Monophasic synovial sarcoma presenting as a primary ileal mass: a case report and review of the literature

<p>Abstract</p> <p>Introduction</p> <p>Synovial sarcoma is a rare malignant mesenchymal tumor mainly arising in the peri-articular tissue in young adults. There are few cases reported in other areas.</p> <p>Case presentation</p> <p>We report the case of a 29-year-old Saudi woman of Arabian ethnicity with synovial sarcoma arising primarily from the ileum who presented with abdominal pain, a palpable mass and incomplete intestinal obstruction. A literature review was performed to gather information on this rare gastrointestinal tract sarcoma.</p> <p>Conclusions</p> <p>Although it is a rare tumor of the pre-articular tissues, synovial sarcoma can present, in exceedingly rare cases, in unusual anatomical sites such as the gastrointestinal tract. We believe the reporting of all rare or unexpected presentations of sarcoma will eventually improve our understanding of this relatively unusual malignancy.</p

Deformation quantisation for unshifted symplectic structures on derived Artin stacks

We prove that every $0$-shifted symplectic structure on a derived Artin $n$-stack admits a curved $A_{\infty}$ deformation quantisation. The classical method of quantising smooth varieties via quantisations of affine space does not apply in this setting, so we develop a new approach. We construct a map from DQ algebroid quantisations of unshifted symplectic structures on a derived Artin $n$-stack to power series in de Rham cohomology, depending only on a choice of Drinfeld associator. This gives an equivalence between even power series and certain involutive quantisations, which yield anti-involutive curved $A_{\infty}$ deformations of the dg category of perfect complexes. In particular, there is a canonical quantisation associated to every symplectic structure on such a stack, which agrees for smooth varieties with the Kontsevich--Tamarkin quantisation for even associators.Comment: 27pp.; v2 Propositions 1.23 and 3.10 added; v3 several small additions; v4 several changes following referee's comments, to appear in Select

5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5)

The ESO-ESMO 5th international consensus recommendations for advanced breast cancer (ABC 5) provide the latest updates on the management of patients with all breast cancer subtypes, locally advanced breast cancer, follow-up, palliative and supportive care and integrative medicine. Updated diagnostic and treatment algorithms are also provided, as well as several new therapies/indications in advanced breast cancer now approved by the European Medicines Agency

Diminishing benefits of urban living for children and adolescents’ growth and development

AbstractOptimal growth and development in childhood and adolescence is crucial for lifelong health and well-being1–6. Here we used data from 2,325 population-based studies, with measurements of height and weight from 71 million participants, to report the height and body-mass index (BMI) of children and adolescents aged 5–19 years on the basis of rural and urban place of residence in 200 countries and territories from 1990 to 2020. In 1990, children and adolescents residing in cities were taller than their rural counterparts in all but a few high-income countries. By 2020, the urban height advantage became smaller in most countries, and in many high-income western countries it reversed into a small urban-based disadvantage. The exception was for boys in most countries in sub-Saharan Africa and in some countries in Oceania, south Asia and the region of central Asia, Middle East and north Africa. In these countries, successive cohorts of boys from rural places either did not gain height or possibly became shorter, and hence fell further behind their urban peers. The difference between the age-standardized mean BMI of children in urban and rural areas was &lt;1.1 kg m–2 in the vast majority of countries. Within this small range, BMI increased slightly more in cities than in rural areas, except in south Asia, sub-Saharan Africa and some countries in central and eastern Europe. Our results show that in much of the world, the growth and developmental advantages of living in cities have diminished in the twenty-first century, whereas in much of sub-Saharan Africa they have amplified.</jats:p

Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults

Background Underweight and obesity are associated with adverse health outcomes throughout the life course. We estimated the individual and combined prevalence of underweight or thinness and obesity, and their changes, from 1990 to 2022 for adults and school-aged children and adolescents in 200 countries and territories. Methods We used data from 3663 population-based studies with 222 million participants that measured height and weight in representative samples of the general population. We used a Bayesian hierarchical model to estimate trends in the prevalence of different BMI categories, separately for adults (age ≥20 years) and school-aged children and adolescents (age 5–19 years), from 1990 to 2022 for 200 countries and territories. For adults, we report the individual and combined prevalence of underweight (BMI 2 SD above the median). Findings From 1990 to 2022, the combined prevalence of underweight and obesity in adults decreased in 11 countries (6%) for women and 17 (9%) for men with a posterior probability of at least 0·80 that the observed changes were true decreases. The combined prevalence increased in 162 countries (81%) for women and 140 countries (70%) for men with a posterior probability of at least 0·80. In 2022, the combined prevalence of underweight and obesity was highest in island nations in the Caribbean and Polynesia and Micronesia, and countries in the Middle East and north Africa. Obesity prevalence was higher than underweight with posterior probability of at least 0·80 in 177 countries (89%) for women and 145 (73%) for men in 2022, whereas the converse was true in 16 countries (8%) for women, and 39 (20%) for men. From 1990 to 2022, the combined prevalence of thinness and obesity decreased among girls in five countries (3%) and among boys in 15 countries (8%) with a posterior probability of at least 0·80, and increased among girls in 140 countries (70%) and boys in 137 countries (69%) with a posterior probability of at least 0·80. The countries with highest combined prevalence of thinness and obesity in school-aged children and adolescents in 2022 were in Polynesia and Micronesia and the Caribbean for both sexes, and Chile and Qatar for boys. Combined prevalence was also high in some countries in south Asia, such as India and Pakistan, where thinness remained prevalent despite having declined. In 2022, obesity in school-aged children and adolescents was more prevalent than thinness with a posterior probability of at least 0·80 among girls in 133 countries (67%) and boys in 125 countries (63%), whereas the converse was true in 35 countries (18%) and 42 countries (21%), respectively. In almost all countries for both adults and school-aged children and adolescents, the increases in double burden were driven by increases in obesity, and decreases in double burden by declining https://researchonline.ljmu.ac.uk/images/research_banner_face_lab_290.jpgunderweight or thinness. Interpretation The combined burden of underweight and obesity has increased in most countries, driven by an increase in obesity, while underweight and thinness remain prevalent in south Asia and parts of Africa. A healthy nutrition transition that enhances access to nutritious foods is needed to address the remaining burden of underweight while curbing and reversing the increase in obesity

