Sulfur-bearing species in molecular clouds

We study several molecules that could help in the solution of the missing sulfur problem in dense clouds and circumstellar regions, as well as in the clarification of the sulfur chemistry in comets. These sulfur molecules are: the trimer (CH2S)3 and the tetramer (CH2S)4 of thioformaldehyde, pentathian S5CH2, hexathiepan S6CH2, thiirane C2H4S, trisulfane HSSSH, and thioacetone (CH3)2CS. Infrared spectra of these species are calculated using density functional theory methods. The majority of calculated bands belong to the mid-infrared, with some of them occurring in the near and far-infrared region. We suggest that some of unidentified spectral features measured by Infrared Space Observatory in several active galactic nuclei and starburst galaxies could be caused by 1,3,5-trithiane ((CH2S)3), 1,3,5,7-tetrathiocane ((CH2S)4), and thiirane (C2H4S). The objects whose unidentified infrared features we compare with calculated bands are: NGC 253, M82, NGC 1068, Circinus, Arp 220, 30 Doradus, Orion KL, and Sgr B2.Comment: accepted for publication in MNRA

Dejavniki vplivanja na uspešnost reševanja strogo geometrijskega problema pri učencih med 14. in 15. letom starosti

This paper investigates and considers factors that affect success in solving a stand-alone geometrical problem by 182 students of the 7th and 8th grades of elementary school. The starting point for consideration is a geometrical task from the National Secondary School Leaving Exam in Croatia (State Matura), utilising elementary-level geometry concepts. The task was presented as a textual problem with an appropriate drawing and a task within a given context. After data processing, the key factors affecting the process of problem solving were singled out: visualisation skills, detection and connection of concepts, symbolic notations, and problem-solving culture. The obtained results are the basis of suggestions for changes in the geometry teaching-learning process. (DIPF/Orig.

Effects of Temperature–Climate Patterns on the Production of Some Competitive Species on Grounds of Modelling

Climate change has serious effects on the setting up and the operation of natural ecosystems. Small increase in temperature could cause rise in the amount of some species or potential disappearance of others. During our researches, the dispersion of the species and biomass production of a theoretical ecosystem were examined on the effect of the temperature–climate change. The answers of the ecosystems which are given to the climate change could be described by means of global climate modelling and dynamic vegetation models. The examination of the operation of the ecosystems is only possible in huge centres on supercomputers because of the number and the complexity of the calculation. The number of the calculation could be decreased to the level of a PC by considering the temperature and the reproduction during modelling a theoretical ecosystem, and several important theoretical questions could be answered

Comparative Assessment of Climate Change Scenarios Based on Aquatic Food Web Modeling

In the years 2004 and 2005, we collected samples of phytoplankton, zooplankton, and macroinvertebrates in an artificial small pond in Budapest (Hungary). We set up a simulation model predicting the abundances of the cyclopoids, Eudiaptomus zachariasi, and Ischnura pumilio by considering only temperature and the abundance of population of the previous day. Phytoplankton abundance was simulated by considering not only temperature but the abundances of the three mentioned groups. When we ran the model with the data series of internationally accepted climate change scenarios, the different outcomes were discussed. Comparative assessment of the alternative climate change scenarios was also carried out with statistical methods

Pharmacological characterization of N-[(2S)-5-(6-fluoro-3-pyridinyl)-2, 3-dihydro-1H-inden-2-yl]-2-propanesulfonamide: a novel, clinical AMPA receptor positive allosteric modulator

BACKGROUND AND PURPOSE AMPA receptor positive allosteric modulators represent a potential therapeutic strategy to improve cognition in people with schizophrenia. These studies collectively constitute the preclinical pharmacology data package used to build confidence in the pharmacology of this molecule and enable a clinical trial application. EXPERIMENTAL APPROACH [N-[(2S)-5-(6-fluoro-3-pyridinyl)-2,3-dihydro 1H–inden-2-yl]-2-propanesulfonamide] (UoS12258) was profiled in a number of in vitro and in vivo studies to highlight its suitability as a novel therapeutic agent. KEY RESULTS We demonstrated that UoS12258 is a selective, positive allosteric modulator of the AMPA receptor. At rat native heterooligomeric AMPA receptors, UoS12258 displayed a minimum effective concentration of approximately 10 nM in vitro and enhanced AMPA receptor-mediated synaptic transmission at an estimated free brain concentration of approximately 15 nM in vivo. UoS12258 reversed a delay-induced deficit in novel object recognition in rats after both acute and sub-chronic dosing. Subchronic dosing reduced the minimum effective dose from 0.3 to 0.03mg·kg�1. UoS12258 was also effective at improving performance in two other cognition models, passive avoidance in scopolamine-impaired rats and water maze learning and retentionin aged rats. In side-effect profiling studies, UoS12258 did not produce significant changes in the maximal electroshock thresholdtest at doses below 10 mg·kg�1. CONCLUSION AND IMPLICATIONS We conclude that UoS12258 is a potent and selective AMPA receptor modulator exhibiting cognition enhancing properties in several rat behavioural models superior to other molecules that have previously entered clinical evaluation

Socialni kapital in izobrazevalni dosezki: Coleman - Bourdieu

The influence of social capital on an individual’s educational achievements is the subject of numerous scientific papers. Research on social capital is most frequently based on Coleman’s (1988) or Bourdieu’s (1986) theories of capital, which are related to different paradigms of social theory: whereas Coleman’s approach has its roots in structural functionalism, Bourdieu’s approach contains elements of conflict theory. A number of authors, starting with Bourdieu, attempt to explain and prove that, when connected with the education of individuals, the activity of social capital facilitates social reproduction. Other authors support the notion that social capital is, in fact, a powerful weapon that encourages social mobility. A third group of researchers emphasise that neither of these approaches in isolation can entirety explain the influences of social capital on an individual’s education (Ho, 2003). The present paper offers a review of research focusing on the influences of social capital on educational achievements, while outlining the fundamental differences between the two theoretical approaches that are most frequently used for research of this topic. The aim of the paper is to explain the influence of social capital on an individual’s educational achievements under Bourdieu’s and Coleman’s theoretical concepts, and to establish whether combining the approaches is possible. The conclusion and arguments show that it is legitimate to use all three theoretical approaches. (DIPF/Orig.