La realtà dei senza fissa dimora a Lucca: percorsi innovativi di intervento sociale.

Questo lavoro vuole evidenziare la condizione di coloro che usualmente rimangono “fuori”, le frange “insignificanti” e marginali rispetto alla vita del sistema sociale, persone ritenute socialmente improduttive ed emarginate: i senza fissa dimora. L’essere senza dimora, ossia senza accesso ad una dimora adeguata, è probabilmente la più grave manifestazione dell’emarginazione sociale. Ciò che questo lavoro si propone è porre attenzione ad una realtà presente e tuttavia nascosta, andare più in profondità rispetto a questa situazione di emarginazione grave che uomini e donne del nostro tempo si trovano a vivere proprio accanto a noi. Il capitolo 1 introduce l’immagine del senza fissa dimora, ripercorrendo gli stereotipi che nel corso della storia si sono costruiti. Verranno in seguito tracciate le caratteristiche ricorrenti, quegli aspetti che ritroviamo prevalentemente nei senza fissa dimora oggi, evidenziando come una persona che vive tale condizione sia un soggetto in stato di povertà materiale ed immateriale, portatore di un disagio complesso, dinamico e multiforme. Ponendo quindi l’accento sul fatto che la presenza delle persone senza dimora costituisce la punta maggiormente visibile e toccante della povertà, analizzeremo le dimensioni della povertà, andando ad evidenziare il fatto che è nell’ambito della povertà estrema che possono collocarsi le persone che vivono nella strada, una povertà non soltanto più intensa delle altre, ma una povertà diversa perché correlata all’esclusione sociale e al disagio psico-sociale. Il capitolo 2 descrive alcuni elementi che sono in genere presenti nelle storie di vita degli homeless, elementi che vogliono essere gli aspetti tematici della nostra indagine: i “punti di rottura”, ossia quegli eventi che rivestono un ruolo decisivo nella dinamica dello scivolamento della persona nel processo di emarginazione; l’aspetto relazionale, quindi l’ambito degli affetti e delle reti di supporto; la dimensione lavorativa e la percezione di sé nelle biografie dell’abbandono. Il capitolo 3 intende costruire una sorta di mappa dei servizi che si rivolgono ai soggetti che vivono nell’emarginazione grave, con particolare riguardo ai Centri d’Ascolto, agli asili notturni, ai centri d’accoglienza e alle mense presenti nella realtà lucchese. Nel capitolo 4 sono riportate le storie di vita raccolte ascoltando alcune persone senza fissa dimora che vivono attualmente a Lucca. Il capitolo 5 tratta alcune considerazioni finali in merito ai racconti e alle biografie che sono state esposte nel capitolo precedente

Materials selection for food processing professional appliances

Professional appliances are characterized by an intense use in harsh environments; therefore, they need to communicate, through materials sensorial attributes, robustness and reliability. During their lifetime, professional appliances face specific chemical compatibility problems related to daily contact with food chemicals and detergent compounds compliance, and to misuse practices. These products are developed as tailor-made solutions, designed to satisfy both client needs and usability, even in very specific operative conditions. For this reason, they are developed on one hand through a performance driven technical design process, and on the other through a sensorial oriented materials selection, to improve the user experience with the product. From the Ashby method, the implementation of a flexible materials selection process, able to match sensorial attributes with the real products performances, needs for improvements, due to the highly competitive professional appliances market. The most common design approach in the industrial production of business to business market appliances sees the designer and the engineer as separate figures, which compel respectively to the aesthetical and emotional issues and to the technical and performances requirements. Both these figures operate materials selection with two different perspectives: the lack of communication among the two roles is often due to the different levels of analysis of the process. Electrolux Professional is trying to overcome this limit using an innovative approach, being an appropriate environment to test new solutions. A unique selection method applied to real products, able to couple qualitative and quantitative properties, and to consider both the modification of the technical and chemical properties and the material sensorial perceptions along the products life, can be the driving force of an innovative materials selection approach. The related design process will be then integrated to reach in a unique step a concept that satisfies both the technical performances and the user perception requirements

Editorial: immunomodulation of innate immune cells

Sem resumo disponívelpublishe

Materials selection tools in professional appliances: hypothesis to estimate materials’ performance and impact on industrial processes

