High-responsivity graphene photodetectors integrated on silicon microring resonators.

Graphene integrated photonics provides several advantages over conventional Si photonics. Single layer graphene (SLG) enables fast, broadband, and energy-efficient electro-optic modulators, optical switches and photodetectors (GPDs), and is compatible with any optical waveguide. The last major barrier to SLG-based optical receivers lies in the current GPDs' low responsivity when compared to conventional PDs. Here we overcome this by integrating a photo-thermoelectric GPD with a Si microring resonator. Under critical coupling, we achieve >90% light absorption in a ~6 μm SLG channel along a Si waveguide. Cavity-enhanced light-matter interactions cause carriers in SLG to reach ~400 K for an input power ~0.6 mW, resulting in a voltage responsivity ~90 V/W, with a receiver sensitivity enabling our GPDs to operate at a 10-9 bit-error rate, on par with mature semiconductor technology, but with a natural generation of a voltage, rather than a current, thus removing the need for transimpedance amplification, with a reduction of energy-per-bit, cost, and foot-print

A transgenic zebrafish model expressing KIT-D816V recapitulates features of aggressive systemic mastocytosis

Summary: Systemic mastocytosis (SM) is a rare myeloproliferative disease without curative therapy. Despite clinical variability, the majority of patients harbour a KIT-D816V mutation, but efforts to inhibit mutant KIT with tyrosine kinase inhibitors have been unsatisfactory, indicating a need for new preclinical approaches to identify alternative targets and novel therapies in this disease. Murine models to date have been limited and do not fully recapitulate the most aggressive forms of SM. We describe the generation of a transgenic zebrafish model expressing the human KIT-D816V mutation. Adult fish demonstrate a myeloproliferative disease phenotype, including features of aggressive SM in haematopoeitic tissues and high expression levels of endopeptidases, consistent with SM patients. Transgenic embryos demonstrate a cell-cycle phenotype with corresponding expression changes in genes associated with DNA maintenance and repair, such as reduced dnmt1. In addition, epcam was consistently downregulated in both transgenic adults and embryos. Decreased embryonic epcam expression was associated with reduced neuromast numbers, providing a robust in vivo phenotypic readout for chemical screening in KIT-D816V-induced disease. This study represents the first zebrafish model of a mast cell disease with an aggressive adult phenotype and embryonic markers that could be exploited to screen for novel agents in SM

Mapping the complex refractive index of single layer graphene on semiconductor or polymeric substrates at terahertz frequencies

Abstract Assessing experimentally the main optical parameters of graphene (e.g. complex refractive index, carrier density, mobility) in the far-infrared (0.1–10 THz) is important for quantum science, due to the possibility to devise miniaturized devices (frequency combs, random lasers), components (optical switches, spatial light modulators, metamaterial mirrors and modulators) or photonic circuits, in which graphene can be integrated with existing semiconductor technologies to manipulate their optical properties and induce novel functionalities. Here, we combine time domain terahertz (THz) spectroscopy and Fourier transform infrared spectroscopy to extract the complex refractive index of large (∼1cm2) area single layer graphene on thin (∼0.1-1 µm) polymeric suspended substrates, flexible and transparent films, and high reflectivity Si substrates in the 0.4–1.8 THz range. We model our data to extract the relevant optical (refractive index, absorption coefficient, penetration length) electronic (Fermi velocity) and electrical (carrier density, mobility) properties of the different graphene samples.</jats:p

Magnetic Field Dependence of Electronic Specific Heat in Pr_{1.85} Ce_{0.15} CuO_4

The specific heat of electron-doped Pr_{1.85} Ce_{0.15} CuO_4 single crystals is reported for the temperature range 2 - 10 K and magnetic field range 0 - 10 T. A non-linear magnetic field dependence is observed for the field range 0 - 2 T. Our data supports a model with lines of nodes in the gap function of these superconductors. Theoretical calculations of the electronic specific heat for dirty d-wave, clean d-wave, and s-wave symmetries are compared to our data.Comment: 10 pages Latex and 4 eps figures, submitted to Phys. Rev.

Testing in the incremental design and development of complex products

Testing is an important aspect of design and development which consumes significant time and resource in many companies. However, it has received less research attention than many other activities in product development, and especially, very few publications report empirical studies of engineering testing. Such studies are needed to establish the importance of testing and inform the development of pragmatic support methods. This paper combines insights from literature study with findings from three empirical studies of testing. The case studies concern incrementally developed complex products in the automotive domain. A description of testing practice as observed in these studies is provided, confirming that testing activities are used for multiple purposes depending on the context, and are intertwined with design from start to finish of the development process, not done after it as many models depict. Descriptive process models are developed to indicate some of the key insights, and opportunities for further research are suggested

Hot Spots and Transition from d-Wave to Another Pairing Symmetry in the Electron-Doped Cuprate Superconductors

We present a simple theoretical explanation for a transition from d-wave to another superconducting pairing observed in the electron-doped cuprates. The d_{x^2-y^2} pairing potential Delta, which has the maximal magnitude and opposite signs at the hot spots on the Fermi surface, becomes suppressed with the increase of electron doping, because the hot spots approach the Brillouin zone diagonals, where Delta vanishes. Then, the d_{x^2-y^2} pairing is replaced by either singlet s-wave or triplet p-wave pairing. We argue in favor of the latter and discuss experiments to uncover it.Comment: 6 pages, 4 figures, RevTeX 4. V.2: Extra figure and many references added. V.3: Minor update of references for the proof

Seafloor biodiversity of Canada's three oceans: patterns, hotspots and potential drivers

