The local functors of points of Supermanifolds

We study the local functor of points (which we call the Weil-Berezin functor) for smooth supermanifolds, providing a characterization, representability theorems and applications to differential calculus

Supporting the professional growth of educators through video analysis : a research conducted in Trento’s preschools = Sostenere la professionalità degli educatori attraverso la videoanalisi : una ricerca condotta nei nidi d’infanzia di Trento

In this paper we will present a two-year training project, conducted in two kindergartens in the province of Trento, in which video-analysis was used as a training tool aimed at supporting and accompanying the professional growth of educators. In order to support an intentional and conscious process of didactic innovation, the training set out to work on the development of observational and reflective skills that would enable the educators to maintain a continuous dialogue between the pedagogical theories and daily educational practices. Through the analysis of video-frames depicting children’s learning experiences, it is possible to reflect not only on “what” educators propose to children but especially on “how” they do it, in order to understand what relational and communicative ways of negotiating and coconstructing, together with children, the delicate balance between support and autonomy and between care and education. Nel presente articolo saranno presentati gli esiti di un progetto di formazione biennale, condotto in due nidi di infanzia della provincia di Trento, nel quale è stata usata la videoanalisi come strumento di formazione volto a sostenere e accompagnare la crescita professionale delle educatrici. Per supportare un processo di innovazione didattica intenzionale e consapevole, il percorso di formazione si è posto l’obiettivo di lavorare sullo sviluppo di competenze osservative e riflessive che consentissero alle educatrici di mantenere un dialogo continuo tra le teorie pedagogiche di riferimento e le pratiche educative quotidiane. Infatti, attraverso l’analisi di video-frammenti che ritraggono le esperienze di apprendimento dei bambini, è possibile riflettere non solamente su che cosa le educatrici propongano ai bambini ma soprattutto sul come esse lo facciano, per comprendere quali siano quelle modalità relazionali che consentono di co-costruire, insieme ai bambini, il delicato equilibrio tra sostegno e autonomia e tra cura ed educazione

CFD analysis of the fuel-air mixture formation process in passive prechambers for use in a high-pressure direct injection (HPDI) Two-stroke engine

The research on two-stroke engines has been focused lately on the development of direct injection systems for reducing the emissions of hydrocarbons by minimizing the fuel shortcircuiting. Low temperature combustion (LTC) may be the next step to further improve emissions and fuel consumption; however, LTC requires unconventional ignition systems. Jet ignition, i.e., the use of prechambers to accelerate the combustion process, turned out to be an effective way to perform LTC. The present work aims at proving the feasibility of adopting passive prechambers in a high-pressure, direct injection, two-stroke engine through non-reactive computational fluid dynamics analyses. The goal of the analysis is the evaluation of the prechamber performance in terms of both scavenging efficiency of burnt gases and fuel/air mixture formation inside the prechamber volume itself, in order to guarantee the mixture ignitability. Two prechamber geometries, featuring different aspect ratios and orifice numbers, were investigated. The analyses were replicated for two different locations of the injection and for three operating conditions of the engine in terms of revolution speed and load. Upon examination of the results, the effectiveness of both prechambers was found to be strongly dependent on the injection setup

Cytokine release syndrome after CAR infusion in pediatric patients with refractory/relapsed B-ALL: is there a role for diclofenac?

BACKGROUND: Cytokine release syndrome (CRS) is a major complication after chimeric-antigen receptor T-cell treatment, characterized by an uncontrolled systemic inflammatory reaction. We investigated the potential role of diclofenac in the management of CRS in five pediatric patients treated for relapsed/refractory B-lineage acute lymphoblastic leukemia. METHODS: In case of persistent fever with fever-free intervals shorter than 3 hours, diclofenac continuous infusion was initiated, at the starting dose of 0.5 mg/Kg/day, the lowest effective pediatric dose in our experience, possibly escalated up to 1 mg/Kg/day, as per institutional guidelines. RESULTS: CRS occurred at a median of 20 hours (range 8–27) after tisagenlecleucel infusion. Diclofenac was started at a median of 20 hours (range 13–33) after fever onset. A mean of 3.07 febrile peaks without diclofenac and 0.95 with diclofenac were reported (p = 0.02). Clinical benefit was achieved by hampering the progression of tachypnea and tachycardia. Despite fever control, CRS progressed in four of the five patients, and hypotension requiring vasopressors and fluid retention, as well as hypoxia, occurred. Vasopressors were followed by 1–2 doses of tocilizumab (one in patient 2 and two in patients 3, 4, and 5), plus steroids in patients 4 and 5. CONCLUSION: Based on a limited number of patients, diclofenac leads to better fever control, which translates into symptom relief and improvement of tachycardia, but could not prevent the progression of CRS

A phase II study of primary dose-dense sequential doxorubicin plus cyclophosphamide and docetaxel in cT4 breast cancer

