Mechanistic understanding of innate and adaptive immune responses in SARS-CoV-2 infection

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections have triggered global pandemic that continue to impact adversely human health. New understanding has emerged about the innate and adaptive immune responses elicited in SARS-CoV-2 infection. The understanding of innate immune responses generated in hosts early in SARS-CoV-2 infection is vital for treatment efforts. Antiviral cytokines are released by innate immune cells in response to viral infections that play a pivotal role in limiting viral replication, pathology and generating optimal adaptive immune responses alongside the long-term memory responses against reinfections. One aspect of innate immune response generated against SARS-CoV-2 in vivo and which has received much attention has been high proinflammatory cytokine release in COVID-19 patients. Another vital discovery has been that the antiviral cytokine type I Interferon (IFN) family IFN-α mediates upregulation of angiotensin converting enzyme 2 (ACE2) membrane protein in airway epithelial cells. ACE2 is a receptor that SARS-CoV-2 binds to infect host cells. New understanding has emerged about the mechanism of SARS-CoV-2 induced exaggerated proinflammatory cytokine release as well as transcriptional regulation of ACE2. This review discusses various mechanisms underlying SARS-CoV-2 induced exaggerated proinflammatory cytokine response as well as transcriptional regulation of ACE2 receptor. We further elaborate on adaptive and memory responses generated against SARS-CoV-2

2015 \u27Why Humanities?\u27 Winner: Humanities, the Science of the Soul

Winning the 2015 University of Windsor’s Humanities Research Group’s ‘Why Humanities?’ undergraduate essay/creative project contest, Bibi Hijab Balkhi reflects on the decision to pursue an English degree, instead of becoming a doctor, and the less than enthusiastic reaction of their parents

Trends in Medicaid fee-for-service outpatient drug utilization, expenditures, and pharmacy reimbursement rates (2010–2012)

Purpose: To assess drug utilization and expenditure trends in Medicaid fee-for-service program during the period 2010 – 2012 in the United States of America.Methods: A retrospective, descriptive analysis of the trend in drug utilization and expenditures in the Medicaid fee-for-service (FFS) program was performed using Medicaid state drug utilization data provided by Centers for Medicare and Medicaid Services (CMS) in the United States. Descriptive analyses were performed for all variables in the study. Association between prescription-drug utilization and reimbursement rate was examined using a linear regression model.Results: The results indicate that prescription-drug utilization of Medicaid FFS program decreased by 20 % during the period (2010 – 2012) as also drug expenditure during the same period. Although constituting nearly 70 % and about 75 % of the total drug utilization in 2010 and 2012, respectively, generics represent only around 18 % of the total drug expenditures. No statistically significant association was found between total expenditures and the reimbursement rate.Conclusion: FFS Medicaid drug expenditures decreased from 2010 to 2012 mainly due to a reduction in the total number of prescriptions as also the prices of generic drugs. Thus, higher utilization of generic drugs may offer substantial savings to Medicaid programs at the state level.Keywords: Fee-for-service programs, Medicaid program, Generic drug utilization; Branded drugs, Patient Protection and Affordable Care Ac

Health risks for population living in the neighborhood of a cement factory

In order to assess the health risks associated with the manufacturing of Portland cement for the population living in the neighborhood of a cement industry in Khrew, Kashmir, India, particulate matter and trace gas samplings were done between March and December 2011 in the cement affected area. The main parameters considered for study included suspended particulate matter (SPM), respirable suspended particulate matter (RSPM), non-respirable suspended particulate matter (NRSPM), nitrogen oxides (NOx) and sulfur dioxide (SO2). The population considered most suitable for study was the people residing in 2 - 3 km radius of the cement emission zone and for this, questionnaire based study was performed. The air temperature, air humidity, wind speed, wind direction and light intensity were studied at the sites for the sampling days. The results indicate that there was high level of air pollution with mean SO2 concentration of 115.2 μg/m3 at site I and 28.13 μg/m3 at site II when compared. Similarly, Ox concentration at site I was 117.09 μg/m3 when compared with control site II where it was found to be 19.46 μg/m3 with high prevalence of diseases particularly, respiratory problems, 97% suffered from eye irritations and 95% suffered from dermatological problems among population living in the neighborhood of cement factory at site I. The assessment of oxidative and nitrosative stress among population was carried out by quantification of ROS and NO levels in serum of subjects. The results show that there was high level of air pollution in the area, adverse health impacts, over production of nitrogen species as well as ROS in subjects residing around cement pollution affected area.Key words: Cement industry, trace gas samplings, human health, dermatological, respiratory problems, eye irritations

