CD8+ T-cells count in acute myocardial infarction in HIV diseases in a predominantly male cohort

Human Immunodeficiency Virus- (HIV-) infected persons have a higher risk for acute myocardial infarction (AMI) than HIV-uninfected persons. Earlier studies suggest that HIV viral load, CD4+ T-cell count, and antiretroviral therapy are associated with cardiovascular disease (CVD) risk. Whether CD8+ T-cell count is associated with CVD risk is not clear. We investigated the association between CD8+ T-cell count and incident AMI in a cohort of 73,398 people (of which 97.3% were men) enrolled in the U.S. Veterans Aging Cohort Study-Virtual Cohort (VACS-VC). Compared to uninfected people, HIV-infected people with high baseline CD8+ T-cell counts (\u3e1065 cells/mm3) had increased AMI risk (adjusted , 95% CI: 1.46 to 2.28). There was evidence that the effect of CD8+ T-cell tertiles on AMI risk differed by CD4+ T-cell level: compared to uninfected people, HIV-infected people with CD4+ T-cell counts ≥200 cells/mm3 had increased AMI risk with high CD8+ T-cell count, while those with CD4+ T-cell counts \u3c200 cells/mm3 had increased AMI risk with low CD8+ T-cell count. CD8+ T-cell counts may add additional AMI risk stratification information beyond that provided by CD4+ T-cell counts alone

Ascorbate Biosynthesis during Early Fruit Development Is the Main Reason for Its Accumulation in Kiwi

Background: Ascorbic acid (AsA) is a unique antioxidant as well as an enzyme cofactor. Although it has multiple roles in plants, it is unclear how its accumulation is controlled at the expression level, especially in sink tissues. Kiwifruit (Actinidia) is well-known for its high ascorbate content. Our objective was to determine whether AsA accumulates in the fruits primarily through biosynthesis or because it is imported from the foliage. Methodology/Principal Findings: We systematically investigated AsA levels, biosynthetic capacity, and mRNA expression of genes involved in AsA biosynthesis in kiwi (A. deliciosa cv. Qinmei). Recycling and AsA localization were also monitored during fruit development and among different tissue types. Over time, the amount of AsA, with its capacity for higher biosynthesis and lower recycling, peaked at 30 days after anthesis (DAA), and then decreased markedly up to 60 DAA before declining more slowly. Expression of key genes showed similar patterns of change, except for L-galactono-1,4-lactone dehydrogenase and L-galactose-1-phosphate phosphatase (GPP). However, GPP had good correlation with the rate of AsA accumulation. The expression of these genes could be detected in phloem of stem as well as petiole of leaf and fruit. Additionally, fruit petioles had greater ascorbate amounts, although that was the site of lowest expression by most genes. Fruit microtubule tissues also had higher AsA. However, exogenous applications of AsA to those petioles did not lead to its transport into fruits, and distribution of ascorbate was cell-specific in the fruits, with more accumulation occurring in large

CD8+ T-cells count in acute myocardial infarction in HIV disease in a predominantly male cohort.

Human Immunodeficiency Virus- (HIV-) infected persons have a higher risk for acute myocardial infarction (AMI) than HIV-uninfected persons. Earlier studies suggest that HIV viral load, CD4+ T-cell count, and antiretroviral therapy are associated with cardiovascular disease (CVD) risk. Whether CD8+ T-cell count is associated with CVD risk is not clear. We investigated the association between CD8+ T-cell count and incident AMI in a cohort of 73,398 people (of which 97.3% were men) enrolled in the U.S. Veterans Aging Cohort Study-Virtual Cohort (VACS-VC). Compared to uninfected people, HIV-infected people with high baseline CD8+ T-cell counts (\u3e1065 cells/mm3) had increased AMI risk (adjusted HR=1.82,

Action to protect the independence and integrity of global health research

Storeng KT, Abimbola S, Balabanova D, et al. Action to protect the independence and integrity of global health research. BMJ GLOBAL HEALTH. 2019;4(3): e001746

Efficacy of Quasi Agro Binding Fibre on the Hybrid Composite Used in Advance Application

The choice for natural fibre obtained from agricultural products is on the rise due to its solution to eco-friendly, environmental and improved mechanical properties concerns. Its abundant availability, low cost, emission reduction and adaptability to base material for composite make it a prime material for selection. This review explores diverse perspectives to the future trend of agro fibre in terms of the thermo-mechanical properties as it applies to advanced application in building structures. It is important to investigate the ecofriendliness of the products of composites from fibres in agricultural wastes so as to achieve a green and sustainable environment. This will come to fore by the combined efforts of both researchers and feedback from building stakeholders

MORPHOMETRICS AND PARASITIC LOAD OF VARROA MITES (ACARI: VARROIDAE) ON COLONIES OF APIS MELLIFERA ADANSONII (HYMENOPTERA: APIDAE) IN SOUTH WESTERN NIGERIA

The parasitic mite Varroa destructor has been the dominant subject of discussion among bee scientists and bee-keepers worldwide. Unfortunately, few literatures has reported the presence of this dreaded honey bee parasites in Sub-Saharan Africa until 2012 when Nigeria was listed among impacted countries. In Sub-Saharan Africa, beekeeping activities have long been plagued with many problems such as low honey yield, frequent bee swarming and colony absconding. A three year field study was carried out to investigate the degree and pattern of infestation, the species and haplotypes of the Varroa mite parasitizing the bees A. m. adansonii in South Western Nigeria. Survey pathologies were carried out using alcohol wash method to dislodge mites from 42 colonies evenly sampled from 14 apiaries selected in Ogun, Osun and Lagos States. Thirty one colonies (73.8%) sampled were infested with Varroa mites, no significant difference were found between the levels of infestation during the dry and wet seasons at confidence interval of 95% (t = 1.542, df = 13, p = 0.147 (p> 0.05)). Average mite load on adult bees range from 0.01 to 0.10 mites per bee and mite load in colonies ranged from 4 to 55 mites per 100 bees. All the colonies can be rated as Varroa tolerant because infestation is not more than 0.15 mites per adult bee. Morphometric analysis of samples of the female mites from colonies in different locations showed there was no significant difference at 95% confidence intervals between the mean body lengths (t = 0.545, df = 19, p = 0.592 (p > 0.05)), mean body widths (t = 0.374, df = 19, p = 0.713 (p > 0.05)) and similarly, between the second and fourth leg segments of the mites. Comparing these morphometric data with the data base of other workers confirmed the only one species found in the area as Varroa destructor. Haplotype confirmation of the species further revealed the mites were the Korean haplotype “K’ type referred to as the virulent type