8 research outputs found
Dipeptidyl peptidase-1 inhibition in patients hospitalised with COVID-19: a multicentre, double-blind, randomised, parallel-group, placebo-controlled trial
- Author
- Abdelrahim Mohamed
- Abo-Leyah Hani
- Abo-Leyah Hani
- Adamson Simon
- Adamson Simon
- Almaden-Boyle Christine
- Anderson Samantha
- Baker-Moffat Michelle
- Balan Andrea
- Bamgboye Adefunke
- Band Margaret
- Band Margaret
- Barker Joann
- Barnes Debi
- Baryschpolec Sonia
- Birchall Katie
- Bird Sarah
- Bourne Michelle
- Bowler Helen
- Brightling Christopher
- Brightling Christopher
- Broad Lauren
- Brogan Fiona
- Brown Tom
- Bungue-Tuble Roneleeh
- Burns Tricia
- Burrows Kate
- Cassidy Diane
- Cawthron Kay
- Chalmers James
- Chalmers James D.
- Collini Paul
- Collins Andrea
- Colton Hayley
- Condliffe Alison
- Condliffe Alison M.
- Connell David
- Connell David
- Cook Chris
- Cook Gemma
- Cooper Jamie
- Cooper Jamie
- Coote Elizabeth
- Couser Mandy
- Cowen Elena
- Darbyshire Alexander
- Davey Fleur
- Davies Rhys
- Delgado Lilia
- Dhasmana Devesh
- Dhasmana Devesh
- Diver Sarah
- Diwakar Lavanya
- Diwakar Lavanya
- Dosanjh Davinder
- Dosanjh Davinder P.S.
- Dowey Rebecca
- Dowey Rebecca
- Ducker Shelley
- Dyer Nichole
- Edmond Ian
- Elneima Omer
- Emery Anna
- Evans Terriann
- Finn Joanne
- Ford Amber
- Forde Donal
- Fox Lauren
- Frayling Sharon
- Gabriel Zoé
- George Jacob
- George Jacob
- Giam Yan Hui
- Giles Benjamin
- Gilmour Amy
- Goodall Vicky
- Haboubi Dr
- Hardman Simon
- Hargadon Beverley
- Harrington Kate
- Harrington-Davies Yasmin
- Harris Sophie
- Hartley Tom
- Hawes Elizabeth
- Haynes Matthew
- Henderson Eilidh
- Hicks Alexander
- Hicks Alexander
- Hilton Zoe
- Hogarth Fiona
- Housley Kay
- Howe Serena
- Howell Alice
- Hughes Chloe
- Hull Rebecca
- Hull Rebecca C.
- Hurditch Elizabeth
- Jackson Tracy
- Jackson Yvonne
- Jaques Carol
- Jones Laura
- Keiller Marney
- Keir Holly R.
- Kibutu Faith
- Kirby Alison
- Lahnsteiner Eva
- Lahnsteiner Eva
- Lenagh Rebecca
- Liu Patrick
- Loftus Heather
- Long Merete B.
- Longhurst Bev
- Macharia Irene
- MacKenzie Rob
- MacLennan Graeme
- Marchand Clare
- Masan Vidan
- Mason Rebecca
- Mbuyisa Angeline
- McAuley Hamish
- McCourt Paula
- McGenily Laura
- McLaren-Neil Fiona
- McLaren-Neil Fiona
- McQueen Alison
- Meda Manjula
- Middle Janet
- Miller David
- Minnis Chrissie
- Moon Maria
- Morrow Ana
- Muir Carol
- Murray Lisa
- New Benjamin J.M.
- New Benjamin J.M.
