART for Pancreatic SBRT

PURPOSE: To determine the dosimetric impact of using unedited autocontours in daily plan adaptation of patients with locally advanced pancreatic cancer (LAPC) treated with stereotactic body radiotherapy using tumor tracking. MATERIALS AND METHODS: The study included 98 daily CT scans of 35 LAPC patients. All scans were manually contoured (MAN), and included the PTV and main organs-at-risk (OAR): stomach, duodenum and bowel. Precision and MIM deformable image registration (DIR) methods followed by contour propagation were used to generate autocontour sets on the daily CT scans. Autocontours remained unedited, and were compared to MAN on the whole organs and at 3, 1 and 0.5 cm from the PTV. Manual and autocontoured OAR were used to generate daily plans using the VOLO™ optimizer, and were compared to non-adapted plans. Resulting planned doses were compared based on PTV coverage and OAR dose-constraints. RESULTS: Overall, both algorithms reported a high agreement between unclipped MAN and autocontours, but showed worse results when being evaluated on the clipped structures at 1 cm and 0.5 cm from the PTV. Replanning with unedited autocontours resulted in better OAR sparing than non-adapted plans for 95% and 84% plans optimized using Precision and MIM autocontours, respectively, and obeyed OAR constraints in 64% and 56% of replans. CONCLUSION: For the majority of fractions, manual correction of autocontours could be avoided or be limited to the region closest to the PTV. This practice could further reduce the overall timings of adaptive radiotherapy workflows for patients with LAPC

ChaLearn LAP 2016: First Round Challenge on First Impressions - Dataset and Results

This paper summarizes the ChaLearn Looking at People 2016 First Impressions challenge data and results obtained by the teams in the first round of the competition. The goal of the competition was to automatically evaluate five “apparent” personality traits (the so-called “Big Five”) from videos of subjects speaking in front of a camera, by using human judgment. In this edition of the ChaLearn challenge, a novel data set consisting of 10,000 shorts clips from YouTube videos has been made publicly available. The ground truth for personality traits was obtained from workers of Amazon Mechanical Turk (AMT). To alleviate calibration problems between workers, we used pairwise comparisons between videos, and variable levels were reconstructed by fitting a Bradley-Terry-Luce model with maximum likelihood. The CodaLab open source platform was used for submission of predictions and scoring. The competition attracted, over a period of 2 months, 84 participants who are grouped in several teams. Nine teams entered the final phase. Despite the difficulty of the task, the teams made great advances in this round of the challenge

ChaLearn Looking at People Challenge 2014: Dataset and Results

This paper summarizes the ChaLearn Looking at People 2014 challenge data and the results obtained by the participants. The competition was split into three independent tracks: human pose recovery from RGB data, action and interaction recognition from RGB data sequences, and multi-modal gesture recognition from RGB-Depth sequences. For all the tracks, the goal was to perform user-independent recognition in sequences of continuous images using the overlapping Jaccard index as the evaluation measure. In this edition of the ChaLearn challenge, two large novel data sets were made publicly available and the Microsoft Codalab platform were used to manage the competition. Outstanding results were achieved in the three challenge tracks, with accuracy results of 0.20, 0.50, and 0.85 for pose recovery, action/interaction recognition, and multi-modal gesture recognition, respectively

Surgical Treatment of Spinal Meningiomas in the Elderly (≥75 Years): Which Factors Affect the Neurological Outcome? An International Multicentric Study of 72 Cases