Concept The use of materials’ selection in professional appliances increased in recent times, thanks to its potential pre-evaluation of materials’ performance and impact on industrial production processes. Through a collaboration among Politecnico di Milano (Department of Design and Department of Chemistry, Materials and Chemical Engineering “Giulio Natta”) and Electrolux Professional S.p.A. (Global Research & Development, Innovation & Technologies Area), an evaluation of materials’ tangible and intangible properties has been developed using non-traditional methods. Among all the currently professional appliances, the oven environment has been chosen as the most emblematic study case. In the first part, this work evidences the major limits and critical points of the materials’ selection tools currently and most commonly proposed in industrial applications. Within these, the main key points highlighted are the translation and connection of quantitative and qualitative properties and the risk associated to the materials selection process reliability. In a second step, some ameliorative hypotheses are built to overcome these limits, using a repeatable and suitable method for different materials selection cases. Motivations and Objectives The research aim is to develop an innovative and versatile method for the materials selection in professional appliances field, used by engineers and designers. From the Ashby [1] and the Karana [2] selection strategies, the non-traditional materials selection methodology would offer a complete evaluation of materials’ tangible and intangible properties. Different variables, indeed, have been taken into consideration: material’s technical properties (e.g. mechanical, thermal and processability parameters), durability (e.g. food chemicals and detergents), food-material compliance and customer perception of properties. The need of a unique materials selection method, able to convert quantitative to qualitative evaluation of properties and to estimate the risk associated to the materials selection reliability, driven the research. A procedure, which evaluates components’ life and possible failure modes (based on DOE and FMEA) [3] [4] [5], is under development in order to integrate these information into the future products development. Results and Discussion The research presents the development of the materials selection methodology under consideration supported by some case studies that focus on durability properties of materials

Left hemispatial neglect and overt orienting in naturalistic conditions: Role of high-level and stimulus-driven signals

Deficits of visuospatial orienting in brain-damaged patients affected by hemispatial neglect have been extensively investigated. Nonetheless, spontaneous spatial orienting in naturalistic conditions is still poorly understood. Here, we investigated the role played by top-down and stimulus-driven signals in overt spatial orienting of neglect patients during free-viewing of short videos portraying everyday life situations. In Experiment 1, we assessed orienting when meaningful visual events competed on the left and right side of space, and tested whether sensory salience on the two sides biased orienting. In Experiment 2, we examined whether the spatial alignment of visual and auditory signals modulates orienting. The results of Experiment 1 showed that in neglect patients severe deficits in contralesional orienting were restricted to viewing conditions with bilateral visual events competing for attentional capture. In contrast, orienting towards the contralesional side was largely spared when the videos contained a single event on the left side. In neglect patients the processing of stimulus-driven salience was relatively spared and helped orienting towards the left side when multiple events were present. Experiment 2 showed that sounds spatially aligned with visual events on the left side improved orienting towards the otherwise neglected hemispace. Anatomical scans indicated that neglect patients suffered grey and white matter damages primarily in the ventral frontoparietal cortex. This suggests that the improvement of contralesional orienting associated with visual salience and audiovisual spatial alignment may be due to processing in the relatively intact dorsal frontoparietal areas. Our data show that in naturalistic environments, the presence of multiple meaningful events is a major determinant of spatial orienting deficits in neglect patients, whereas the salience of visual signals and the spatial alignment between auditory and visual signals can counteract spatial orienting deficits. These results open new perspectives to develop novel rehabilitation strategies based on the use of naturalistic stimuli

Erectile dysfunction and quality of life in type 2 diabetic patients: a serious problem too often overlooked.

OBJECTIVE—Within the context of a large, nationwide outcomes research program in type 2 diabetes, we assess the prevalence of self-reported erectile dysfunction and evaluate its impact on quality of life. RESEARCH DESIGN AND METHODS—The study involved 1,460 patients enrolled by 114 diabetes outpatient clinics and 112 general practitioners. Patients were asked to complete a questionnaire investigating their ability to achieve and maintain an erection. Various aspects of quality of life were also assessed depressive using the following instruments: SF-36 Health Survey, diabetes health distress, psychological adaptation to diabetes, depressive symptoms (CES-D scale), and quality of sexual life. RESULTS—Overall, 34% of the patients reported frequent erectile problems, 24% reported occasional problems, and 42% reported no erectile problems. After adjusting for patient characteristics, erectile dysfunction was associated with higher levels of diabetes-specific health distress and worse psychological adaptation to diabetes, which were, in turn, related to worse metabolic control. Erectile problems were also associated with a dramatic increase in the prevalence of severe depressive symptoms, lower scores in the mental components of the SF-36, and a less satisfactory sexual life. A total of 63% of the patients reported that their physicians had never investigated their sexual problems. CONCLUSIONS—Erectile dysfunction is extremely common among type 2 diabetic patients and is associated with poorer quality of life, as measured with generic and diabetes-specific instruments. Despite their relevance, sexual problems are seldom investigated by general practitioners and specialists

