Investigating the Impact of Eight Weeks of Aerobic Training on Liver Enzymes and Hematological Profile in Children with Leukemia

Objectives: The objective of the evaluation was to study and determine the impact of eight weeks of aerobic training (AT) on liver enzymes and changes in hematological profile in children with leukemia.Methods: This is a semi-experimental and applied study. Statistical samples include 24 children aged 7 to 10 years that referred to hospital and were divided randomly into two control (n=12) and experimental (n=12) groups. Eight-week AT with 40 to 70 percent of heart rate reserve, three sessions per week, no exercise training program was observed in the controls during the study. We measure Liver enzymes such as Aspartate aminotransferase (AST) and alanine aminotransferase (ALT), Hemoglobin (Hb), White Blood Cells (WBC), platelets (PLT), and bilirubin. Data analysis using a paired t-test and analysis of covariance was performed with software SPSS version 20.Results: The results showed that moderate-intensity AT has a significant effect on hemoglobin and liver enzyme levels and a significant increase in Hb (p<0.05) and significant reduction the ALT and AST (p<0.05) whereas there was no significant influence on WBC, ALT, and bilirubin (p>0.05).Conclusion: AT may accelerate the oxygen supply and reduce liver damage caused by medications in children diagnosed with leukemia without having corrupting effect on PLT, bilirubin, and safety factors

Effect of combined balance exercises and kinesio taping on balance, postural stability, and severity of ankle instability in female athletes with functional ankle instability

Ankle sprain is a common musculoskeletal injury, and recurrent ankle sprains often lead to ankle instability. This study aimed to examine whether a 6-week balance training on a wobble board (WB) combined with kinesio taping (KT) is effective in improving balance, postural stability, and ankle stability among female athletes with functional ankle instability (FAI). Twenty-four female athletes with FAI were randomly assigned to study (SG) or control groups (CG). SG attended a 6-week training protocol of combined balance training on the wobble board with KT applied to ankles during exercise. CG only went through a 6-week balance training procedure that was the same as the SG. Before and after the training program, balance and postural stability and the severity of ankle instability were assessed by single-leg Biodex Balance system and Cumberland Ankle Instability Tool (CAIT), respectively. The analysis revealed that the scores of balance and postural stability decreased after the 6-week training for CG (p = 0.002) and SG (p = 0.001), which indicates an improvement for these variables, and the score of CAIT increased, which means the severity of instability reduced (p = 0.001 for both groups). Significant between-group differences were found for balance and postural stability (t = 2.79, p = 0.011, g = −1.99) and the severity of instability (t = 2.082, p = 0.049, g = 1.36), favoring SG compared with CG. This study showed that the addition of KT to balance training is more effective than balance training alone in improving balance, postural stability, and severity of ankle instability in female athletes with FAI. Our findings could provide a preliminary reference for designing combined balance and KT programs for delivering health benefits to females with FAI.info:eu-repo/semantics/publishedVersio

The Comparison of Knee Joint Muscles Flexibility between Women with and without Radiographic Knee Osteoarthritis

Background: Approximately 60% of individuals above 50 years of age are affected by knee osteoarthritis (KOA). KOA is most commonly assessed through radiographic evaluation and classified using the Kellgren -Lawrence (KL) grading system with KL Grade 0 (KLG0) indicating a definite absence of radiographic KOA (RKOA) and KLG2 presenting a definite presence of RKOA. The current study compared knee joint muscle flexibility among three groups with KLG0, KLG2, and KLG3 RKOA. Methods: In this descriptive cross-sectional study, 94 KLG0, KLG2, and KLG3 knees on 57 women aged ≥40 years were examined. The flexibility of the quadriceps, hamstring, iliotibial band, adductor, and gastrocnemius muscles was compared. Results: Iliotibial band flexibility was lower in subjects with KLG3 RKOA than those with KLG2 (p 0.05). Conclusion: In patients with RKOA, the flexibility of the iliotibial band and quadriceps muscles may decrease as the disease progresses from KLG2 to KLG3. Moreover, quadriceps and iliotibial band flexibility may be lower in KLG3 compared to KLG0, with a lower likelihood of quadriceps flexibility in KLG2 compared to KLG0. These results suggest that quadriceps and iliotibial band stretching may be potentially important components of treatment

