Active specific immunotherapy for solid tumors

Pinedo, H.M. [Promotor]Scheper, R.J. [Promotor]Eertwegh, A.J.M. van den [Copromotor]Gruijl, T.D. de [Copromotor

Utilizing the Washington Water Markets for the Preservation of Columbia River Basin Salmon Stock

Salmon preservation efforts in Washington State demonstrate the competitive and interconnected nature of water management issues in a water scarce environment. The decline in stream flows in Washington State and the negative impact of low stream flows on anadromous species has severely hindered rehabilitation of endangered Columbia River Basin salmon stocks. Through examining the National Marine Fisheries Service (NMFS) anemic efforts to preserve endangered stocks, primarily through the Endangered Species Act, and through analyzing the Washington Department of Ecology\u27s (DOE) regulatory structure for water market transfers, I propose several changes in the regulatory structure for water that may positively impact the preservation of Columbia River Basin salmon stocks. Decentralizing DOE regulatory authority to enable local water basin planning groups to approve water transfers will decrease transaction costs and improve security of water rights. In turn, programs such as the Washington Water Trust and the incentive based Water Acquisition Program will encourage water rights holder to divert less water from the river. Also, the development of an options market for water transfers will provide further security for water rights holders and will eliminate the need for the antiquated use it or lose it clause. These improvements to Washington State\u27s water markets will help salmon preservationists by easing the process with which the Washington Water Trust can purchase or lease water for in-stream use

Unbiased flux calibration methods for spectral-line radio observations

Position and frequency switching techniques used for the removal of the bandpass dependence of radio astronomical spectra are presented and discussed in detail. Both methods are widely used, although the frequency dependence of the system temperature and/or noise diode is often neglected. This leads to systematic errors in the calibration that potentially have a significant impact on scientific results, especially when using large-bandwidth receivers or performing statistical analyses. We present methods to derive an unbiased calibration using a noise diode, which is part of many heterodyne receivers. We compare the proposed methods and describe the advantages and bottlenecks of the various approaches. Monte Carlo simulations are used to qualitatively investigate both systematics and the error distribution of the reconstructed flux estimates about the correct flux values for the new methods but also the 'classical' case. Finally, the determination of the frequency-dependent noise temperature of the calibration diode using hot-cold measurements or observations of well-known continuum sources is also briefly discussed.Comment: 25 pages, 30 figures. Accepted for publication in A&

Near-Field Radio Holography of Large Reflector Antennas

We summarise the mathematical foundation of the holographic method of measuring the reflector profile of an antenna or radio telescope. In particular, we treat the case, where the signal source is located at a finite distance from the antenna under test, necessitating the inclusion of the so-called Fresnel field terms in the radiation integrals. We assume a ``full phase'' system with reference receiver to provide the reference phase. We describe in some detail the hardware and software implementation of the system used for the holographic measurement of the 12m ALMA prototype submillimeter antennas. We include a description of the practicalities of a measurement and surface setting. The results for both the VertexRSI and AEC (Alcatel-EIE-Consortium) prototype ALMA antennas are presented.Comment: 14 pages, 14 figures, to appear in IEEE Antennas and Propagation Magazine, Vol. 49, No. 5, October 2007. Version 2 includes nice mug-shots of the author

Radio Emission Signatures in the Crab Pulsar

Our high time resolution observations of individual pulses from the Crab pulsar show that both the time and frequency signatures of the interpulse are distinctly different from those of the main pulse. Main pulses can occasionally be resolved into short-lived, relatively narrow-band nanoshots. We believe these nanoshots are produced by soliton collapse in strong plasma turbulence. Interpulses at centimeter wavelengths are very different. Their dynamic spectrum contains regular, microsecond-long emission bands. We have detected these bands, proportionately spaced in frequency, from 4.5 to 10.5 GHz. The bands cannot easily be explained by any current theory of pulsar radio emission; we speculate on possible new models.Comment: 26 pages, 10 figures, to appear in Ap

Imaging the Radio Photospheres of Mira Variables

We have used the VLA at 43 GHz to image the radio continuum emission from o Ceti, R Leo, and W Hya and to precisely locate their SiO maser emission with respect to the star. The radio continuum emission region for all three stars has a diameter close to 5.6 AU. These diameters are similar to those measured at infrared wavelengths in bands containing strong molecular opacity and about twice those measured in line-free regions of the infrared spectrum. Thus, the radio photosphere and the infrared molecular layer appear to be coextensive. The 43 GHz continuum emission is consistent with temperatures near 1600 K and opacity from H-minus free-free interactions. While the continuum image of o Ceti appears nearly circular, both R Leo and W Hya display significant elongations. The SiO masers for all three stars show partial rings with diameters close to 8 AU.Comment: 14 pages; 3 figure