Economic loss assessment on juvenile fish catch due to forced non-selectivity in a selective fishing gear, gillnet along Mumbai coast, India

A study on quantity and value of juvenile fish landings was carried out in the gillnet fishery of three selected landing centers along Mumbai coast viz., Versova, Cuff Parade and Mahim in India using Out board motors (OBM), Inboard motors (IBM) and non-motorised gillnetters respectively. The data on the quantity and value of landed juveniles were collected and analysed to reach a consensus on the gross economic loss on account of juvenile fishing. A bio-economic model was used to estimate economic loss due to juvenile fishing of 18 commercially important species of finfish and shellfish. A huge economic loss was recorded due to fishing of juveniles of 18 species by three different gillnet sectors. The analysis indicated that IBM gillnetters at Cuff Parade incurred maximum loss of Rs. 62.26 crores with major contribution from juveniles of seerfish followed by non-motorised gillnetter (Rs.29.98 crores) at Mahim and 25.33 crores in OBM gillnetters at Versova

Peri-partum cardiomyopathy in a pregnant woman at term revealed by acute pulmonary edema: what to do in front this catastrophic situation?

Peripartum Cardiomyopathy is insufficient congestive heart occurring in the last month of pregnancy and 5  months after delivery, in the absence of preexisting heart disease and identified etiology. This heart disease is associated with echocardiography systolic dysfunction and left ventricular dilatation. Its incidence ranges from 1/3000 to 1/15000, depending on the region, including much higher in some African countries, it particularlyconcern women over 30 years, multiparous and multiple pregnancies. The pathogenesis remains unclear, the prognosis is closely related to the complete recovery of cardiac function. We report through the clinical case of a woman aged 33 years admitted to the ICU for acute pulmonary edema of sudden onset of a term pregnancy and what to do before this critical situationKey words: Peri-partum, cardiomyopathy, acute pulmonary edem

Polypharmacy among patients with diabetes: a cross-sectional retrospective study in a tertiary hospital in Saudi Arabia

Abstract Patients with diabetes are at high risk for polypharmacy (ie, use of multiple medications) for treatment of diabetes, associated comorbidities and other coexisting conditions. This study aims to estimate the prevalence of polypharmacy and factors associated with polypharmacy among adult patients with diabetes.Methods A cross-sectional retrospective observational study of adults with diabetes, who visited the outpatient clinic of a tertiary teaching hospital in Saudi Arabia, was conducted. Data were extracted from the Electronic Health Record database for a period of 12 months (January– December 2016). Polypharmacy was defined as the cumulative use of five or more medications. Polypharmacy among adults with diabetes was measured by calculating the average number of medications prescribed per patient. A multivariable logistic regression model was used to examine the factors associated with polypharmacy. Results A total of 8932 adults with diabetes were included in this study. Of these, nearly 78% had polypharmacy which was more likely among women as compared with men and more likely among older adults (age ≥60 years) as compared with the adults. Also, polypharmacy was two times as likely among patients with coexisting cardiovascular conditions (adjusted OR (AOR)=2.89; 95% CI 2.54 to 3.29), respiratory disease (AOR=2.42; 95% CI 1.92 to 3.03) and mental health conditions (AOR=2.19; 95% CI 1.74 to 2.76), and three times as likely among patients with coexisting musculoskeletal disease (AOR=3.16; 95% CI 2.31 to 4.30) as compared with those without these coexisting chronic conditions categories. Conclusions Polypharmacy is common among patients with diabetes, with an even higher rate in older adults patients. Healthcare providers can help in detecting polypharmacy and in providing recommendations for simplifying medication regimens and minimising medications to enhance the outcome of diabetes care

Dredging induced changes in zooplankton community and water quality in Dal Lake, Kashmir, India

A study was conducted from July 2013 to June 2014 to assess the outcome of dredging activity on the water characteristics and zooplankton community structure in Dal Lake. An assessment was done with respect to alterations in physico-chemical  parameters and zooplankton community changes in predredged and post-dredging periods. The results showed a considerable  reduction in Secchi transparency while water depth, conductivity, total dissolved solids, nitrate and total phosphorous concentrations increased noticeably in post dredging scenario. Variations in the values of dissolved oxygen, pH and temperature as a result of dredging were not statistically significant. The environmental changes as a result of dredging activity affected the structure and distribution of zooplankton community; the abundance of rotifers decreased, while the crustaceans increased. The prominent taxa were Brachionus sp., Keratella cochlearis, Bosmina longirostris, Chydorus sphaericus and Diaptomus sp.Key words: Dredging, water quality, zooplankton, rotifer, crustacean