6,542 research outputs found
Multirelational Organization of Large-scale Social Networks in an Online World
The capacity to collect fingerprints of individuals in online media has
revolutionized the way researchers explore human society. Social systems can be
seen as a non-linear superposition of a multitude of complex social networks,
where nodes represent individuals and links capture a variety of different
social relations. Much emphasis has been put on the network topology of social
interactions, however, the multi-dimensional nature of these interactions has
largely been ignored in empirical studies, mostly because of lack of data.
Here, for the first time, we analyze a complete, multi-relational, large social
network of a society consisting of the 300,000 odd players of a massive
multiplayer online game. We extract networks of six different types of
one-to-one interactions between the players. Three of them carry a positive
connotation (friendship, communication, trade), three a negative (enmity, armed
aggression, punishment). We first analyze these types of networks as separate
entities and find that negative interactions differ from positive interactions
by their lower reciprocity, weaker clustering and fatter-tail degree
distribution. We then proceed to explore how the inter-dependence of different
network types determines the organization of the social system. In particular
we study correlations and overlap between different types of links and
demonstrate the tendency of individuals to play different roles in different
networks. As a demonstration of the power of the approach we present the first
empirical large-scale verification of the long-standing structural balance
theory, by focusing on the specific multiplex network of friendship and enmity
relations.Comment: 7 pages, 5 figures, accepted for publication in PNA
Longitudinal measurement of the developing grey matter in preterm subjects using multi-modal MRI.
Preterm birth is a major public health concern, with the severity and occurrence of adverse outcome increasing with earlier delivery. Being born preterm disrupts a time of rapid brain development: in addition to volumetric growth, the cortex folds, myelination is occurring and there are changes on the cellular level. These neurological events have been imaged non-invasively using diffusion-weighted (DW) MRI. In this population, there has been a focus on examining diffusion in the white matter, but the grey matter is also critically important for neurological health. We acquired multi-shell high-resolution diffusion data on 12 infants born at ≤28weeks of gestational age at two time-points: once when stable after birth, and again at term-equivalent age. We used the Neurite Orientation Dispersion and Density Imaging model (NODDI) (Zhang et al., 2012) to analyse the changes in the cerebral cortex and the thalamus, both grey matter regions. We showed region-dependent changes in NODDI parameters over the preterm period, highlighting underlying changes specific to the microstructure. This work is the first time that NODDI parameters have been evaluated in both the cortical and the thalamic grey matter as a function of age in preterm infants, offering a unique insight into neuro-development in this at-risk population
A far-UV survey of three hot, metal-polluted white dwarf stars: WD0455-282, WD0621-376, and WD2211-495
Using newly obtained high-resolution data () from the
\textit{Hubble Space Telescope}, and archival UV data from the \textit{Far
Ultraviolet Spectroscopic Explorer} we have conducted a detailed UV survey of
the three hot, metal-polluted white dwarfs WD0455-282, WD0621-376, and
WD2211-495. Using bespoke model atmospheres we measured , log
, and photospheric abundances for these stars. In conjunction with data from
Gaia we measured masses, radii, and gravitational redshift velocities for our
sample of objects. We compared the measured photospheric abundances with those
predicted by radiative levitation theory, and found that the observed Si
abundances in all three white dwarfs, and the observed Fe abundances in
WD0621-376 and WD2211-495, were larger than those predicted by an order of
magnitude. These findings imply not only an external origin for the metals, but
also ongoing accretion, as the metals not supported by radiative levitation
would sink on extremely short timescales. We measured the radial velocities of
several absorption features along the line of sight to the three objects in our
sample, allowing us to determine the velocities of the photospheric and
interstellar components along the line of sight for each star. Interestingly,
we made detections of circumstellar absorption along the line of sight to
WD0455-282 with three velocity components. To our knowledge, this is the first
such detection of multi-component circumstellar absorption along the line of
sight to a white dwarf.Comment: 19 pages, 23 figures, 8 tables. Accepted for publication in the
Monthly Notices of the Royal Astronomical Societ
Curvature-induced stiffening of a fish fin
How fish modulate their fin stiffness during locomotive manoeuvres remains
unknown. We show that changing the fin's curvature modulates its stiffness.
