Agreement of Anterior Segment Parameters Obtained From Swept-Source Fourier-Domain and Time-Domain Anterior Segment Optical Coherence Tomography.

PurposeTo assess the interdevice agreement between swept-source Fourier-domain and time-domain anterior segment optical coherence tomography (AS-OCT).MethodsFifty-three eyes from 41 subjects underwent CASIA2 and Visante OCT imaging. One hundred eighty-degree axis images were measured with the built-in two-dimensional analysis software for the swept-source Fourier-domain AS-OCT (CASIA2) and a customized program for the time-domain AS-OCT (Visante OCT). In both devices, we examined the angle opening distance (AOD), trabecular iris space area (TISA), angle recess area (ARA), anterior chamber depth (ACD), anterior chamber width (ACW), and lens vault (LV). Bland-Altman plots and intraclass correlation (ICC) were performed. Orthogonal linear regression assessed any proportional bias.ResultsICC showed strong correlation for LV (0.925) and ACD (0.992) and moderate agreement for ACW (0.801). ICC suggested good agreement for all angle parameters (0.771-0.878) except temporal AOD500 (0.743) and ARA750 (nasal 0.481; temporal 0.481). There was a proportional bias in nasal ARA750 (slope 2.44, 95% confidence interval [CI]: 1.95-3.18), temporal ARA750 (slope 2.57, 95% CI: 2.04-3.40), and nasal TISA500 (slope 1.30, 95% CI: 1.12-1.54). Bland-Altman plots demonstrated in all measured parameters a minimal mean difference between the two devices (-0.089 to 0.063); however, evidence of constant bias was found in nasal AOD250, nasal AOD500, nasal AOD750, nasal ARA750, temporal AOD500, temporal AOD750, temporal ARA750, and ACD. Among the parameters with constant biases, CASIA2 tends to give the larger numbers.ConclusionsBoth devices had generally good agreement. However, there were proportional and constant biases in most angle parameters. Thus, it is not recommended that values be used interchangeably

Two-dimensional Vesicle dynamics under shear flow: effect of confinement

Dynamics of a single vesicle under shear flow between two parallel plates is studied using two-dimensional lattice-Boltzmann simulations. We first present how we adapted the lattice-Boltzmann method to simulate vesicle dynamics, using an approach known from the immersed boundary method. The fluid flow is computed on an Eulerian regular fixed mesh while the location of the vesicle membrane is tracked by a Lagrangian moving mesh. As benchmarking tests, the known vesicle equilibrium shapes in a fluid at rest are found and the dynamical behavior of a vesicle under simple shear flow is being reproduced. Further, we focus on investigating the effect of the confinement on the dynamics, a question that has received little attention so far. In particular, we study how the vesicle steady inclination angle in the tank-treading regime depends on the degree of confinement. The influence of the confinement on the effective viscosity of the composite fluid is also analyzed. At a given reduced volume (the swelling degree) of a vesicle we find that both the inclination angle, and the membrane tank-treading velocity decrease with increasing confinement. At sufficiently large degree of confinement the tank-treading velocity exhibits a non-monotonous dependence on the reduced volume and the effective viscosity shows a nonlinear behavior.Comment: 12 pages, 8 figure

Business artifacts discovery and modeling

Changes in business conditions have forced enterprises to continuously re-engineer their business processes. Traditional business process modeling approaches, being activity-centric, have proven to be inadequate for handling this re-engineering. Recent research has focused on developing data-centric business process modeling approaches based on (business) artifacts. However, formal approaches for deriving artifacts out of business requirements currently do not exist. This paper describes a method for artifact discovery and modeling. The method is illustrated with an example in the purchase order domain. © 2010 Springer-Verlag

Business Artifacts for E-Business Interoperability

Traditional solutions to address interoperability issues are mainly process-centric so that consistent interactions among collaborating enterprises are ensured. These solutions examine interoperability from a technological perspective with focus on exchanging information messages between distributed and heterogeneous applications. However, interoperability from a business perspective has been overlooked in the past due to the complexity of reconciling diverse business strategies, organizational constraints, and IT infrastructures. Business interoperability denotes the ability of diverse enterprises to collaborate together to coproduce added-value products and services. In this chapter, a new line of thinking is promoted whereby interoperability is data-centric instead of process-centric. Business interoperability is dealt with by adopting business artifacts that are able to cross organizational boundaries, and by introducing a stack of three layers - strategy, service, and resource. Artifacts are self-contained business records that include attributes, states, and life cycles that reflect the changes in these states. The artifact concept not only describes a business entity, but also encompasses knowledge about what to process without explaining how to do it. The shift from processes to artifacts makes business interoperability quite simple\u27\u27 to deploy and renders collaboration easy to manage and analyze. The chapter also introduces several interaction patterns that regulate the exchange of artifacts between enterprises. The ideas and proposals in this chapter are discussed via a realistic case-study to demonstrate how business people can seamlessly manage their day-to-day activities and intuitively construct interoperable and sustainable collaborations at the business and technological levels

