Thyroid papillary carcinoma presenting with femoral neck metastasis: a case report

Thyroid carcinoma is relatively uncommon, accounting for 2% of all cancers. Although they usually present as a neck lump, occasionally they may be presented with a distant metastasis. In this study, a 65 year-old woman was referred to our clinic with a pain on her left hip at both rest and walking. A lytic area at the inferior femoral neck was found with plain radiography. To clarify the characteristics of the lesion, left hip magnetic resonance imaging (MRI) had been performed displaying 3×5 cm hyperintense lesion extending from medial part of the left femoral neck to the left femoral head. Laboratory findings were normal. An open biopsy had then been performed from the left femoral neck with a suspicion of a metastatic tumor. After Immunohistochemical assesment diagnosis was consistent with metastatic thyroid papillary cancer. Proximal femoral resection with clear margins were achieved by proximal femur tumor endoprosthesis.  In conclusion, papillary thyroid cancer have an excellent prognosis and doesn’t tend to metastese. But rarely, as seen in our case it can even present with syptoms of metastasic disease. Management strategy is the same as other solitary bone metastasis. Papillary thyroid cancer must be kept in mind as a differential diagnosis in solitary bone metatasis

The negative prognostic impact of bone metastasis with a tumor mass

OBJECTIVE: Typically, bone metastasis causes osteolytic and osteoblastic lesions resulting from the interactions of tumor cells with osteoclasts and osteoblasts. In addition to these interactions, tumor tissues may grow inside bones and cause mass lesions. In the present study, we aimed to demonstrate the negative impact of a tumor mass in a large cohort of patients with bone metastatic cancer. METHODS: Data from 335 patients with bone metastases were retrospectively reviewed. For the analysis, all patients were divided into three subgroups with respect to the type of bone metastasis: osteolytic, osteoblastic, or mixed. The patients were subsequently categorized as having bone metastasis with or without a tumor mass, and statistically significant differences in median survival and 2-year overall survival were observed between these patients (the median survival and 2-year overall survival were respectively 3 months and 16% in patients with a tumor mass and 11 months and 26% in patients without a tumor mass;

Evaluation of patients with fibrotic interstitial lung disease: Preliminary results from the Turk-UIP study

OBJECTIVE: Differential diagnosis of idiopathic pulmonary fibrosis (IPF) is important among fibrotic interstitial lung diseases (ILD). This study aimed to evaluate the rate of IPF in patients with fibrotic ILD and to determine the clinical-laboratory features of patients with and without IPF that would provide the differential diagnosis of IPF. MATERIAL AND METHODS: The study included the patients with the usual interstitial pneumonia (UIP) pattern or possible UIP pattern on thorax high-resolution computed tomography, and/or UIP pattern, probable UIP or possible UIP pattern at lung biopsy according to the 2011 ATS/ERSARS/ALAT guidelines. Demographics and clinical and radiological data of the patients were recorded. All data recorded by researchers was evaluated by radiology and the clinical decision board. RESULTS: A total of 336 patients (253 men, 83 women, age 65.8 +/- 9.0 years) were evaluated. Of the patients with sufficient data for diag-nosis (n=300), the diagnosis was IPF in 121 (40.3%), unclassified idiopathic interstitial pneumonia in 50 (16.7%), combined pulmonary fibrosis and emphysema (CPFE) in 40 (13.3%), and lung involvement of connective tissue disease (CTD) in 16 (5.3%). When 29 patients with definite IPF features were added to the patients with CPFE, the total number of IPF patients reached 150 (50%). Rate of male sex (p<0.001), smoking history (p<0.001), and the presence of clubbing (p=0.001) were significantly high in patients with IPE None of the women <50 years and none of the men <50 years of age without a smoking history were diagnosed with IPE Presence of at least 1 of the symptoms suggestive of CTD, erythrocyte sedimentation rate (ESR), and antinuclear antibody (FANA) positivity rates were significantly higher in the non-IPF group (p<0.001, p=0.029, p=0.009, respectively). CONCLUSION: The rate of IPF among patients with fibrotic ILD was 50%. In the differential diagnosis of IPF, sex, smoking habits, and the presence of clubbing are important. The presence of symptoms related to CTD, ESR elevation, and EANA positivity reduce the likelihood of IPF

Çukurova taban ve kıraç koşullarında bazı ekmeklik ve makarnalık buğday genotiplerinde stoma iletkenliği ve diğer yaprak özellikleri ile verim ve verim unsurları arasındaki ilişkiler üzerine bir araştırma

TEZ5173Tez (Doktora) -- Çukurova Üniversitesi, Adana, 2004.Kaynakça (s. 146-156) var.xıv, 156 s. ; 30 cm.

