Reducing liver lesion incidence in the Dutch pork supply chain

Livers with lesions are an cmportant quality aspect among slaughter pig producers and slaughterhouses. Total losses of non-marketable livers with lesions, lower growth and higher feed intake of pigs in the Netherlands in 2003 were estimated at €3.5 million. The major cause of liver lesions is the roundworm Ascaris suum. Worm treatment on the farm can be effective in reducing liver lesions. Before July 2004 an insurance with a fixed premium for each slaughtered pig was in place in the Netherlands to compensate slaughterhouses for pathological lesions. Individual pig producers had low incentcves to take control measures. In July 2004 a new incentive mechanism was introduced: a reduction in the payment of €1 for each pig with a liver lesion. Thcs placed the financcal burden of levers with lesions on the producer, thereby increasing incentives to treat roundworm infections. We analysed the data of 1,104 farms wcth 55,802 deliveries from 2003 to 2006. The mean liver lesion incidence decreased from 8% in 2003 when a collectcve insurance was in place to 5% in 2006, after the change to the price reduction. Of the producers, 68% reduced liver lesion mcidence. Of the producers with an increased incidence, 83% showed a low increase (less than 5%). We conclude that the price reduction was effective in reducing the mean incidence of liver lesions, although large differences between individual producers exist. Further research is needed to determme what causes these large differences

Epidemiological and economic effects of Salmonella control in the pork supply chain

In this paper a salmonella simulation model for the pork production chain is presented to evaluate the epidemiological and economic effects of hygiene measures and price differentiation on Salmonella. Results indicate that the farm stages in the chain are the most important stages to achieve reduction of Salmonella in pork. To reach an acceptable overall level of Salmonella however, every stage has to contribute. With a new system of price differentiation between infected and Salmonella free piglets and pork, the stages can be motivated to take measures for reduction and control of Salmonella

Geotomography with solar and supernova neutrinos

We show how by studying the Earth matter effect on oscillations of solar and supernova neutrinos inside the Earth one can in principle reconstruct the electron number density profile of the Earth. A direct inversion of the oscillation problem is possible due to the existence of a very simple analytic formula for the Earth matter effect on oscillations of solar and supernova neutrinos. From the point of view of the Earth tomography, these oscillations have a number of advantages over the oscillations of the accelerator or atmospheric neutrinos, which stem from the fact that solar and supernova neutrinos are coming to the Earth as mass eigenstates rather than flavour eigenstates. In particular, this allows reconstruction of density profiles even over relatively short neutrino path lengths in the Earth, and also of asymmetric profiles. We study the requirements that future experiments must meet to achieve a given accuracy of the tomography of the Earth.Comment: 35 pages, 7 figures; minor textual changes in section

Fast Light-Driven Motion of Polydopamine Nanomembranes

[Image: see text] The actuation of micro- and nanostructures controlled by external stimuli remains one of the exciting challenges in nanotechnology due to the wealth of fundamental questions and potential applications in energy harvesting, robotics, sensing, biomedicine, and tunable metamaterials. Photoactuation utilizes the conversion of light into motion through reversible chemical and physical processes and enables remote and spatiotemporal control of the actuation. Here, we report a fast light-to-motion conversion in few-nanometer thick bare polydopamine (PDA) membranes stimulated by visible light. Light-induced heating of PDA leads to desorption of water molecules and contraction of membranes in less than 140 μs. Switching off the light leads to a spontaneous expansion in less than 20 ms due to heat dissipation and water adsorption. Our findings demonstrate that pristine PDA membranes are multiresponsive materials that can be harnessed as robust building blocks for soft, micro-, and nanoscale actuators stimulated by light, temperature, and moisture level

