The loop-quantum-gravity vertex-amplitude

Spinfoam theories are hoped to provide the dynamics of non-perturbative loop quantum gravity. But a number of their features remain elusive. The best studied one -the euclidean Barrett-Crane model- does not have the boundary state space needed for this, and there are recent indications that, consequently, it may fail to yield the correct low-energy $n$-point functions. These difficulties can be traced to the SO(4) -> SU(2) gauge fixing and the way certain second class constraints are imposed, arguably incorrectly, strongly. We present an alternative model, that can be derived as a bona fide quantization of a Regge discretization of euclidean general relativity, and where the constraints are imposed weakly. Its state space is a natural subspace of the SO(4) spin-network space and matches the SO(3) hamiltonian spin network space. The model provides a long sought SO(4)-covariant vertex amplitude for loop quantum gravity.Comment: 6page

On the relation between the connection and the loop representation of quantum gravity

Using Penrose binor calculus for $SU(2)$ ($SL(2,C)$) tensor expressions, a graphical method for the connection representation of Euclidean Quantum Gravity (real connection) is constructed. It is explicitly shown that: {\it (i)} the recently proposed scalar product in the loop-representation coincide with the Ashtekar-Lewandoski cylindrical measure in the space of connections; {\it (ii)} it is possible to establish a correspondence between the operators in the connection representation and those in the loop representation. The construction is based on embedded spin network, the Penrose graphical method of $SU(2)$ calculus, and the existence of a generalized measure on the space of connections modulo gauge transformations.Comment: 19 pages, ioplppt.sty and epsfig.st

Matrix Elements of Thiemann's Hamiltonian Constraint in Loop Quantum Gravity

We present an explicit computation of matrix elements of the hamiltonian constraint operator in non-perturbative quantum gravity. In particular, we consider the euclidean term of Thiemann's version of the constraint and compute its action on trivalent states, for all its natural orderings. The calculation is performed using graphical techniques from the recoupling theory of colored knots and links. We exhibit the matrix elements of the hamiltonian constraint operator in the spin network basis in compact algebraic form.Comment: 32 pages, 22 eps figures. LaTeX (Using epsfig.sty,ioplppt.sty and bezier.sty). Submited to Classical and Quantum Gravit

Lorentzian spin foam amplitudes: graphical calculus and asymptotics

The amplitude for the 4-simplex in a spin foam model for quantum gravity is defined using a graphical calculus for the unitary representations of the Lorentz group. The asymptotics of this amplitude are studied in the limit when the representation parameters are large, for various cases of boundary data. It is shown that for boundary data corresponding to a Lorentzian simplex, the asymptotic formula has two terms, with phase plus or minus the Lorentzian signature Regge action for the 4-simplex geometry, multiplied by an Immirzi parameter. Other cases of boundary data are also considered, including a surprising contribution from Euclidean signature metrics.Comment: 30 pages. v2: references now appear. v3: presentation greatly improved (particularly diagrammatic calculus). Definition of "Regge state" now the same as in previous work; signs change in final formula as a result. v4: two references adde

Latitude gradient influences the age of onset of rheumatoid arthritis : a worldwide survey

The age of onset of rheumatoid arthritis (RA) is an important outcome predictor. Northern countries report an age of RA onset of around 50 years, but apparently, variability exists across different geographical regions. The objective of the present study is to assess whether the age of onset of RA varies across latitudes worldwide. In a proof-of-concept cross-sectional worldwide survey, rheumatologists from preselected cities interviewed 20 consecutive RA patients regarding the date of RA onset (RAO, when the patient first noted a swollen joint). Other studied variables included location of each city, rheumatologist settings, latitudes (10A degrees increments, south to north), longitudes (three regions), intracountry consistency, and countries' Inequality-adjusted Human Development Index (IHDI). Data from 2481 patients (82% females) were obtained from 126 rheumatologists in 77 cities of 41 countries. Worldwide mean age of RAO was 44 +/- 14 years (95% CI 44-45). In 28% of patients, RA began before age 36 years and before age 46 years in 50% of patients. RAO was 8 years earlier around the Tropic of Cancer when compared with northern latitudes (p <0.001, 95% CI 3.5-13). Multivariate analysis showed that females, western cities, and latitudes around the Tropic of Cancer are associated with younger age of RAO (R (2) 0.045, p <0.001). A positive correlation was found between the age of RAO and IHDI (r = 0.7, p <0.01, R (2) 0.5). RA often begins at an early age and onset varies across latitudes worldwide. We postulate that countries' developmental status and their geographical and geomagnetic location influence the age of RAO.Peer reviewe

Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

Funder: NCI U24CA211006Abstract: The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts

Jahresbericht. Hochspannungsinstitut, Universitaet Karlsruhe. 1985

SIGLETIB: ZN 6772 (1985) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman

Impact of Hepatitis B and Hepatitis C Virus Infections in a Hematology-Oncology Unit at a Children's Hospital in Nicaragua, 1997 to 1999

The risk of acquiring both hepatitis B virus (HBV) and hepatitis C virus (HCV) infections in patients with hematological-oncological disorders has been documented. However, the impact and risk factors for such infections from different geographical areas vary, and the use of both immunological and molecular assays to determine HCV infections has been our approach. Children from a hematology-oncology unit (HOU) in Nicaragua were studied for both HBV and HCV serological markers; studies for the latter used both immunological (anti-HCV) and molecular (HCV RNA) assays. The children from the HOU included patients with leukemia, lymphoma, other neoplasias, and anemia and a smaller group with other hematological diseases. As a control group, children from other units at the same hospital were enrolled, as well as health care workers attending both patient populations. Pertinent clinical and personal data for each child at the HOU were obtained for statistical analysis. Of the 625 children from the HOU enrolled in this study 53.3% were infected with HCV and 29.4% had a prior or present HBV infection. In the child patient control group 3.2% had HBV markers and all were negative for HCV. The group of children with leukemia had the highest infection rate for both HBV and HCV. However, the determination of anti-HCV was found to have an overall low sensitivity in children from HOU, and a retest consisting of a molecular assay to determine HCV RNA was performed to better establish the total number of HCV-infected subjects in this group. The highest independent risk factor for infection was hospitalization. The very high prevalence rates for both HBV and HCV infection in this patient group indicate an urgent need to implement better control of known risk factors and to consider the use of both immunological and molecular assays for HCV diagnostic purposes