Aim We examined the relationships between bathymetry, latitude and energy and the diversity of marine benthic invertebrates across wide environmental ranges of Canada's three oceans. Location Canadian Pacific, Arctic and Atlantic Oceans from the intertidal zone to upper bathyal depths, encompassing 13 marine ecoregions. Methods We compiled 35 benthic datasets that encompass 3,337 taxa (70% identified to species and 21% to genus) from 13,172 samples spanning 6,117 sites. Partitioning the analyses by different gear types, ecoregions or sites, we used Hill numbers to examine spatial patterns in α‐diversity. We used resampling and extrapolation to standardized sampling effort and examined the effects of depth, latitude, chemical energy (export particulate organic carbon [POC] flux), thermal energy (bottom temperature) and seasonality of primary production on the benthic biodiversity. Results The Canadian Arctic harboured the highest benthic diversity (e.g. epifauna and common and dominant infauna species), whereas the lowest diversity was found in the Atlantic. The Puget Trough (Pacific), Beaufort Sea, Arctic Archipelago, Hudson Bay, Northern Labrador and Southern Grand Bank (Atlantic) were the “hotspots" of diversity among the ecoregions. The infauna and epifauna both exhibited hump‐shaped diversity–depth relationships, with peak diversity near shelf breaks; latitude (positively) predicted infaunal diversity, albeit weakly. Food supply, as inferred from primary production and depth, was more important than thermal energy in controlling diversity patterns. Limitations with respect to calculating POC flux in coastal (e.g. terrestrial runoff) and ice‐covered regions or biological interactions may explain the negative POC flux–infaunal diversity relationship. Main Conclusions We show previously unreported diversity hotspots in the Canadian Arctic and in other ecoregions. Our analyses reveal potential controlling mechanisms of large‐scale benthic biodiversity patterns in Canada's three oceans, which are inconsistent with the prevailing view of seafloor energy–diversity relationships. These results provide insightful information for conservation that can help to implement further MPA networks

Evidence of a d to s-wave pairing symmetry transition in the electron-doped cuprate superconductor Pr2−x_{2-x}Cex_xCuO4_4

We present point contact spectroscopy (PCS) data for junctions between a normal metal and the electron doped cuprate superconductor Pr$_{2-x}$Ce$_x$CuO$_4$ (PCCO). For the underdoped compositions of this cuprate ($x \sim 0.13$) we observe a peak in the conductance-voltage characteristics of the point contact junctions. The shape and magnitude of this peak suggests the presence of Andreev bound states at the surface of underdoped PCCO which is evidence for a d-wave pairing symmetry. For overdoped PCCO ($x \sim 0.17$) the PCS data does not show any evidence of Andreev bound states at the surface suggesting an s-wave pairing symmetry.Comment: 4 pages Latex, 4 eps figures included. Submitted to Phys. Rev. Let

Effects of TNFalpha, NOS3, MDR1 gene polymorphisms on clinical parameters, prognosis and survival of multiple myeloma cases

It is not clear how gene polymorphisms affecting drugs can contributes totheir efficacy in multiple myeloma (MM). We here aimed to explore associations among gene polymorphisms of tumor necrosis factor alpha (TNFalpha), nitric oxide synthesis 3 (NOS3) and multi-drug resistance 1 (MDR1), clinical parameters, prognosis and survival in MM patients treated with VAD (vincristine-adriamycine-dexamethasone), MP (mephalane-prednisolone), autolougus stem cell transplantation (ASCT), BODEC (bortezomib-dexamethasonecyclophosphamide) and TD (thalidomide-dexamethasone). We analyzed TNFalpha, NOS 3 and MDR1 in 77 patients with MM and 77 healthy controls. The genotyping was performed with PCR and/or PCR-RFLP. There was no clinically significant difference between MM and control groups when TNFalpha (-238) and (-857) and MDR1 gene polymorphisms were studied. However, the TNFalpha gene polymorphism (-308) GG genotype (p=0.012) and NOS3 (+894) TT genotype (p=0.008) were more common in the MM group compared to healthy controls. NOS3 (VNTR) AA (p=0.007) and NOS3 (+894) GG genotypes (p=0.004) were decreased in the MM group in contrast. In conclusion, the NOS3 (+894) TT and TNFalpha (-308) GG genotypes may have roles in myeloma pathogenesis

Quantum phase transitions from topology in momentum space

Many quantum condensed matter systems are strongly correlated and strongly interacting fermionic systems, which cannot be treated perturbatively. However, physics which emerges in the low-energy corner does not depend on the complicated details of the system and is relatively simple. It is determined by the nodes in the fermionic spectrum, which are protected by topology in momentum space (in some cases, in combination with the vacuum symmetry). Close to the nodes the behavior of the system becomes universal; and the universality classes are determined by the toplogical invariants in momentum space. When one changes the parameters of the system, the transitions are expected to occur between the vacua with the same symmetry but which belong to different universality classes. Different types of quantum phase transitions governed by topology in momentum space are discussed in this Chapter. They involve Fermi surfaces, Fermi points, Fermi lines, and also the topological transitions between the fully gapped states. The consideration based on the momentum space topology of the Green's function is general and is applicable to the vacua of relativistic quantum fields. This is illustrated by the possible quantum phase transition governed by topology of nodes in the spectrum of elementary particles of Standard Model.Comment: 45 pages, 17 figures, 83 references, Chapter for the book "Quantum Simulations via Analogues: From Phase Transitions to Black Holes", to appear in Springer lecture notes in physics (LNP