183 research outputs found

    Self-reported psychopathic traits and socio-emotional function in 9-12 year old children from the community

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    The aim of this thesis was to enhance our understanding of the concept of psychopathic traits in preadolescent children. It did so by investigating a new assessment tool providing a previously unexplored perspective on psychopathic traits in preadolescent children: that of the child itself. This is important because children are in the unique position to report on feelings, attitudes and behaviors across a range of situations, including the home, the classroom and the playground. Furthermore, it sought to provide a deeper understanding of the nature of psychopathic traits and their relations to problematic socio-emotional functioning. It was concluded that psychopathic traits can be indeed measured reliably and meaningfully through self-report in 9 to 12 year olds. Furthermore, children with high levels of psychopathic traits were shown to suffer from impaired social functioning emotionally, motivationally, and interpersonally. These problems may be important targets for future interventions for this group. Finally, it was demonstrated that that children with psychopathic traits are prone to act aggressively, but also that this aggression is dynamic and is dependent upon circumstances. Their aggression can be attenuated by a salient display of others__ distress. These results suggest that empathy based treatment techniques may reduce aggression in children with psychopathic traits.UBL - phd migration 201

    PRM60 Assessing Relative Clinical Value Across Tumor Types in Metastatic Disease

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    PND9 WITHIN-TRIAL COST EFFECTIVENESS ANALYSIS OF ARIPIPRAZOLE COMPARED TO STANDARD-OF-CARE IN THE SCHIZOPHRENIA TRIAL OF ARIPIPRAZOLE (STAR)

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    Quantum Statistical Physics of Glasses at Low Temperatures

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    We present a quantum statistical analysis of a microscopic mean-field model of structural glasses at low temperatures. The model can be thought of as arising from a random Born von Karman expansion of the full interaction potential. The problem is reduced to a single-site theory formulated in terms of an imaginary-time path integral using replicas to deal with the disorder. We study the physical properties of the system in thermodynamic equilibrium and develop both perturbative and non-perturbative methods to solve the model. The perturbation theory is formulated as a loop expansion in terms of two-particle irreducible diagrams, and is carried to three-loop order in the effective action. The non-perturbative description is investigated in two ways, (i) using a static approximation, and (ii) via Quantum Monte Carlo simulations. Results for the Matsubara correlations at two-loop order perturbation theory are in good agreement with those of the Quantum Monte Carlo simulations. Characteristic low-temperature anomalies of the specific heat are reproduced, both in the non-perturbative static approximation, and from a three-loop perturbative evaluation of the free energy. In the latter case the result so far relies on using Matsubara correlations at two-loop order in the three-loop expressions for the free energy, as self-consistent Matsubara correlations at three-loop order are still unavailable. We propose to justify this by the good agreement of two-loop Matsubara correlations with those obtained non-perturbatively via Quantum Monte Carlo simulations.Comment: 13 pages, 6 figure

    Towards user-adapted training paradigms: physiological responses to physical threat during cognitive task performance

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    Feedback of physiological responses have a great potential to support virtual training paradigms aimed to increase cognitive task performance under stressful threatening conditions. In the current study, we examined the sensitivity of a range of physiological indicators derived from electrodermal activity (EDA), blood pressure (BP) and heart rate (HR) to measure stress as induced by the threat of an electric shock (ES). In contrast to previous work that studied physiological stress responses compared to a rest condition, we compared conditions with high cognitive load combined with stress caused by threat of an ES, to conditions with high cognitive load without such stress. Twenty-five participants performed a cognitively demanding task in an experimental setup. At certain 10 s time intervals, indicated by a continuous tone, participants were either asked to do their best and increase cognitive task performance (non-threat condition), or they were told that they could receive an ES during this interval if cognitive task performance was not high enough (threat condition). Physiological measures, task performance and self-reported measures of stress and workload were analysed. Task performance and self-reported measures of stress and workload were roughly the same in both conditions. Especially EDA measures were affected by the threat of an ES. Threat and non-threat conditions could be distinguished with an across-participant classifier using EDA and BP features with an accuracy of 70%. These results suggest that EDA and BP can be used to evaluate stress coping training paradigms or to individually adapt the stress levels in virtual training environments.Stress-related psychiatric disorders across the life spa

    Cost-effectiveness of a community-integrated home-based depression intervention in older African Americans.