- Newell Helen
- Nye Clemency
- Oliver Catherine
- Parker Sarah
- Patel Manish
- Patel Manish
- Pembridge Thomas
- Pilvinyte Kristina
- Rahilly Karen
- Rauchhaus Petra
- Richardson Hollian
- Rowley Megan
- Rupani Hitasha
- Russell Peter
- Russell Peter
- Russell Richard
- Sage Beth
- Sage Elizabeth
- Salutous Dario
- Scott Rhona
- Shoemark Amelia
- Simpson Phillip
- Smart Lynne
- Smith Andrew
- Smith Andrew
- Spears Mark
- Spears Mark
- Staines Nikki
- Strachan Angela
- Strachan Jodie
- Sturney Sharon
- Suntharalingam Jay
- Suntharalingam Jay
- Sutton Benjamin
- Taylor Jennifer
- Thompson A.A. Roger
- Thompson A.A. Roger
- Turner Charlotte
- Turner Kim
- Turton Helena
- Turton Helena
- Udale Emily
- Underwood Jonathan
- Underwood Jonathan
- Vadiveloo Thenmalar
- Walker Sara
- Wands Mary
- Watkins Lynn
- Watson Lisa
- Wesonga Joan
- White Katie
- Whitham Rachel
- Wiffen Laura
- Williams Jennie
- Wilson Anna
- Wilson Jayne
- Wong Charlotte
- Yang Yingjia
- Young Lesley
- Yousuf Ahmed
- Publication venue
- 'Elsevier BV'
- Publication date
- 05/09/2022
- Field of study
Background
Neutrophil serine proteases are involved in the pathogenesis of COVID-19 and increased serine protease activity has been reported in severe and fatal infection. We investigated whether brensocatib, an inhibitor of dipeptidyl peptidase-1 (DPP-1; an enzyme responsible for the activation of neutrophil serine proteases), would improve outcomes in patients hospitalised with COVID-19.
Methods
In a multicentre, double-blind, randomised, parallel-group, placebo-controlled trial, across 14 hospitals in the UK, patients aged 16 years and older who were hospitalised with COVID-19 and had at least one risk factor for severe disease were randomly assigned 1:1, within 96 h of hospital admission, to once-daily brensocatib 25 mg or placebo orally for 28 days. Patients were randomly assigned via a central web-based randomisation system (TruST). Randomisation was stratified by site and age (65 years or â„65 years), and within each stratum, blocks were of random sizes of two, four, or six patients. Participants in both groups continued to receive other therapies required to manage their condition. Participants, study staff, and investigators were masked to the study assignment. The primary outcome was the 7-point WHO ordinal scale for clinical status at day 29 after random assignment. The intention-to-treat population included all patients who were randomly assigned and met the enrolment criteria. The safety population included all participants who received at least one dose of study medication. This study was registered with the ISRCTN registry, ISRCTN30564012.
Findings
Between June 5, 2020, and Jan 25, 2021, 406 patients were randomly assigned to brensocatib or placebo; 192 (47·3%) to the brensocatib group and 214 (52·7%) to the placebo group. Two participants were excluded after being randomly assigned in the brensocatib group (214 patients included in the placebo group and 190 included in the brensocatib group in the intention-to-treat population). Primary outcome data was unavailable for six patients (three in the brensocatib group and three in the placebo group). Patients in the brensocatib group had worse clinical status at day 29 after being randomly assigned than those in the placebo group (adjusted odds ratio 0·72 [95% CI 0·57â0·92]). Prespecified subgroup analyses of the primary outcome supported the primary results. 185 participants reported at least one adverse event; 99 (46%) in the placebo group and 86 (45%) in the brensocatib group. The most common adverse events were gastrointestinal disorders and infections. One death in the placebo group was judged as possibly related to study drug.
Interpretation
Brensocatib treatment did not improve clinical status at day 29 in patients hospitalised with COVID-19
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two
- Author
- Abassi Yama
- Abelin Jennifer G
- Abolhalaj Milad
- Abraham Tara S
- Adam Ammar
- Adams David
- Adams Homer
- Adams Sarah F
- Adamus Tomasz
- Addepalli Murali
- Addepalli Murali
- Adjei Alex A
- Agapova Larissa
- Agarwala Sanjiv
- Ager Casey
- Aggarwal Charu
- Agnello Giulia
- Agudo Judith
- Aguilar Ethan G
- Aguilera Todd
- Ahamadi Malidi
- Ahn Yong-Oon
- Ahrens Eric T
- Aizer Ayal
- Ajina Reham
- Akerley Wallace
- Al-Muftah Mariam
- Albershardt Tina C
- Albershardt Tina C
- Albrekt Ann-Sofie
- Alekar Shilpa
- Alemany Ramon
- Alemany Ramon
- Alexander Brian
- Allbritton Omaira
- Allen Clint T
- Alley Evan W
- Allison James
- Allison James
- Allison James
- Alston Tesha
- Alt JĂŒrgen
- Alters Susan
- Amatulli Michael
