O RACIONALISMO DOGMÁTICO KELSENIANO COMO PARADOXO E ABERTURA PARA UMA ANÁLISE MULTIDIMENSIONAL E COMPLEXA DO DIREITO CONTEMPORÂNEO

A partir de uma perspectiva reflexiva, este artigo trata de questões pontuais que envolvem o atual lugar do racionalismo dogmático kelseniano, corporificado na Teoria Pura do Direito, e os paradoxos que dele emergem e produzem as necessárias aberturas para situá-lo na concepção multidimensional, complexa e sistêmica do direito contemporâneo. Além disso, é tratada a questão da sua atualidade e a necessidade de novos estudos, pautados, não apenas na Teoria Pura do Direito, mas no conjunto da obra de Hans Kelsen, bem como daqueles que o influenciaram e dos seus críticos, possibilitando, com isso, a sua atualização, correção e superação das fissuras que decorrem da incompletude que subiste na sua teoria

Contribution for new genetic markers of rheumatoid arthritis activity and severity : sequencing of the tumor necrosis factor-alpha gene promoter

© 2007 Fonseca et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly citedThe objective of this study was to assess whether clinical measures of rheumatoid arthritis activity and severity were influenced by tumor necrosis factor-alpha (TNF-alpha) promoter genotype/haplotype markers. Each patient's disease activity was assessed by the disease activity score using 28 joint counts (DAS28) and functional capacity by the Health Assessment Questionnaire (HAQ) score. Systemic manifestations, radiological damage evaluated by the Sharp/van der Heijde (SvdH) score, disease-modifying anti-rheumatic drug use, joint surgeries, and work disability were also assessed. The promoter region of the TNF-alpha gene, between nucleotides -1,318 and +49, was sequenced using an automated platform. Five hundred fifty-four patients were evaluated and genotyped for 10 single-nucleotide polymorphism (SNP) markers, but 5 of these markers were excluded due to failure to fall within Hardy-Weinberg equilibrium or to monomorphism. Patients with more than 10 years of disease duration (DD) presented significant associations between the -857 SNP and systemic manifestations, as well as joint surgeries. Associations were also found between the -308 SNP and work disability in patients with more than 2 years of DD and radiological damage in patients with less than 10 years of DD. A borderline effect was found between the -238 SNP and HAQ score and radiological damage in patients with 2 to 10 years of DD. An association was also found between haplotypes and the SvdH score for those with more than 10 years of DD. An association was found between some TNF-alpha promoter SNPs and systemic manifestations, radiological progression, HAQ score, work disability, and joint surgeries, particularly in some classes of DD and between haplotypes and radiological progression for those with more than 10 years of DD.This work was supported by grant POCTI/SAU-ESP/59111/2004 from Fundação Ciência e Tecnologia.info:eu-repo/semantics/publishedVersio

Educomunicação e diversidade: tecendo saberes

Com esta publicação Educomunicação e Diversidade: Tecendo Saberes, a Associação Brasileira de Pesquisadores e Profissionais de Educomunicação socializa uma importante contribuição para o aprofundamento e aprimorando de estudos e práticas educativas e comunicativas numa perspectiva de respeito às diversidades. A publicação está estruturada em quatro partes, a saber: I. Educomunicação e Políticas para a Cidadania; II. Práxis Educomunicativa: o principio da indissociabilidade entre ensino-pesquisa-extensão; III. Educomunicação e Formação em EAD; IV – Mediação Tecnológica. Trata-se, assim, de um trabalho coletivo que contém 19 capítulos onde contribuem 35 autores e coautores. Eis uma publicação que se destina não somente aos educomunicadores, mas a todos os que assumem o desafio de pensar numa outra forma possível de educar e de comunicar, mais colaborativa, intercultural, criativa e emancipatória, menos colonizadora e arrogante. Desejamos à leitora-interlocutora, ou ao leitor-interlocutor, uma leitura prazerosa, crítica e problematizadora dessa publicação que se  apresenta como um ensaio, mas com a pretensão e o potencial de contribuir para o avanço dos estudos em torno do campo de interface entre Comunicação e Educação, sempre com o imprescindível respeito às diversidades

Estimated distribution of the Sharp/van der Heijde (SvdH) score according to the duration of the disease (DD)

<p><b>Copyright information:</b></p><p>Taken from "Contribution for new genetic markers of rheumatoid arthritis activity and severity: sequencing of the tumor necrosis factor-alpha gene promoter"</p><p>http://arthritis-research.com/content/9/2/R37</p><p>Arthritis Research & Therapy 2007;9(2):R37-R37.</p><p>Published online 4 Apr 2007</p><p>PMCID:PMC1906815.</p><p></p

AMAZONIA CAMTRAP: A data set of mammal, bird, and reptile species recorded with camera traps in the Amazon forest

The Amazon forest has the highest biodiversity on Earth. However, information on Amazonian vertebrate diversity is still deficient and scattered across the published, peer-reviewed, and gray literature and in unpublished raw data. Camera traps are an effective non-invasive method of surveying vertebrates, applicable to different scales of time and space. In this study, we organized and standardized camera trap records from different Amazon regions to compile the most extensive data set of inventories of mammal, bird, and reptile species ever assembled for the area. The complete data set comprises 154,123 records of 317 species (185 birds, 119 mammals, and 13 reptiles) gathered from surveys from the Amazonian portion of eight countries (Brazil, Bolivia, Colombia, Ecuador, French Guiana, Peru, Suriname, and Venezuela). The most frequently recorded species per taxa were: mammals: Cuniculus paca (11,907 records); birds: Pauxi tuberosa (3713 records); and reptiles: Tupinambis teguixin (716 records). The information detailed in this data paper opens up opportunities for new ecological studies at different spatial and temporal scales, allowing for a more accurate evaluation of the effects of habitat loss, fragmentation, climate change, and other human-mediated defaunation processes in one of the most important and threatened tropical environments in the world. The data set is not copyright restricted; please cite this data paper when using its data in publications and we also request that researchers and educators inform us of how they are using these data