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    OBJECTIVES: To test the cost-effectiveness of a home-based depression program: Beat the Blues (BTB). DESIGN: A cost-effectiveness analysis as part of a previously reported randomized controlled trial that compared BTB with a wait-list control group. SETTING: Community. PARTICIPANTS: English-speaking, cognitively intact (Mini-Mental State Examination score ≥24), African Americans aged 55 and older with depressive symptoms (Patient Health Questionnaire score ≥5) (N = 129). INTERVENTION: Participants randomly assigned to BTB received up to 10 home visits over 4 months from licensed social workers who provided care management, referral and linkage, stress reduction, depression education, and behavioral activation to help participants achieve self-identified goals. MEASUREMENTS: Incremental cost-effectiveness ratios (ICERs) of BTB versus wait-list controls during the 4-month study period. The primary ICER was defined as cost per quality-adjusted life year (QALY) using the Euro Quality of Life 5D (EQ-5D) and secondarily using the Health Utilities Index-3 (HUI-3). Additional ICERs were calculated using clinical measures (cost per depression improvement, cost per depression remission). Costs included BTB intervention, depression-related healthcare visits and medications, caregiver time, and social services. RESULTS: BTB cost per participant per month was 146.BasecaseICERswere146. Base case ICERs were 64,896 per QALY (EQ-5D) and 36,875perQALY(HUI3).Incrementalcostwas36,875 per QALY (HUI-3). Incremental cost was 2,906 per depression improvement and 3,507perremission.Univariateandprobabilisticsensitivityanalysesyieldedacost/QALYrangeof3,507 per remission. Univariate and probabilistic sensitivity analyses yielded a cost/QALY range of 20,500 to $76,500. CONCLUSION: Based on the range of cost-effectiveness values resulting from this study, BTB is a cost-effective treatment for managing depressive symptoms in older African Americans that compares favorably with the cost-effectiveness of previously tested approaches

    The effects of changes in the order of verbal labels and numerical values on children's scores on attitude and rating scales

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    Research with adults has shown that variations in verbal labels and numerical scale values on rating scales can affect the responses given. However, few studies have been conducted with children. The study aimed to examine potential differences in children’s responses to Likert-type rating scales according to their anchor points and scale direction, and to see whether or not such differences were stable over time. 130 British children, aged 9 to 11, completed six sets of Likert-type rating scales, presented in four different ways varying the position of positive labels and numerical values. The results showed, both initially and 8-12 weeks later, that presenting a positive label or a high score on the left of a scale led to significantly higher mean scores than did the other variations. These findings indicate that different arrangements of rating scales can produce different results which has clear implications for the administration of scales with children

    Interpersonal and affective dimensions of psychopathic traits in adolescents : development and validation of a self-report instrument

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    We report the development and psychometric evaluations of a self-report instrument designed to screen for psychopathic traits among mainstream community adolescents. Tests of item functioning were initially conducted with 26 adolescents. In a second study the new instrument was administered to 150 high school adolescents, 73 of who had school records of suspension for antisocial behavior. Exploratory factor analysis yielded a 4-factor structure (Impulsivity α = .73, Self-Centredness α = .70, Callous-Unemotional α = .69, and Manipulativeness α = .83). In a third study involving 328 high school adolescents, 130 with records of suspension for antisocial behaviour, competing measurement models were evaluated using confirmatory factor analysis. The superiority of a first-order model represented by four correlated factors that was invariant across gender and age was confirmed. The findings provide researchers and clinicians with a psychometrically strong, self-report instrument and a greater understanding of psychopathic traits in mainstream adolescents
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