Application of machine learning techniques for identifying productive zones in unconventional reservoir

Unconventional reservoirs are the productive zones in other words the rock quality and the mechanical properties of the rocks this process is devastating if humans or people try to search for the best reservoirs. So we can use machine learning (ML) algorithms to help us find and search easily and fast for the best reservoirs with less human interaction as possible. The objectives of this paper is to use machine learning (ML) techniques to predict and classify the reservoirs based on the properties of each reservoirs and choose the best reservoir. In this paper we have made a comparison between the different types of machine learning algorithm and described how we get the best and worst result for each one, the comparison we made gave us that the AdaBoost algorithm gave the worst performance measured in the accuracy while the random forest (RF) algorithm gave the best performance, this paper aim to make improvement of the process of searching for productive zones using ML algorithms

Global age-sex-specific mortality, life expectancy, and population estimates in 204 countries and territories and 811 subnational locations, 1950–2021, and the impact of the COVID-19 pandemic: a comprehensive demographic analysis for the Global Burden of Disease Study 2021

Background: Estimates of demographic metrics are crucial to assess levels and trends of population health outcomes. The profound impact of the COVID-19 pandemic on populations worldwide has underscored the need for timely estimates to understand this unprecedented event within the context of long-term population health trends. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 provides new demographic estimates for 204 countries and territories and 811 additional subnational locations from 1950 to 2021, with a particular emphasis on changes in mortality and life expectancy that occurred during the 2020–21 COVID-19 pandemic period. Methods: 22 223 data sources from vital registration, sample registration, surveys, censuses, and other sources were used to estimate mortality, with a subset of these sources used exclusively to estimate excess mortality due to the COVID-19 pandemic. 2026 data sources were used for population estimation. Additional sources were used to estimate migration; the effects of the HIV epidemic; and demographic discontinuities due to conflicts, famines, natural disasters, and pandemics, which are used as inputs for estimating mortality and population. Spatiotemporal Gaussian process regression (ST-GPR) was used to generate under-5 mortality rates, which synthesised 30 763 location-years of vital registration and sample registration data, 1365 surveys and censuses, and 80 other sources. ST-GPR was also used to estimate adult mortality (between ages 15 and 59 years) based on information from 31 642 location-years of vital registration and sample registration data, 355 surveys and censuses, and 24 other sources. Estimates of child and adult mortality rates were then used to generate life tables with a relational model life table system. For countries with large HIV epidemics, life tables were adjusted using independent estimates of HIV-specific mortality generated via an epidemiological analysis of HIV prevalence surveys, antenatal clinic serosurveillance, and other data sources. Excess mortality due to the COVID-19 pandemic in 2020 and 2021 was determined by subtracting observed all-cause mortality (adjusted for late registration and mortality anomalies) from the mortality expected in the absence of the pandemic. Expected mortality was calculated based on historical trends using an ensemble of models. In location-years where all-cause mortality data were unavailable, we estimated excess mortality rates using a regression model with covariates pertaining