Business Artifacts for E-Business Interoperability

Traditional solutions to address interoperability issues are mainly process-centric so that consistent interactions among collaborating enterprises are ensured. These solutions examine interoperability from a technological perspective with focus on exchanging information messages between distributed and heterogeneous applications. However, interoperability from a business perspective has been overlooked in the past due to the complexity of reconciling diverse business strategies, organizational constraints, and IT infrastructures. Business interoperability denotes the ability of diverse enterprises to collaborate together to coproduce added-value products and services. In this chapter, a new line of thinking is promoted whereby interoperability is data-centric instead of process-centric. Business interoperability is dealt with by adopting business artifacts that are able to cross organizational boundaries, and by introducing a stack of three layers - strategy, service, and resource. Artifacts are self-contained business records that include attributes, states, and life cycles that reflect the changes in these states. The artifact concept not only describes a business entity, but also encompasses knowledge about what to process without explaining how to do it. The shift from processes to artifacts makes business interoperability quite simple\u27\u27 to deploy and renders collaboration easy to manage and analyze. The chapter also introduces several interaction patterns that regulate the exchange of artifacts between enterprises. The ideas and proposals in this chapter are discussed via a realistic case-study to demonstrate how business people can seamlessly manage their day-to-day activities and intuitively construct interoperable and sustainable collaborations at the business and technological levels

Correlation between thyroid hormone status and hepatic hyperplasia and hypertrophy caused by the peroxisome proliferator-activated receptor alpha agonist Wy-14,643

BACKGROUND: The metabolic inhibitor rotenone inhibits hepatocellular proliferation and the incidence of liver cancer resulting from exposure to the PPARα agonist Wy-14,643, via unknown mechanisms. Since the absence of thyroid hormones diminishes hepatomegaly, an early biomarker for the hepatocarcinogenicity induced by PPARα agonists, this study was undertaken to investigate whether rotenone might interference with the ability of Wy-14,643 to alter the animal thyroid status. METHODS: Male B6C3F1 mice were given Wy-14,643 (100 ppm), rotenone (600 ppm) or a mixture of both, in the feed for 7 days. Bromodeoxyuridine (BrDU), marker of cell replication, was delivered through subcutaneously implanted osmotic mini-pumps. At the end of the experiment, sera were collected and corticosterone and thyroid hormone levels were measured by solid-phase radioimmunoassay kits. In addition, liver tissue samples were stained immunohistochemically for BrDU to determine percentages of labeled cells. Further, cell surface area was determined from images generated by a Zeiss Axioplan microscope equipped with a plan Neofluar ×40 0.75 na objective. Tracings of individual hepatocyte perimeters were then analyzed and cell-surface areas were calculated using MicroMeasure FL-4000. RESULTS: Wy-14,643 caused a significant increase in liver weights, hepatocyte BrDU labeling index (LI), and hepatocyte surface area. In animals which received both Wy-14,643 and rotenone simultaneously, all of these effects were significantly less pronounced compared with mice that received Wy-14,643 alone. Rotenone alone decreased liver weights, LI and surface area. The Free Thyroid Index (FTI), which provides an accurate reflection of the animal's thyroid status, was 5.0 ± 0.3 in control mice. In animals exposed to rotenone, these values decreased to 2.0 ± 0.9, but in animals which received Wy-14,643, levels increased significantly to 7.7 ± 0.9. FTI values decreased to 3.4 ± 0.8 in mice receiving both rotenone and Wy-14,643. CONCLUSION: A strong correlation was observed between the animal thyroid status and both, hepatocyte proliferation (r(2 )= 0.62), and hepatocyte surface area (r(2 )= 0.83). These results support the hypothesis that the thyroid status of the animal plays a role in PPARα-induced hepatocellular proliferation and liver cell enlargement. Both these events are known to contribute to the expression of liver cancer in response to the activation of PPARα

Effect of width and temperature of a vertical parallel plate channel on the transition of the developing thermal boundary layer