Plangebied Dobbestraat en ijsbaan te Woltersum

Uit de resultaten van het booronderzoek is gebleken dat ter plaatse van de Dobbestraat een wierdelaag aanwezig is op een diepte vanaf 0,1 m –mv (0,65 m NAP). Tevens zijn in boringen 3 en 6 mogelijk archeologische sporen aangetroffen. De kans wordt daarom groot geacht dat zich binnen het onderzoeksgebied aan de Dobbestraat intacte wierdegerelateerde resten bevinden. Daarnaast zijn in de boringen 1 en 6 direct onder de bouwvoor/ophogingslaag resten van een muur/fundering aangetroffen. Mogelijk betreft dit resten van bebouwing uit (het begin van) de vorige eeuw. Ter plaatse van de ijsbaan locatie zijn geen archeologisch relevante lagen aangetroffen

Plangebied Vrijburgh, fase 2 en 3 te Drachten

Aangezien tijdens het booronderzoek geen veen is aangetroffen, kan worden geconcludeerd dat in het verleden waarschijnlijk ontginningsactiviteiten hebben plaatsgevonden die tot bodemverstoringen hebben geleid. Daarnaast hebben ook andere landbouwactiviteiten in het verleden (zoals ploegen en egaliseren) het archeologisch relevante niveau (top van het dekzand) verstoord. Hoewel niet volledig is uit te sluiten dat binnen het plangebied archeologische sporen in het dekzand/keizand zijn ingegraven, kan de verwachting voor archeologische resten uit de ijzertijd - middeleeuwen worden bijgesteld naar laag. De verwachting voor archeologische resten uit de steentijd - bronstijd blijft laag

Plangebied Hink Oostingstraat in 't Zandt

Uit het veldonderzoek blijkt dat de bodemopbouw binnen het plangebied bestaat uit een verstoorde toplaag op kwelderafzettingen op wadafzettingen. Omdat men zich in de (late) middeleeuwen direct op de kwelder(wal) vestigde, kunnen in de kwelderafzettingen archeologische sporen aanwezig zijn

Zendmast Muldersweg nabij Appelscha

Tijdens het veldwerk is gebleken dat de bodem in het plangebied is verstoord door graafwerkzaamheden in het verleden. Onder de bouwvoor/verstoorde laag volgt direct het dekzand; C- horizont. De oorspronkelijke top van het dekzand, het archeologisch relevante niveau, is niet meer aanwezig. Er zijn geen archeologische indicatoren aangetroffen

Aanleg bermsloot langs fietspad "Stroobossertrekvaart" nabij Dokkum

• Zijn de archeologisch relevante niveaus intact? De bodemopbouw in het plangebied bestaat uit opgebrachte grond en/of een bouw-voor/verstoorde laag op klei op veen op pleistoceen zand. Het niveau uit de IJzertijd en Middeleeuwen/Nieuwe tijd (het klei- en veenpakket) is grotendeels intact. Door landbouw activiteiten is de top van het kleipakket enigszins verstoord. Het niveau uit de Steentijd – Bronstijd (het pleistocene zand) is intact. • Heeft dat gevolgen voor de archeologische verwachting? Voor de tracédelen A1 en A2 kan door het ontbreken van archeologische indicatoren worden bijgesteld naar laag voor beide perioden. Voor tracédeel B blijft de archeologische verwachting voor de voor nederzettingen uit de Steentijd - Bronstijd hoog en voor de Middeleeuwen/Nieuwe tijd middelhoog tot hoog. • Zijn er aanwijzingen voor (grotere) archeologische nederzettingen? In de tracédelen A1 en A2 zijn geen archeologische indicatoren aangetroffen. Aanwijzingen voor (grotere) archeologische nederzettingen ontbreken in deze tracédelen. In tracédeel B is in één boring houtskool in de top van het pleistocene zand aangetroffen. De top van dit zand ligt hier aanzienlijk hoger dan in de tracédelen A1 en A2