946 research outputs found
Control of cellular automata
We study the problem of master-slave synchronization and control of
totalistic cellular automata (CA) by putting a fraction of sites of the slave
equal to those of the master and finding the distance between both as a
function of this fraction. We present three control strategies that exploit
local information about the CA, mainly, the number of nonzero Boolean
derivatives. When no local information is used, we speak of synchronization. We
find the critical properties of control and discuss the best control strategy
compared with synchronization
An Inner Gaseous Disk around the Herbig Be Star MWC 147
We present high-spectral-resolution, optical spectra of the Herbig Be star
MWC 147, in which we spectrally resolve several emission lines, including the
[O I] lines at 6300 and 6363\deg. Their highly symmetric, double-peaked line
profiles indicate that the emission originates in a rotating circumstellar
disk. We deconvolve the Doppler-broadened [O I] emission lines to obtain a
measure of emission as a function of distance from the central star. The
resulting radial surface brightness profiles are in agreement with a disk
structure consisting of a flat, inner, gaseous disk and a flared, outer, dust
disk. The transition between these components at 2 to 3 AU corresponds to the
estimated dust sublimation radius. The width of the double-peaked Mg II line at
4481\deg suggests that the inner disk extends to at least 0.10 AU, close to the
corotation radius.Comment: accepted for ApJ Letters (Oct. 2010
Electromagnetic superconductivity of vacuum induced by strong magnetic field: numerical evidence in lattice gauge theory
Using numerical simulations of quenched SU(2) gauge theory we demonstrate
that an external magnetic field leads to spontaneous generation of quark
condensates with quantum numbers of electrically charged rho mesons if the
strength of the magnetic field exceeds the critical value eBc = 0.927(77) GeV^2
or Bc =(1.56 \pm 0.13) 10^{16} Tesla. The condensation of the charged rho
mesons in strong magnetic field is a key feature of the magnetic-field-induced
electromagnetic superconductivity of the vacuum.Comment: 14 pages, 5 figures, 2 tables, elsarticle style; continuum limit is
analyzed, best fit parameters are presented in Table 2, published versio
Towards generalized measures grasping CA dynamics
In this paper we conceive Lyapunov exponents, measuring the rate of separation between two initially close configurations, and Jacobians, expressing the sensitivity of a CA's transition function to its inputs, for cellular automata (CA) based upon irregular tessellations of the n-dimensional Euclidean space. Further, we establish a relationship between both that enables us to derive a mean-field approximation of the upper bound of an irregular CA's maximum Lyapunov exponent. The soundness and usability of these measures is illustrated for a family of 2-state irregular totalistic CA
New lessons on TDP-43 from old N.Ā furzeri killifish
Frontotemporal dementia and amyotrophic lateral sclerosis are fatal and incurable neurodegenerative diseases linked to the pathological aggregation of the TDP-43 protein. This is an essential DNA/RNA-binding protein involved in transcription regulation, pre-RNA processing, and RNA transport. Having suitable animal models to study the mechanisms of TDP-43 aggregation is crucial to develop treatments against disease. We have previously demonstrated that the killifish Nothobranchius furzeri offers the advantage of being the shortest-lived vertebrate with a clear aging phenotype. Here, we show that the two N. furzeri paralogs of TDP-43 share high sequence homology with the human protein and recapitulate its cellular and biophysical behavior. During aging, N. furzeri TDP-43 spontaneously forms insoluble intracellular aggregates with amyloid characteristics and colocalizes with stress granules. Our results propose this organism as a valuable new model of TDP-43-related pathologies making it a powerful tool for the study of disease mechanism
A Genome-Wide Screening and SNPs-to-Genes Approach to Identify Novel Genetic Risk Factors Associated with Frontotemporal Dementia
Frontotemporal dementia (FTD) is the second most prevalent form of early onset dementia after Alzheimerās disease (AD). We performed a case-control association study in an Italian FTD cohort (n = 530) followed by the novel SNPs-to-genes approach and functional annotation analysis. We identified two novel potential loci for FTD. Suggestive SNPs reached p-values ~10-7 and OR > 2.5 (2p16.3) and 1.5 (17q25.3). Suggestive alleles at 17q25.3 identified a disease-associated haplotype causing decreased expression of -cis genes such as RFNG and AATK involved in neuronal genesis and differentiation, and axon outgrowth, respectively. We replicated this locus through the SNPs-to-genes approach. Our functional annotation analysis indicated significant enrichment for functions of the brain (neuronal genesis, differentiation and maturation), the synapse (neurotransmission and synapse plasticity), and elements of the immune system, the latter supporting our recent international FTD-GWAS. This is the largest genome-wide study in Italian FTD to date. Although our results are not conclusive, we set the basis for future replication studies and identification of susceptible molecular mechanisms involved in FTD pathogenesis
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