Search for SUSY in (Leptons +) Jets + E_T^miss final states

We study the observability of the squarks and gluinos in CMS at LHC. Classical E_T^miss + jets final state as well as a number of additional multilepton signatures (0 leptons, 1 lepton, 2 leptons of the same sign, 2 leptons of the opposite sign and 3 leptons) are investigated . The detection of these sparticles relies on the observation of an excess of events over Standard Model background expectations. The study is made in the framework of a minimal SU(5) mSUGRA model as a function of m_0, m_1/2 for 4 sets of model parameters : tan(beta) = 2 or 35 and sign(mu) = +/- 1 and for fixed value of A_0 = 0. The CMS detector response is modelled using CMSJET 4.51 fast MC code (non-GEANT). The results obtained are presented as 5 sigma detection contours in the m_0, m_1/2 planes and with optimized selection cuts in various regions of the parameter space. The result of these investigations is that with integrated luminosity L=10^5 pb^-1 the squark and gluino mass reach is about 2.5 TeV and covers most of the interesting parts of parameter space according to neutralino relic density expectations. The influence of signal and background cross-section uncertainties on the reach contours is estimated. The effect of pile-up on signal and background is also discussed. This effect is found to be insignificant for E_T^miss and single lepton signatures, whilst only a minor deterioration is seen for multilepton final states.Comment: 28 pages, 28 figure

Spontaneous Mutations Decrease Sensitivity of Gene Expression to Random Environmental Variation in Caenorhabditis elegans

Biological phenotypes are described as “canalized” if they are robust to minor variation of environment and/or genetic background. The existence of a robust phenotype logically implies that some underlying mechanism must be variable, in the sense of “able to vary”, in order to compensate for variation in the environment and/or genetic effects. Several lines of evidence lead to the conclusion that deleterious mutations predictably render morphological, developmental, and life-history traits more sensitive to small random environmental perturbations - that is, mutations de-canalize the phenotype. and the common (unmutated) ancestor. There was significantly less environmental variance in the MA lines than in the ancestor, both among replicates of the same gene and among genes.Deleterious mutations consistently decrease the within-line component of variance in transcript abundance, which is straightforwardly interpreted as reducing the sensitivity of gene expression to small random variation in the environment. This finding is consistent with the idea that underlying variability in gene expression might be mechanistically responsible for phenotypic robustness

Final Report for the Study on S-Implanted Alloy 22 in 1 M NaCl Solutions

The objective of this study was to examine the effects of high levels of S in the near-surface region on the passivity of Alloy 22, a corrosion resistant Ni-Cr-Mo alloy, in deaerated 1 M NaCl solution. Near-surface concentrations of S up to 2 at.% were achieved in Alloy 22 test specimens by implanting them with S. The S-implanted samples were then evaluated in short-term electrochemical tests in the salt solution and subsequently analyzed with X-ray Photoelectron Spectroscopy (XPS) for film thickness and composition. Specimens tested included non-implanted and annealed Alloy 22 samples, samples implanted with S, and “blanks” implanted with Ar as an ion that would simulate the “damage” of S implantation without the chemical effect. A sample of S-implanted Alloy 22 was also exposed to solution for 29 days and analyzed for evidence of S accumulation at the surface over longer times

Does Mutation Rate Depend on Itself?

Recent evidence suggests that mutation rates are fitness-dependent, broadening our view of the impacts of mutation on the genetic health of populations

High Rate of Large Deletions in Caenorhabditis briggsae Mitochondrial Genome Mutation Processes

