110 research outputs found
Galactic Plane H Surveys: IPHAS & VPHAS+
The optical Galactic Plane H surveys IPHAS and VPHAS+ are
dramatically improving our understanding of Galactic stellar populations and
stellar evolution by providing large samples of stars in short lived, but
important, evolutionary phases, and high quality homogeneous photometry and
images over the entire Galactic Plane. Here I summarise some of the
contributions these surveys have already made to our understanding of a number
of key areas of stellar and Galactic astronomy.Comment: 5 pages, 2 figures, refereed proceeding of the "The Universe of
Digital Sky Surveys" conference, November 2014, to be published in the
Astrophysics and Space Science Proceeding
Trophoblast-Specific Knockdown of the System A Amino Acid Transporter, Slc38a2/SNAT2, Causes Fetal Growth Restriction in Mice.
Placenta-specific Slc38a2/SNAT2 knockdown causes fetal growth restriction in mice
Fetal growth restriction (FGR) is a complication of pregnancy that reduces birth weight, markedly increases infant mortality and morbidity and is associated with later-life cardiometabolic disease. No specific treatment is available for FGR. Placentas of human FGR infants have low abundance of sodium-coupled neutral amino acid transporter 2 (Slc38a2/SNAT2), which supplies the fetus with amino acids required for growth. We determined the mechanistic role of placental Slc38a2/SNAT2 deficiency in the development of restricted fetal growth, hypothesizing that placenta-specific Slc38a2 knockdown causes FGR in mice. Using lentiviral transduction of blastocysts with a small hairpin RNA (shRNA), we achieved 59% knockdown of placental Slc38a2, without altering fetal Slc38a2 expression. Placenta-specific Slc38a2 knockdown reduced near-term fetal and placental weight, fetal viability, trophoblast plasma membrane (TPM) SNAT2 protein abundance, and both absolute and weight-specific placental uptake of the amino acid transport System A tracer, 14C-methylaminoisobutyric acid (MeAIB). We also measured human placental SLC38A2 gene expression in a well-defined term clinical cohort and found that SLC38A2 expression was decreased in late-onset, but not early-onset FGR, compared with appropriate for gestational age (AGA) control placentas. The results demonstrate that low placental Slc38a2/SNAT2 causes FGR and could be a target for clinical therapies for late-onset FGR
The Gaia-ESO Survey: Chromospheric Emission, Accretion Properties, and Rotation in Velorum and Chamaeleon I
We use the fundamental parameters delivered by the GES consortium in the
first internal data release to select the members of Vel and Cha I
among the UVES and GIRAFFE spectroscopic observations. A total of 140
Vel members and 74 Cha I members were studied. We calculated stellar
luminosities through spectral energy distributions, while stellar masses were
derived by comparison with evolutionary tracks. The spectral subtraction of
low-activity and slowly rotating templates, which are rotationally broadened to
match the of the targets, enabled us to measure the equivalent widths
(EWs) and the fluxes in the H and H lines. The H line
was also used for identifying accreting objects and for evaluating the mass
accretion rate (). The distribution of for the
members of Vel displays a peak at about 10 km s with a tail
toward faster rotators. There is also some indication of a different
distribution for the members of its two kinematical populations. Only a handful
of stars in Vel display signatures of accretion, while many more
accretors were detected in the younger Cha~I. Accreting and active stars occupy
two different regions in a -flux diagram and we propose a
criterion for distinguishing them. We derive in the ranges
-yr and -yr
for Vel and Cha I accretors, respectively. We find less scatter in the
relation derived through the H EWs, when
compared to the H diagnostics, in agreement with other authors
K2-138 g: Spitzer Spots a Sixth Planet for the Citizen Science System
K2 greatly extended Kepler's ability to find new planets, but it was typically limited to identifying transiting planets with orbital periods below 40 days. While analyzing K2 data through the Exoplanet Explorers project, citizen scientists helped discover one super-Earth and four sub-Neptune sized planets in the relatively bright (V = 12.21, K = 10.3) K2-138 system, all which orbit near 3:2 mean-motion resonances. The K2 light curve showed two additional transit events consistent with a sixth planet. Using Spitzer photometry, we validate the sixth planet's orbital period of 41.966 ± 0.006 days and measure a radius of 3.44_(-0.31)^(+0.32) R_⊕, solidifying K2-138 as the K2 system with the most currently known planets. There is a sizeable gap between the outer two planets, since the fifth planet in the system, K2-138 f, orbits at 12.76 days. We explore the possibility of additional nontransiting planets in the gap between f and g. Due to the relative brightness of the K2-138 host star, and the near resonance of the inner planets, K2-138 could be a key benchmark system for both radial velocity and transit-timing variation mass measurements, and indeed radial velocity masses for the inner four planets have already been obtained. With its five sub-Neptunes and one super-Earth, the K2-138 system provides a unique test bed for comparative atmospheric studies of warm to temperate planets of similar size, dynamical studies of near-resonant planets, and models of planet formation and migration
Placenta-specific Slc38a2/SNAT2 knockdown causes fetal growth restriction in mice