- Anand Snjezana
- Anand Snjezana
- Anand Snjezana
- Anderson Clark
- Anderson Mark
- Andersson Bengt
- Andre Pascale
- Andtbacka Robert H I
- Andtbacka Robert H I
- Angiuoli Sam
- Ansari Tameem
- Anthony Scott
- Antonarakis Emmanuel S
- Antonia Scott J
- Anwar Firoz
- Aquino-Michaels Keston
- Archer Jacob F
- Arina Ainhoa
- Armand Philippe
- Armenta Paul
- Armet Caroline M
- Arnoux Thomas
- Ascarateil Stephane
- Askmyr David
- Atkins Michael
- Atkins Michael B
- Atkinson Victoria
- Au Katrina
- Autio Karen A
- Awad Mark
- Bagarazzi Mark
- Bai Dina
- Baia Gilson
- Baird Jason
- Bajaj Anshika
- Balatoni Timea
- Balboni Tracy
- Balch Leslie
- Bang Andrew
- Bao Riyue
- Bao Yangyi
- Bao Yangyi
- Barakat David
- Barberi Theresa
- Barker Christopher A
- Barnea Eytan
- Barras David
- Bartkowiak Todd
- Bartlett David
- Bartlett David
- Bartlett David
- Bartlett David
- Barton Sunjay M
- Barve Minal
- Bauer Todd
- Bauer Todd W
- Bauman Julie
- Baumgaertner Petra
- Bauml Joshua
- Beceren-Braun Figen
- Beck Kristen
- Becker Annette
- Beckers Johannes
- Beckett Michael A
- Bedognetti Davide
- Bedognetti Davide
- Bedognetti Davide
- Bell Bryan
- Bell Charles J M
- Bell Peter
- Beltran Pedro
- Bender Lewis H
- Bender Steven
- Bennett Mark K
- Benz Steven
- Bera Tapan
- Berglund Peter
- Berglund Peter
- Berkey Sara
- Bernatchez Chantale
- Berry John S
- Berzofsky Jay A
- Bhardwaj Nina
- Bian Zhen
- Bianco Alberto
- Biediger Ronald J
- Bifulco Carlo
- Bigley Alison
- Bingham Patrick
- Biniszkiewicz Detlev M
- Bischoff Helge
- Blake Zoe
- Blake Zoe
- Blakely Collin
- Blazar Bruce R
- Blogowski Wojciech
- Bloom Anja C
- Boehm Jesse
- Bokovanov Vladimir
- Bommareddy Praveen K
- Bommareddy Praveen K
- Bommareddy Praveen K
- Bommareddy Praveen K
- Booth Jamie
- Bornschlegl Svetlana
- Bose Nandita
- Bossenmaier Birgit
- Boughorbel Sabri
- Boyer Jean
- Bramante Simona
- Branstetter Daniel
- Brech Dorothee
- Brenin David
- Broaddus V. C
- Brockstedt Dirk G
- Brockstedt Dirk G
- Brody Joshua
- Bronson Roderick
- Brooks Alan
- Brooks Alan D
- Broucek Joseph
- Brown Alice
- Brown Brian
- Brown Brittany
- Brown Gail L
- Brown Sheila
- Bruce Jeffrey N
- Brunet Laura R
- Bruno Tullia C
- Bryan Jennifer
- Bryant Richard
- Buchbinder Elizabeth
- Bucsek Mark
- Budhu Sadna
- Budhu Sadna
- Budkowska Marta
- Bueno Raphael
- Buettner Florian
- Buettner Nico
- Bullock Kim
- Bullock Kim
- Burova Elena
- Burrill Joel
- Bussler Holm
- Butterfield Lisa H
- Butterfield Lisa H
- Byrne-Steele Miranda
- Cagney Daniel
- Calderon Hugo
- Callahan Margaret K
- Campesato Luis F
- Campogan Dwayne
- Cao Felicia
- Capasso Cristian
- Capasso Cristian
- Caplazi Patrick
- Cappuccini Federica
- Carcaboso Angel M
- Carlino Matteo S
- Carpi Sara
- Carrasco Ruben
- Carrera Diego A
- Carrero Rosa M S
- Carson Dennis A
- Castellini Laura
- Cathomas Richard
- Cauvin Annick
- Cauwenberghs Sandra
- Caux Christophe
- Cebon Jonathan S
- Ceccarelli Michele
- Celis Esteban
- Cerignoli Fabio
- Cerullo Vincenzo
- Cerullo Vincenzo
- Cervera-CarrascĂłn VĂctor
- Cesareni Gianni
- Cha John
- Cha John
- Cha John
- Champion Brian
- Chan Anissa S H
- Chan Chanty
- Chan Chanty
- Chan Ivan
- Chan Leo
- Chan Timothy A
- Chang Alfred E
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- Chang Joe
- Chang Nancy N
- Chang Thomas
- Chanuc Fabien
- Chapelin Fanny
- Chaplin Jenny
- Chappel Scott C
- Charych Deborah H
- Charych Deborah H
- Chaudhuri Amitabha
- Chaussabel Damien
- Chen Ada
- Chen Ada
- Chen Gang
- Chen Jason
- Chen Jason
- Chen Xiaomu
- Chen Xin
- Chen Xiufen
- Chen Yu
- Chen Yu
- Chenchik Alex
- Chheda Zinal
- Chiang Eugene
- Chikina Maria
- Chittenden Thomas
- Chiu Hsiling
- Cho Charles
- Chongyung Fang
- Chou Margaret
- Choueiri Toni K
- Choy Carmen
- Clark Joseph I
- Clavijo Paul E
- Clifton Guy T
- Clynes Raphael
- Cobbold Mark
- Cobbold Mark
- Cobbold Mark
- Coder Brandon
- Coffman Robert L
- Cohen Cyrille
- Cohen Ezra E W
- Cohen Roger
- Colen Rivka
- Colevas A. D
- Collins Natalie
- Colrain Jillian
- Coltharp Carla
- Concha-Benavente Fernando
- Connolly Eileen P
- Conwell Darwin
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- Corrales Leticia P
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- Coukos George
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- Coussens Lisa M
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- Craggs Graham
- Craig Andrew
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- Cron Kyle R
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- Crooks James
- Crosby Andrea
- Crosignani Stefano
- Crowder Robert
- Cruickshank Scott
- Csuka Orsolya
- Curbishley Stuart