Families of spherical caps: spectra and ray limit

We consider a family of surfaces of revolution ranging between a disc and a hemisphere, that is spherical caps. For this family, we study the spectral density in the ray limit and arrive at a trace formula with geodesic polygons describing the spectral fluctuations. When the caps approach the hemisphere the spectrum becomes equally spaced and highly degenerate whereas the derived trace formula breaks down. We discuss its divergence and also derive a different trace formula for this hemispherical case. We next turn to perturbative corrections in the wave number where the work in the literature is done for either flat domains or curved without boundaries. In the present case, we calculate the leading correction explicitly and incorporate it into the semiclassical expression for the fluctuating part of the spectral density. To the best of our knowledge, this is the first calculation of such perturbative corrections in the case of curvature and boundary.Comment: 28 pages, 7 figure

Variational Principles for Stellar Structure

The four equations of stellar structure are reformulated as two alternate pairs of variational principles. Different thermodynamic representations lead to the same hydromechanical equations, but the thermal equations require, not the entropy, but the temperature as the thermal field variable. Our treatment emphasizes the hydrostatic energy and the entropy production rate of luminosity produced and transported. The conceptual and calculational advantages of integral over differential formulations of stellar structure are discussed along with the difficulties in describing stellar chemical evolution by variational principles.Comment: 28 pages, LaTeX, requires AASTeX, 1 PostScript figure, revisions: erratum; accepted by Astrophysical Journa

Exciton bimolecular annihilation dynamics in supramolecular nanostructures of conjugated oligomers

We present femtosecond transient absorption measurements on $\pi$-conjugated supramolecular assemblies in a high pump fluence regime. Oligo(\emph{p}-phenylenevinylene) monofunctionalized with ureido-\emph{s}-triazine (MOPV) self-assembles into chiral stacks in dodecane solution below 75$^{\circ}$C at a concentration of $4\times 10^{-4}$ M. We observe exciton bimolecular annihilation in MOPV stacks at high excitation fluence, indicated by the fluence-dependent decay of $1^1$B$_{u}$-exciton spectral signatures, and by the sub-linear fluence dependence of time- and wavelength-integrated photoluminescence (PL) intensity. These two characteristics are much less pronounced in MOPV solution where the phase equilibrium is shifted significantly away from supramolecular assembly, slightly below the transition temperature. A mesoscopic rate-equation model is applied to extract the bimolecular annihilation rate constant from the excitation fluence dependence of transient absorption and PL signals. The results demonstrate that the bimolecular annihilation rate is very high with a square-root dependence in time. The exciton annihilation results from a combination of fast exciton diffusion and resonance energy transfer. The supramolecular nanostructures studied here have electronic properties that are intermediate between molecular aggregates and polymeric semiconductors

Mutation in Mouse Hei10, an E3 Ubiquitin Ligase, Disrupts Meiotic Crossing Over

Crossing over during meiotic prophase I is required for sexual reproduction in mice and contributes to genome-wide genetic diversity. Here we report on the characterization of an N-ethyl-N-nitrosourea-induced, recessive allele called mei4, which causes sterility in both sexes owing to meiotic defects. In mutant spermatocytes, chromosomes fail to congress properly at the metaphase plate, leading to arrest and apoptosis before the first meiotic division. Mutant oocytes have a similar chromosomal phenotype but in vitro can undergo meiotic divisions and fertilization before arresting. During late meiotic prophase in mei4 mutant males, absence of cyclin dependent kinase 2 and mismatch repair protein association from chromosome cores is correlated with the premature separation of bivalents at diplonema owing to lack of chiasmata. We have identified the causative mutation, a transversion in the 5′ splice donor site of exon 1 in the mouse ortholog of Human Enhancer of Invasion 10 (Hei10; also known as Gm288 in mouse and CCNB1IP1 in human), a putative B-type cyclin E3 ubiquitin ligase. Importantly, orthologs of Hei10 are found exclusively in deuterostomes and not in more ancestral protostomes such as yeast, worms, or flies. The cloning and characterization of the mei4 allele of Hei10 demonstrates a novel link between cell cycle regulation and mismatch repair during prophase I