Electrolyte Imbalance Determination of a Vanadium Redox Flow Battery by Potential‐Step Analysis of the Initial Charging

Vanadium redox flow batteries (VRFB) suffer from capacity fades owing to side reactions and crossover effects through the membrane. These processes lead to a deviation of the optimal initial average oxidation state (AOS=+3.5) of vanadium species in both half‐cell electrolytes. To rebalance the electrolyte solutions, it is first necessary to determine the current AOS. In this study, a new method was developed that enables an accurate determination of the AOS. A potential‐step analysis was performed with mixed electrolyte solutions of both half‐cells during the initial charging. The potential was recorded with a simple open‐circuit voltage (OCV) cell, and the potential‐steps were analyzed. A correlation between the duration of the potential plateaus in the OCV and the amount of vanadium ions of a certain oxidation state in the half‐cell electrolytes was found and used to precisely determine the AOS with a maximum error of 3.6 %

Quality of Care and Outcomes in Type 2 Diabetic Patients A comparison between general practice and diabetes clinics

OBJECTIVE—The role of general practice and diabetes clinics in the management of diabetes is still a matter of debate. Methodological flaws in previous studies may have led to inaccurate conclusions when comparing the care provided in these different settings. We compared the care provided to type 2 diabetic patients attending diabetes outpatient clinics (DOCs) or being treated by a general practitioner (GP) using appropriate statistical methods to adjust for patient case mix and physician-level clustering. RESEARCH DESIGN AND METHODS—We prospectively evaluated the process and intermediate outcome measures over 2 years in a sample of 3,437 patients recruited by 212 physicians with different specialties practicing in 125 DOCs and 103 general practice offices. Process measures included frequency of HbA1c, lipids, microalbuminuria, and serum creatinine measurements and frequency of foot and eye examinations. Outcome measures included HbA1c, blood pressure, and total and LDL cholesterol levels. RESULTS—Differences for most process measures were statistically significantly in favor of DOCs. The differences were more marked for patients who were always treated by the same physician within a DOC and if that physician had a specialty in diabetology. Less consistent differences in process measures were detected when patients followed by GPs were compared with those followed by physicians with a specialty other than diabetology. As for the outcomes considered, patients attending DOCs attained better total cholesterol levels, whereas no major differences emerged in terms of metabolic control and blood pressure levels between DOCs and GPs. Physicians' specialties were not independently related to patient outcomes. CONCLUSIONS—Being followed always by the same physician in a DOC, particularly if the physician had a specialty in diabetes, ensured better quality of care in terms of process measures. In the short term, care provided by DOCs was also associated with better intermediate outcome measures, such as total cholesterol levels

Sirtuin 6 localization at cortical brain level of young diabetic mice

The metabolic syndrome, characterized by visceral obesity, dyslipidaemia, hyperglycaemia and hypertension, has become one of the major public-health challenges worldwide and it is strictly associated with the development of type II diabetes and neurodegenerative diseases (Alberti et al. 2005; Panza et al. 2010). Increased metabolic flux to the brain during overnutrition can orchestrate stress response, blood-brain barrier alteration, microglial cells activation and neuroinflammation (Nerurkar et al., 2011). The protein sirtuin family is a class of nicotinamide adenine dinucleotide (NAD+)-dependent histone deacetylase that act on a variety of targets and so play a key role in central physiological regulation (Sebastian et al., 2012; Wang et al., 2012). To assess the physiopathological significance of sirtuin6 (SIRT6) at brain cortical level, we analysed its specific expression and subcellular localization in young db/db mice, animal model of type II diabetes mellitus, and respective control lean mice. In particular, we analysed the cytoarchitecture of the brain cortex, evaluated SIRT6 expression and its localization by immunohistochemistry comparing young db/db mice to lean control mice, distinguishing among the six cortical layers and between motor and somatosensory cortex. We observed that SIRT6 is mainly localized in the nucleus of both lean and db/db mice. Diabetic mice showed few SIRT6 positive cells respect to lean control mice in all cortical layers without significant differences between motor and somatosensory cortex. No morphological alteration have been find. In conclusion, our findings contribute to further understand SIRT6 protein expression in the early steps of type II diabetes mellitus and suggest its implication in the pathogenic processes of diabetes mellitus and diabetes–induced neurodegeneration