- Curiel Tyler
- Curran Emily
- Curran Michael
- Curti Brendan
- Curti Brendan
- Da Costa Andre
- Dai Fu
- Dai Jie
- Dai Peihong
- Dalgleish Angus
- Dalvie Deepak
- Daniels Gregory A
- Daud Adil
- David Justin M
- Davies Bronwyn
- de Boisferon Marc H
- de Groot Patricia
- de Gruijl Tanja
- De Henau Olivier
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- De Maeseneire Coraline
- De Sanctis Francesco
- de Silva Suresh
- Deacon Donna
- Deacon Donna H
- DeBenedette Mark
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- Declerck Paul
- Decock Julie
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- DeFalco Jeff
- Dela Cruz Filemon
- Delgoffe Greg
- Delgoffe Greg M
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- Delgoffe Greg M
- Delogu Lucia
- Delorenzi Mauro
- Demaria Sandra
- Demaria Sandra
- Deng Liang
- Deng Weiwen
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- Denies Sofie
- Denis Caroline
- Desbien Anthony L
- deVries Michele
- Dhupkar Pooja
- Diab Adi
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- Diaz Luis
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- Dillhoff Mary
- Dillon Patrick
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- Dimberg Anna
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- Dobkin Julie
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- Dolegowska Barbara
- Doleschall Zoltan
- Doman Thompson
- Dominguez George
- Donahue Renee
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- Downs-Canner Stephanie
- Drake Charles
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- Driessens Gregory
- Driscoll Kyla
- Druker Brian J
- Dubensky Thomas W
- Dubensky Thomas W
- Dudimah Duafalia
- Duff Susan
- Dumontet Charles
- Dunai Cordelia
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- Dutcher Janice P
- Duttagupta Priyanka
- Duvvuri Uma
- Dyson Mike
- DâApuzzo Massimo
- Ebner Peggy
- Edwards Robert
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- Eisenhower Mary
- El Alaoui Meddy
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- Eles Klara
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- Elvecrog James
- Emberley Ethan
- Emerling Daniel
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- English Jessie
- Enstrom Amanda
- Eremeev Artem
- Eriksson Emma
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- Eriksson Emma
- Ertelt Kathleen
- Eswarappa Rajesh
- Evans Elizabeth
- Evans Kathy
- Facciabene Andrea
- Facciabene Andrea
- Facciabene Andrea
- Facciponte John
- Facciponte John
- Falchook Gerald
- Fantini Massimo
- Fantini Massimo
- Fantini Massimo
- Farkas Emil
- Farren Matthew
- Faustman Denise
- Faâak Faisal
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- Feng Yan
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- Francis Julie-Ann
- Frangou Costa
- Franklin Marilyn
- Franklin Wilbur
- Frascaro Federica
- Fraser Kathryn
- Frederix Kim
- Freimark Bruce
- Freimark Bruce
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- Frey Alan
- Fridman Leticia
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- Hu Yangyang
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- Ju Xiaoming
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- Kalinski Pawel
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- Kapp Kerstin
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- Karpathy Roberta
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- Kasler Miklos
- Katibah George
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- Kern Jeffrey
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- Kleinerman Eugenie S
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- Kluger Harriet
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- Knudson Karin M
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- Koch Sven D
- Kodumudi Krithika
- Kohanbash Gary
- Kohlhapp Frederick
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- Kolarkar Shalini
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- Komar Hannah
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- Komarov Andrey
- Konakova Marina
- Koong Albert
- Korman Alan J
- Kornbluth Richard S
- Kortylewski Marcin
- Kortylewski Marcin
- Kosaka Yoko
- Kosoff Rachelle
- Kostarelos Kostas
- Koti Madhuri
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- Koziol Marie E
- Kradjian Giorgio
- Krasovskaia Liudmila
- Kraus Manfred
- Kraynyak Kim
- Krejsa Cecile M
- Krishnan Monica
- Krishnan Suba
- Krisko John
- Kuai Rui
- Kumai Takumi
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- Kuo Peiwen
- Kuppen Peter
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- Lai Venus