(1) Background: With the increasing life expectancy in the Western world, an increasing number of old patients presents with spinal meningioma. Considering the benign nature of these tumors, the functional outcome remains of great importance, since more people reach old age in general conditions of well-being and satisfactory autonomy. (2) Methods: We conducted an international multicenter retrospective study to investigate demographic, clinical and radiological data in a population of elderly patients (≥75 years of age) undergoing surgery for SM from January 2000 to December 2020 in four European referral centers. The aim was to identify prognostic and predictive factors for a good postoperative functional outcome. (3) Results: 72 patients were included in the study. Complete tumor resection (Simpson I or II) was achieved in 67 (95.7%) cases. Intraoperative complications were reported in 7 (9.9%) patients while postoperative complications were found in 12 (16.7%). An excellent general postoperative status (McCormick I and II) was achieved in 65.3%. Overall, surgical resection had a good impact on patients’ functional outcome (86.1% either showing an improvement or maintaining a good preoperative status). Uni- and multivariate analyses found that both age and preoperative modified McCormick independently correlated with relative outcome (coeff = −0.058, p = 0.0251; coeff = 0.597, p < 0.0001) and with postoperative status (coeff = 0.058, p = 0.02507; coeff = 0.402, p = 0.00027), respectively. (4) Conclusions: Age and preoperative modified McCormick were found to be independent prognostic factors. Nevertheless, advanced age (≥75), per se, did not seem to contraindicate surgery, even in those with severe preoperative neurological deficits. The functional results sustain the need for surgical resection of SM in the elderly

ChaLearn Joint Contest on Multimedia Challenges Beyond Visual Analysis: An overview

This paper provides an overview of the Joint Contest on Multimedia Challenges Beyond Visual Analysis. We organized an academic competition that focused on four problems that require effective processing of multimodal information in order to be solved. Two tracks were devoted to gesture spotting and recognition from RGB-D video, two fundamental problems for human computer interaction. Another track was devoted to a second round of the first impressions challenge of which the goal was to develop methods to recognize personality traits from short video clips. For this second round we adopted a novel collaborative-competitive (i.e., coopetition) setting. The fourth track was dedicated to the problem of video recommendation for improving user experience. The challenge was open for about 45 days, and received outstanding participation: almost 200 participants registered to the contest, and 20 teams sent predictions in the final stage. The main goals of the challenge were fulfilled: the state of the art was advanced considerably in the four tracks, with novel solutions to the proposed problems (mostly relying on deep learning). However, further research is still required. The data of the four tracks will be available to allow researchers to keep making progress in the four tracks

New records of rare fish species for the Gulf of Cádiz

Comunicación a congresoThe Gulf of Cádiz represents an area with a high faunistic biodiversity due to the coexistence of species from different biogeografical regions (Lusitanian, Mediterranean, Mauritanian). The natural distribution of these species includes latitudinal (African and north Atlantic species) or longitudinal gradients (Mediterranean and anfiatlantic species). Information on the distribution/presence of species in the Gulf of Cádiz is scarce for deep-sea ones and it is of interest for biodiversity studies and further monitoring of global warming effects (colonization of species from lower latitudes), among others. During the scientific surveys INDEMARES/CHICA 0211 and ARSA 0311, carried out by the IEO on board R/V Cornide de Saavedra, some rare fish species were caught using diferent fishing gears such as otter-trawl and beam-trawl. Some of them represents first records for the Gulf of Cádiz area or the European margin

Plasmodium vivax gametocytes in the bone marrow of an acute malaria patient and changes in the erythroid miRNA profile

Plasmodium vivax is the most widely distributed human malaria parasite and responsible for large amounts of disease and burden [1]. The presence of P. vivax in the bone marrow was first noticed in the late 19th century [2], and examinations of sternal bone marrow aspirates were performed as an accessory to examinations of peripheral blood in malaria, including P. vivax [3]. Since then, little progress has been made in studying P. vivax infections in this tissue. One report explored accumulation of dyserythropoietic cells in anaemic infected patients [4]. In addition, two case studies reported P. vivax infections after autologous bone marrow transplantation [5][6], and a third one documented an accidental P. vivax infection due to bone marrow transplantation between a malaria-infected donor and a malaria-free receptor [7]. In Brazil, one patient with persistent thrombocytopaenia and an enlarged spleen was diagnosed with chronic P. vivax malaria after the finding of schizonts in the bone marrow aspirate [8]. In all these reports and case studies, however, parasite loads and life stages found in the bone marrow were not investigated, and no molecular tools were available to rule out mixed infections or to characterize specific parasite stages