Modelling the fin as bendable bony rays held together by a membrane, we deduce
that fin curvature is manifested as a misalignment of the principal bending
axes between neighbouring rays. An external force causes neighbouring rays to
bend and splay apart, and thus stretches the membrane. This coupling between
bending the rays and stretching the membrane underlies the increase in
stiffness. Using analysis of a 3D reconstruction of a Mackerel (Scomber
japonicus) pectoral fin, we calculate the range of stiffnesses this fin is
expected to span by changing curvature. The 3D reconstruction shows that, even
in its geometrically flat state, a functional curvature is embedded within the
fin microstructure owing to the morphology of individual rays. Since the
ability of a propulsive surface to transmit force to the surrounding fluid is
limited by its stiffness, the fin curvature controls the coupling between the
fish and its surrounding fluid. Thereby, our results provide mechanical
underpinnings and morphological predictions for the hypothesis that the spanned
range of fin stiffnesses correlates with the behaviour and the ecological niche
of the fish
Improved hepatic arterial fraction estimation using cardiac output correction of arterial input functions for liver DCE MRI
Liver dynamic contrast enhanced (DCE) MRI pharmacokinetic modelling could be useful in the assessment of diffuse liver disease and focal liver lesions, but is compromised by errors in arterial input function (AIF) sampling. In this study, we apply cardiac output correction to arterial input functions (AIFs) for liver dynamic contrast enhanced (DCE) MRI and investigate the effect on dual-input single compartment hepatic perfusion parameter estimation and reproducibility. Thirteen healthy volunteers (28.7±1.94 years, seven males) underwent liver DCE MRI and cardiac output measurement using aortic root phase contrast MRI (PCMRI), with reproducibility (n=9) measured at seven days. Cardiac output AIF correction was undertaken by constraining the first pass AIF enhancement curve using the indicator-dilution principle. Hepatic perfusion parameters with and without cardiac output AIF correction were compared and seven-day reproducibility assessed. Differences between cardiac output corrected and uncorrected liver DCE MRI portal venous (PV) perfusion (p=0.066), total liver blood flow (TLBF)(p=0.101), hepatic arterial (HA) fraction (p=0.895), mean transit time (MTT)(p=0.646), distribution volume (DV)(p=0.890) were not significantly different. Seven-day corrected HA fraction reproducibility was improved (mean difference 0.3%, Bland-Altman 95% Limits-of-Agreement (BA95%LoA) ±27.9%, Coefficient of Variation (CoV) 61.4% vs 9.3%, ±35.5%, 81.7% respectively without correction). Seven-day uncorrected PV perfusion was also improved (mean difference 9.3 ml/min/100g, BA95%LoA ±506.1 ml/min/100g, CoV 64.1% vs 0.9 ml/min/100g, ±562.8 ml/min/100g, 65.1% respectively with correction) as was uncorrected TLBF(mean difference 43.8 ml/min/100g, BA95%LoA ±586.7 ml/min/100g, CoV 58.3% vs 13.3 ml/min/100g, ±661.5 ml/min/100g, 60.9% respectively with correction). Reproducibility of uncorrected MTT was similar (uncorrected mean difference 2.4s, BA95%LoA ±26.7s, CoV 60.8% uncorrected vs 3.7s, ±27.8s, 62.0% respectively with correction), as was and DV (uncorrected mean difference 14.1%, BA95%LoA ±48.2%, CoV 24.7% vs 10.3%, ±46.0%, 23.9% respectively with correction). Cardiac output AIF correction does not significantly affect the estimation of hepatic perfusion parameters but demonstrates improvements in normal volunteer seven-day HA fraction reproducibility, but deterioration in PV perfusion and TLBF reproducibility. Improved HA fraction reproducibility maybe important as arterialisation of liver perfusion is increased in chronic liver disease and within malignant liver lesions
Data acquisition software for the CMS strip tracker
The CMS silicon strip tracker, providing a sensitive area of approximately 200 m2 and comprising 10 million readout channels, has recently been completed at the tracker integration facility at CERN. The strip tracker community is currently working to develop and integrate the online and offline software frameworks, known as XDAQ and CMSSW respectively, for the purposes of data acquisition and detector commissioning and monitoring. Recent developments have seen the integration of many new services and tools within the online data acquisition system, such as event building, online distributed analysis, an online monitoring framework, and data storage management. We review the various software components that comprise the strip tracker data acquisition system, the software architectures used for stand-alone and global data-taking modes. Our experiences in commissioning and operating one of the largest ever silicon micro-strip tracking systems are also reviewed
Monitoring the CMS strip tracker readout system
The CMS Silicon Strip Tracker at the LHC comprises a sensitive area of approximately 200 m2 and 10 million readout channels. Its data acquisition system is based around a custom analogue front-end chip. Both the control and the readout of the front-end electronics are performed by off-detector VME boards in the counting room, which digitise the raw event data and perform zero-suppression and formatting. The data acquisition system uses the CMS online software framework to configure, control and monitor the hardware components and steer the data acquisition. The first data analysis is performed online within the official CMS reconstruction framework, which provides many services, such as distributed analysis, access to geometry and conditions data, and a Data Quality Monitoring tool based on the online physics reconstruction. The data acquisition monitoring of the Strip Tracker uses both the data acquisition and the reconstruction software frameworks in order to provide real-time feedback to shifters on the operational state of the detector, archiving for later analysis and possibly trigger automatic recovery actions in case of errors. Here we review the proposed architecture of the monitoring system and we describe its software components, which are already in place, the various monitoring streams available, and our experiences of operating and monitoring a large-scale system
Simcluster: clustering enumeration gene expression data on the simplex space
Transcript enumeration methods such as SAGE, MPSS, and sequencing-by-synthesis EST "digital northern", are important high-throughput techniques for digital gene expression measurement. As other counting or voting processes, these measurements constitute compositional data exhibiting properties particular to the simplex space where the summation of the components is constrained. These properties are not present on regular Euclidean spaces, on which hybridization-based microarray data is often modeled. Therefore, pattern recognition methods commonly used for microarray data analysis may be non-informative for the data generated by transcript enumeration techniques since they ignore certain fundamental properties of this space.

Here we present a software tool, Simcluster, designed to perform clustering analysis for data on the simplex space. We present Simcluster as a stand-alone command-line C package and as a user-friendly on-line tool. Both versions are available at: http://xerad.systemsbiology.net/simcluster.

Simcluster is designed in accordance with a well-established mathematical framework for compositional data analysis, which provides principled procedures for dealing with the simplex space, and is thus applicable in a number of contexts, including enumeration-based gene expression data
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