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- Lee Dean
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- Lee Yu S
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- Lemmens Edward E
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- Leonardo Steven
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- Letai Anthony
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- Li Jin
- Li Qiao
- Li Qiao
- Li Weiqun
- Li Wenlin
- Li Yanxia
- Li Yanyun
- Li Yanyun
- Li Zihai
- Liang Xiaoling
- Lieber Andre
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- Lifke Valeria
- Lin Jing
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- Lindstedt Malin
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- Liszkay Gabriella
- Litton Jennifer
- Liu Bei
- Liu Biao
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- Liu Glenn
- Liu Hao
- Liu Hongtao
- Liu Linying
- Liu Matt
- Liu Shouchun
- Liu Shouchun
- Liu Shuming
- Liu Weiqun
- Liu Xiu-fen
- Liu Yuan
- Liu Zhuqing
- Liu Zhuqing
- Lo Kin-Ming
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- Zhang Yanping
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- Zhao Leyna
- Zhao Xingli
- Zheng Lianxing
- Zheng Wenxin
- Zheng Xianxian
- Zheng Yi
- Zhong Hong
- Zhou Li
- Zhou Xiangjun
- Zippelius Alfred
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zou Jun
- Zuba-Surma Ewa
- Zubkova Olga
- Zureikat Amer
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Background
The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd.
Methods
We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background.
Results
First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001).
Conclusions
In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival
Evidence based surgical management of endometriosis
- Publication venue
- Middle East Fertility Society
- Publication date
- 01/03/2012
- Field of study
The management approach to patients with pelvic endometriosis is
multidimensional. One must consider several factors such as
patientâs age, parity, extent of the disease, and menopausal
status when planning treatment strategies. The main goals of therapy
are targeted at symptom control and achieving fertility in women who so
desire. Medical and/or surgical therapies can be considered in these
patients. Individualized patient care is essential for the success of
treatment. In this review, we focus our discussion on surgical approach
strategies and the management of endometriosis with an emphasis on pain
and fertility outcomes
Evidence based surgical management of endometriosis
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/03/2012
- Field of study
The management approach to patients with pelvic endometriosis is multidimensional. One must consider several factors such as patientâs age, parity, extent of the disease, and menopausal status when planning treatment strategies. The main goals of therapy are targeted at symptom control and achieving fertility in women who so desire. Medical and/or surgical therapies can be considered in these patients. Individualized patient care is essential for the success of treatment. In this review, we focus our discussion on surgical approach strategies and the management of endometriosis with an emphasis on pain and fertility outcomes
Proteoglycans in Leiomyoma and Normal Myometrium
- Author
- Publication venue
- 'SAGE Publications'
- Publication date
- Field of study
Diagnosis and Management of Endometrial Hyperplasia
- Author
- Aarnio
- Agorastos
- Agorastos
- Amy J. Armstrong
- Ash
- Atiomo
- Attard Montalto
- Auranen
- Azziz
- Baak
- Balen
- Barsoum
- Beresford
- Bergendal
- Bergeron
- Bese
- Bruun Boilesen
- Buttini
- Chamlian
- Cummings
- de Groot
- Eichner
- Elwood
- Epplein
- Farquhar
- Fisher
- Fraser
- Friberg
- Gallagher
- Gallos
- Gol
- Goldstein
- Goldstein
- Gunderson
- Haoula
- Heinemann
- Indermaur
- Jacobs
- Jarvela
- Kalandidi
- Kaye
- Kristine M. Zanotti
- Kurman
- Lacey
- Laurelli
- Legro
- Li
- Lidegaard Ă
- Linkov
- MacDonald
- McKenney
- Mueck
- Muneyyirci-Delale
- Mutter
- Nichole M. Barker
- Nilsson
- Opolskiene
- Ozdegirmenci
- Pardthaisong
- Park
- Pecorelli
- Polyzos
- Rodriguez
- Runowicz
- Salman
- Salman
- Schnatz
- Scully
- Session
- Shirali
- Sonia Elguero
- Stoffel
- Suh-Bergmann
- Suhonen
- Takac
- Tan
- Trimble
- van Hylckama Vlieg
- Vasilakis
- Vilos
- von Gruenigen
- Whitehead
- Wild
- William W. Hurd
- Win
- Zaino
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Search for intermediate-mass black hole binaries in the third observing run of Advanced LIGO and Advanced Virgo
- Author
- Abbott Rich
- Abbott Thomas D.