Background: Dose-dense chemotherapy with anthracyclines and taxanes has improved either disease free survival or overall survival in high risk patients with early breast cancer. Patients and Methods: The activity and safety of a dose-dense schedule (q14 days) of adriamycin 60 mg/sqm and cyclophosphamide 600 mg/sqm (AC) x 4 cycles followed by docetaxel 75 mg/sqm for 4 cycles with hematopoietic support in patients with stage IIIB breast cancer was explored. Patients with ER >= 10% tumors received concomitant endocrine therapy with 3-month triptorelin and letrozole. Results: Fifteen patients with histologically proven cT4b (three patients) and cT4d (twelve patients) MO breast cancer were enrolled. Median age was 48 years (range 25-66). Eight clinical responses including one pathological complete remission (pCR), three stable disease (including minor responses) and four progression of disease, one during AC and three during taxotere, were observed. Four patients had grade 3-4 non hematological toxicities and all except one discontinued treatment. Conclusion: Due to the high rate of progressive disease, this schedule should not represent a standard option in cT4 breast cancer

A review of the literature of surgical and nonsurgical treatments of invasive squamous cells carcinoma

Cutaneous squamous cell carcinoma (cSCC) is an increasing public health problem. It is a primary malignant skin tumor with Malpighian differentiation and together with basal cell carcinoma is classified among nonmelanoma skin cancers (NMSCs). cSCC usually occurs on photoexposed areas, such as the head, the neck, and the extremities, and its incidence increases with age. Invasive forms of this skin tumor tend to be more aggressive showing a higher metastatic potential, usually regarding regional lymph nodes. Treatment options for invasive cSCCs include both surgical and nonsurgical options. The therapeutic choice depends on several factors, such as anatomic location, risk factors for tumor recurrence, age, and health status of the patient. This review aims to provide an overview of the current evidence on therapeutic surgical and nonsurgical management of invasive cSCC

Low-speed preconditioning for strongly coupled integration of Reynolds-averaged Navier–Stokes equations and two-equation turbulence models

Computational fluid dynamics codes using the density-based compressible flow formulation of the Navier–Stokes equations have proven to be very successful for the analysis of high-speed flows. However, solution accuracy degradation and, for explicit solvers, reduction of the residual convergence rates occur as the local Mach number decreases below the threshold of 0.1. This performance impairment worsens remarkably in the presence of flow reversals at wall boundaries and unbounded high-vorticity flow regions. These issues can be resolved using low-speed preconditioning, but there exists an outstanding problem regarding the use of this technology in the strongly coupled integration of the Reynolds-averaged Navier–Stokes equations and two-equation turbulence models, such as the k − ω shear stress transport model. It is not possible to precondition only the RANS equations without altering parts of the governing equations, and there did not exist an approach for preconditioning both the RANS and the SST equations. This study solves this problem by introducing a turbulent low-speed preconditioner of the RANS and SST equations that does not require any alteration of the governing equations. The approach has recently been shown to significantly improve convergence rates in the case of a one-equation turbulence model. The study focuses on the explicit multigrid integration of the governing equations, but most algorithms are applicable also to implicit integration methods. The paper provides all algorithms required for implementing the presented turbulent preconditioner in other computational fluid dynamics codes. The new method is applicable to all low- and mixed-speed aeronautical and propulsion flow problems, and is demonstrated by analyzing the flow field of a Darrieus wind turbine rotor section at two operating conditions, one of which is characterized by significant blade/vortex interaction. Verification and further validation of the new method is also based on the comparison of the results obtained with the developed density-based code and those obtained with a commercial pressure-based code

Predictive Role Of Body Composition Parameters In Operable Breast Cancer Patients Treated With Neoadjuvant Chemotherapy.

BACKGROUND: Fat tissue is strongly involved in BC tumorigenesis inducing insulin resistance, chronic inflammation and hormonal changes. Computed tomography (CT) imaging instead of body mass index (BMI) gives a reliable measure of skeletal muscle mass and body fat distribution. The impact of body composition parameters (BCPs) on chemosensitivity is still debated. We examined the associations between BCPs and tumor response to neoadjuvant chemotherapy (NC) in patients treated for operable breast cancer (BC). METHODS: A retrospective review of BC patients treated with NC in Modena Cancer Center between 2005 and 2017 was performed. BCPs, such as subcutaneous fat area (SFA), visceral fat area (VFA), lumbar skeletal muscle index (LSMI) and liver-to-spleen (L/S) ratio were calculated by Advance workstation (General Electric), software ADW server 3.2 or 4.7. BMI and BCPs were correlated with pathological complete response (pCR) and survival outcomes. RESULTS: 407 patients were included in the study: 55% with BMI < 25 and 45% with BMI 65 25. 137 of them had pre-treatment CT scan imagines. Overweight was significantly associated with postmenopausal status and older age. Hormonal receptor positive BC was more frequent in overweight patients (p<0.05). Postmenopausal women had higher VFA, fatty liver disease and obesity compared to premenopausal patients. No association between BMI classes and tumor response was detected. High VFA and liver steatosis were negative predictive factors for pCR (pCR rate: 36% normal VFA vs 20% high VFA, p= 0.048; no steatosis 32% vs steatosis 13%, p=0.056). Neither BMI classes nor BCPs significantly influenced overall survival and relapse-free survival. CONCLUSION: Visceral adiposity as well as steatosis were closely involved in chemosensitivity in BC patients treated with NC. Their measures from clinically acquired CT scans provide significant predictive information that outperform BMI value. More research is required to evaluate the relationship among adiposity site and survival outcomes