The late time radio emission from SN 1993J at meter wavelengths

We present the investigations of SN 1993J using low frequency observations with the Giant Meterwave Radio Telescope. We analyze the light curves of SN 1993J at 1420, 610, 325 and 243 MHz during $7.5-10$ years since explosion.The supernova has become optically thin early on in the 1420 MHz and 610 MHz bands while it has only recently entered the optically thin phase in the 325 MHz band. The radio light curve in the 235 MHz band is more or less flat. This indicates that the supernova is undergoing a transition from an optically thick to optically thin limit in this frequency band. In addition, we analyze the SN radio spectra at five epochs on day 3000, 3200, 3266, 3460 and 3730 since explosion. Day 3200 spectrum shows a synchrotron cooling break. SN 1993J is the only young supernova for which the magnetic field and the size of the radio emitting region are determined through unrelated methods. Thus the mechanism that controls the evolution of the radio spectra can be identified. We suggest that at all epochs, the synchrotron self absorption mechanism is primarily responsible for the turn-over in the spectra. Light curve models based on free free absorption in homogeneous or inhomogeneous media at high frequencies overpredict the flux densities at low frequencies. The discrepancy is increasingly larger at lower and lower frequencies. We suggest that an extra opacity, sensitively dependent on frequency, is likely to account for the difference at lower frequencies. The evolution of the magnetic field (determined from synchrotron self absorption turn-over) is roughly consistent with $B \propto t^{-1}$. Radio spectral index in the optically thin part evolves from $\alpha \sim 0.8-1.0$ at few tens of days to $\sim 0.6$ in about 10 years.Comment: 37 pages, 9 figures in LaTex; scheduled for ApJ 10 September 2004, v612 issue; send comments to: [email protected]

Thermal design issues and performance of microcalorimeter arrays at sub-Kelvin temperatures

We have produced 5/spl times/5 pixel arrays of microcalorimeters using bulk micromachining. Analysis of our data provides the thermal conductivity parameters of Si/sub x/N/sub y/ 1 /spl mu/m thick membranes at 100 mK. Moreover we find that the thermal transport at 100 mK in Si beams, with dimensions 1.25 mm /spl times/ 0.35mm /spl times/ 35/spl mu/m (length /spl times/ height /spl times/ width) is dominated by ballistic phonons with a mean free path of 110 /spl mu/m. These thermal parameters can be used for modelling future 32 /spl times/ 32 pixel arrays. In addition we operated three pixels in a 5 /spl times/ 5 array of microcalorimeters and find that the pixel to pixel reproducibility is very good. When used as an X-ray microcalorimeter individual pixels have a thermal decay time of 200 /spl mu/s is and their energy resolution is between 6 and 7 eV for 5.89 keV X-ray photons

Cicrumnuclear Supernova Remnants and HII Regions in NGC 253

Archival VLA data has been used to produce arcsecond-resolution 6- and 20-cm images of the region surrounding the nuclear 200-pc (~15") starburst in NGC 253. Twenty-two discrete sources stronger than 0.4 mJy have been detected within ~2 kpc (~3') of the galaxy nucleus; almost all these sources must be associated with the galaxy. None of the radio sources coincides with a detected X-ray binary, so they appear to be due to supernova remnants and H II regions. The region outside the central starburst has a derived radio supernova rate of <~0.1/yr, and may account for at least 20% of the recent star formation in NGC 253. Most of the newly identified sources have steep, nonthermal radio spectra, but several relatively strong thermal sources also exist, containing the equivalent of tens of O5 stars. These stars are spread over tens of parsecs, and are embedded in regions having average ionized gas densities of 20-200/cm^3, much lower than in the most active nuclear star-forming regions in NGC 253 or in the super star clusters seen in other galaxies. The strongest region of thermal emission coincides with a highly reddened area seen at near-infrared wavelengths, possibly containing optically obscured H II regions.Comment: 17 pages, 3 postscript figures, AASTeX format, in press for Astronomical Journal, July 200