Colour and musical pitch

Individual reactions to musical stimuli imply the extraction of more information regarding pitch than a uni-dimensional pitch theory can accommodate} the phenomenology of Absolute Pitch (AP) suggests a rare sensitivity to qualities varying on separate dimensions of 'tone-height* and 'tone-chroma'. Introspective reports by synaesthetes indicate the coding of both pitch dimensions in terms parallel to those of simple visual sensation. In EXP/A, normal discrimination of tone-height qualities is reflected in the forced-choice equation of low notes and dark colours, high notes and bright; while in EXP/B a quality consistent with the definition of tone-chroma is evident in the systematic association by chronaesthetes of colour-brightness and the cyclic sequence of fifths that underlies musical tonality relationships. By an objective decision-time technique (EXPS/C and P), the speed of visual judgments is seen to be influenced by auditory pre-stimulation, and vice versa. Individual differences in the intersensory effects observed are dichotomised by reference to measures of neuroticism and Extraversion. A battery of tests for the identification of 'genuine AI” is presented, and further differences noted in the decision-time responses to tone-height and tone-chroma by groups of AP, non-AP, and non-musical subjects. The systematic fluctuation of colour-tore integration measures across the tonality dimension provides objective support for the tone-chroma effect isolated in EXP’/B. Further confirmation of the chroma effect is noted in a questionnaire study of 'key-brightness' ratings, and each of the pitch quality is considered in relation to the discrimination of beats arising from mistimed consonances. The possible coding of chroma in AP is discussed, and implications suggested in areas of imagery and aesthetics, intersensory integration, education, musical psychology and musicology

Modelling turbulent flow of superfluid 4^4He past a rough solid wall in the T=0T = 0 limit

We present a numerical study, using the vortex filament model, of vortex tangles in a flow of pure superfluid $^4$He in the $T = 0$ limit through a channel of width $D = 1$ mm for various applied velocities $V$. The flat channel walls are assumed to be microscopically rough such that vortices terminating at the walls are permanently pinned; vortices are liberated from their pinned ends exclusively through self-reconnection with their images. Sustained tangles were observed, for a period of 80 s, above the critical velocity $V_c \sim 0.20$ cm s$^{-1} = 20 \kappa/D$. The coarse-grained velocity profile was akin to a classical parabolic profile of the laminar Poiseuille flow, albeit with a non-zero slip velocity $\sim$ 0.20 cm s$^{-1}$ at the walls. The friction force was found to be proportional to the applied velocity. The effective kinematic viscosity was $\sim 0.1\kappa$, and effective Reynolds numbers within $\mathrm{Re'} < 15$. The fraction of the polarized vortex length varied between zero in the middle of the channel and $\sim$ 60% within the shear flow regions $\sim D/4$ from the walls. Therefore, we studied a state of polarized ultraquantum (Vinen) turbulence fuelled at short lengthscales by vortex reconnections, including those with vortex images due to the relative motion between the vortex tangle and the pinning rough surface.Comment: 12 pages, 8 figures. Contribution to Journal of Low Temperature Physics QFS2023 Special Editio

Towards Water Soluble Mitochondria-Targeting Theranostic Osmium(II) Triazole-Based Complexes

The complex [Os(btzpy)2][PF6]2 (1, btzpy = 2,6-bis(1-phenyl-1,2,3-triazol-4-yl)pyridine) has been prepared and characterised. Complex 1 exhibits phosphorescence (λem = 595 nm, τ = 937 ns, φem = 9.3% in degassed acetonitrile) in contrast to its known ruthenium(II) analogue, which is non-emissive at room temperature. The complex undergoes significant oxygen-dependent quenching of emission with a 43-fold reduction in luminescence intensity between degassed and aerated acetonitrile solutions, indicating its potential to act as a singlet oxygen sensitiser. Complex 1 underwent counterion metathesis to yield [Os(btzpy)2]Cl2 (1 Cl), which shows near identical optical absorption and emission spectra to those of 1. Direct measurement of the yield of singlet oxygen sensitised by 1 Cl was carried out (φ ( 1O2) = 57%) for air equilibrated acetonitrile solutions. On the basis of these photophysical properties, preliminary cellular uptake and luminescence microscopy imaging studies were conducted. Complex 1 Cl readily entered the cancer cell lines HeLa and U2OS with mitochondrial staining seen and intense emission allowing for imaging at concentrations as low as 1 µM. Long-term toxicity results indicate low toxicity in HeLa cells with LD50 >100 µM. Osmium(II) complexes based on 1 therefore present an excellent platform for the development of novel theranostic agents for anticancer activity

Aboriginal artefacts on the continental shelf reveal ancient drowned cultural landscapes in northwest Australia