- Acernese Fausto
- Ackley Kendall
- Adams Carl
- Adhikari Naresh
- Adhikari Rana X.
- Adya Vaishali B.
- Affeldt Christoph
- Agarwal Deepali
- Agathos Michalis
- Agatsuma Kazuhiro
- Aggarwal Nancy
- Aguiar Odylio D.
- Aiello Lorenzo
- Ain Anirban
- Ajith P.
- Akutsu Tomotada
- Albanesi Simone
- Allocca Annalisa
- Altin Paul A.
- Amato Alex
- Anand Chandana
- Anand Shreya
- Ananyeva Alena
- Anderson Stuart B.
- Anderson Warren G.
- Ando Masaki
- Andrade Tomas
- Andres Nicolas
- AndriÄ Tomislav
- Angelova Svetoslava V.
- Ansoldi Stefano
- Antelis J.M.
- Antier Sarah
- Appert Stephen
- Arai Koji
- Arai Koya
- Arai Yuya
- Araki Sakae
- Araya Akito
- Araya Melody C.
- Areeda Joseph S.
- Arellano Fabian E. Peña
- Aritomi Naoki
- Arnaud Nicolas
- Aronson Scott M.
- Arun Kg G.
- ArĂšne Marc
- Asada Hideki
- Asali Yasmeen
- Ashton Gregory
- Aso Yoichi
- Assiduo Maria
- Aston Stuart M.
- Astone Pia
- Aubin Florian
- Austin Corey
- Babak Stanislav
- Badaracco Francesca
- Bader Maria K.M.
- Badger Charles
- Bae Sangwook
- Bae Y.
- Baer Anne M.
- Bagnasco Stefano
- Bai Yuntao
- Baiotti Luca
- Baird Jonathon
- Bajastani L.M. Daneshgaran
- Bajpai Rishabh
- Ball Matthew
- Ballardin Giulio
- Ballmer Stefan W.
- Balsamo Alexander
- Baltus Gregory
- Banagiri Sharan
- Bankar Deepak
- Barayoga Juan C.
- Barbieri Claudio
- Barish Barry C.
- Barker David
- Barneo Pablo
- Barone Fabrizio
- Barr Bryan
- Barsotti Lisa
- Barsuglia Matteo
- Barta Daniel
- Bartlett Jeffrey
- Barton Mark A.
- Bartos Imre
- Bassiri Riccardo
- Basti Andrea
- Bawaj Mateusz
- Bayley Joseph C.
- Baylor Amanda C.
- Bazzan Marco
- Bedakihale Vijaykumar M.
- Bejger Michal
- Belahcene Imene
- Benedetto V.
- Beniwal Deeksha
- Bennett Timothy F.
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- BenYaala M.
- Bergamin Fabio
- Berger B.K.
- Bernuzzi Sebastiano
- Berry Christopher P.L.
- Bersanetti Diego
- Bertolini Alessandro
- Betzwieser Joseph
- Beveridge Damon
- Bhandare Rohan
- Bhardwaj U.
- Bhattacharjee Dripta
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- Bilenko Igor A.
- Billingsley Garilynn
- Bini Sophie
- Birney Ross
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- Blackburn J.K.
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- Weller R.
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- Wette Karl
- WeĂels Peter
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- Whiting Bernard F.
- Whittle Chris
- Wilken Dennis
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- Williams Michael J.
- Williamson Andrew R.
- Willis Joshua L.
- Willke Benno
- Wilson Dalziel J.
- Winkler Walter
- Wipf Christopher C.
- Wlodarczyk Tom
- Woan Graham
- Woehler Janis
- Wofford Jared K.
- Wong I.C. F.
- Wu C.
- Wu David S.
