Development and evaluation of a novel predictive nomogram for assessing the risk of intraoperative hypothermia in patients undergoing thoracoscopic pulmonary tumor surgery

Background: The prevalence of unplanned intraoperative hypothermia during thoracoscopic pulmonary tumor resection under general anesthesia is considerable, which may result in numerous adverse reactions. Objective: The aim of this study was to develop and validate a nomogram-based prediction model for assessing the risk of intraoperative hypothermia in patients undergoing thoracoscopic pulmonary tumor resection under general anesthesia. Design: This was a retrospective study conducted at a tertiary class A hospital.The study included 506 adult patients who underwent thoracoscopic lung tumor resection under general anesthesia in 2022. Methods: The clinical data of 506 patients who underwent thoracoscopic pulmonary tumor surgery from January 1 to December 31, 2022 were collected and randomly divided into the modeling group (n = 356) and the validation group (n = 50). The data of 356 patients were used establish a prediction model for intraoperative hypothermia. A total of 17 factors covering patient demographics, disease characteristics, and surgical conditions were gathered. The least absolute shrinkage and selection operator regression model was utilized to optimize the risk model's features. Multivariate logistic regression analysis was employed to construct the final predictive model. Rresults: Gender, body mass index, preoperative body temperature and operation time were used as predictors to construct the nomogram. The C-index of the model was 0.831 (95%CI: 0.799–0.863). The C-index of external validation was 0.820, which verified the calibration of the model. Decision curve analysis validated the clinical utility of the nomogram, particularly when using a threshold probability of unplanned intraoperative hypothermia 1 %.-74 %. Conclusions: The nomogram constructed in this study can effectively predict the risk of intraoperative hypothermia in patients undergoing thoracoscopic lung tumor resection under general anesthesia. The nomogram incorporated readily available predictors such as sex, body mass index, preoperative body temperature, and duration of surgery

Temperature-regulation liquid gating membrane with controllable gas/liquid separation

Membrane separation technology with the ability to regulate gas/liquid transport and separation is critical for environmental fields, such as sewerage treatment, multiphase separation, and desalination. Although numerous membranes can dynamically control liquid-phase fluids transport via external stimuli, the transport and separation of gas-phase fluids remains a challenge. Here, we show a temperature-regulation liquid gating membrane that allows in-situ dynamically controllable gas/liquid transfer and multiphase separation by integrating a thermo-wettability responsive porous membrane with functional gating liquid. Experiments and theoretical analysis have demonstrated the temperature-regulation mechanism of this liquid gating system, which is based on thermo-responsive changes of porous membrane surface polarity, leading to changes in affinity between the porous membrane and the gating liquid. In addition, the sandwich configuration with dense Au-coated surfaces and heterogeneous internal components by a bistable interface design enables the liquid gating system to enhance response sensitivity and maintain working stability. This temperature-regulation gas/liquid transfer strategy expands the application range of liquid gating membranes, which are promising in environmental governance, water treatment and multiphase separation

Therapeutic potential pf phenylethanoid glycosides: A systematic review

Phenylethanoid glycosides (PhGs) are generally water-soluble phenolic compounds that occur in many medicinal plants. Until June 2020, more than 572 PhGs have been isolated and identified. PhGs possess antioxidant, neuroprotective, anti-inflammatory, antibacterial, antiviral, antidiabetic, anticancer, and antiobesity properties. Despite these promising benefits, PhGs have failed to fulfill their therapeutic applications due to their poor bioavailability. The attempts to understand their metabolic pathways to improve their bioavailability are investigated. In this review article, we will first summarize the number of PhGs compounds which is not accurate in the literature. The latest information on the biological activities, structure-activity relationships, mechanisms and especially the clinical applications of PhGs will be reviewed. The bioavailability of PhGs will be summarized and factors leading to the low bioavailability will be analyzed. Recent advances in methods such as bioenhancers and nanotechnology to improve the bioavailability of PhGs are also summarized. The existing scientific gaps of PhGs in knowledge are also discussed, highlighting research directions in the future