This article reports Australia’s first confirmed ancient underwater archaeological sites from the continental shelf, located off the Murujuga coastline in north-western Australia. Details on two underwater sites are reported: Cape Bruguieres, comprising > 260 recorded lithic artefacts at depths down to −2.4 m below sea level, and Flying Foam Passage where the find spot is associated with a submerged freshwater spring at −14 m. The sites were discovered through a purposeful research strategy designed to identify underwater targets, using an iterative process incorporating a variety of aerial and underwater remote sensing techniques and diver investigation within a predictive framework to map the submerged landscape within a depth range of 0–20 m. The condition and context of the lithic artefacts are analysed in order to unravel their depositional and taphonomic history and to corroborate their in situ position on a pre-inundation land surface, taking account of known geomorphological and climatic processes including cyclone activity that could have caused displacement and transportation from adjacent coasts. Geomorphological data and radiometric dates establish the chronological limits of the sites and demonstrate that they cannot be later than 7000 cal BP and 8500 cal BP respectively, based on the dates when they were finally submerged by sea-level rise. Comparison of underwater and onshore lithic assemblages shows differences that are consistent with this chronological interpretation. This article sets a foundation for the research strategies and technologies needed to identify archaeological targets at greater depth on the Australian continental shelf and elsewhere, building on the results presented. Emphasis is also placed on the need for legislation to better protect and manage underwater cultural heritage on the 2 million square kilometres of drowned landscapes that were once available for occupation in Australia, and where a major part of its human history must lie waiting to be discovered

Underwater Shell Middens : Excavation and Remote Sensing of a Submerged Mesolithic site at Hjarnø, Denmark

Shell middens, or shell-matrix deposits, occur in large numbers across the coastlines of the world from the mid-Holocene (c. 6000-5000 cal. BC) onwards, often forming substantial mounds. However, they become smaller, rarer or absent as one goes back into earlier periods, suggesting a world-wide process of economic intensification. Since sea level was generally much lower during these earlier periods, a critical question is the extent to which mounded shell middens could have accumulated on now-submerged palaeoshorelines, and if so, how they were affected by the potentially destructive impact of sea-level rise. Further, and important to modern practice, it is essential that archaeologists consider how such sites can be discovered through underwater investigation. Here we offer a proof of concept that shell middens can survive submergence and can be detected, using systematic investigation of a rare example of a confirmed underwater shell midden at the Mesolithic site of Hjarnø (c. 5300-4300 cal. BC) in Denmark. We compare the excavation results with the results of geophysical survey, explore the problems of distinguishing underwater cultural shell middens from natural shell beds and conclude that shell middens can survive inundation by sea-level rise and can be detected by remote sensing, but require at least minimally invasive sampling to establish their cultural status. We suggest the methods developed may be applicable to coastal and marine sites impacted by postglacial sea-level rise worldwide

The effectiveness of public health interventions to reduce the health impact of climate change:a systematic review of systematic reviews

Climate change is likely to be one of the most important threats to public health in the coming years. Yet despite the large number of papers considering the health impact of climate change, few have considered what public health interventions may be of most value in reducing the disease burden. We aimed to evaluate the effectiveness of public health interventions to reduce the disease burden of high priority climate sensitive diseases

Kidney function in tenofovir disoproxil fumarate-based oral pre-exposure prophylaxis users: a systematic review and meta-analysis of published literature and a multi-country meta-analysis of individual participant data

BACKGROUND: Previous WHO guidance on tenofovir disoproxil fumarate-based oral pre-exposure prophylaxis (PrEP) suggests measuring creatinine levels at PrEP initiation and regularly afterwards, which might represent barriers to PrEP implementation and uptake. We aimed to systematically review published literature on kidney toxicity among tenofovir disoproxil fumarate-based oral PrEP users and conducted an individual participant data meta-analysis (IPDMA) on kidney function among PrEP users in a global implementation project dataset. METHODS: In this systematic review and meta-analysis we searched PubMed up to June 30, 2021, for randomised controlled trials (RCTs) or cohort studies that reported on graded kidney-related adverse events among oral PrEP users (tenofovir disoproxil fumarate-based PrEP alone or in combination with emtricitabine or lamivudine). We extracted summary data and conducted meta-analyses with random-effects models to estimate relative risks of grade 1 and higher and grade 2 and higher kidney-related adverse events, measured by elevated serum creatinine or decline in estimated creatinine clearance or estimated glomerular filtration rate. The IPDMA included (largely unpublished) individual participant data from 17 PrEP implementation projects and two RCTs. Estimated baseline creatinine clearance and creatinine clearance change after initiation were described by age, gender, and comorbidities. We used random-effects regressions to estimate the risk in decline of creatinine clearance to less than 60 mL/min. FINDINGS: We identified 62 unique records and included 17 articles reporting on 11 RCTs with 13 523 participants in meta-analyses. PrEP use was associated with increased risk of grade 1 and higher kidney adverse events (pooled odds ratio [OR] 1·49, 95% CI 1·22-1·81; I2=25%) and grade 2 and higher events (OR 1·75, 0·68-4·49; I2=0%), although the grade 2 and higher association was not statistically significant and events were rare (13 out of 6764 in the intervention group vs six out of 6782 in the control group). The IPDMA included 18 676 individuals from 15 countries (1453 [7·8%] from RCTs) and 79 (0·42%) had a baseline estimated creatinine clearance of less than 60 mL/min (increasing proportions with increasing age). Longitudinal analyses included 14 368 PrEP users and 349 (2·43%) individuals had a decline to less than 60 mL/min creatinine clearance, with higher risks associated with increasing age and baseline creatinine clearance of 60·00-89·99 mL/min (adjusted hazard ratio [aHR] 8·49, 95% CI 6·44-11·20) and less than 60 mL/min (aHR 20·83, 12·83-33·82). INTERPRETATION: RCTs suggest that risks of kidney-related adverse events among tenofovir disoproxil fumarate-based oral PrEP users are increased but generally mild and small. Our global PrEP user analysis found varying risks by age and baseline creatinine clearance. Kidney function screening and monitoring might focus on older individuals, those with baseline creatinine clearance of less than 90 mL/min, and those with kidney-related comorbidities. Less frequent or optional screening among younger individuals without kidney-related comorbidities may reduce barriers to PrEP implementation and use. FUNDING: Unitaid, Bill & Melinda Gates Foundation, WHO

