Friends with Benefits: Other Regard in Epicurean Ethics

Friendship and hedonism are both major components of Epicureanism. I attempt to relieve the tension that seems to follow from endorsing both of these. I argue that Epicurean friendships require valuing a friend’s well-being in the same way as one’s own and that embarking on such friendships is what David Schmidtz terms a maieutic end – one that is achieved by taking on a new set of ends. This conception fits with other-regarding concern that is espoused throughout the Epicurean texts discussing friendship and, as I argue, remains consistent with other psychological and ethical commitments of Epicureanism

Using Coupled Eulerian and Lagrangian Grids to Model Explosive Interactions with Buildings

This paper presents the development of a computational model that can be used to study the interactions between structures and detonating explosives contained within them. This model was developed as part of an effort to develop a rubble characterization model for use in AmmoSIM, an agent based urban tactical decision aid (UTDA) software for weapon-target pairing. The rubble pile created following the collapse of a building in a combat situation can significantly impact mission accomplishment, particularly in the area of movement and maneuver. The information provided by AmmoSIM will enable both platoon level and command center staff to make informed decisions concerning urban attack tactics. Computational models were created using a combination of AUTODYN 2D and 3D. The detonation was modeled using a 2D wedge, which is a common method used in AUTODYN. The information obtained from the wedge calculation was then written to a data file and subsequently remapped into a larger 3D Euler air grid. The air grid loaded with blast pressure information was coupled to interact with the Lagrangian building parts. The Riedel, Hiermaier and Thoma (RHT) Concrete Model from the AUTODYN material library was utilized to create the components of the building. Results of the latest models will be given. Additionally, the paper details the development of the model at length including topics such as grid sizing, computational cost comparisons, grid interactions, multi-solver coupling, strain erosion, and material parameters and selections

Severe Spotted Fever Group Rickettsiosis, Australia

We report 3 cases of spotted fever group rickettsial infection (presumed Queensland tick typhus) in residents of northern Queensland, Australia, who had unusually severe clinical manifestations. Complications included renal failure, purpura fulminans, and severe pneumonia. Clinical illness caused by Rickettsia australis may not be as benign as previously described

Rubble Pile Characterization Model

Rubble piles created following the collapse of a building in a combat situation can significantly impact mission accomplishment, particularly in the area of movement and maneuver. Rubble characteristics must be known, for example, in order to predict the ability of a vehicle to override the collateral damage from weapon effects in urban areas. Two types of models are developed: a first-order model and a first-principles-based model. In both models, we assume complete rubblization of the building and develop a rubble profile model using the size and composition of the collapsed structure to predict the rubble volume. In both cases, this profile model includes the size of the footprint area surrounding the original building assuming that the rubble is free to expand horizontally as well as the resulting height of such a rubble pile. Empirical data is now needed to verify the predictive capabilities of these models

Near-Real-Time Acoustic Monitoring of Beaked Whales and Other Cetaceans Using a Seaglider™

In most areas, estimating the presence and distribution of cryptic marine mammal species, such as beaked whales, is extremely difficult using traditional observational techniques such as ship-based visual line transect surveys. Because acoustic methods permit detection of animals underwater, at night, and in poor weather conditions, passive acoustic observation has been used increasingly often over the last decade to study marine mammal distribution, abundance, and movements, as well as for mitigation of potentially harmful anthropogenic effects. However, there is demand for new, cost-effective tools that allow scientists to monitor areas of interest autonomously with high temporal and spatial resolution in near-real time. Here we describe an autonomous underwater vehicle – a glider – equipped with an acoustic sensor and onboard data processing capabilities to passively scan an area for marine mammals in near-real time. The glider was tested extensively off the west coast of the Island of Hawai'i, USA. The instrument covered approximately 390 km during three weeks at sea and collected a total of 194 h of acoustic data. Detections of beaked whales were successfully reported to shore in near-real time. Manual analysis of the recorded data revealed a high number of vocalizations of delphinids and sperm whales. Furthermore, the glider collected vocalizations of unknown origin very similar to those made by known species of beaked whales. The instrument developed here can be used to cost-effectively screen areas of interest for marine mammals for several months at a time. The near-real-time detection and reporting capabilities of the glider can help to protect marine mammals during potentially harmful anthropogenic activities such as seismic exploration for sub-sea fossil fuels or naval sonar exercises. Furthermore, the glider is capable of under-ice operation, allowing investigation of otherwise inaccessible polar environments that are critical habitats for many endangered marine mammal species

