767 research outputs found
A mobile data acquisition system
A mobile data aquisition (MobiDAQ) was developed for the ATLAS central hadronic
calorimeter (TileCal). MobiDAQ has been designed in order to test the functionalities of the TileCal
front-end electronics and to acquire calibration data before the final back-end electronics were built
and tested. MobiDAQ was also used to record the first cosmic ray events acquired by an ATLAS
subdetector in the underground experimental area
Measurement of the Fermi Constant by FAST
An initial measurement of the lifetime of the positive muon to a precision of
16 parts per million (ppm) has been performed with the FAST detector at the
Paul Scherrer Institute. The result is tau_mu = 2.197083 (32) (15) microsec,
where the first error is statistical and the second is systematic. The muon
lifetime determines the Fermi constant, G_F = 1.166353 (9) x 10^-5 GeV^-2 (8
ppm).Comment: 15 pages, 6 figure
PReS-FINAL-2332: Activation-induced cell death of human monocytes as a novel mechanism fine-tuning inflammation and autoimmunity
Electroweak Physics, Experimental Aspects
Collider measurements on electroweak physics are summarised. Although the
precision on some observables is very high, no deviation from the Standard
Model of electroweak interactions is observed. The data allow to set stringent
limits on some models for new physics.Comment: Plenary Talk at the UK Phenomenology Workshop on Collider Physics,
Durham, 199
Gross Properties and Isotopic Phenomena in Spectator Fragmentation
A systematic study of isotopic effects in the break-up of projectile
spectators at relativistic energies has been performed with the ALADiN
spectrometer at the GSI laboratory. Searching for signals of criticality in the
fragment production we have applied the model independent universal
fluctuations theory already proposed to track criticality signals in
multifragmentation to our data. The fluctuation of the largest fragment charge
and of the asymmetry of the two and three largest fragments and their bimodal
distribution have also been analysed.Comment: 6 pages, 4 figures, IX International Conference on Nucleus-Nucleus
Collisions, Rio de Janeiro, Brazil, August 28 - September 1, 200
Neutron recognition in the LAND detector for large neutron multiplicity
The performance of the LAND neutron detector is studied. Using an
event-mixing technique based on one-neutron data obtained in the S107
experiment at the GSI laboratory, we test the efficiency of various analytic
tools used to determine the multiplicity and kinematic properties of detected
neutrons. A new algorithm developed recently for recognizing neutron showers
from spectator decays in the ALADIN experiment S254 is described in detail. Its
performance is assessed in comparison with other methods. The properties of the
observed neutron events are used to estimate the detection efficiency of LAND
in this experiment.Comment: 16 pages, 8 figure
Tracing a phase transition with fluctuations of the largest fragment size: Statistical multifragmentation models and the ALADIN S254 data
A phase transition signature associated with cumulants of the largest
fragment size distribution has been identified in statistical
multifragmentation models and examined in analysis of the ALADIN S254 data on
fragmentation of neutron-poor and neutron-rich projectiles. Characteristics of
the transition point indicated by this signature are weakly dependent on the
A/Z ratio of the fragmenting spectator source. In particular, chemical
freeze-out temperatures are estimated within the range 5.9 to 6.5 MeV. The
experimental results are well reproduced by the SMM model.Comment: 7 pages, 3 figures, Proceedings of the International Workshop on
Multifragmentation and Related Topics (IWM2009), Catania, Italy, November
2009
Isotopic Dependence of the Nuclear Caloric Curve
The A/Z dependence of projectile fragmentation at relativistic energies has
been studied with the ALADIN forward spectrometer at SIS. A stable beam of
124Sn and radioactive beams of 124La and 107Sn at 600 MeV per nucleon have been
used in order to explore a wide range of isotopic compositions. Chemical
freeze-out temperatures are found to be nearly invariant with respect to the
A/Z of the produced spectator sources, consistent with predictions for expanded
systems. Small Coulomb effects (\Delta T \approx 0.6 MeV) appear for residue
production near the onset of multifragmentation.Comment: 11 pages, 3 figures, accepted for publ. in Phys. Rev. Let
Educating a New Generation of Library and Information Science Professionals: A United States Perspective
This article examines the U.S model of library and information science (LIS) education in light of the changes brought about by information and communication technology. The accepted model of professional preparation in the United States has emphasized graduate education on a Master’s level from LIS programs accredited by the American Library Association (ALA). The authors trace the historical development of this approach and provide an overview of the ALA accreditation process. Furthermore, they examine the strategies of LIS programs in adjusting to the changing information environment, present the debate about the iSchool movement, and discuss the evolution of the core curriculum. In addition, the article explores the relationship between LIS education and the field of practice and presents a practitioner’s perspective on educating library professionals. The authors conclude that the model of advanced professional preparation for librarianship is still relevant in the digital environment, but it requires greater flexibility and close cooperation with the field of practice
Anti-cancer effects and mechanism of actions of aspirin analogues in the treatment of glioma cancer
INTRODUCTION: In the past 25 years only modest advancements in glioma treatment have been made, with patient prognosis and median survival time following diagnosis only increasing from 3 to 7 months. A substantial body of clinical and preclinical evidence has suggested a role for aspirin in the treatment of cancer with multiple mechanisms of action proposed including COX 2 inhibition, down regulation of EGFR expression, and NF-κB signaling affecting Bcl-2 expression. However, with serious side effects such as stroke and gastrointestinal bleeding, aspirin analogues with improved potency and side effect profiles are being developed. METHOD: Effects on cell viability following 24 hr incubation of four aspirin derivatives (PN508, 517, 526 and 529) were compared to cisplatin, aspirin and di-aspirin in four glioma cell lines (U87 MG, SVG P12, GOS – 3, and 1321N1), using the PrestoBlue assay, establishing IC50 and examining the time course of drug effects. RESULTS: All compounds were found to decrease cell viability in a concentration and time dependant manner. Significantly, the analogue PN517 (IC50 2mM) showed approximately a twofold increase in potency when compared to aspirin (3.7mM) and cisplatin (4.3mM) in U87 cells, with similar increased potency in SVG P12 cells. Other analogues demonstrated similar potency to aspirin and cisplatin. CONCLUSION: These results support the further development and characterization of novel NSAID derivatives for the treatment of glioma
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