to the pandemic. Population size was computed using a Bayesian hierarchical cohort component model. Life expectancy was calculated using age-specific mortality rates and standard demographic methods. Uncertainty intervals (UIs) were calculated for every metric using the 25th and 975th ordered values from a 1000-draw posterior distribution. Findings: Global all-cause mortality followed two distinct patterns over the study period: age-standardised mortality rates declined between 1950 and 2019 (a 62·8% [95% UI 60·5–65·1] decline), and increased during the COVID-19 pandemic period (2020–21; 5·1% [0·9–9·6] increase). In contrast with the overall reverse in mortality trends during the pandemic period, child mortality continued to decline, with 4·66 million (3·98–5·50) global deaths in children younger than 5 years in 2021 compared with 5·21 million (4·50–6·01) in 2019. An estimated 131 million (126–137) people died globally from all causes in 2020 and 2021 combined, of which 15·9 million (14·7–17·2) were due to the COVID-19 pandemic (measured by excess mortality, which includes deaths directly due to SARS-CoV-2 infection and those indirectly due to other social, economic, or behavioural changes associated with the pandemic). Excess mortality rates exceeded 150 deaths per 100 000 population during at least one year of the pandemic in 80 countries and territories, whereas 20 nations had a negative excess mortality rate in 2020 or 2021, indicating that all-cause mortality in these countries was lower during the pandemic than expected based on historical trends. Between 1950 and 2021, global life expectancy at birth increased by 22·7 years (20·8–24·8), from 49·0 years (46·7–51·3) to 71·7 years (70·9–72·5). Global life expectancy at birth declined by 1·6 years (1·0–2·2) between 2019 and 2021, reversing historical trends. An increase in life expectancy was only observed in 32 (15·7%) of 204 countries and territories between 2019 and 2021. The global population reached 7·89 billion (7·67–8·13) people in 2021, by which time 56 of 204 countries and territories had peaked and subsequently populations have declined. The largest proportion of population growth between 2020 and 2021 was in sub-Saharan Africa (39·5% [28·4–52·7]) and south Asia (26·3% [9·0–44·7]). From 2000 to 2021, the ratio of the population aged 65 years and older to the population aged younger than 15 years increased in 188 (92·2%) of 204 nations. Interpretation: Global adult mortality rates markedly increased during the COVID-19 pandemic in 2020 and 2021, reversing past decreasing trends, while child mortality rates continued to decline, albeit more slowly than in earlier years. Although COVID-19 had a substantial impact on many demographic indicators during the first 2 years of the pandemic, overall global health progress over the 72 years evaluated has been profound, with considerable improvements in mortality and life expectancy. Additionally, we observed a deceleration of global population growth since 2017, despite steady or increasing growth in lower-income countries, combined with a continued global shift of population age structures towards older ages. These demographic changes will likely present future challenges to health systems, economies, and societies. The comprehensive demographic estimates reported here will enable researchers, policy makers, health practitioners, and other key stakeholders to better understand and address the profound changes that have occurred in the global health landscape following the first 2 years of the COVID-19 pandemic, and longer-term trends beyond the pandemic

Global age-sex-specific mortality, life expectancy, and population estimates in 204 countries and territories and 811 subnational locations, 1950–2021, and the impact of the COVID-19 pandemic: a comprehensive demographic analysis for the Global Burden of Disease Study 2021

