6 research outputs found
R.H. Moreno-DurĂĄn: fantasĂa y verdad. ValoraciĂłn mĂșltiple
Pocos escritores colombianos han explorado diversos gĂ©neros literarios con resultados satisfactorios; Moreno-DurĂĄn destaca en el panorama artĂstico de Colombia al cosechar logros en una amplia producciĂłn creativa que incluye novelas, cuentos, ensayos y en los Ășltimos tiempos el teatro. / Contenido. Preliminares; CapĂtulo 1 - R.H. Moreno-DurĂĄn: a fondo; CapĂtulo 2 - R.H. Moreno-DurĂĄn: en breve; Anexos
Improved outcome in children compared to adolescents and young adults after allogeneic hematopoietic stem cell transplant for acute myeloid leukemia: a retrospective study from the Francophone Society of Bone Marrow Transplantation and Cell Therapy (SFGM-TC).
BACKGROUND: There are currently few data on the outcome of acute myeloid leukemia (AML) in adolescents after allogeneic HSCT. The aim of this study is to describe the outcome and its specific risk factors for children, adolescents and young adults after a first allogeneic HSCT for AML. METHODS: In this retrospective study, we compared the outcome of AML patients receiving a first allogeneic HSCT between 2005 and 2017 according to their age at transplantation's time: children (<â15Â years, nâ=â564), adolescent and post-adolescent (APA) patients (15-25Â years, nâ=â647) and young adults (26-40Â years; nâ=â1434). RESULTS: With a median follow-up of 4.37Â years (min-max 0.18-14.73Â years), the probability of 2-year overall survival (OS) was 71.4% in children, 61.1% in APA patients and 62.9% in young adults (pâ=â0.0009 for intergroup difference). Both relapse and non-relapse mortality (NRM) Cumulative Incidence (CI) estimated at 2Â years were different between the age groups (30.8% for children, 35.2% for APA patients and 29.4% for young adults-pâ=â0.0254, and 7.0% for children, 10.6% for APA patients and 14.2% for young adults, pâ<â0.0001; respectively). Whilst there was no difference between the three groups for grade I to IV acute GVHD CI at 3Â months, the chronic GVHD CI at 2Â years was higher in APA patients and young adults (31.4% and 36.4%, respectively) in comparison to the children (17.5%) (pâ<â0.0001). In multivariable analysis, factors associated with death were AML cytogenetics (HR1.73 [1.29-2.32] for intermediate risk 1, HR 1.50 [1.13-2.01] for intermediate risk 2, HR 2.22 [1.70-2.89] for high cytogenetics risk compared to low risk), use of TBIââ„â8 Grays (HR 1.33 [1.09-1.61]), disease status at transplant (HR 1.40 [1.10-1.78] for second Complete Remission (CR), HR 2.26 [1.02-4.98] for third CR and HR 3.07 [2.44-3.85] for active disease, compared to first CR), graft source (HR 1.26 [1.05-1.50] for Peripheral Blood Stem Cells compared to Bone Marrow) and donor age (HR 1.01 (1-1.02] by increase of 1 year). CONCLUSION: Age is an independent risk factor for NRM and extensive chronic GVHD. This study suggests that APA patients with AML could be beneficially treated with a chemotherapy-based MAC regimen and bone marrow as a stem cells source
L'ordinaire des sciences et techniques. Cultures populaires, cultures informelles (1)
International audienceLa prĂ©sente Ă©dition de la Lucarne matĂ©rialise la poursuite dâun travail engagĂ© depuis 2013. Il a Ă©tĂ© rĂ©alisĂ© dans le cadre dâun atelier collaboratif dâhistoire socioculturelle. Lâatelier lui-mĂȘme est animĂ© par un collectif formĂ© des enseignantâeâs et auditeurâriceâs des formations du CNAM dĂ©diĂ©es Ă la mĂ©diation socioculturelle des sciences et techniques. Certificat de compĂ©tences, Licence professionnelle ou Magister sâattĂšlent ainsi Ă la rĂ©flexion, Ă la conception et Ă la rĂ©alisation de dispositifs pour la mĂ©diation des sciences et techniques en sociĂ©tĂ© par le design culturel. Câest dans ce cadre de rĂ©alisation pĂ©dagogique que sont rassemblĂ©s ces textes et documents pour lesquels sont proposĂ©s de courtes analyses sur leur fonction de support de diffusion massive dans lâespace public dâune culture populaire et ordinaire des sciences et techniques. Tous ont Ă©tĂ© rĂ©digĂ©s dans le cadre dâun exercice exigĂ© pour la validation dâun enseignement. Si le rĂ©sultat final peut sâavĂ©rer inĂ©galement satisfaisant Ă lâaune des critĂšres de leurs commanditaires, tous les textes apportent cependant un regard jugĂ© pertinent sur un des aspects des manifestations des sciences et techniques dans leurs rapports Ă la sociĂ©tĂ© au travers de la production et de la consommation culturelle de masse. Quelques-uns ont Ă©tĂ© un peu remaniĂ©s pour la prĂ©sente Ă©dition. Retrouvez-les tous, ainsi que dâautres non publiĂ©s dans ce volume, sur le site de la Lucarne : http://ateliercst.hypotheses.org