Numerical simulations are performed to study the transition of the development of the thermal boundary layer of air along an isothermal heated plate in a large channel which is bounded by an adiabatic plate. In particular, the aim is to investigate the effects of the channel width (b) on the transition of the flow under various plate temperatures. Three different RANS based turbulent k–ε models namely standard, RNG and Realizable with an enhanced wall function are employed in the simulations. The channel width was varied from 0.04 m to 0.45 m and the numerical results of the maximum values of the flow velocity, turbulent kinetic energy were recorded along the vertical axis to examine the critical distance of the developing flow. The results show that the transition delays when the width is increased from 0.04 m to 0.08 m and particularly, the critical distance at b = 0.08 m reaches its maximum with the Grashof number of 2.8 × 1010. However, the critical distance drops when b is increased further from 0.08 m to 0.45 m, indicating an early transition of the flow. The transition remains unaffected by the adiabatic plate when b is greater than 0.45 m. Comparisons of selected numerical results are made with available experimental data of turbulent flow and a satisfied agreement is received

New heat treatment to prepare high quality polycrystalline and single crystal MgB2 in single process

We report here on a new heat treatment to prepare both dense polycrystalline and single crystal MgB2 high quality samples in one single process. Resistivity measurements for polycrystalline part of the sample gives a residual resistivity ratio RRR=16.6 and a very low normal state resistivity rho(40K)= 0.28 microOhmcm. Both SEM and SQUID study on polycrystals reveal the high quality, dense character and well coupling of grain boundaries. On the other hand, the high quality single crystals have a unique shape that resembles the hexagonal crystal structure. SQUID measurements reveals very weak flux pinning character implying our single crystals to be very clean. In this study, we conclude that heat treatment is playing a major rule on the characteristics of both polycrystalline and single crystal MgB2. Samples are thoroughly characterized by x-ray, resistivity, dc SQUID and SEM

Effect of salt intake on beat‐to‐beat blood pressure nonlinear dynamics and entropy in salt‐sensitive versus salt‐protected rats

Blood pressure exhibits substantial short‐ and long‐term variability (BPV). We assessed the hypothesis that the complexity of beat‐to‐beat BPV will be differentially altered in salt‐sensitive hypertensive Dahl rats (SS) versus rats protected from salt‐induced hypertension (SSBN13) maintained on high‐salt versus low‐salt diet. Beat‐to‐beat systolic and diastolic BP series from nine SS and six SSBN13 rats (http://www.physionet.org) were analyzed following 9 weeks on low salt and repeated after 2 weeks on high salt. BP complexity was quantified by detrended fluctuation analysis (DFA), short‐ and long‐range scaling exponents (αS and αL), sample entropy (SampEn), and traditional standard deviation (SD) and coefficient of variation (CV(%)). Mean systolic and diastolic BP increased on high‐salt diet (P < 0.01) particularly for SS rats. SD and CV(%) were similar across groups irrespective of diet. Salt‐sensitive and ‐protected rats exhibited similar complexity indices on low‐salt diet. On high salt, (1) SS rats showed increased scaling exponents or smoother, systolic (P = 0.007 [αL]) and diastolic (P = 0.008 [αL]) BP series; (2) salt‐protected rats showed lower SampEn (less complex) systolic and diastolic BP (P = 0.046); and (3) compared to protected SSBN13 rats, SS showed higher αL for systolic (P = 0.01) and diastolic (P = 0.005) BP. Hypertensive SS rats are more susceptible to high salt with a greater rise in mean BP and reduced complexity. Comparable mean pressures in sensitive and protective rats when on low‐salt diet coupled with similar BPV dynamics suggest a protective role of low‐salt intake in hypertensive rats. This effect likely reflects better coupling of biologic oscillators.We investigated the non‐linear dynamical properties of blood pressure variability, specifically complexity analysis and detrended fluctuation analysis (DFA), of the systolic and diastolic blood pressure time series in 9 salt sensitive and 6 protected rats. We showed that salt sensitive rats exhibit varying non linear BP dynamics compared to protected rats (smoother time series), irrespective of diet; we also showed the differential impat of salt intake on complexity and DFA metrics in both strains of rats.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/122419/1/phy212823_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/122419/2/phy212823.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/122419/3/phy212823-sup-0001-SupInfo.pd

Building Classroom and Organizational Structure Around Positive Cultural Values

The Compass Project is a self-formed group of graduate and undergraduate students in the physical sciences at UC Berkeley. Our goals are to improve undergraduate physics education, provide opportunities for professional development, and increase retention of students-especially those from populations typically underrepresented in the physical sciences. Compass fosters a diverse, collaborative student community by providing a wide range of services, including a summer program and fall/spring seminar courses. We describe Compass's cultural values, discuss how community members are introduced to and help shape those values, and demonstrate how a single set of values informs the structure of both our classroom and organization.We emphasize that all members of the Compass community participate in, and benefit from, our cultural values, regardless of status as student, teacher, or otherwise.Comment: 4 pages, to be submitted to PERC 2012 proceeding