Çukurova koşullarında farklı buğday genotiplerinin hasat öncesi çimlenmeye duyarlılığı ve dayanıklılığının saptanması

TEZ3056Tez (Yüksek Lisans) -- Çukurova Üniversitesi, Adana, 1999.Kaynakça (s. 72-76) var.viii, 76 s. ; rnk. res. ; 30 cm.

Trabzon İç Kalesi ve Sarayı

The Citadel and the Palace of Trebizond which was the administration center of one of the Byzantine states founded after 1204, constitutes the main theme of our thesis. Although studied by Anthony Bryer and David Winfield as part of the Black Sea Region surveys there is not a monographic study on Trebizond city defense system and the palace of Grand Comnenus and has not been studied in detail. The aim of our thesis is to document the architectural remains which in the today’s city center and to evaluate them with the methods of art history discipline. In the light of the data obtained from field studies and literature surveys, the restitution proposals were presented. Space and buildings organizations and functions of Trabzon ‘Komnenos Kingdom’ palace evaluated together with the architectural style and technical features and associated them with the descriptions from the sources. The construction periods of the palace structures were determined and their dates were tried to be clarified. On the ideology and identity of the dominance formed by the Komnenos Kingdom, the effects of the Byzantine culture and the surrounding cultures to which the roots belong, were examined with their architectural reflections. The documentation and examination of today's physical condition of the Trabzon palace provided important data for understanding of the establishment and organization of the late period palace of the Byzantine Empire. The similarities and differences of the two headquarters were discussed within the scope of our thesis.Trabzon İç Kalesi ve 1204 yılından sonra kurulan Bizans devletlerinden birinin yönetim merkezi olan saray, tezimizin ana temasını oluşturmaktadır. Anthony Bryer ve David Winfield tarafından Karadeniz Bölgesi araştırmalarının bir bölümü olarak ele alınmışsa da Trabzon İç Kalesi ve Sarayını konu alan monografik bir çalışma yapılmamıştır ve ayrıntılı olarak incelenmemiştir. Tez kapsamında bugün kent merkezinde yer alan mimari kalıntıların belgelenmesi ve sanat tarihi disiplini yöntemleri ile değerlendirilmesi amaçlanmıştır. Yapılan arazi çalışmaları ve literatür araştırmaları sonucunda elde edilen veriler ışığında restitüsyon önerileri sunulmuştur. Trabzon ‘Komnenos Krallığı’ sarayının, mekân ve yapı organizasyonları ve işlevleri, mimari üslup ve teknik özellikleri ile birlikte değerlendirilmiş ve dönem kaynaklarındaki tasvirler ile ilişkilendirilmiştir. Saray yapılarının inşa dönemleri belirlenerek tarihleri aydınlatılmaya çalışılmıştır. Komnenos Krallığı’nın oluşturduğu hâkimiyet ideolojisi ve kimliği üzerinde, köklerinin bağlı olduğu Bizans kültürünün ve çevre kültürlerin etkileri, mimari yansımaları ile incelenmiştir Trabzon sarayının bugünkü fiziksel durumunun belgelenmesi ve incelenmesi ile Bizans İmparatorluğu'nun geç dönem sarayının kuruluşu ve organizasyonunun anlaşılması için de önemli veriler sağlanmıştır. İki yönetim merkezinin benzerlik ve farklılıkları tezimiz kapsamında tartışılmıştır

Izmit Körfezi Bizans Dönemi Savunma Yapıları Bağlamında Gebze, Eskihisar Kalesi

The subject of our thesis is Gebze Eskihisar Fortress located in Eskişehir village which the name is the Byzantine period has been accepted as Niketiaton .Tez konumuzu oluşturan Gebze, Eskişehir Kalesi, Bizans dönemindeki adı Niketiaton olduğu düşünülen Eskihisar köyünde yer almaktadır