Fetal growth restriction (FGR) is a complication of pregnancy that reduces birth weight, markedly increases infant mortality and morbidity and is associated with later-life cardiometabolic disease. No specific treatment is available for FGR. Placentas of human FGR infants have low abundance of sodium-coupled neutral amino acid transporter 2 (Slc38a2/SNAT2), which supplies the fetus with amino acids required for growth. We determined the mechanistic role of placental Slc38a2/SNAT2 deficiency in the development of restricted fetal growth, hypothesizing that placenta-specific Slc38a2 knockdown causes FGR in mice. Using lentiviral transduction of blastocysts with a small hairpin RNA (shRNA), we achieved 59% knockdown of placental Slc38a2, without altering fetal Slc38a2 expression. Placenta-specific Slc38a2 knockdown reduced near-term fetal and placental weight, fetal viability, trophoblast plasma membrane (TPM) SNAT2 protein abundance, and both absolute and weight-specific placental uptake of the amino acid transport System A tracer, 14C-methylaminoisobutyric acid (MeAIB). We also measured human placental SLC38A2 gene expression in a well-defined term clinical cohort and found that SLC38A2 expression was decreased in late-onset, but not early-onset FGR, compared with appropriate for gestational age (AGA) control placentas. The results demonstrate that low placental Slc38a2/SNAT2 causes FGR and could be a target for clinical therapies for late-onset FGR
The second data release of the INT Photometric Ha Survey of the Northern Galactic Plane (IPHAS DR2)
The INT/WFC Photometric Hα Survey of the Northern Galactic Plane (IPHAS) is a 1800 deg2 imaging survey covering Galactic latitudes |b| < 5° and longitudes ℓ = 30°–215° in the r, i, and Hα filters using the Wide Field Camera (WFC) on the 2.5-m Isaac Newton Telescope (INT) in La Palma. We present the first quality-controlled and globally calibrated source catalogue derived from the survey, providing single-epoch photometry for 219 million unique sources across 92 per cent of the footprint. The observations were carried out between 2003 and 2012 at a median seeing of 1.1 arcsec (sampled at 0.33 arcsec pixel−1) and to a mean 5σ depth of 21.2 (r), 20.0 (i), and 20.3 (Hα) in the Vega magnitude system. We explain the data reduction and quality control procedures, describe and test the global re-calibration, and detail the construction of the new catalogue. We show that the new calibration is accurate to 0.03 mag (root mean square) and recommend a series of quality criteria to select accurate data from the catalogue. Finally, we demonstrate the ability of the catalogue's unique (r − Hα, r − i) diagram to (i) characterize stellar populations and extinction regimes towards different Galactic sightlines and (ii) select and quantify Hα emission-line objects. IPHAS is the first survey to offer comprehensive CCD photometry of point sources across the Galactic plane at visible wavelengths, providing the much-needed counterpart to recent infrared surveys
Planetary Candidates Observed by Kepler. VIII. A Fully Automated Catalog With Measured Completeness and Reliability Based on Data Release 25
We present the Kepler Object of Interest (KOI) catalog of transiting
exoplanets based on searching four years of Kepler time series photometry (Data
Release 25, Q1-Q17). The catalog contains 8054 KOIs of which 4034 are planet
candidates with periods between 0.25 and 632 days. Of these candidates, 219 are
new and include two in multi-planet systems (KOI-82.06 and KOI-2926.05), and
ten high-reliability, terrestrial-size, habitable zone candidates. This catalog
was created using a tool called the Robovetter which automatically vets the
DR25 Threshold Crossing Events (TCEs, Twicken et al. 2016). The Robovetter also
vetted simulated data sets and measured how well it was able to separate TCEs
caused by noise from those caused by low signal-to-noise transits. We discusses
the Robovetter and the metrics it uses to sort TCEs. For orbital periods less
than 100 days the Robovetter completeness (the fraction of simulated transits
that are determined to be planet candidates) across all observed stars is
greater than 85%. For the same period range, the catalog reliability (the
fraction of candidates that are not due to instrumental or stellar noise) is
greater than 98%. However, for low signal-to-noise candidates between 200 and
500 days around FGK dwarf stars, the Robovetter is 76.7% complete and the
catalog is 50.5% reliable. The KOI catalog, the transit fits and all of the
simulated data used to characterize this catalog are available at the NASA
Exoplanet Archive.Comment: 61 pages, 23 Figures, 9 Tables, Accepted to The Astrophysical Journal
Supplement Serie
Campaign 9 of the K2 mission: Observational parameters, scientific drivers, and community involvement for a simultaneous space-and ground-based microlensing survey
K2ʼs Campaign 9 (K2C9) will conduct a ∼3.7 deg2 survey toward the Galactic bulge from 2016 April 22 through July 2 that will leverage the spatial separation between K2 and the Earth to facilitate measurement of the microlens parallax πE for ≳170 microlensing events. These will include several that are planetary in nature as well as many short-timescale microlensing events, which are potentially indicative of free-floating planets (FFPs). These satellite parallax measurements will in turn allow for the direct measurement of the masses of and distances to the lensing systems. In this article we provide an overview of the K2C9 space- and ground-based microlensing survey. Specifically, we detail the demographic questions that can be addressed by this program, including the frequency of FFPs and the Galactic distribution of exoplanets, the observational parameters of K2C9, and the array of resources dedicated to concurrent observations. Finally, we outline the avenues through which the larger community can become involved, and generally encourage participation in K2C9, which constitutes an important pathfinding mission and community exercise in anticipation of WFIRST
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