The Burden of Trachoma in Ayod County of Southern Sudan

Trachoma, a neglected tropical disease, is the leading cause of infectious blindness and is targeted for global elimination by the year 2020. We conducted a survey in Ayod County of Jonglei State, Southern Sudan, to determine whether blinding trachoma was a public health problem and to plan interventions to control this disease. We found the burden of trachoma in Ayod to be one of the most severe ever documented. Not only were adults affected by the advanced manifestations of the disease as is typical for older age groups, but young children were also affected. At least one person with clinical signs of trachoma was found in nearly every household, and 1 in 3 households had a person with severe blinding trachoma. Characteristics previously identified as risk factors were ubiquitous among surveyed households, but we were unable to identify why trachoma is so severe in this location. Surgical interventions are needed urgently to improve vision and prevent irreversible blindness in children and adults. Mass antibiotic distribution may alleviate current infections and transmission of trachoma may be reduced if communities adopt the behavior of face washing and safe disposal of human waste. Increasing access to improved water sources may not only improve hygiene but also reduce the spread of guinea worm and other water-borne diseases

Risk Factors for Ocular Chlamydia after Three Mass Azithromycin Distributions

Trachoma, which is the leading infectious cause of blindness worldwide, is caused by repeated ocular infection with Chlamydia trachomatis. Treatment for trachoma includes mass azithromycin treatments to the entire community. The World Health Organization recommends at least 3 rounds of annual mass antibiotic distributions in areas with trachoma, with further mass treatments based on the prevalence of trachoma. However, there are other options for communities that have received several rounds of treatment. For example, programs could continue antibiotic treatments only in those households most likely to have infected individuals. In this study, we performed trachoma monitoring on children from 12 Ethiopian communities one year after a third mass azithromycin treatment, and conducted a household survey at the same time. We found that children were more likely to be infected with ocular chlamydia if they had ocular inflammatory signs or ocular discharge, or if they had missed the preceding antibiotic treatment, had an infected sibling, or came from a larger community. These risk factors suggest that after mass azithromycin treatments, trachoma programs could consider continuing antibiotic distributions to households that have missed prior antibiotic distributions, in households with children who have the clinical signs of trachoma, and in larger communities

Mitochondria-localising DNA-binding biscyclometalated phenyltriazole iridium(III) dipyridophenazene complexes: syntheses and cellular imaging properties

Two new biscyclometalated complexes [Ir(ptzR)2(dppz)]+ (dppz = dipyridophenazene; ptzRH = 4-phenyl-1-benzyl-1,2,3-triazole (1+) and 4-phenyl-1-propyl-1,2,3-triazole (2+)) have been prepared. The hexafluorophosphate salts of these complexes have been fully characterized and, in one case, the X-ray structure of a nitrate salt was obtained. The DNA binding properties of the chloride salts of the complexes were investigated, as well as their cellular uptake by A2780 and MCF7 cell lines. Both complexes display an increase in the intensity of phosphorescence upon titration with duplex DNA, indicating the intercalation of the dppz ligand and, given that they are monocations, the complexes exhibit appreciable DNA binding affinity. Optical microscopy studies reveal that both complexes are taken up by live cancer cell lines displaying cytosol based luminescence. Colocalization studies with commercial probes show high Pearson coefficients with mitotracker dyes confirming that the new complexes specifically localize on mitochondria