Reading handwritten digits: a ZIP code recognition system

A neural network algorithm-based system that reads handwritten ZIP codes appearing on real US mail is described. The system uses a recognition-based segmenter, that is a hybrid of connected-components analysis (CCA), vertical cuts, and a neural network recognizer. Connected components that are single digits are handled by CCA. CCs that are combined or dissected digits are handled by the vertical-cut segmenter. The four main stages of processing are preprocessing, in which noise is removed and the digits are deslanted, CCA segmentation and recognition, vertical-cut-point estimation and segmentation, and directly lookup. The system was trained and tested on approximately 10000 images, five- and nine-digit ZIP code fields taken from real mail

BioTIME: A database of biodiversity time series for the Anthropocene.

MotivationThe BioTIME database contains raw data on species identities and abundances in ecological assemblages through time. These data enable users to calculate temporal trends in biodiversity within and amongst assemblages using a broad range of metrics. BioTIME is being developed as a community-led open-source database of biodiversity time series. Our goal is to accelerate and facilitate quantitative analysis of temporal patterns of biodiversity in the Anthropocene.Main types of variables includedThe database contains 8,777,413 species abundance records, from assemblages consistently sampled for a minimum of 2 years, which need not necessarily be consecutive. In addition, the database contains metadata relating to sampling methodology and contextual information about each record.Spatial location and grainBioTIME is a global database of 547,161 unique sampling locations spanning the marine, freshwater and terrestrial realms. Grain size varies across datasets from 0.0000000158 km2 (158 cm2) to 100 km2 (1,000,000,000,000 cm2).Time period and grainBioTIME records span from 1874 to 2016. The minimal temporal grain across all datasets in BioTIME is a year.Major taxa and level of measurementBioTIME includes data from 44,440 species across the plant and animal kingdoms, ranging from plants, plankton and terrestrial invertebrates to small and large vertebrates.Software format.csv and .SQL

A bovine lymphosarcoma cell line infected with theileria annulata exhibits an irreversible reconfiguration of host cell gene expression

Theileria annulata, an intracellular parasite of bovine lymphoid cells, induces substantial phenotypic alterations to its host cell including continuous proliferation, cytoskeletal changes and resistance to apoptosis. While parasite induced modulation of host cell signal transduction pathways and NFκB activation are established, there remains considerable speculation on the complexities of the parasite directed control mechanisms that govern these radical changes to the host cell. Our objectives in this study were to provide a comprehensive analysis of the global changes to host cell gene expression with emphasis on those that result from direct intervention by the parasite. By using comparative microarray analysis of an uninfected bovine cell line and its Theileria infected counterpart, in conjunction with use of the specific parasitacidal agent, buparvaquone, we have identified a large number of host cell gene expression changes that result from parasite infection. Our results indicate that the viable parasite can irreversibly modify the transformed phenotype of a bovine cell line. Fifty percent of genes with altered expression failed to show a reversible response to parasite death, a possible contributing factor to initiation of host cell apoptosis. The genes that did show an early predicted response to loss of parasite viability highlighted a sub-group of genes that are likely to be under direct control by parasite infection. Network and pathway analysis demonstrated that this sub-group is significantly enriched for genes involved in regulation of chromatin modification and gene expression. The results provide evidence that the Theileria parasite has the regulatory capacity to generate widespread change to host cell gene expression in a complex and largely irreversible manner