BACKGROUND: Estimates of demographic metrics are crucial to assess levels and trends of population health outcomes. The profound impact of the COVID-19 pandemic on populations worldwide has underscored the need for timely estimates to understand this unprecedented event within the context of long-term population health trends. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 provides new demographic estimates for 204 countries and territories and 811 additional subnational locations from 1950 to 2021, with a particular emphasis on changes in mortality and life expectancy that occurred during the 2020–21 COVID-19 pandemic period. METHODS: 22 223 data sources from vital registration, sample registration, surveys, censuses, and other sources were used to estimate mortality, with a subset of these sources used exclusively to estimate excess mortality due to the COVID-19 pandemic. 2026 data sources were used for population estimation. Additional sources were used to estimate migration; the effects of the HIV epidemic; and demographic discontinuities due to conflicts, famines, natural disasters, and pandemics, which are used as inputs for estimating mortality and population. Spatiotemporal Gaussian process regression (ST-GPR) was used to generate under-5 mortality rates, which synthesised 30 763 location-years of vital registration and sample registration data, 1365 surveys and censuses, and 80 other sources. ST-GPR was also used to estimate adult mortality (between ages 15 and 59 years) based on information from 31 642 location-years of vital registration and sample registration data, 355 surveys and censuses, and 24 other sources. Estimates of child and adult mortality rates were then used to generate life tables with a relational model life table system. For countries with large HIV epidemics, life tables were adjusted using independent estimates of HIV-specific mortality generated via an epidemiological analysis of HIV prevalence surveys, antenatal clinic serosurveillance, and other data sources. Excess mortality due to the COVID-19 pandemic in 2020 and 2021 was determined by subtracting observed all-cause mortality (adjusted for late registration and mortality anomalies) from the mortality expected in the absence of the pandemic. Expected mortality was calculated based on historical trends using an ensemble of models. In location-years where all-cause mortality data were unavailable, we estimated excess mortality rates using a regression model with covariates pertaining to the pandemic. Population size was computed using a Bayesian hierarchical cohort component model. Life expectancy was calculated using age-specific mortality rates and standard demographic methods. Uncertainty intervals (UIs) were calculated for every metric using the 25th and 975th ordered values from a 1000-draw posterior distribution. FINDINGS: Global all-cause mortality followed two distinct patterns over the study period: age-standardised mortality rates declined between 1950 and 2019 (a 62·8% [95% UI 60·5–65·1] decline), and increased during the COVID-19 pandemic period (2020–21; 5·1% [0·9–9·6] increase). In contrast with the overall reverse in mortality trends during the pandemic period, child mortality continued to decline, with 4·66 million (3·98–5·50) global deaths in children younger than 5 years in 2021 compared with 5·21 million (4·50–6·01) in 2019. An estimated 131 million (126–137) people died globally from all causes in 2020 and 2021 combined, of which 15·9 million (14·7–17·2) were due to the COVID-19 pandemic (measured by excess mortality, which includes deaths directly due to SARS-CoV-2 infection and those indirectly due to other social, economic, or behavioural changes associated with the pandemic). Excess mortality rates exceeded 150 deaths per 100 000 population during at least one year of the pandemic in 80 countries and territories, whereas 20 nations had a negative excess mortality rate in 2020 or 2021, indicating that all-cause mortality in these countries was lower during the pandemic than expected based on historical trends. Between 1950 and 2021, global life expectancy at birth increased by 22·7 years (20·8–24·8), from 49·0 years (46·7–51·3) to 71·7 years (70·9–72·5). Global life expectancy at birth declined by 1·6 years (1·0–2·2) between 2019 and 2021, reversing historical trends. An increase in life expectancy was only observed in 32 (15·7%) of 204 countries and territories between 2019 and 2021. The global population reached 7·89 billion (7·67–8·13) people in 2021, by which time 56 of 204 countries and territories had peaked and subsequently populations have declined. The largest proportion of population growth between 2020 and 2021 was in sub-Saharan Africa (39·5% [28·4–52·7]) and south Asia (26·3% [9·0–44·7]). From 2000 to 2021, the ratio of the population aged 65 years and older to the population aged younger than 15 years increased in 188 (92·2%) of 204 nations. INTERPRETATION: Global adult mortality rates markedly increased during the COVID-19 pandemic in 2020 and 2021, reversing past decreasing trends, while child mortality rates continued to decline, albeit more slowly than in earlier years. Although COVID-19 had a substantial impact on many demographic indicators during the first 2 years of the pandemic, overall global health progress over the 72 years evaluated has been profound, with considerable improvements in mortality and life expectancy. Additionally, we observed a deceleration of global population growth since 2017, despite steady or increasing growth in lower-income countries, combined with a continued global shift of population age structures towards older ages. These demographic changes will likely present future challenges to health systems, economies, and societies. The comprehensive demographic estimates reported here will enable researchers, policy makers, health practitioners, and other key stakeholders to better understand and address the profound changes that have occurred in the global health landscape following the first 2 years of the COVID-19 pandemic, and longer-term trends beyond the pandemic. FUNDING: Bill & Melinda Gates Foundation