- Wu H.
- Wu S.
- Wysocki Daniel M.
- Xiao Liting
- Xu W-R.
- Yamada Tomohiro
- Yamamoto Hiro
- Yamamoto Kazuhiro
- Yamamoto Kohei
- Yamamoto Takahiro
- Yamashita Kanta
- Yamazaki Ryo
- Yang Fengwei W.
- Yang Le
- Yang Yang
- Yang Yi
- Yang Ziyan
- Yap M.J.
- Yeeles David W.
- Yelikar Anjali B.
- Ying Make
- Yokogawa Kazuya
- Yokoyama J.
- Yokozawa Takaaki
- Yoo Jooheon
- Yoshioka Toshiya
- Yu Hang
- Yu Haocun
- Yuzurihara Hirotaka
- ZadroĆŒny Adam
- Zanolin Michele
- Zeidler Simon
- Zelenova Tatiana
- Zendri J.-P.
- Zevin Michael
- Zhan Mingsheng
- Zhang Hong
- Zhang Jue
- Zhang Liyuan
- Zhang Teng
- Zhang Yanqi
- Zhao Chunnong
- Zhao Guoying
- Zhao Yue
- Zhao Yuhang
- Zhou Ruinan
- Zhou Zifan
- Zhu Xingjiang J.
- Zhu Z.-H.
- Zimmerman Aaron B.
- Zlochower Y.
- Zucker Michael E.
- Zweizig John
- Publication venue
- 'EDP Sciences'
- Publication date
- 01/01/2022
- Field of study
International audienceIntermediate-mass black holes (IMBHs) span the approximate mass range 100â105âMâ, between black holes (BHs) that formed by stellar collapse and the supermassive BHs at the centers of galaxies. Mergers of IMBH binaries are the most energetic gravitational-wave sources accessible by the terrestrial detector network. Searches of the first two observing runs of Advanced LIGO and Advanced Virgo did not yield any significant IMBH binary signals. In the third observing run (O3), the increased network sensitivity enabled the detection of GW190521, a signal consistent with a binary merger of mass âŒ150âMâ providing direct evidence of IMBH formation. Here, we report on a dedicated search of O3 data for further IMBH binary mergers, combining both modeled (matched filter) and model-independent search methods. We find some marginal candidates, but none are sufficiently significant to indicate detection of further IMBH mergers. We quantify the sensitivity of the individual search methods and of the combined search using a suite of IMBH binary signals obtained via numerical relativity, including the effects of spins misaligned with the binary orbital axis, and present the resulting upper limits on astrophysical merger rates. Our most stringent limit is for equal mass and aligned spin BH binary of total mass 200âMâ and effective aligned spin 0.8 at 0.056 Gpcâ3 yrâ1 (90% confidence), a factor of 3.5 more constraining than previous LIGO-Virgo limits. We also update the estimated rate of mergers similar to GW190521 to 0.08 Gpcâ3 yrâ1.Key words: gravitational waves / stars: black holes / black hole physicsCorresponding author: W. Del Pozzo, e-mail: [email protected]â Deceased, August 2020
Recommended from our members
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two: National Harbor, MD, USA. 9-13 November 2016
- Author
- Abassi Yama
- Abelin Jennifer G.
- Abolhalaj Milad
- Abraham Tara S.
- Adam Ammar
- Adams David
- Adams Homer
- Adams Sarah F.
- Adamus Tomasz
- Addepalli Murali
- Adjei Alex A.
- Agapova Larissa
- Agarwala Sanjiv
- Ager Casey
- Aggarwal Charu
- Agnello Giulia
- Agudo Judith
- Aguilar Ethan G.
- Aguilera Todd
- Ahamadi Malidi
- Ahn Yong-Oon
- Ahrens Eric T.
- Aizer Ayal
- Ajina Reham
- Akerley Wallace
- Al-Muftah Mariam
- Albershardt Tina C.
- Albrekt Ann-Sofie
- Alekar Shilpa
- Alemany Ramon
- Alexander Brian
- Allbritton Omaira
- Allen Clint T.
- Alley Evan W.
- Allison James
- Alston Tesha
- Alt JĂŒrgen
- Alters Susan
- Amatulli Michael
- Anand Snjezana
- Anderson Clark
- Anderson Mark
- Andersson Bengt
- Andre Pascale
- Andtbacka Robert H. I.
- Angiuoli Sam
- Ansari Tameem
- Anthony Scott
- Antonarakis Emmanuel S.
- Antonia Scott J.