Mitochondrial DNA (mtDNA) mutations underlie a variety of human genetic disorders and are associated with the aging process. mtDNA polymorphisms are widely used in a variety of evolutionary applications. Although mtDNA mutation spectra are known to differ between distantly related model organisms, the extent to which mtDNA mutation processes vary between more closely related species and within species remains enigmatic. We analyzed mtDNA divergence in two sets of 250-generation Caenorhabditis briggsae mutation-accumulation (MA) lines, each derived from a different natural isolate progenitor: strain HK104 from Okayama, Japan, and strain PB800 from Ohio, United States. Both sets of C. briggsae MA lines accumulated numerous large heteroplasmic mtDNA deletions, whereas only one similar event was observed in a previous analysis of Caenorhabditis elegans MA line mtDNA. Homopolymer length change mutations were frequent in both sets of C. briggsae MA lines and occurred in both intergenic and protein-coding gene regions. The spectrum of C. briggsae mtDNA base substitution mutations differed from the spectrum previously observed in C. elegans. In C. briggsae, the HK104 MA lines experienced many different base substitution types, whereas the PB800 lines displayed only C:G → T:A transitions, although the difference was not significant. Over half of the mtDNA base substitutions detected in the C. briggsae MA lines were in a heteroplasmic state, whereas all those previously characterized in C. elegans MA line mtDNA were fixed changes, indicating a narrower mtDNA bottleneck in C. elegans as compared with C. briggsae. Our results show that C. briggsae mtDNA is highly susceptible to large deletions and that the mitochondrial mutation process varies between Caenorhabditis nematode species

In Pursuit Of General Behavioral Relations

Efforts to develop behavioral technologies from advances in basic research assume that results from studies with nonhuman subjects can, in some instances, be applied to human behavior. The behavioral principles likely to be most useful for application are those that represent robust general behavioral relations. Basic and applied research on behavioral momentum suggests that there is a general behavioral relation between the persistence of behavior and the rate of reinforcement obtained in a given situation. Understanding the factors that affect behavioral persistence may have important implications for applied behavior analysts that justify studies aimed at establishing the generality and limits of the functional relation between reinforcement rate and behavioral persistence. Strategies for establishing the generality of behavioral relations are reviewed, followed by a brief summary of the evidence for the generality of behavioral momentum

Evolution of a Higher Intracellular Oxidizing Environment in Caenorhabditis elegans under Relaxed Selection

We explored the relationship between relaxed selection, oxidative stress, and spontaneous mutation in a set of mutation-accumulation (MA) lines of the nematode Caenorhabditis elegans and in their common ancestor. We measured steady-state levels of free radicals and oxidatively damaged guanosine nucleosides in the somatic tissues of five MA lines for which nuclear genome base substitution and GC-TA transversion frequencies are known. The two markers of oxidative stress are highly correlated and are elevated in the MA lines relative to the ancestor; point estimates of the per-generation rate of mutational decay (DM) of these measures of oxidative stress are similar to those reported for fitness-related traits. Conversely, there is no significant relationship between either marker of oxidative stress and the per-generation frequencies of base substitution or GC-TA transversion. Although these results provide no direct evidence for a causative relationship between oxidative damage and base substitution mutations, to the extent that oxidative damage may be weakly mutagenic in the germline, the case for condition-dependent mutation is advanced

Flavour and Collider Interplay for SUSY at LHC7

The current 7 TeV run of the LHC experiment shall be able to probe gluino and squark masses up to values larger than 1 TeV. Assuming that hints for SUSY are found in the jets plus missing energy channel by the end of a 5 fb$^{-1}$ run, we explore the flavour constraints on three models with a CMSSM-like spectrum: the CMSSM itself, a Seesaw extension of the CMSSM, and Flavoured CMSSM. In particular, we focus on decays that might have been measured by the time the run is concluded, such as $B_s\to\mu\mu$ and $\mu\to e\gamma$. We also analyse constraints imposed by neutral meson bounds and electric dipole moments. The interplay between collider and flavour experiments is explored through the use of three benchmark scenarios, finding the flavour feedback useful in order to determine the model parameters and to test the consistency of the different models.Comment: 44 pages, 15 figures; v3: minor corrections, added references, updated figures. Version accepted for publicatio