294 research outputs found
Image-Based Cardiac Diagnosis With Machine Learning: A Review
Cardiac imaging plays an important role in the diagnosis of cardiovascular disease (CVD). Until now, its role has been limited to visual and quantitative assessment of cardiac structure and function. However, with the advent of big data and machine learning, new opportunities are emerging to build artificial intelligence tools that will directly assist the clinician in the diagnosis of CVDs. This paper presents a thorough review of recent works in this field and provide the reader with a detailed presentation of the machine learning methods that can be further exploited to enable more automated, precise and early diagnosis of most CVDs
Transitions between levels of a quantum bouncer induced by a noise-like perturbation
The probability of transition between levels of a quantum bouncer, induced by
a noise-like perturbation, is calculated. The results are applied to two
sources of noise (vibrations and mirror surface waviness) which might play an
important role in future GRANIT experiment, aiming at precision studies of/with
the neutron quantum bouncer
Crossover quintessence and cosmological history of fundamental "constants"
Crossover quintessence predicts that the time variation of fundamental
couplings is substantially faster at redshift than over the past
few billion years. This could reconcile the reported time variation of the fine
structure constant from quasar absorption lines with severe bounds from
archeo-nuclear physics and high precision tests of the equivalence principle.
We present a model that is consistent with all present data on time varying
couplings, tests of the equivalence principle and cosmology.Comment: numerical example adapted to WMAP,published version,9 pages,LaTe
Lessons from the decoupling limit of Horava gravity
We consider the so-called "healthy" extension of Horava gravity in the limit
where the Stuckelberg field decouples from the graviton. We verify the alleged
strong coupling problem in this limit, under the assumption that no large
dimensionless parameters are put in by hand. This follows from the fact that
the dispersion relation for the Stuckelberg field does not have the desired z =
3 anisotropic scaling in the UV. To get the desired scaling and avoid strong
coupling one has to introduce a low scale of Lorentz violation and retain some
coupling between the graviton and the Stuckelberg field. We also make use of
the foliation preserving symmetry to show how the Stuckelberg field couples to
some violation of energy conservation. We source the Stuckelberg field using a
point particle with a slowly varying mass and show that two such particles feel
a constant attractive force. In this particular example, we see no Vainshtein
effect, and violations of the Equivalence Principle. The latter is probably
generic to other types of source and could potentially be used to place lower
bounds on the scale of Lorentz violation.Comment: 18 pages, 1 figure. Version to appear in JHEP. Conclusions with
respect to strong coupling modified - our strong coupling analysis does not
apply to a low scale of Lorentz violation. Expanded Equivalence Principle
violation discussion, noting it presents a challenge to low scale Lorentz
violation, exactly the scenario designed to cure strong coupling. Other minor
corrections and references adde
The anatomical limits of the posterior vaginal vault toward its use as route for intra-abdominal procedures
Background: The use of natural openings for abdominal surgery started at the beginning of the 21th century. A trans-Douglas endoscopic device has been designed to perform most of the intra-abdominal operations in women through the pouch of Douglas. The posterior vaginal vault is limited in size and could be damaged by an oversized instrument. This study investigates the optimal dimensions of the instrument by measuring the limiting factor in the passage. Methods: In ten female embalmed bodies the transversal and sagittal diameter of the fornix posterior vaginalis was measured by two observers. The pouch of Douglas was filled to its maximal capacity with mouldable latex through an open abdomen. By internal vaginal examination the connective tissue borders of the fornix posterior were palpated and the impression in the cast was measured. The mean value of these two diameters was evaluated in this study. The level of agreement between the observers was calculated. Results: The mean fornix posterior diameter was 2.6 cm (standard deviation, SD 0.5 cm) with a range of 2.0-3.4 cm. The mean difference between the two observers of all measurements was 0.08 cm (not significant). Both observers had an acceptable intraobserver variation. The interobserver agreement was excellent. Conclusion: Instruments with dimensions within the measured limits can be used safely for intra-abdominal operations via the natural orifice of the vagina
Neutralization of (NK-cell-derived) B-cell activating factor by Belimumab restores sensitivity of chronic lymphoid leukemia cells to direct and Rituximab-induced NK lysis.
Natural killer (NK) cells are cytotoxic lymphocytes that substantially contribute to the therapeutic benefit of antitumor antibodies like Rituximab, a crucial component in the treatment of B-cell malignancies. In chronic lymphocytic leukemia (CLL), the ability of NK cells to lyse the malignant cells and to mediate antibody-dependent cellular cytotoxicity upon Fc receptor stimulation is compromised, but the underlying mechanisms are largely unclear. We report here that NK-cells activation-dependently produce the tumor necrosis factor family member 'B-cell activating factor' (BAFF) in soluble form with no detectable surface expression, also in response to Fc receptor triggering by therapeutic CD20-antibodies. BAFF in turn enhanced the metabolic activity of primary CLL cells and impaired direct and Rituximab-induced lysis of CLL cells without affecting NK reactivity per se. The neutralizing BAFF antibody Belimumab, which is approved for treatment of systemic lupus erythematosus, prevented the effects of BAFF on the metabolism of CLL cells and restored their susceptibility to direct and Rituximab-induced NK-cell killing in allogeneic and autologous experimental systems. Our findings unravel the involvement of BAFF in the resistance of CLL cells to NK-cell antitumor immunity and Rituximab treatment and point to a benefit of combinatory approaches employing BAFF-neutralizing drugs in B-cell malignancies
The Nab Experiment: A Precision Measurement of Unpolarized Neutron Beta Decay
Neutron beta decay is one of the most fundamental processes in nuclear
physics and provides sensitive means to uncover the details of the weak
interaction. Neutron beta decay can evaluate the ratio of axial-vector to
vector coupling constants in the standard model, , through
multiple decay correlations. The Nab experiment will carry out measurements of
the electron-neutrino correlation parameter with a precision of and the Fierz interference term to
in unpolarized free neutron beta decay. These results, along with a more
precise measurement of the neutron lifetime, aim to deliver an independent
determination of the ratio with a precision of that will allow an evaluation of and sensitively
test CKM unitarity, independent of nuclear models. Nab utilizes a novel, long
asymmetric spectrometer that guides the decay electron and proton to two large
area silicon detectors in order to precisely determine the electron energy and
an estimation of the proton momentum from the proton time of flight. The Nab
spectrometer is being commissioned at the Fundamental Neutron Physics Beamline
at the Spallation Neutron Source at Oak Ridge National Lab. We present an
overview of the Nab experiment and recent updates on the spectrometer,
analysis, and systematic effects.Comment: Presented at PPNS201
The fundamental constants and their variation: observational status and theoretical motivations
This article describes the various experimental bounds on the variation of
the fundamental constants of nature. After a discussion on the role of
fundamental constants, of their definition and link with metrology, the various
constraints on the variation of the fine structure constant, the gravitational,
weak and strong interactions couplings and the electron to proton mass ratio
are reviewed. This review aims (1) to provide the basics of each measurement,
(2) to show as clearly as possible why it constrains a given constant and (3)
to point out the underlying hypotheses. Such an investigation is of importance
to compare the different results, particularly in view of understanding the
recent claims of the detections of a variation of the fine structure constant
and of the electron to proton mass ratio in quasar absorption spectra. The
theoretical models leading to the prediction of such variation are also
reviewed, including Kaluza-Klein theories, string theories and other
alternative theories and cosmological implications of these results are
discussed. The links with the tests of general relativity are emphasized.Comment: 56 pages, l7 figures, submitted to Rev. Mod. Phy
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