- Anwar Firoz
- Aquino-Michaels Keston
- Archer Jacob F.
- Arina Ainhoa
- Armand Philippe
- Armenta Paul
- Armet Caroline M.
- Arnoux Thomas
- Ascarateil Stephane
- Askmyr David
- Atkins Michael
- Atkins Michael B.
- Atkinson Victoria
- Au Katrina
- Autio Karen A.
- Awad Mark
- Bagarazzi Mark
- Bai Dina
- Baia Gilson
- Baird Jason
- Bajaj Anshika
- Balatoni Timea
- Balboni Tracy
- Balch Leslie
- Bang Andrew
- Bao Riyue
- Bao Yangyi
- Barakat David
- Barberi Theresa
- Barker Christopher A.
- Barnea Eytan
- Barras David
- Bartkowiak Todd
- Bartlett David
- Barton Sunjay M.
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- Bauer Todd W.
- Bauman Julie
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- Bauml Joshua
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- Bramante Simona
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- Byrne-Steele Miranda
- Cagney Daniel
- Calderon Hugo
- Callahan Margaret K.
- Campesato Luis Felipe
- Campogan Dwayne
- Cao Felicia
- Capasso Cristian
- Caplazi Patrick
- Cappuccini Federica
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- Carpi Sara
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- Carrera Diego A.
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- Castellini Laura
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- Cruickshank Scott
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- Dhupkar Pooja
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- Dobkin Julie
- Doener Fatma
- Dolegowska Barbara
- Doleschall Zoltan
- Doman Thompson
- Dominguez George
- Donahue Renee
- Dorsey Frank Charles
- Dovedi Simon
- Downs-Canner Stephanie
- Drake Charles
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- Weiner Louis M.
- Weinstein Gregory
- Weiss Christian
- Welden Scott
- Wellstein Anton
- Welsh James
- Wennerberg Erik
- Wenthe Jessica
- Werner Lauryn R.
- West Brian
- West James
- Wheatley Courtney
- Whetstone Ryan
- White James
- White-Stern Ashley
- Whiteside Melinda
- Whiting Chan C.
- Wicha Max S.
- Wieckowski Eva
- Wijeratne Kithsiri
- Wilhite Tyler
- Wilkinson Robert W.
- Williams Matthew
- Williamson Kevin
- Willingham Stephen
- Wilson James M.
- Wilson Nicholas
- Winters Kevin
- Withers Sita
- Wittig Burghardt
- Wolchok Jedd D.
- Wolfreys Alison
- Won Haejung
- Wong Chihunt
- Wong Deborah J.
- Wong Gabriel
- Wong Kenneth R.
- Wong Michael KK
- Wood Laura
- Woodside Darren G.
- Workman Creg
- Wu Bill X.
- Wu Dongyun
- Wu Jennifer
- Wu Yeting
- Wyant Timothy
- Wythes Martin
- Xi Biao
- Xia Leiming
- Xia Yang
- Xiang Bo
- Xiao Christine
- Xiao Hong
- Xiao Zhilan
- Xu Chun-wei
- Xu Chunxiao
- Xu Guifen
- Xu Xiaomei
- Xu Xin
- Xu Ya-Ming
- Xu Yitong
- Yadav Mahesh
- Yagiz Kader
- Yamashiro Darrell J.
- Yan Jian
- Yang Chou
- Yang Ning
- Yang Zane
- Yano Hiroshi
- Yao Shiyin
- Ye Yun-bin
- Yin Catherine
- YlösmÀki Erkko
- Young Gregory
- Young Kristina
- Young Rob
- Young Steve W.
- Youssoufian Hagop
- Yu Huakui
- Yu Ling
- Yu Naichen
- Zafar Sadia
- Zalevsky Jonathan
- Zappasodi Roberta
- Zauderer Maurice
- Zeh Herbert
- Zelenetz Andrew D.
- Zeng Weiping
- Zeng Xue
- Zha Yuanyuan
- Zhang Danhui
- Zhang Jing
- Zhang Ping
- Zhang Qifang
- Zhang Shannon S.
- Zhang Theresa
- Zhang Winter
- Zhang Yanping
- Zhao Fei
- Zhao Leyna
- Zhao Xingli
- Zheng Lianxing
- Zheng Wenxin
- Zheng Xianxian
- Zheng Yi
- Zhong Hong
- Zhou Li
- Zhou Xiangjun
- Zippelius Alfred
- Zloza Andrew
- Zou Jun
- Zuba-Surma Ewa
- Zubkova Olga
- Zureikat Amer
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 03/01/2017
- Field of study