Cancer Patient Beliefs and Attitudes Regarding Immune Checkpoint Inhibitor Therapy

The development and widespread use of immune checkpoint inhibitors (ICIs) have advanced the field of oncology in a short period of time. Despite this, patient perception regarding this new medication class has not been adequately assessed, which may affect treatment decisions and adherence. The Belief about Medicines Questionnaire (BMQ) is a validated survey composed of 18 questions which analyzes patient’s beliefs about the necessity of prescribed medication and concern about the potential adverse events caused by the medication. General medication overuse and harm are also determined. This is the first study to utilize the BMQ for patients on ICI therapy

Об устойчивости движения математического маятника, взаимодействующего со струной

В линейной и нелинейной постановках решена задача об устойчивости стационарных движений однозвенного маятника в гибридной модели механической системы, состоящей из горизонтально закрепленной струны, нагруженной колеблющейся сосредоточенной массой.У лінійній і нелінійній постановках розв'язано задачу про стійкість стаціонарних рухів одноланкового маятника в гібридній моделі механічної системи, яка складається з горизонтально розміщеної струни, навантаженої коливною зосередженою масою.The problem of stability of the stationary motions of a single-mass pendulum in the hybrid model of one mechanical system is solved in the linear and nonlinear statements. The mechanical system consists of a string which is horizontally disposed and loaded by an oscillating localized mass

An evaluative baseline for geo-semantic relatedness and similarity

In geographic information science and semantics, the computation of semantic similarity is widely recognised as key to supporting a vast number of tasks in information integration and retrieval. By contrast, the role of geo-semantic relatedness has been largely ignored. In natural language processing, semantic relatedness is often confused with the more specific semantic similarity. In this article, we discuss a notion of geo-semantic relatedness based on Lehrer’s semantic fields, and we compare it with geo-semantic similarity. We then describe and validate the Geo Relatedness and Similarity Dataset (GeReSiD), a new open dataset designed to evaluate computational measures of geo-semantic relatedness and similarity. This dataset is larger than existing datasets of this kind, and includes 97 geographic terms combined into 50 term pairs rated by 203 human subjects. GeReSiD is available online and can be used as an evaluation baseline to determine empirically to what degree a given computational model approximates geo-semantic relatedness and similarity

Dasymetric distribution of votes in a dense city

[EN] A large proportion of electoral analyses using geography are performed on a small area basis, such as polling units. Unfortunately, polling units are frequently redrawn, provoking breaks in their data series. Previous electoral results play a key role in many analyses. They are used by political party workers and journalists to present quick assessments of outcomes, by political scientists and electoral geographers to perform detailed scrutinizes and by pollsters and forecasters to anticipate electoral results. In this paper, we study to what extent more complex geographical approaches (based on a proper location of electors on the territory using dasymetric techniques) are of value in comparison to simple methods (like areal weighting) for the problem of reallocating votes in a large, dense city. Barcelona is such a city and, having recently redrawn the boundaries of its census sections, it is an ideal candidate for further scrutiny. Although previous studies show the approaches based on dasymetric techniques outperforming simpler solutions for interpolating census figures, our results show that improvements in the process of reallocating votes are marginal. This brings into question the extra effort that entails introducing ancillary sources of information in a dense urban area for this kind of data. Additional research is required to know whether and when these results are extendable. (C) 2017 Elsevier Ltd. All rights reserved.This work was supported by the Spanish Ministry of Economics and Competitiveness under Grant CSO2013-43054-R.Pavia, JM.; Cantarino-Martí, I. (2017). Dasymetric distribution of votes in a dense city. Applied Geography. 86:22-31. https://doi.org/10.1016/j.apgeog.2017.06.021S22318

Partner in fat metabolism: role of KLFs in fat burning and reproductive behavior

The abnormalities caused by excess fat accumulation can result in pathological conditions which are linked to several interrelated diseases, such as cardiovascular disease and obesity. This set of conditions, known as metabolic syndrome, is a global pandemic of enormous medical, economic, and social concern affecting a significant portion of the world’s population. Although genetics, physiology and environmental components play a major role in the onset of disease caused by excessive fat accumulation, little is known about how or to what extent each of these factors contributes to it. The worm, Caenorhabditis elegans offers an opportunity to study disease related to metabolic disorder in a developmental system that provides anatomical and genomic simplicity relative to the vertebrate animals and is an excellent eukaryotic genetic model which enable us to answer the questions concerning fat accumulation which remain unresolved. The stored triglycerides (TG) provide the primary source of energy during periods of food deficiency. In nature, lipid stored as TGs are hydrolyzed into fatty acids which are broken down through β-oxidation to yield acetyl-CoA. Our recent study suggests that a member of C. elegans Krüppel-like factor, klf-3 regulates lipid metabolism by promoting FA β-oxidation and in parallel may contribute in normal reproduction and fecundity. Genetic and epigenetic factors that influence this pathway may have considerable impact on fat related diseases in human. Increasing number of studies suggest the role of mammalian KLFs in adipogenesis. This functional conservation should guide our further effort to explore C. elegans as a legitimate model system for studying the role of KLFs in many pathway components of lipid metabolism

REAL TIME SEMANTIC INTEROPERABILITY IN AD HOC NETWORKS OF GEOSPATIAL DATA SOURCES: CHALLENGES, ACHIEVEMENTS AND PERSPECTIVES

Recent advances in geospatial technologies have made available large amount of geospatial data. Meanwhile, new developments in Internet and communication technologies created a shift from isolated geospatial databases to ad hoc networks of geospatial data sources, where data sources can join or leave the network, and form groups to share data and services. However, effective integration and sharing of geospatial data among these data sources and their users are hampered by semantic heterogeneities. These heterogeneities affect the spatial, temporal and thematic aspects of geospatial concepts. There have been many efforts to address semantic interoperability issues in the geospatial domain. These efforts were mainly focused on resolving heterogeneities caused by different and implicit representations of the concepts. However, many approaches have focused on the thematic aspects, leaving aside the explicit representation of spatial and temporal aspects. Also, most semantic interoperability approaches for networks have focused on automating the semantic mapping process. However, the ad hoc network structure is continuously modified by source addition or removal, formation of groups, etc. This dynamic aspect is often neglected in those approaches. This paper proposes a conceptual framework for real time semantic interoperability in ad hoc networks of geospatial data sources. The conceptual framework presents the fundamental elements of real time semantic interoperability through a hierarchy of interrelated semantic states and processes. Then, we use the conceptual framework to set the discussion on the achievements that have already been made, the challenges that remain to be addressed and perspectives with respect to these challenges

Acknowledgement of manuscript reviewers, the underappreciated contributors

<p>Contributing reviewers</p> <p>We and the Editorial Board acknowledge and thank all reviewers for their active participation and contribution during 2012. We greatly appreciate their dedication and behind the scenes contribution. It is largely due to their support and expertise that we have been able to publish high-standard manuscripts. We would also like to thank authors for choosing Nutrition & Metabolism and contributing their cherished work.</p