The Effect of Various Standing Positions in Muscles Activity between Healthy Young Men and those with Genu Varum

Objective: Genu varum is considered a risk factor for knee osteoarthritis. Being aware of the changes in muscles activity in various standing positions among genu varum patients, can provide insight for preventing osteoarthritis in this population. This study is undertaken to compare muscles activity in various standing positions between young healthy and genu varum male individuals. Methods: 80 healthy male university students, 40 normal and 40 subjects with genu varum deformity, participated in this study. Deformity of genu varum was assessed with caliper and Goniometer. Each subject stood in five different positions and muscles activity was recorded with EMG device. For data analysis, Matlab and SPSS software were employed and Mixed variance analysis test (Mixed ANOVA) was run to compare the dependent variables at a significance level of P ≤ 0.05. Results: Significant differences were observed between the two groups for muscles activity of the tensor fasia latae (at single leg with closed eye position), tertius fibulae and gluteus medius muscles (at single leg with closed eye and upward head postions)( p≤0.05) while no significant differences were observed in other muscles. Conclusion: According to the obtained results, it can be suggested that frontal knee angle may affect muscles activity. Perhaps one of the reasons for higher injury risk and knee osteoarthritis in genu varum population is the increase in muscles activity. Therefor, It is proposed that focusing on corrective exercises can reduce these risks

Comparison of the Effect of Eight Weeks of Core Stability Training and Kegel on Diastasis Rectus Abdominis in Multiparous Women

Objectives: Due to the importance of postpartum maternal health and the effect of pregnancy on the increase of recti diastasis rectus abdominis (DRA), this study aimed to compare the effect of eight weeks of core and Kegel exercise with emphasis on correcting the respiratory pattern on DRA in multiparous women. Methods: This is a semi-experimental study that was conducted on 45 pregnant women who had given birth six weeks ago selected according to the inclusion criteria. Individuals were divided into three selected training groups, including central area, Kegel, and control. The covariance analysis was used for intergroup comparison and a correlated t-test was used for comparison within a group. The statistical analysis was done by SPSS software, version 27.  Results: The results of this study showed the effect of both training programs on reducing the distance between the recti-abdominal muscles (P0.045).  Discussion: Due to the reduction of pain and DRA, it seems that using the two training programs can lead to desirable results for the people and represents the importance of using the exercises in the postpartum period

The Effect Rehabilitation Exercise on the Upper Crossed Syndrome in Patients with Coronary Artery Bypass Surgery

Introduction: Due to the importance of correct posture and the association of inappropriate posture with pain in the chest and scapula, the aim of this was to investigate the impact of rehabilitation exercise on the upper crossed syndrome in coronary artery bypass surgery patients.   Materials & Methods: The statistical population consisted of all the 44 to 70-year-old men with coronary artery bypass surgery and upper crossed syndrome referred to Valiasr Hospital of Qom. The participants included 30 subjects (experimental group 10, control group 10 and test group10) who were randomly selected to participate in the study. In the test group a day before surgery and 8 weeks after surgery and in the control and experimental groups, 8 weeks after surgery and 8 weeks after the first test, the associated tests were run. To analyze the data, t-test Wilcoxon, and analysis of covariance were used. Findings: According to the results of the experimental group, the exercises had a significant positive (p<0.05) effect on kyphosis and forward head postures and had a positive, but not significant, effect on rounded shoulders. In the test group, the trainings had a significant positive effect on kyphosis, forward head, and rounded shoulder on the left side (p<0.05), while it had a positive, but non-significant, effect on rounded shoulder on the right side.   Discussion & Conclusions: In the present study, combination trainings using isometric, tread band, and stretching movements were effective in correcting forward head, kyphosis, and rounded shoulder postures in patients undergoing coronary artery bypass surgery